RU2019136972A - Замещенные сукцинимидные производные в качестве пестицидов - Google Patents
Замещенные сукцинимидные производные в качестве пестицидов Download PDFInfo
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
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- A—HUMAN NECESSITIES
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Claims (38)
1. Сукцинимидные соединения формулы I
где W-Z представляет собой -O-N=, -CH2-N= или -СН2-СН=;
R1 представляет собой галогенметил;
R2a представляет собой галоген, галогенметил или галогенметокси;
R2b, R2c независимо представляют собой Н или радикал согласно определению для R2a;
R3 представляет собой галоген, CN, NO2, C1-С2-алкил, галогенметил, C1-С2-алкокси, S(O)m-С1-С2-алкил, C1-С2-галогеналкокси или S(O)m-C1-C2-галогеналкил;
R4 представляет собой Н или радикал согласно определению для R3; или
R3 и R4 вместе с атомами углерода, к которым они присоединены, образуют 5- или 6-членное насыщенное, частично или полностью ненасыщенное карбоциклическое кольцо;
R5, R6 независимо представляют собой Н, CN, C1-С10-алкил, С3-С8-циклоалкил, С2-С10-алкенил, С3-С8-циклоалкенил, С2-С10-алкинил, OR10, S(O)mR10, S(O)mN(R10)2, N(R10)2, где указанные алифатические группы не замещены, частично или полностью галогенированы и/или замещены одним или несколькими Ra; фенил, который не замещен или замещен одним или несколькими RA; и 3-7-членный насыщенный, частично или полностью ненасыщенный гетероцикл, содержащий 1, 2 или 3 гетероатома О, N(O)n или S(O)m в качестве кольцевых членов, где указанный гетероцикл не замещен или замещен одним или несколькими RA,
R10 независимо представляет собой Н, C1-С6-алкил, C1-С6-галогеналкил, С3-С8-циклоалкил, С3-С8-циклоалкил-С1-С4-алкил, С3-С8-галогенциклоалкил, С2-С6-алкенил, С2-С6-галогеналкенил, С2-С6-алкинил, С2-С6-галогеналкинил, где указанные группы не замещены или замещены одним или несколькими Ra,
Ra представляет собой CN, N3, NO2, SCN, SF5, Si(С1-С4-алкил)3, ORa1, OSO2Ra1, S(O)nRa1, N(Ra2)Ra3, C(=O)N(Ra2)Ra3, C(=S)N(Ra2)Ra3, C(=O)Ra1, C(=O)ORa1, CH=NORa1, С3-С8-циклоалкил, С3-С8-галогенциклоалкил, где указанные циклические фрагменты могут быть замещены Ra4; фенил, который не замещен или замещен одним или несколькими RA; и 3-7-членный насыщенный, частично или полностью ненасыщенный гетероцикл, содержащий 1, 2 или 3 гетероатома О, N(O)n или S(O)m в качестве кольцевых членов, где указанный гетероцикл не замещен или замещен одним или несколькими RA,
m представляет собой 0, 1 или 2;
n представляет собой 0 или 1;
Ra1 представляет собой Н, C1-С6-алкил, C1-С6-галогеналкил, С2-С4-алкенил, С2-С4-алкинил, CH2-CN, С3-С6-циклоалкил, С3-С6-галогенциклоалкил, С3-C6-циклоалкилметил, С3-С6-галогенциклоалкилметил, фенил и гетарил, где указанные ароматические кольца не замещены или частично или полностью замещены RA;
Ra2 представляет собой Н или C1-С6-алкил,
Ra3 представляет собой Н, C1-С6-алкил, C1-С6-галогеналкил, С2-С6-алкенил, С2-С6-галогеналкенил, С2-С6-алкинил, С2-С6-галогеналкинил или С3-С6-циклоалкил, С3-С6-галогенциклоалкил, С3-С6-циклоалкилметил или С3-С6-галогенциклоалкилметил, где указанные кольца не замещены или замещены циано;
Ra4 независимо представляет собой ОН, CN, C1-С6-алкокси, C1-С6-галогеналкокси, S(O)m-С1-С6-алкил, S(O)m-С1-С6-галогеналкил, C(=O)N(Ra2)Ra3, С3-С6-циклоалкил или С3-С6-галогенциклоалкил, где циклы не замещены или замещены одним или несколькими Ra11; или
фенил, частично или полностью ненасыщенный гетероцикл, где кольца не замещены или замещены одним или несколькими RA;
Ra11 независимо представляет собой ОН, циано, C1-С2-алкил или С1-С2-галогеналкил;
RA независимо выбран из галогена, CN, NO2, С1-С4-алкила, С1-С4-галогеналкила, С2-С4-алкенила, С2-С4-галогеналкенила, С2-С4-алкинила, С2-С4-галогеналкинила, С3-С6-циклоалкила, С3-С6-галогенциклоалкила, С1-С4-алкокси, С1-С4-галогеналкокси, S(O)m-С1-С4-алкила, S(O)m-С1-С4-галогеналкила, С1-С4-алкилкарбонила, С1-С4-галогеналкилкарбонила, C(=O)N(Ra2)Ra3; или
два RA, присутствующие на одном и том же атоме углерода насыщенного или частично насыщенного кольца, могут образовывать вместе =O или =S; или
два RA, присутствующие на одном и том же S или SO кольцевом члене гетероциклического кольца, могут вместе образовывать группу =N(С1-С6-алкил), =NO(С1-С6-алкил), =NN(Н)(С1-С6-алкил) или =NN(С1-С6-алкил)2;
и их N-оксиды, стереоизомеры и приемлемые в сельском хозяйстве или ветеринарии соли.
