RU2019128204A - Белки, связывающиеся с psma, nkg2d и cd16 - Google Patents
Белки, связывающиеся с psma, nkg2d и cd16 Download PDFInfo
- Publication number
- RU2019128204A RU2019128204A RU2019128204A RU2019128204A RU2019128204A RU 2019128204 A RU2019128204 A RU 2019128204A RU 2019128204 A RU2019128204 A RU 2019128204A RU 2019128204 A RU2019128204 A RU 2019128204A RU 2019128204 A RU2019128204 A RU 2019128204A
- Authority
- RU
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- Prior art keywords
- seq
- amino acid
- variable domain
- acid sequence
- binding site
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title claims 37
- 102000004169 proteins and genes Human genes 0.000 title claims 37
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 title claims 4
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 title claims 4
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 title claims 4
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 title claims 3
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 title claims 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 title claims 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 title claims 2
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 title claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 32
- 239000000427 antigen Substances 0.000 claims 31
- 102000036639 antigens Human genes 0.000 claims 31
- 108091007433 antigens Proteins 0.000 claims 31
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 6
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 6
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 6
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 6
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000001608 potassium adipate Substances 0.000 claims 1
- 239000001601 sodium adipate Substances 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/804—Blood cells [leukemia, lymphoma]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762457785P | 2017-02-10 | 2017-02-10 | |
| US62/457,785 | 2017-02-10 | ||
| PCT/US2018/017718 WO2018148610A1 (en) | 2017-02-10 | 2018-02-10 | Proteins binding psma, nkg2d and cd16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2019128204A true RU2019128204A (ru) | 2021-03-10 |
| RU2019128204A3 RU2019128204A3 (enExample) | 2021-07-16 |
Family
ID=63107819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019128204A RU2019128204A (ru) | 2017-02-10 | 2018-02-10 | Белки, связывающиеся с psma, nkg2d и cd16 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20200024353A1 (enExample) |
| EP (1) | EP3579878A4 (enExample) |
| JP (2) | JP2020507577A (enExample) |
| KR (1) | KR20190120770A (enExample) |
| CN (1) | CN110913902A (enExample) |
| AU (1) | AU2018217834A1 (enExample) |
| BR (1) | BR112019016553A2 (enExample) |
| CA (1) | CA3053275A1 (enExample) |
| IL (1) | IL268574A (enExample) |
| MX (1) | MX2019009541A (enExample) |
| RU (1) | RU2019128204A (enExample) |
| SG (1) | SG11201907271PA (enExample) |
| WO (1) | WO2018148610A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3221995C (en) | 2017-02-08 | 2024-05-28 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| SG11201907646YA (en) | 2017-02-20 | 2019-09-27 | Dragonfly Therapeutics Inc | Proteins binding her2, nkg2d and cd16 |
| PT3749346T (pt) | 2018-02-08 | 2024-09-05 | Dragonfly Therapeutics Inc | Combinações de domínios variáveis de anticorpos dirigidas ao receptor nkg2d |
| KR20200118824A (ko) | 2018-02-08 | 2020-10-16 | 드래곤플라이 쎄라퓨틱스, 인크. | 자연 살해 세포를 활성화시키는 다중-특이성 결합 단백질을 수반하는 암의 병용 요법 |
| CA3091424A1 (en) | 2018-02-20 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use |
| CA3108646A1 (en) | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
| AU2019318083A1 (en) | 2018-08-08 | 2021-02-25 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind BCMA, NKG2D and CD16, and methods of use |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| MX2022013944A (es) | 2020-05-06 | 2022-11-30 | Dragonfly Therapeutics Inc | Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a). |
| JP2024508894A (ja) | 2021-03-03 | 2024-02-28 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｎｋｇ２ｄ、ｃｄ１６、及び腫瘍関連抗原に結合する多特異性結合タンパク質を使用して癌を治療する方法 |
