RU2066310C1 - Способ получения производных аминопропанола - Google Patents

Способ получения производных аминопропанола Download PDF

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Publication number
RU2066310C1
RU2066310C1 SU904831489A SU4831489A RU2066310C1 RU 2066310 C1 RU2066310 C1 RU 2066310C1 SU 904831489 A SU904831489 A SU 904831489A SU 4831489 A SU4831489 A SU 4831489A RU 2066310 C1 RU2066310 C1 RU 2066310C1
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RU
Russia
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carried out
method described
out according
yield
calculated
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SU904831489A
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English (en)
Russian (ru)
Inventor
Будаи Золтан
Мецеи Тибор
Петец Луиза
Сечеи Мария
Фекете Мартон
Хоффманн Валерия
Райтер Клара
Сирт Енико
Жила Гизелла
Гиглер Габор
Каполнаи Ласло
Original Assignee
Эгиш Дьедьсердьяр
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Publication of RU2066310C1 publication Critical patent/RU2066310C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/20—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups being part of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/58—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
SU904831489A 1989-08-25 1990-08-24 Способ получения производных аминопропанола RU2066310C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU4401/89 1989-08-25
HU894401A HU212415B (en) 1989-08-25 1989-08-25 Process for producing new cyclic oxym derivatives and pharmaceutical compositions containing them as active components

Publications (1)

Publication Number Publication Date
RU2066310C1 true RU2066310C1 (ru) 1996-09-10

Family

ID=10967860

Family Applications (1)

Application Number Title Priority Date Filing Date
SU904831489A RU2066310C1 (ru) 1989-08-25 1990-08-24 Способ получения производных аминопропанола

Country Status (24)

Country Link
US (1) US5130487A (enExample)
JP (1) JPH03169841A (enExample)
KR (1) KR910004547A (enExample)
AT (1) AT399504B (enExample)
BE (1) BE1004530A3 (enExample)
BG (1) BG92749A (enExample)
CA (1) CA2023957A1 (enExample)
CH (1) CH681369A5 (enExample)
DD (1) DD297402A5 (enExample)
DE (1) DE4027052A1 (enExample)
DK (1) DK203290A (enExample)
ES (1) ES2021261A6 (enExample)
FI (1) FI904191A7 (enExample)
FR (1) FR2651227B1 (enExample)
GB (1) GB2235198B (enExample)
GR (1) GR1000740B (enExample)
HU (1) HU212415B (enExample)
IT (1) IT1243203B (enExample)
NL (1) NL9001865A (enExample)
PL (1) PL163028B1 (enExample)
RU (1) RU2066310C1 (enExample)
SE (1) SE9002727L (enExample)
YU (1) YU48372B (enExample)
ZA (1) ZA906744B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU212262B (en) * 1992-10-30 1996-04-29 Egyt Gyogyszervegyeszeti Gyar Process to prepare benz /e/ indene derivs. and the pharmaceutical compns. contg. them
HUT67314A (en) * 1993-04-09 1995-03-28 Egyt Gyogyszervegyeszeti Gyar Process for prepg. new trisubstituted cykloalkane deriv.s and pharmaceutical compn.s contg. them
HU213421B (en) * 1993-04-09 1997-06-30 Egyt Gyogyszervegyeszeti Gyar New basic ethers, pharmaceutical compns. containing the said compds. and process for prepg. them
US5597822A (en) * 1993-07-20 1997-01-28 Egis Pharmaceutical Pharmaceutical compositions for the prevention and/or treatment a gastrointestinal diseases
HU213472B (en) * 1993-07-20 1997-06-30 Egyt Gyogyszervegyeszeti Gyar Process to preparare pharmaceutical compns. with gastroprotective and anti helicobacter pylori activity
DE19722848A1 (de) * 1997-05-23 1998-11-26 Schering Ag Leukotrien-B¶4¶-Derivate, insbesondere Oximo-LTB¶4¶-Antagonisten
MXPA04006709A (es) * 2002-01-11 2004-10-04 Sankyo Co Derivados de aminoalcohol o derivados de acido fosfonico y composiciones farmaceuticas que los contienen.
KR20110136901A (ko) 2004-02-24 2011-12-21 상꾜 가부시키가이샤 아미노 알코올 화합물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1474316A (en) * 1975-02-12 1977-05-25 Seperic O-aminoalkyl oximes
GB1493222A (en) * 1976-01-27 1977-11-30 Egyt Gyogyszervegyeszeti Gyar Cycloalkanone oxime ethers and process for the preparation thereof
AT339276B (de) * 1976-01-27 1977-10-10 Egyt Gyogyszervegyeszeti Gyar Verfahren zur herstellung von basischen cycloalkanonoximathern und deren saureadditionssalzen
DE2658938A1 (de) * 1976-12-24 1978-07-06 Hoechst Ag Neue basisch substituierte 0-propyloxime, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4308399A (en) * 1977-08-30 1981-12-29 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
US4652586A (en) * 1980-11-07 1987-03-24 The General Hospital Corporation Selective beta-2 adrenergic antagonists for the treatment of glaucoma
FR2521856A1 (fr) * 1982-02-19 1983-08-26 Pos Lab Medicament ophtalmique pour le traitement des glaucomes, a base d'ethers-oxydes ou d'ether-oximes de derives alcoylamines
HU189227B (en) * 1983-02-08 1986-06-30 Egyt Gyogyszervegyeszeti Gyar,Hu Process for preparing basic oxime-ethers
HU189226B (en) * 1983-02-08 1986-06-30 Egyt Gyogyszervegyeszeti Gyar,Hu Process for producing basic oxime-ethers
HU197205B (en) * 1984-07-10 1989-03-28 Egyt Gyogyszervegyeszeti Gyar Process for production of medical compositions against angine
US4803286A (en) * 1987-08-19 1989-02-07 Merck & Co., Inc. Amino-2-hydroxypropyloximinoheterocycle α-blockers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Патент ФРГ N 3404481, кл. С 07 С 131/02, 1981. Патент ЕПВ N 0168245, кл. С 07С 131/02, 1986. *

