YU48748B - Jednofazni postupak za dobijanje kristalnog diritromicina - Google Patents
Jednofazni postupak za dobijanje kristalnog diritromicinaInfo
- Publication number
- YU48748B YU48748B YU87792A YU87792A YU48748B YU 48748 B YU48748 B YU 48748B YU 87792 A YU87792 A YU 87792A YU 87792 A YU87792 A YU 87792A YU 48748 B YU48748 B YU 48748B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- acetal
- diritromycin
- hemiacetal
- producing
- step process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Postupak za dobijanje kristalnog diritromicina, naznačen time, što se acetal predstavljen formulom: gde su R1 i R2 normalne ili razgranate alkil grupe sa od jednog do šest atoma ugljenika koji mogu biti identični ili različiti jedan od drugog ili zajedno jedan sa drugim mogu biti -CH2-CH2-, -CH2-CH2-CH2- ili -CH2-CH2-CH2-CH2-; na taj način obrazujući 5- do 7-člani prsten kada se uzimaju zajedno sa strukturom sa kojom su vezani, rastvara u vodenom acetonitrilu, što rastvoreni acetal hidrolizuje u prisustvu kiselog katalizatora radi obrazovanja odgovarajućeg hemiacetala, i što nastali hemiacetal reaguje sa eritromicilaminom, pri čemu se dobija kristalni diritromicin. - Prijava sadrži još 7 zavisnih zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76880391A | 1991-09-30 | 1991-09-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU87792A YU87792A (sh) | 1995-03-27 |
| YU48748B true YU48748B (sh) | 1999-09-27 |
Family
ID=25083529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU87792A YU48748B (sh) | 1991-09-30 | 1992-09-29 | Jednofazni postupak za dobijanje kristalnog diritromicina |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5578713A (sh) |
| EP (1) | EP0535900B1 (sh) |
| JP (1) | JP3197957B2 (sh) |
| KR (1) | KR100236246B1 (sh) |
| CN (1) | CN1030455C (sh) |
| AR (1) | AR248282A1 (sh) |
| AT (1) | ATE133178T1 (sh) |
| BR (1) | BR9203799A (sh) |
| CA (1) | CA2079430A1 (sh) |
| CZ (1) | CZ281664B6 (sh) |
| DE (1) | DE69207696T2 (sh) |
| DK (1) | DK0535900T3 (sh) |
| ES (1) | ES2083103T3 (sh) |
| FI (1) | FI104969B (sh) |
| GR (1) | GR3018726T3 (sh) |
| HK (1) | HK1006842A1 (sh) |
| HU (1) | HU213620B (sh) |
| IL (1) | IL103276A (sh) |
| MX (1) | MX9205455A (sh) |
| MY (1) | MY113261A (sh) |
| NO (1) | NO178150C (sh) |
| NZ (1) | NZ244495A (sh) |
| PH (1) | PH30959A (sh) |
| RU (1) | RU2045534C1 (sh) |
| SK (1) | SK293592A3 (sh) |
| TW (1) | TW287165B (sh) |
| YU (1) | YU48748B (sh) |
| ZA (1) | ZA927328B (sh) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| US6565882B2 (en) | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
| US6541014B2 (en) | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| AU2004258949B2 (en) | 2003-07-21 | 2011-02-10 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| CA2533292C (en) | 2003-07-21 | 2013-12-31 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| EP1648418A4 (en) | 2003-07-21 | 2011-11-16 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION |
| CA2535177A1 (en) | 2003-08-11 | 2005-02-24 | Advancis Pharmaceutical Corporation | Robust pellet |
| EP1653924A4 (en) | 2003-08-12 | 2009-09-09 | Middlebrook Pharmaceuticals In | ANTIBIOTICS, USE AND FORMULATION ASSOCIATED |
| CA2535780A1 (en) * | 2003-08-29 | 2005-03-17 | Advancis Pharmaceuticals Corporation | Antibiotic product, use and formulation thereof |
| US8460710B2 (en) | 2003-09-15 | 2013-06-11 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| CA2572292A1 (en) | 2004-07-02 | 2006-02-09 | Advancis Pharmaceutical Corporation | Tablet for pulsed delivery |
| US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
| US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
| US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT342770B (de) * | 1975-04-07 | 1978-04-25 | Thomae Gmbh Dr K | Verfahren zur herstellung neuer erythromycinderivate |
| US4438109A (en) * | 1980-07-25 | 1984-03-20 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Tylosin derivatives |
| JPS62103098A (ja) * | 1985-05-13 | 1987-05-13 | Microbial Chem Res Found | タイロシン誘導体 |
-
1992
- 1992-09-24 ZA ZA927328A patent/ZA927328B/xx unknown
- 1992-09-24 CZ CS922935A patent/CZ281664B6/cs not_active IP Right Cessation
- 1992-09-24 SK SK2935-92A patent/SK293592A3/sk unknown
- 1992-09-24 IL IL103276A patent/IL103276A/xx not_active IP Right Cessation
- 1992-09-24 MY MYPI92001713A patent/MY113261A/en unknown
- 1992-09-25 MX MX9205455A patent/MX9205455A/es not_active IP Right Cessation
- 1992-09-25 NZ NZ244495A patent/NZ244495A/en unknown
- 1992-09-25 PH PH44995A patent/PH30959A/en unknown
- 1992-09-28 ES ES92308839T patent/ES2083103T3/es not_active Expired - Lifetime
- 1992-09-28 RU SU5052683/04A patent/RU2045534C1/ru not_active IP Right Cessation
- 1992-09-28 DE DE69207696T patent/DE69207696T2/de not_active Expired - Fee Related
- 1992-09-28 EP EP92308839A patent/EP0535900B1/en not_active Expired - Lifetime
- 1992-09-28 AT AT92308839T patent/ATE133178T1/de not_active IP Right Cessation
- 1992-09-28 NO NO923765A patent/NO178150C/no unknown
- 1992-09-28 DK DK92308839.7T patent/DK0535900T3/da active
- 1992-09-28 KR KR1019920017679A patent/KR100236246B1/ko not_active IP Right Cessation
- 1992-09-29 HU HU9203101A patent/HU213620B/hu not_active IP Right Cessation
- 1992-09-29 CN CN92110845A patent/CN1030455C/zh not_active Expired - Fee Related
- 1992-09-29 YU YU87792A patent/YU48748B/sh unknown
- 1992-09-29 FI FI924360A patent/FI104969B/fi active
- 1992-09-29 JP JP26002192A patent/JP3197957B2/ja not_active Expired - Fee Related
- 1992-09-29 BR BR929203799A patent/BR9203799A/pt not_active Application Discontinuation
- 1992-09-29 CA CA002079430A patent/CA2079430A1/en not_active Abandoned
- 1992-09-29 AR AR92323301A patent/AR248282A1/es active
- 1992-10-27 TW TW081108536A patent/TW287165B/zh active
-
1993
- 1993-07-20 US US08/095,366 patent/US5578713A/en not_active Expired - Fee Related
-
1996
- 1996-01-18 GR GR960400113T patent/GR3018726T3/el unknown
-
1998
- 1998-06-22 HK HK98105921A patent/HK1006842A1/xx not_active IP Right Cessation
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