RU2092558C1 - Способ получения оптически активных s-циангидринов - Google Patents

Способ получения оптически активных s-циангидринов Download PDF

Info

Publication number
RU2092558C1
RU2092558C1 RU9293033481A RU93033481A RU2092558C1 RU 2092558 C1 RU2092558 C1 RU 2092558C1 RU 9293033481 A RU9293033481 A RU 9293033481A RU 93033481 A RU93033481 A RU 93033481A RU 2092558 C1 RU2092558 C1 RU 2092558C1
Authority
RU
Russia
Prior art keywords
membrane
enzyme
aldehyde
binding agent
reaction
Prior art date
Application number
RU9293033481A
Other languages
English (en)
Russian (ru)
Other versions
RU93033481A (ru
Inventor
Вальтер Андриский Стефен
Голдберг Брюс
Original Assignee
Фмк Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фмк Корпорейшн filed Critical Фмк Корпорейшн
Publication of RU93033481A publication Critical patent/RU93033481A/ru
Application granted granted Critical
Publication of RU2092558C1 publication Critical patent/RU2092558C1/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C12P13/004—Cyanohydrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
RU9293033481A 1991-12-17 1992-11-13 Способ получения оптически активных s-циангидринов RU2092558C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US809803 1985-12-16
US07/809,803 US5177242A (en) 1991-12-17 1991-12-17 Process for preparing optically active cyanohydrins with enzymes
US809.803 1991-12-17
PCT/US1992/009945 WO1993012072A1 (en) 1991-12-17 1992-11-13 Process for preparing optically active cyanohydrins with enzymes

Publications (2)

Publication Number Publication Date
RU93033481A RU93033481A (ru) 1995-12-27
RU2092558C1 true RU2092558C1 (ru) 1997-10-10

Family

ID=25202264

Family Applications (1)

Application Number Title Priority Date Filing Date
RU9293033481A RU2092558C1 (ru) 1991-12-17 1992-11-13 Способ получения оптически активных s-циангидринов

Country Status (25)

Country Link
US (1) US5177242A (enExample)
EP (1) EP0590096B1 (enExample)
JP (2) JPH0832243B2 (enExample)
KR (1) KR970009155B1 (enExample)
CN (1) CN1075166A (enExample)
AR (1) AR247921A1 (enExample)
AT (1) ATE135047T1 (enExample)
AU (1) AU647982B2 (enExample)
BG (1) BG61277B1 (enExample)
BR (1) BR9205413A (enExample)
CA (1) CA2093826C (enExample)
CZ (1) CZ280422B6 (enExample)
DE (2) DE69208878T2 (enExample)
FI (1) FI931583A7 (enExample)
HU (1) HUT71308A (enExample)
IL (1) IL104046A0 (enExample)
MW (1) MW4993A1 (enExample)
MX (1) MX9206954A (enExample)
OA (1) OA09873A (enExample)
PL (1) PL170490B1 (enExample)
RO (1) RO112765B1 (enExample)
RU (1) RU2092558C1 (enExample)
SK (1) SK36293A3 (enExample)
TW (1) TW242166B (enExample)
WO (1) WO1993012072A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT396252B (de) * 1991-10-31 1993-07-26 Chemie Linz Gmbh Enzymatisches verfahren zur enantioselektiven herstellung optisch aktiver cyanhydrine
GB9222253D0 (en) * 1992-10-23 1992-12-09 Celltech Ltd Chemical compounds
AT400035B (de) * 1993-06-01 1995-09-25 Chemie Linz Gmbh Enzymatisches verfahren zur herstellung aliphatischer s-cyanhydrine
DE4322064A1 (de) * 1993-07-02 1995-01-12 Chemie Linz Deutschland Enzymatisches Verfahren zur Herstellung aliphatischer S-Cyanhydrine
DE19529116A1 (de) * 1995-08-08 1997-03-06 Chemie Linz Deutschland Gmbh I (S)-Hydroxynitrillyase aus Hevea brasiliensis
DK0799894T3 (da) * 1996-02-09 2004-08-09 Degussa Fremgangsmåde til fremstilling af (S)-cyanhydriner
CN1093531C (zh) * 1998-05-04 2002-10-30 中国科学院上海有机化学研究所 氰醇裂解酶催化合成光学活性氰醇化合物
CN1083009C (zh) * 1999-07-16 2002-04-17 中国科学院上海有机化学研究所 一种新酶源的醇腈裂解酶催化合成光学活性氰醇化合物的方法
AU2668101A (en) * 1999-11-25 2001-06-04 Skw Trostberg Aktiengesellschaft Method for producing optically active cyanhydrins
JP3709317B2 (ja) * 2000-01-12 2005-10-26 株式会社日本触媒 光学活性シアノヒドリンの合成方法
US7078225B2 (en) * 2000-06-02 2006-07-18 Nippon Shokubai Co., Ltd. Method for enzymatically producing an optically active cyanohydrin
WO2007026623A1 (ja) * 2005-08-30 2007-03-08 Sumitomo Chemical Company, Limited ３−アミノ−６−クロロピリダジンの製造方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862030A (en) * 1972-12-13 1975-01-21 Amerace Esna Corp Microporous sub-micron filter media
IL46178A (en) * 1974-12-03 1978-10-31 Rehovot Res Prod Method for the performance of enzymatic reactions
US4102746A (en) * 1975-08-29 1978-07-25 Amerace Corporation Immobilized proteins
US4169014A (en) * 1976-08-16 1979-09-25 Amerace Corporation Method of immobilizing proteinaceous substances
US4795704A (en) * 1985-10-11 1989-01-03 Sepracor, Inc. Multiphase asymmetric membrane reactor systems
US4959467A (en) * 1985-11-27 1990-09-25 Allied-Signal Inc. Control of product selectivity in the addition of HCN to arabinose
US4900667A (en) * 1985-12-19 1990-02-13 Allied-Signal Inc. One carbon homologation of carbohydrates by transcyanohydrination
DE3701383A1 (de) * 1987-01-20 1988-07-28 Degussa Verfahren zur herstellung von optisch aktiven cyanhydrinen
US4800162A (en) * 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
DE3823864A1 (de) * 1988-01-29 1989-08-10 Kernforschungsanlage Juelich Enymatisches verfahren zur herstellung von optisch aktiven cyanhydrinen
DE3917374A1 (de) * 1988-07-14 1990-12-06 Forschungszentrum Juelich Gmbh Verfahren zur herstellung von s-cyanhydrinen
DK0446826T3 (da) * 1990-03-16 1996-02-12 Forschungszentrum Juelich Gmbh Fremgangsmåde til enzymatisk fremstilling af optisk aktive cyanhydriner
AT396252B (de) * 1991-10-31 1993-07-26 Chemie Linz Gmbh Enzymatisches verfahren zur enantioselektiven herstellung optisch aktiver cyanhydrine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
1. US, 4859784, кл. 549-491, 1989. 2. US, 4102746, кл. 195-63, 1978. 3. US, 5008192, кл. C 12 P 13/00, 1991. *

