RU2099335C1 - Диароматические соединения - Google Patents

Диароматические соединения Download PDF

Info

Publication number
RU2099335C1
RU2099335C1 SU925011431A SU5011431A RU2099335C1 RU 2099335 C1 RU2099335 C1 RU 2099335C1 SU 925011431 A SU925011431 A SU 925011431A SU 5011431 A SU5011431 A SU 5011431A RU 2099335 C1 RU2099335 C1 RU 2099335C1
Authority
RU
Russia
Prior art keywords
carbonyl
piperazine
pyridinyl
methylethylamino
indolyl
Prior art date
Application number
SU925011431A
Other languages
English (en)
Russian (ru)
Inventor
Ли Ромеро Донна
Аллен Митчелл Марк
Чарльз Томас Ричард
Реймонд Палмер Джон
Гэри Тарпли Вилльям
Адриан Аристофф Пол
В.Смитт Герман
Original Assignee
Дзе Апджон Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Апджон Компани filed Critical Дзе Апджон Компани
Application granted granted Critical
Publication of RU2099335C1 publication Critical patent/RU2099335C1/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SU925011431A 1989-12-28 1990-12-24 Диароматические соединения RU2099335C1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US45748389A 1989-12-28 1989-12-28
US07/457,483 1989-12-28
US60383890A 1990-10-25 1990-10-25
US07/603,838 1990-10-25
PCT/US1990/007390 WO1991009849A1 (en) 1989-12-28 1990-12-24 Diaromatic substituted anti-aids compounds

Publications (1)

Publication Number Publication Date
RU2099335C1 true RU2099335C1 (ru) 1997-12-20

Family

ID=27038621

Family Applications (1)

Application Number Title Priority Date Filing Date
SU925011431A RU2099335C1 (ru) 1989-12-28 1990-12-24 Диароматические соединения

Country Status (15)

Country Link
EP (1) EP0507861B1 (https=)
JP (1) JPH07110852B2 (https=)
KR (1) KR0179637B1 (https=)
AT (1) ATE142621T1 (https=)
AU (1) AU654808B2 (https=)
CA (1) CA2071529C (https=)
DE (1) DE69028552T2 (https=)
DK (1) DK0507861T3 (https=)
ES (1) ES2093090T3 (https=)
GR (1) GR3021655T3 (https=)
HK (1) HK1002235A1 (https=)
HU (2) HUT61296A (https=)
MX (1) MX9203454A (https=)
RU (1) RU2099335C1 (https=)
WO (1) WO1991009849A1 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2217421C2 (ru) * 1998-03-26 2003-11-27 Шионоги & Ко., Лтд. Производные индола, обладающие антивирусной активностью
RU2256659C2 (ru) * 1999-07-22 2005-07-20 Мерк Патент Гмбх Производные индола
RU2259372C2 (ru) * 2000-02-22 2005-08-27 Бристол-Маерс Сквибб Компани Производные азаиндола
RU2318821C2 (ru) * 2002-06-21 2008-03-10 Н.В.Органон Производное 1-[(индол-3-ил) карбонил] пиперазина, фармацевтическая композиция на его основе и его применение
RU2325389C2 (ru) * 2002-08-07 2008-05-27 Бристол-Маерс Сквибб Компани Композиция и производные замещенного азаиндолоксоацетапиперазина, обладающие противовирусной активностью
RU2374256C2 (ru) * 2004-03-15 2009-11-27 Бристол-Маерс Сквибб Компани Пиперазиновые пролекарства и замещенные пиперидиновые противовирусные агенты

