RU2032703C1 - Аэрозольный препарат и способ его получения - Google Patents
Аэрозольный препарат и способ его получения Download PDFInfo
- Publication number
- RU2032703C1 RU2032703C1 SU915010128A SU5010128A RU2032703C1 RU 2032703 C1 RU2032703 C1 RU 2032703C1 SU 915010128 A SU915010128 A SU 915010128A SU 5010128 A SU5010128 A SU 5010128A RU 2032703 C1 RU2032703 C1 RU 2032703C1
- Authority
- RU
- Russia
- Prior art keywords
- mass
- active substance
- aerosol
- preparation
- preparations
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 36
- 239000000443 aerosol Substances 0.000 title claims abstract description 21
- 238000000034 method Methods 0.000 title claims abstract description 10
- 238000004519 manufacturing process Methods 0.000 title description 3
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 claims abstract description 18
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 claims abstract description 18
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000000126 substance Substances 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 4
- 239000013543 active substance Substances 0.000 claims description 24
- 239000003814 drug Substances 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 10
- 239000003380 propellant Substances 0.000 claims description 9
- 239000004147 Sorbitan trioleate Substances 0.000 claims description 5
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 5
- 235000019337 sorbitan trioleate Nutrition 0.000 claims description 5
- 229960000391 sorbitan trioleate Drugs 0.000 claims description 5
- 125000003118 aryl group Chemical group 0.000 claims description 4
- UCDKONUHZNTQPY-UHFFFAOYSA-N bromhexine hydrochloride Chemical compound Cl.C1CCCCC1N(C)CC1=CC(Br)=CC(Br)=C1N UCDKONUHZNTQPY-UHFFFAOYSA-N 0.000 claims description 4
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- -1 chlorine hydrocarbons Chemical class 0.000 abstract description 6
- 239000000725 suspension Substances 0.000 abstract description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- SAHIZENKTPRYSN-UHFFFAOYSA-N [2-[3-(phenoxymethyl)phenoxy]-6-(trifluoromethyl)pyridin-4-yl]methanamine Chemical compound O(C1=CC=CC=C1)CC=1C=C(OC2=NC(=CC(=C2)CN)C(F)(F)F)C=CC=1 SAHIZENKTPRYSN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001491 aromatic compounds Chemical class 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 21
- 239000007789 gas Substances 0.000 description 15
- 239000002245 particle Substances 0.000 description 9
- 210000004379 membrane Anatomy 0.000 description 6
- 239000012528 membrane Substances 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 5
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 4
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 4
- 235000019404 dichlorodifluoromethane Nutrition 0.000 description 4
- BOSAWIQFTJIYIS-UHFFFAOYSA-N 1,1,1-trichloro-2,2,2-trifluoroethane Chemical compound FC(F)(F)C(Cl)(Cl)Cl BOSAWIQFTJIYIS-UHFFFAOYSA-N 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 210000001331 nose Anatomy 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 description 2
- BAMUEXIPKSRTBS-UHFFFAOYSA-N 1,1-dichloro-1,2,2,2-tetrafluoroethane Chemical compound FC(F)(F)C(F)(Cl)Cl BAMUEXIPKSRTBS-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 description 2
- 239000002612 dispersion medium Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229940075554 sorbate Drugs 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- ZXUJWPHOPHHZLR-UHFFFAOYSA-N 1,1,1-trichloro-2-fluoroethane Chemical compound FCC(Cl)(Cl)Cl ZXUJWPHOPHHZLR-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical class S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000001088 anti-asthma Effects 0.000 description 1
- 239000000924 antiasthmatic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 239000011942 biocatalyst Substances 0.000 description 1
- OJGDCBLYJGHCIH-UHFFFAOYSA-N bromhexine Chemical compound C1CCCCC1N(C)CC1=CC(Br)=CC(Br)=C1N OJGDCBLYJGHCIH-UHFFFAOYSA-N 0.000 description 1
- 229960003870 bromhexine Drugs 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000012928 buffer substance Substances 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 229960000265 cromoglicic acid Drugs 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU7070/90 | 1990-11-09 | ||
| HU907070A HU205249B (en) | 1990-11-09 | 1990-11-09 | Process for producing suspensive aerosole composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2032703C1 true RU2032703C1 (ru) | 1995-04-10 |
Family
ID=10972137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU915010128A RU2032703C1 (ru) | 1990-11-09 | 1991-11-06 | Аэрозольный препарат и способ его получения |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JP2617389B2 (cs) |
| AT (1) | AT402014B (cs) |
| AU (1) | AU645366B2 (cs) |
| BG (1) | BG95444A (cs) |
