RU2045534C1 - Способ получения кристаллического 9-деоксо-11-деокси- 9,11-{имино[2- (2-метоксиэтокси)- этилиден]окси} -(9s)-эритромицина - Google Patents

Способ получения кристаллического 9-деоксо-11-деокси- 9,11-{имино[2- (2-метоксиэтокси)- этилиден]окси} -(9s)-эритромицина Download PDF

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Publication number
RU2045534C1
RU2045534C1 SU5052683/04A SU5052683A RU2045534C1 RU 2045534 C1 RU2045534 C1 RU 2045534C1 SU 5052683/04 A SU5052683/04 A SU 5052683/04A SU 5052683 A SU5052683 A SU 5052683A RU 2045534 C1 RU2045534 C1 RU 2045534C1
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Russia
Prior art keywords
acid
acetal
erythromycylamine
amount
reaction
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SU5052683/04A
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English (en)
Russian (ru)
Inventor
МакНейл МакГилл Джон
Us]
Original Assignee
Эли Лилли Энд Компани
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Publication of RU2045534C1 publication Critical patent/RU2045534C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SU5052683/04A 1991-09-30 1992-09-28 Способ получения кристаллического 9-деоксо-11-деокси- 9,11-{имино[2- (2-метоксиэтокси)- этилиден]окси} -(9s)-эритромицина RU2045534C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76880391A 1991-09-30 1991-09-30
US07/768803 1991-09-30

Publications (1)

Publication Number Publication Date
RU2045534C1 true RU2045534C1 (ru) 1995-10-10

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ID=25083529

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Application Number Title Priority Date Filing Date
SU5052683/04A RU2045534C1 (ru) 1991-09-30 1992-09-28 Способ получения кристаллического 9-деоксо-11-деокси- 9,11-{имино[2- (2-метоксиэтокси)- этилиден]окси} -(9s)-эритромицина

Country Status (28)

Country Link
US (1) US5578713A (enExample)
EP (1) EP0535900B1 (enExample)
JP (1) JP3197957B2 (enExample)
KR (1) KR100236246B1 (enExample)
CN (1) CN1030455C (enExample)
AR (1) AR248282A1 (enExample)
AT (1) ATE133178T1 (enExample)
BR (1) BR9203799A (enExample)
CA (1) CA2079430A1 (enExample)
CZ (1) CZ281664B6 (enExample)
DE (1) DE69207696T2 (enExample)
DK (1) DK0535900T3 (enExample)
ES (1) ES2083103T3 (enExample)
FI (1) FI104969B (enExample)
GR (1) GR3018726T3 (enExample)
HK (1) HK1006842A1 (enExample)
HU (1) HU213620B (enExample)
IL (1) IL103276A (enExample)
MX (1) MX9205455A (enExample)
MY (1) MY113261A (enExample)
NO (1) NO178150C (enExample)
NZ (1) NZ244495A (enExample)
PH (1) PH30959A (enExample)
RU (1) RU2045534C1 (enExample)
SK (1) SK279270B6 (enExample)
TW (1) TW287165B (enExample)
YU (1) YU48748B (enExample)
ZA (1) ZA927328B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2266295C2 (ru) * 1995-08-03 2005-12-20 Чугаи Сейяку Кабусики Кайся Способы получения кристаллических форм a, c и d фумарата производного эритромицина, сами формы и способы получения промежуточных соединений

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US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
WO2005009364A2 (en) 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
EP1648415A4 (en) 2003-07-21 2011-11-16 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
WO2005009368A2 (en) 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
CA2535177A1 (en) 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Robust pellet
JP2007502294A (ja) 2003-08-12 2007-02-08 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
AU2004270170B2 (en) * 2003-08-29 2011-01-27 Shionogi, Inc. Antibiotic product, use and formulation thereof
WO2005027877A1 (en) 2003-09-15 2005-03-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
CA2572292A1 (en) 2004-07-02 2006-02-09 Advancis Pharmaceutical Corporation Tablet for pulsed delivery
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
US4438109A (en) * 1980-07-25 1984-03-20 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Tylosin derivatives
JPS62103098A (ja) * 1985-05-13 1987-05-13 Microbial Chem Res Found タイロシン誘導体

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Drugs in Future 14, 112, 1989. *
Патент США N 4048306, кл. A 61K 31/70 ,1988. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2266295C2 (ru) * 1995-08-03 2005-12-20 Чугаи Сейяку Кабусики Кайся Способы получения кристаллических форм a, c и d фумарата производного эритромицина, сами формы и способы получения промежуточных соединений

Also Published As

Publication number Publication date
FI924360A0 (fi) 1992-09-29
KR930006044A (ko) 1993-04-20
IL103276A0 (en) 1993-02-21
FI104969B (fi) 2000-05-15
EP0535900B1 (en) 1996-01-17
CZ293592A3 (en) 1993-04-14
TW287165B (enExample) 1996-10-01
HUT62308A (en) 1993-04-28
AU645443B2 (en) 1994-01-13
DE69207696T2 (de) 1996-06-05
CN1070914A (zh) 1993-04-14
HU9203101D0 (en) 1992-12-28
DK0535900T3 (da) 1996-02-12
ATE133178T1 (de) 1996-02-15
CN1030455C (zh) 1995-12-06
MY113261A (en) 2002-01-31
BR9203799A (pt) 1993-04-20
CA2079430A1 (en) 1993-03-31
IL103276A (en) 1997-06-10
DE69207696D1 (de) 1996-02-29
YU87792A (sh) 1995-03-27
NZ244495A (en) 1995-04-27
NO178150C (no) 1996-01-31
KR100236246B1 (ko) 1999-12-15
HU213620B (en) 1997-08-28
EP0535900A1 (en) 1993-04-07
NO923765L (no) 1993-03-31
AR248282A1 (es) 1995-07-12
HK1006842A1 (en) 1999-03-19
MX9205455A (es) 1993-05-01
YU48748B (sh) 1999-09-27
ES2083103T3 (es) 1996-04-01
US5578713A (en) 1996-11-26
GR3018726T3 (en) 1996-04-30
JPH05213983A (ja) 1993-08-24
SK293592A3 (en) 1998-08-05
JP3197957B2 (ja) 2001-08-13
PH30959A (en) 1997-12-23
ZA927328B (en) 1994-03-24
NO178150B (no) 1995-10-23
NO923765D0 (no) 1992-09-28
AU2536592A (en) 1993-04-01
CZ281664B6 (cs) 1996-12-11
FI924360L (fi) 1993-03-31
SK279270B6 (sk) 1998-08-05

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20030929