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5563142A (en) * 1989-12-28 1996-10-08 The Upjohn Company Diaromatic substituted compounds as anti-HIV-1 agents
US5599930A (en) * 1991-07-03 1997-02-04 The Upjohn Company Substituted indoles as anti-AIDS pharmaceuticals
DE69217224T2 (de) * 1991-07-03 1997-06-05 Pharmacia & Upjohn Co., Kalamazoo, Mich. Substituierte indole als anti-aids pharmaceutische zubereitungen
WO1993005020A1 (en) * 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles as inhibitors of hiv reverse transcriptase
US5527819A (en) * 1991-09-06 1996-06-18 Merck & Co., Inc. Inhibitors of HIV reverse transcriptase
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
PH30258A (en) * 1991-12-30 1997-02-05 Janssen Pharmaceutica Nv Heterocycle-substituted benzenemethanamine derivatives
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
ATE184787T1 (de) * 1992-05-13 1999-10-15 Wellcome Found Therapeutische kombinationen
US5665720A (en) * 1992-08-07 1997-09-09 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
HUT74614A (en) * 1993-02-24 1997-01-28 Merck & Co Inc Nindol derivates suitable for treatment of infection by hiv and pharmaceutical compositions containing them
US6169107B1 (en) 1993-04-28 2001-01-02 Sumitomo Pharmaceutical Co., Ltd. Indoloylguanidine derivatives
SK282424B6 (sk) * 1994-04-15 2002-01-07 Pharmacia + Upjohn Company "S" a "T" kryštalické formy 1-[5-metánsulfónamidoindolyl-2- karbonyl]-4-[3-(1-metyl-etylamino)-2-pyridinyl] piperazínu
TW406075B (en) * 1994-12-13 2000-09-21 Upjohn Co Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
UA56992C2 (uk) * 1995-05-08 2003-06-16 Фармація Енд Апджон Компані <font face="Symbol">a</font>-ПІРИМІДИНТІОАЛКІЛЗАМІЩЕНІ ТА <font face="Symbol">a</font>-ПІРИМІДИНОКСОАЛКІЛЗАМІЩЕНІ СПОЛУКИ
AT403803B (de) 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
CN1254334A (zh) * 1997-05-27 2000-05-24 同和药品工业株式会社 新颖的对苯二甲酰胺衍生物
JP4219554B2 (ja) * 1997-10-01 2009-02-04 協和発酵キリン株式会社 ベンゾフラン誘導体
ATE491689T1 (de) * 1997-10-27 2011-01-15 Neurosearch As Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren
US6228880B1 (en) 1998-04-13 2001-05-08 American Home Products Corp 4-amino-(ethylamino)-oxindole dopamine autoreceptor agonists
JP4865129B2 (ja) 1999-01-13 2012-02-01 ザ・リサーチ・ファウンデーション・オブ・ステイト・ユニバーシティ・オブ・ニューヨーク タンパク質キナーゼ阻害剤を設計するための新規の方法
US7635690B2 (en) * 1999-01-22 2009-12-22 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US7115584B2 (en) * 1999-01-22 2006-10-03 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
WO2002072548A2 (en) * 2001-03-09 2002-09-19 Ortho-Mcneil Pharmaceutical, Inc. Heterocyclic compounds and their use as histamine h4 ligands.
US7005445B2 (en) 2001-10-22 2006-02-28 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors and methods for designing them
US7129225B2 (en) 2001-10-22 2006-10-31 The Research Foundation Of State University Of New York Protection against and treatment of hearing loss
WO2004022060A2 (en) * 2002-09-06 2004-03-18 Janssen Pharmaceutica, N.V. (1h-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine h4-receptor antagonists for the treatment of inflammatory and allergic disorders
WO2004108671A1 (en) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
US7829712B2 (en) 2004-09-20 2010-11-09 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
CA2580762A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
CA2580857A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AR051091A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
EP1807085B1 (en) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AU2005286648A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
EP2289510A1 (en) 2004-09-20 2011-03-02 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
EP1870401A4 (en) 2005-04-06 2011-06-15 Msd Kk 1,4-SUBSTITUTED PIPERAZINE DERIVATIVE
AU2006343359A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
CN100463907C (zh) * 2006-02-10 2009-02-25 上海医药工业研究院 一种1-(5-硝基-1h-吲哚-2-羰基)-4-{3-[(1-甲基乙基)氨基]-2-吡啶}哌嗪的制备方法
CA2655933C (en) 2006-06-23 2014-09-09 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in cancer
US7838542B2 (en) 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
BRPI0915720A2 (pt) 2008-06-12 2015-08-04 Janssen Pharmaceutica Nv Moduladores de diaminopiridina, pirimidina, e piridazina do receptor de histamina h4
WO2010025375A1 (en) * 2008-08-29 2010-03-04 Treventis Corporation Compositions and methods of treating amyloid disease
KR20110084280A (ko) 2008-11-03 2011-07-21 알레시아 바이오쎄라퓨틱스 인코포레이티드 종양 항원의 생물 활성을 특이적으로 차단하는 항체
WO2010141805A1 (en) 2009-06-05 2010-12-09 Janssen Pharmaceutica Nv Heterocyclic amides as modulators of trpa1
CN114010776A (zh) 2010-06-09 2022-02-08 疫苗技术股份有限公司 用于增强抗逆转录病毒治疗的hiv感染者的治疗性免疫
RS59080B1 (sr) 2011-03-31 2019-09-30 Adc Therapeutics Sa Antitela protiv antigena 1 povezanog sa bubrezima i njihovi fragmenti koji se vezuju za antigen
CN102952062B (zh) * 2011-08-12 2016-06-08 中国医学科学院医药生物技术研究所 取代苯并杂环类化合物及其制备方法和应用
DE102011113749A1 (de) * 2011-09-14 2013-03-14 Aicuris Gmbh & Co. Kg Sulfonsäuresalze Heterocyclylamid-substituiertr Imidazole
HRP20190946T1 (hr) 2012-01-09 2019-07-26 Adc Therapeutics Sa Sredstva za liječenje trostruko negativnog raka dojke
CA2889903C (en) 2012-10-29 2021-03-09 Manjinder Singh Phull Antiviral phosphonate analogues and process for preparation thereof
CN103351328A (zh) * 2013-07-27 2013-10-16 上海泰坦科技股份有限公司 一种氟代吲哚酯的制备方法
CN109776403B (zh) * 2019-02-22 2022-06-14 吉林大学 一种制备1-叔丁氧羰基-4-[3-(烷基胺基)-2-吡啶基]哌嗪的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302589A (en) * 1980-05-08 1981-11-24 American Cyanamid Company Cis-mono and disubstituted-2-methyl-3-[(piperazinyl) and (piperidino)ethyl]indolines, intermediates for their preparation and methods of preparation
US4613598A (en) * 1984-03-13 1986-09-23 Mitsubishi Chemical Industries Limited Piperazine derivatives and their acid addition salts
CA1338012C (en) * 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WO 88/08424, кл. C 07 D 401/14, 1988. US, патент, 4302589, кл. A 61 K 31/445, 1981. EP, патент, 0345808, кл. C 07 D 401/12, 1989. EP, патент, 0154969, кл. C 07 D 295/08, 1985. *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2217421C2 (ru) * 1998-03-26 2003-11-27 Шионоги & Ко., Лтд. Производные индола, обладающие антивирусной активностью
RU2256659C2 (ru) * 1999-07-22 2005-07-20 Мерк Патент Гмбх Производные индола
RU2259372C2 (ru) * 2000-02-22 2005-08-27 Бристол-Маерс Сквибб Компани Производные азаиндола
RU2318821C2 (ru) * 2002-06-21 2008-03-10 Н.В.Органон Производное 1-[(индол-3-ил) карбонил] пиперазина, фармацевтическая композиция на его основе и его применение
RU2325389C2 (ru) * 2002-08-07 2008-05-27 Бристол-Маерс Сквибб Компани Композиция и производные замещенного азаиндолоксоацетапиперазина, обладающие противовирусной активностью
RU2374256C2 (ru) * 2004-03-15 2009-11-27 Бристол-Маерс Сквибб Компани Пиперазиновые пролекарства и замещенные пиперидиновые противовирусные агенты