Also Published As

Publication number Publication date
BE1004530A3 (fr) 1992-12-08
DE4027052A1 (de) 1991-03-07
PL163028B1 (pl) 1994-02-28
GR900100627A (en) 1991-12-30
KR910004547A (ko) 1991-03-28
GB2235198B (en) 1993-06-02
AT399504B (de) 1995-05-26
SE9002727L (sv) 1991-02-26
HUT58282A (en) 1992-02-28
DE4027052C2 (enExample) 1993-09-09
US5130487A (en) 1992-07-14
GB9018583D0 (en) 1990-10-10
FR2651227B1 (fr) 1992-07-31
ATA174290A (de) 1994-10-15
CH681369A5 (enExample) 1993-03-15
PL286613A1 (en) 1991-05-06
JPH03169841A (ja) 1991-07-23
SE9002727D0 (sv) 1990-08-24
HU212415B (en) 1996-06-28
GR1000740B (el) 1992-12-30
FR2651227A1 (fr) 1991-03-01
YU48372B (sh) 1998-07-10
CA2023957A1 (en) 1991-02-26
BG92749A (bg) 1993-12-24
IT9021305A0 (it) 1990-08-24
IT9021305A1 (it) 1992-02-24
ZA906744B (en) 1991-06-26
DK203290D0 (da) 1990-08-24
YU160990A (sh) 1992-12-21
DD297402A5 (de) 1992-01-09
NL9001865A (nl) 1991-03-18
FI904191A0 (fi) 1990-08-24
GB2235198A (en) 1991-02-27
DK203290A (da) 1991-02-26
FI904191A7 (fi) 1991-02-26
ES2021261A6 (es) 1991-10-16
IT1243203B (it) 1994-05-24

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