| CA (1) | CA2055180A1 (cs) |
| CY (1) | CY1873A (cs) |
| CZ (1) | CZ281475B6 (cs) |
| DE (1) | DE4136837C2 (cs) |
| EG (1) | EG19809A (cs) |
| FR (1) | FR2673635B1 (cs) |
| GB (1) | GB2251626B (cs) |
| HU (2) | HU205249B (cs) |
| IL (1) | IL100009A (cs) |
| IT (1) | IT1251990B (cs) |
| NZ (1) | NZ240518A (cs) |
| RO (1) | RO113610B1 (cs) |
| RU (1) | RU2032703C1 (cs) |
| SK (1) | SK278930B6 (cs) |
| UA (1) | UA27708C2 (cs) |
| ZA (1) | ZA918865B (cs) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2212234C1 (ru) * | 2001-12-27 | 2003-09-20 | Закрытое акционерное общество "Брынцалов-А" | Муколитическое средство бромгексин-ферейн |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU214582B (hu) * | 1994-07-26 | 1998-04-28 | EGIS Gyógyszergyár Rt. | Porlasztható, vérnyomáscsökkentő hatású gyógyszerkészítmény és eljárás előállítására |
| DK1102579T3 (da) * | 1998-08-04 | 2003-07-14 | Jago Res Ag | Medicinske aerosolformuleringer |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE556587A (cs) * | 1957-01-31 | 1957-04-11 | ||
| US3095355A (en) * | 1961-10-12 | 1963-06-25 | Revlon | Aerosol composition |
| GB993702A (en) * | 1961-11-10 | 1965-06-02 | Takeda Chemical Industries Ltd | An aerosol dispersing agent |
| GB1454105A (en) * | 1972-11-04 | 1976-10-27 | Hoechst Ag | Preparation containing luteinizing hormone-releasing factor |
| AU522792B2 (en) * | 1977-07-19 | 1982-06-24 | Fisons Plc | Pressure pack formulation |
| DE3324192A1 (de) * | 1983-07-05 | 1985-01-17 | Troponwerke Gmbh & Co Kg | Depot-antiphlogistika |
| GB8828477D0 (en) * | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
| GB8829478D0 (en) * | 1988-12-16 | 1989-02-01 | Harris Pharma Ltd | Formulations |
| IL95952A0 (en) * | 1989-10-19 | 1991-07-18 | Sterling Drug Inc | Aerosol composition for topical medicament |
| JPH03133915A (ja) * | 1989-10-19 | 1991-06-07 | Shiseido Co Ltd | 油中水型乳化型泡沫化粧料 |
| DE4003272A1 (de) * | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen |
-
1990
- 1990-11-09 HU HU907070A patent/HU205249B/hu unknown
-
1991
- 1991-11-06 UA UA5010128A patent/UA27708C2/uk unknown
- 1991-11-06 RU SU915010128A patent/RU2032703C1/ru not_active IP Right Cessation
- 1991-11-08 GB GB9123776A patent/GB2251626B/en not_active Expired - Fee Related
- 1991-11-08 FR FR919113784A patent/FR2673635B1/fr not_active Expired - Fee Related
- 1991-11-08 IL IL10000991A patent/IL100009A/xx not_active IP Right Cessation
- 1991-11-08 IT ITMI912986A patent/IT1251990B/it active IP Right Grant
- 1991-11-08 BG BG95444A patent/BG95444A/xx unknown
- 1991-11-08 CA CA002055180A patent/CA2055180A1/en not_active Abandoned
- 1991-11-08 DE DE4136837A patent/DE4136837C2/de not_active Expired - Fee Related
- 1991-11-08 RO RO148710A patent/RO113610B1/ro unknown
- 1991-11-08 ZA ZA918865A patent/ZA918865B/xx unknown
- 1991-11-08 AU AU87733/91A patent/AU645366B2/en not_active Ceased
- 1991-11-08 CZ CS913397A patent/CZ281475B6/cs not_active IP Right Cessation
- 1991-11-08 SK SK3397-91A patent/SK278930B6/sk unknown
- 1991-11-08 NZ NZ240518A patent/NZ240518A/xx unknown
- 1991-11-08 AT AT0221591A patent/AT402014B/de not_active IP Right Cessation
- 1991-11-09 EG EG68091A patent/EG19809A/xx active
- 1991-11-11 JP JP3321474A patent/JP2617389B2/ja not_active Expired - Lifetime
-
1995
- 1995-06-20 HU HU95P/P00272P patent/HU211496A9/hu unknown
-
1996
- 1996-04-05 CY CY187396A patent/CY1873A/en unknown
Non-Patent Citations (1)
| Title |
|---|
| Патент США N 3088874, кл. C 09K 3/30, 1969. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2212234C1 (ru) * | 2001-12-27 | 2003-09-20 | Закрытое акционерное общество "Брынцалов-А" | Муколитическое средство бромгексин-ферейн |
Also Published As
| Publication number | Publication date |
|---|---|
| SK278930B6 (sk) | 1998-04-08 |
| CA2055180A1 (en) | 1992-05-10 |
| JP2617389B2 (ja) | 1997-06-04 |
| FR2673635A1 (fr) | 1992-09-11 |
| DE4136837C2 (de) | 1998-09-10 |
| DE4136837A1 (de) | 1992-05-14 |
| IL100009A (en) | 1997-01-10 |
| NZ240518A (en) | 1993-01-27 |
| CY1873A (en) | 1996-04-05 |
| ATA221591A (de) | 1996-06-15 |
| IT1251990B (it) | 1995-05-27 |
| HU211496A9 (en) | 1995-11-28 |
| ZA918865B (en) | 1992-08-26 |
| AU8773391A (en) | 1992-05-14 |
| HU907070D0 (en) | 1991-05-28 |
| JPH05148185A (ja) | 1993-06-15 |
| GB2251626A (en) | 1992-07-15 |
| GB9123776D0 (en) | 1992-01-02 |
| RO113610B1 (ro) | 1998-09-30 |
| EG19809A (en) | 1996-02-29 |
| HU205249B (en) | 1992-04-28 |
| ITMI912986A0 (it) | 1991-11-08 |
| IL100009A0 (en) | 1992-08-18 |
| FR2673635B1 (fr) | 1994-09-09 |
| BG95444A (en) | 1994-03-24 |
| ITMI912986A1 (it) | 1993-05-08 |
| UA27708C2 (uk) | 2000-10-16 |
| AT402014B (de) | 1997-01-27 |
| CS339791A3 (en) | 1992-05-13 |
| AU645366B2 (en) | 1994-01-13 |
| CZ281475B6 (cs) | 1996-10-16 |
| GB2251626B (en) | 1994-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20041107 |