YU48748B - Jednofazni postupak za dobijanje kristalnog diritromicina - Google Patents

Jednofazni postupak za dobijanje kristalnog diritromicina

Info

Publication number
YU48748B
YU48748B YU87792A YU87792A YU48748B YU 48748 B YU48748 B YU 48748B YU 87792 A YU87792 A YU 87792A YU 87792 A YU87792 A YU 87792A YU 48748 B YU48748 B YU 48748B
Authority
YU
Yugoslavia
Prior art keywords
acetal
diritromycin
hemiacetal
producing
step process
Prior art date
Application number
YU87792A
Other languages
English (en)
Other versions
YU87792A (sh
Inventor
Mcneil John Mcgill
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of YU87792A publication Critical patent/YU87792A/sh
Publication of YU48748B publication Critical patent/YU48748B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Postupak za dobijanje kristalnog diritromicina, naznačen time, što se acetal predstavljen formulom: gde su R1 i R2 normalne ili razgranate alkil grupe sa od jednog do šest atoma ugljenika koji mogu biti identični ili različiti jedan od drugog ili zajedno jedan sa drugim mogu biti -CH2-CH2-, -CH2-CH2-CH2- ili -CH2-CH2-CH2-CH2-; na taj način obrazujući 5- do 7-člani prsten kada se uzimaju zajedno sa strukturom sa kojom su vezani, rastvara u vodenom acetonitrilu, što rastvoreni acetal hidrolizuje u prisustvu kiselog katalizatora radi obrazovanja odgovarajućeg hemiacetala, i što nastali hemiacetal reaguje sa eritromicilaminom, pri čemu se dobija kristalni diritromicin. - Prijava sadrži još 7 zavisnih zahteva.
YU87792A 1991-09-30 1992-09-29 Jednofazni postupak za dobijanje kristalnog diritromicina YU48748B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76880391A 1991-09-30 1991-09-30

Publications (2)

Publication Number Publication Date
YU87792A YU87792A (sh) 1995-03-27
YU48748B true YU48748B (sh) 1999-09-27

Family

ID=25083529

Family Applications (1)

Application Number Title Priority Date Filing Date
YU87792A YU48748B (sh) 1991-09-30 1992-09-29 Jednofazni postupak za dobijanje kristalnog diritromicina

Country Status (28)

Country Link
US (1) US5578713A (sh)
EP (1) EP0535900B1 (sh)
JP (1) JP3197957B2 (sh)
KR (1) KR100236246B1 (sh)
CN (1) CN1030455C (sh)
AR (1) AR248282A1 (sh)
AT (1) ATE133178T1 (sh)
BR (1) BR9203799A (sh)
CA (1) CA2079430A1 (sh)
CZ (1) CZ281664B6 (sh)
DE (1) DE69207696T2 (sh)
DK (1) DK0535900T3 (sh)
ES (1) ES2083103T3 (sh)
FI (1) FI104969B (sh)
GR (1) GR3018726T3 (sh)
HK (1) HK1006842A1 (sh)
HU (1) HU213620B (sh)
IL (1) IL103276A (sh)
MX (1) MX9205455A (sh)
MY (1) MY113261A (sh)
NO (1) NO178150C (sh)
NZ (1) NZ244495A (sh)
PH (1) PH30959A (sh)
RU (1) RU2045534C1 (sh)
SK (1) SK279270B6 (sh)
TW (1) TW287165B (sh)
YU (1) YU48748B (sh)
ZA (1) ZA927328B (sh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
WO2005009364A2 (en) 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
EP1648407A4 (en) 2003-07-21 2011-08-31 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, CORRESPONDING USE AND FORMULATION
JP2006528189A (ja) 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質産物、その使用法および製剤
EP1653925A1 (en) 2003-08-11 2006-05-10 Advancis Pharmaceutical Corporation Robust pellet
JP2007502294A (ja) 2003-08-12 2007-02-08 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
EP1658034A4 (en) * 2003-08-29 2011-06-22 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
CA2538064C (en) 2003-09-15 2013-12-17 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2006014427A1 (en) 2004-07-02 2006-02-09 Advancis Pharmaceutical Corporation Tablet for pulsed delivery
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
US4438109A (en) * 1980-07-25 1984-03-20 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Tylosin derivatives
JPS62103098A (ja) * 1985-05-13 1987-05-13 Microbial Chem Res Found タイロシン誘導体

Also Published As

Publication number Publication date
EP0535900A1 (en) 1993-04-07
GR3018726T3 (en) 1996-04-30
YU87792A (sh) 1995-03-27
DE69207696T2 (de) 1996-06-05
HU9203101D0 (en) 1992-12-28
KR930006044A (ko) 1993-04-20
AR248282A1 (es) 1995-07-12
IL103276A (en) 1997-06-10
FI104969B (fi) 2000-05-15
HUT62308A (en) 1993-04-28
NO923765D0 (no) 1992-09-28
CN1030455C (zh) 1995-12-06
HU213620B (en) 1997-08-28
NO178150C (no) 1996-01-31
SK293592A3 (en) 1998-08-05
NO178150B (no) 1995-10-23
JP3197957B2 (ja) 2001-08-13
DK0535900T3 (da) 1996-02-12
US5578713A (en) 1996-11-26
AU645443B2 (en) 1994-01-13
TW287165B (sh) 1996-10-01
CN1070914A (zh) 1993-04-14
ATE133178T1 (de) 1996-02-15
BR9203799A (pt) 1993-04-20
KR100236246B1 (ko) 1999-12-15
FI924360A0 (fi) 1992-09-29
DE69207696D1 (de) 1996-02-29
FI924360A (fi) 1993-03-31
JPH05213983A (ja) 1993-08-24
PH30959A (en) 1997-12-23
NZ244495A (en) 1995-04-27
HK1006842A1 (en) 1999-03-19
RU2045534C1 (ru) 1995-10-10
MX9205455A (es) 1993-05-01
CA2079430A1 (en) 1993-03-31
MY113261A (en) 2002-01-31
AU2536592A (en) 1993-04-01
CZ293592A3 (en) 1993-04-14
IL103276A0 (en) 1993-02-21
EP0535900B1 (en) 1996-01-17
SK279270B6 (sk) 1998-08-05
CZ281664B6 (cs) 1996-12-11
ZA927328B (en) 1994-03-24
NO923765L (no) 1993-03-31
ES2083103T3 (es) 1996-04-01

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