2. Соединения формулы I по п. 1, которые соответствуют формуле I.a
3. Соединения формулы I по п. 1 или 2, которые соответствуют формуле I.Aa
4. Соединения формулы I по любому из пп. 1-3, которые соответствуют формуле I.1
5. Соединения формулы I по любому из пп.1-3, которые соответствуют формуле I.2
6. Соединения формулы I по любому из пп. 1-3, которые соответствуют формуле I.3
7. Соединения формулы I по любому из пп. 1-6, где R1 представляет собой галогенметил.
8. Соединения формулы I по любому из пп. 1-7, где R3 представляет собой галоген, NO2, CN, СН3, фторметил, CF3, SCH3 или ОСН3, и R4 представляет собой Н.
9. Соединения формулы I по любому из пп. 1-8, где R5 представляет собой Н, C1-С6-алкил, С3-С6-циклоалкил, С2-С6-алкенил или С2-С6-алкинил.
10. Соединения формулы I по любому из пп. 1-9, где R6 представляет собой C1-С6-алкил, который не замещен или замещен фенилом или С(=O)-С1-С6-алкокси; или R6 представляет собой С1-С4-алкил, C1-C3-галогеналкил, С3-С4-циклоалкил, C1-С3-алкокси, C1-С3-галогеналкокси, С1-С4-алкиламино и ди-С1-С4-алкиламино.
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EP17168101.8 | 2017-04-26 | ||
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PCT/EP2018/060439 WO2018197466A1 (en) | 2017-04-26 | 2018-04-24 | Substituted succinimide derivatives as pesticides |
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US (1) | US20200190073A1 (ru) |
EP (1) | EP3615530B1 (ru) |
JP (1) | JP2020517672A (ru) |
KR (1) | KR20190141232A (ru) |
CN (1) | CN110582492A (ru) |
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CA3118033A1 (en) * | 2018-11-06 | 2020-05-14 | Basf Se | Process for preparation of optically enriched isoxazolines |
MX2021006661A (es) * | 2018-12-04 | 2021-07-07 | Basf Se | Proceso para la preparacion de 5-bromo-1,3-dicloro-2-fluoro-bencen o. |
EP3696177A1 (en) | 2019-02-12 | 2020-08-19 | Basf Se | Heterocyclic compounds for the control of invertebrate pests |
AU2021263047A1 (en) * | 2020-04-29 | 2022-11-10 | Syngenta Crop Protection Ag | Crop enhancement |
CN111948302B (zh) * | 2020-06-29 | 2022-07-29 | 中国农业科学院茶叶研究所 | 一种氟噻唑吡乙酮对映体的拆分制备方法 |
CA3205997A1 (en) * | 2020-12-21 | 2022-06-30 | University Of Georgia Research Foundation Inc. | Parasiticidal collar comprising isoxazoline compounds |
EP4043444A1 (en) * | 2021-02-11 | 2022-08-17 | Basf Se | Substituted isoxazoline derivatives |
BR112023016031A2 (pt) * | 2021-02-11 | 2023-12-05 | Basf Se | Compostos de fórmula i, composições agrícolas, métodos para combater ou controlar pragas invertebradas, para proteger plantas em crescimento e para tratar ou proteger um animal e semente |
WO2023222724A1 (en) * | 2022-05-16 | 2023-11-23 | Syngenta Crop Protection Ag | Method for mosquito control |
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- 2018-04-24 RU RU2019136972A patent/RU2019136972A/ru not_active Application Discontinuation
- 2018-04-24 AU AU2018260098A patent/AU2018260098A1/en not_active Abandoned
- 2018-04-24 EP EP18718837.0A patent/EP3615530B1/en active Active
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- 2018-04-24 CN CN201880027145.7A patent/CN110582492A/zh active Pending
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CA3058104A1 (en) | 2018-11-01 |
WO2018197466A1 (en) | 2018-11-01 |
EP3615530B1 (en) | 2021-04-14 |
US20200190073A1 (en) | 2020-06-18 |
CN110582492A (zh) | 2019-12-17 |
MX2019012813A (es) | 2020-01-14 |
CL2019003047A1 (es) | 2020-01-24 |
JP2020517672A (ja) | 2020-06-18 |
AU2018260098A1 (en) | 2019-10-31 |
AR111427A1 (es) | 2019-07-10 |
KR20190141232A (ko) | 2019-12-23 |
EP3615530A1 (en) | 2020-03-04 |
BR112019020449A2 (pt) | 2020-04-28 |
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