Also Published As

Publication number Publication date
DE69208878T2 (de) 1996-10-31
FI931583L (fi) 1993-06-18
HU9301020D0 (en) 1993-11-29
SK36293A3 (en) 1993-10-06
AU3141493A (en) 1993-07-19
JPH0832243B2 (ja) 1996-03-29
KR970009155B1 (ko) 1997-06-07
JPH05507736A (ja) 1993-11-04
TW242166B (enExample) 1995-03-01
MW4993A1 (en) 1994-10-12
DE590096T1 (de) 1994-07-28
CA2093826A1 (en) 1993-06-18
JPH06506674A (ja) 1994-07-28
WO1993012072A1 (en) 1993-06-24
MX9206954A (es) 1993-06-01
OA09873A (en) 1994-09-15
EP0590096A1 (en) 1994-04-06
CZ65193A3 (en) 1994-04-13
DE69208878D1 (de) 1996-04-11
PL170490B1 (pl) 1996-12-31
CZ280422B6 (cs) 1996-01-17
BR9205413A (pt) 1994-05-31
BG61277B1 (en) 1997-04-30
CN1075166A (zh) 1993-08-11
IL104046A0 (en) 1993-05-13
CA2093826C (en) 1995-08-29
RO112765B1 (ro) 1997-12-30
FI931583A0 (fi) 1993-04-07
EP0590096B1 (en) 1996-03-06
ATE135047T1 (de) 1996-03-15
AU647982B2 (en) 1994-03-31
FI931583A7 (fi) 1993-06-18
EP0590096A4 (en) 1994-02-18
US5177242A (en) 1993-01-05
AR247921A1 (es) 1995-04-28
HUT71308A (en) 1995-11-28
BG97619A (bg) 1994-03-31

Similar Documents

Publication Publication Date Title
US3983053A (en) Coated adsorbent materials
RU2092558C1 (ru) Способ получения оптически активных s-циангидринов
US4102746A (en) Immobilized proteins
US4169014A (en) Method of immobilizing proteinaceous substances
US4202775A (en) Adsorbent for adsorbing organic compounds adsorbed on proteins
US6599620B2 (en) Cellulosic particles, spherical object comprising cross-linked polymer particles, and adsorbent for body fluid purification
US4828882A (en) Particle encapsulation technique
CA2121747C (en) Hydrophilic polymer coated perfluorocarbon polymer-based matrices, their preparation and use in bioaffinity
FI93124C (fi) Menetelmä liuenneen valkuaisaineen immobilisoimiseksi
Horvath Pellicular immobilized enzymes
JPH0458311B2 (enExample)
US20040076845A1 (en) Hemocompatible polymer systems & related methods
US6884829B2 (en) Hemocompatible coated polymer and related one-step methods
JPS61179354A (ja) 流体透過性の繊維質マトリツクスおよびその製法
US4721652A (en) Composite for decomposing and adsorbing urea dissolved in liquid
GB2063228A (en) Process for producing carbonaceous sorbent
JPH06256434A (ja) 多孔体、多孔体からなる多孔性担体、多孔性担体を用いた固定化機能性物質、これらの製造方法および多孔体製造用組成物
JPH01119309A (ja) 異方透過性反応型多孔質分離膜
JPS6211614B2 (enExample)
Pişkin Structural and transport properties of polymeric carriers for bioagents and immobilization techniques and their applications
Morishita et al. Microencapsulation of Activated Charcoal and Its Biochemical Applications
JPS6254127B2 (enExample)
JPH0416158B2 (enExample)
JPS62136241A (ja) 血液浄化用吸着剤