Also Published As

Publication number Publication date
WO1991009849A1 (en) 1991-07-11
HU211241A9 (en) 1995-11-28
GR3021655T3 (en) 1997-02-28
EP0507861B1 (en) 1996-09-11
HUT61296A (en) 1992-12-28
KR0179637B1 (en) 1999-03-20
DK0507861T3 (https=) 1997-03-03
CA2071529C (en) 2001-03-20
DE69028552D1 (de) 1996-10-17
AU7173291A (en) 1991-07-24
HU9202131D0 (en) 1992-10-28
KR927003556A (ko) 1992-12-18
JPH07110852B2 (ja) 1995-11-29
ES2093090T3 (es) 1996-12-16
CA2071529A1 (en) 1991-06-29
EP0507861A1 (en) 1992-10-14
DE69028552T2 (de) 1997-03-06
MX9203454A (es) 1992-08-01
AU654808B2 (en) 1994-11-24
HK1002235A1 (en) 1998-08-07
ATE142621T1 (de) 1996-09-15
JPH05503929A (ja) 1993-06-24

Similar Documents

Publication Publication Date Title
RU2099335C1 (ru) Диароматические соединения
US5563142A (en) Diaromatic substituted compounds as anti-HIV-1 agents
JP3119485B2 (ja) 抗−エイズ薬としての置換インドール類
JP6728208B2 (ja) ベンザゼピンジカルボキサミド化合物
HK1002235B (en) Diaromatic substituted anti-aids compounds
US5866589A (en) Alkyl substituted piperadinyl and piperazinyl anti-AIDS compounds
CA3211347A1 (en) Indazole based compounds and associated methods of use
CA2908098A1 (en) Mk2 inhibitors and uses thereof
JPH11513382A (ja) ５員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法
HUE025313T2 (en) Piperidine and piperazine-1-carboxylic acid amide derivatives and related compounds as Fatty Acid Hydrolase (FAAH) modulators for the treatment of anxiety, pain and other conditions
JP3165181B2 (ja) 新規の３−アリールインドールおよび３−アリールインダゾール誘導体
BG99879A (bg) Инхибитори на нiv реверсивна транскриптаза
JP5281890B2 (ja) Ｎ−（ヘテロアリール）−１−ヘテロアリールアルキル−１ｈ−インドール−２−カルボキサミド誘導体、その調製およびその使用
US5599930A (en) Substituted indoles as anti-AIDS pharmaceuticals
WO2008022747A1 (en) Tricyclic lactam derivatives, their manufacture and use as pharmaceutical agents
RU2385866C2 (ru) Новые производные 2,6-диаминопиридин-3-она
WO2023245123A2 (en) Multi-cyclic irak and flt3 inhibiting compounds and uses thereof
LV10264B (en) Diaryl- or diheteroaryl-substituted anti-aids compounds
CN110655516A (zh) 一种抗凝血药物的晶型
HK1123050B (en) N-(heteroaryl)-1-heteroarylalkyl-1h-indole-2-carboxamide derivatives, preparation and use thereof