| WO2023011431A1 (zh) * | 2021-08-03 | 2023-02-09 | 江苏先声药业有限公司 | 一种cd16抗体及其应用 |
| CN117915950A (zh) * | 2021-08-06 | 2024-04-19 | 甘李药业股份有限公司 | 一种多特异性抗体及其用途 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0300919A2 (hu) * | 2000-03-24 | 2003-07-28 | Micromet Ag | Többfunkciós polipeptidek NKG2D receptor komplex epitóp kötőhellyel |
| US6455712B1 (en) * | 2000-12-13 | 2002-09-24 | Shell Oil Company | Preparation of oxirane compounds |
| JP2009500346A (ja) * | 2005-06-29 | 2009-01-08 | ユニバーシティー・オブ・マイアミ | 癌処置用の抗体−免疫細胞リガンド融合タンパク質 |
| JP2009514537A (ja) * | 2005-11-03 | 2009-04-09 | ジェネンテック・インコーポレーテッド | 治療的抗ｈｅｒ２抗体融合ポリペプチド |
| CN105837690A (zh) * | 2006-06-12 | 2016-08-10 | 新兴产品开发西雅图有限公司 | 具有效应功能的单链多价结合蛋白 |
| CA2708854C (en) * | 2007-12-14 | 2017-11-28 | Novo Nordisk A/S | Antibodies against human nkg2d and uses thereof |
| US8629247B2 (en) * | 2009-04-14 | 2014-01-14 | Proscan Rx Pharma Inc. | Antibodies against prostate specific membrane antigen |
| TW201109438A (en) * | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| KR20130062264A (ko) * | 2010-04-15 | 2013-06-12 | 제넨테크, 인크. | 항-폴리유비퀴틴 항체 및 사용 방법 |
| UY33492A (es) * | 2010-07-09 | 2012-01-31 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| JP6400470B2 (ja) * | 2011-05-16 | 2018-10-03 | ジェネロン（シャンハイ）コーポレイション リミテッド | 多重特異性Ｆａｂ融合タンパク質および使用法 |
| US8852599B2 (en) * | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| RU2630637C2 (ru) * | 2011-08-05 | 2017-09-11 | Дженентек, Инк. | Анти-полиубиквитиновые антитела и способы применения |
| US10156574B2 (en) * | 2013-04-29 | 2018-12-18 | Adimab, Llc | Polyspecificity reagents, methods for their preparation and use |
| RU2718692C2 (ru) * | 2014-05-29 | 2020-04-13 | Мэкроудженикс, Инк. | Триспецифичные связывающие молекулы, которые специфически связывают антигены множества злокачественных опухолей, и способы их применения |
| US20180125988A1 (en) * | 2014-11-11 | 2018-05-10 | Amunix Operating Inc. | Targeted xten conjugate compositions and methods of making same |
| CA2973180A1 (en) * | 2015-01-08 | 2016-07-14 | Kyowa Hakko Kirin Co., Ltd. | Bispecific antibody binding to trailr2 and psma |
| EP3245227A4 (en) * | 2015-01-14 | 2018-07-25 | Compass Therapeutics LLC | Multispecific immunomodulatory antigen-binding constructs |
| KR102606190B1 (ko) * | 2015-02-20 | 2023-11-23 | 오하이오 스테이트 이노베이션 파운데이션 | Nkg2d 및 종양 연관 항원에 대해 유도된 이가 항체 |
| WO2016135041A1 (en) * | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
| PT3280432T (pt) * | 2015-04-06 | 2021-04-22 | Subdomain Llc | Polipéptidos que contêm domínio de ligação de novo e seus usos |
| EP3313876B1 (en) * | 2015-06-23 | 2025-01-22 | Innate Pharma | Multispecific antigen binding proteins |
-
2018
- 2018-02-10 WO PCT/US2018/017718 patent/WO2018148610A1/en not_active Ceased
- 2018-02-10 CA CA3053275A patent/CA3053275A1/en active Pending
- 2018-02-10 AU AU2018217834A patent/AU2018217834A1/en not_active Abandoned
- 2018-02-10 CN CN201880024146.6A patent/CN110913902A/zh active Pending
- 2018-02-10 BR BR112019016553-3A patent/BR112019016553A2/pt not_active Application Discontinuation
- 2018-02-10 US US16/483,788 patent/US20200024353A1/en not_active Abandoned
- 2018-02-10 RU RU2019128204A patent/RU2019128204A/ru unknown
- 2018-02-10 MX MX2019009541A patent/MX2019009541A/es unknown
- 2018-02-10 KR KR1020197026585A patent/KR20190120770A/ko not_active Withdrawn
- 2018-02-10 EP EP18751484.9A patent/EP3579878A4/en not_active Withdrawn
- 2018-02-10 SG SG11201907271PA patent/SG11201907271PA/en unknown
- 2018-02-10 JP JP2019543270A patent/JP2020507577A/ja not_active Withdrawn
-
2019
- 2019-08-07 IL IL268574A patent/IL268574A/en unknown
-
2022
- 2022-04-28 JP JP2022074378A patent/JP2022105121A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| MX2019009541A (es) | 2019-12-16 |
| CN110913902A (zh) | 2020-03-24 |
| AU2018217834A1 (en) | 2019-08-22 |
| BR112019016553A2 (pt) | 2020-03-31 |
| EP3579878A4 (en) | 2020-11-18 |
| KR20190120770A (ko) | 2019-10-24 |
| RU2019128204A3 (enExample) | 2021-07-16 |
| US20200024353A1 (en) | 2020-01-23 |
| EP3579878A1 (en) | 2019-12-18 |
| JP2022105121A (ja) | 2022-07-12 |
| JP2020507577A (ja) | 2020-03-12 |
| WO2018148610A1 (en) | 2018-08-16 |
| SG11201907271PA (en) | 2019-09-27 |
| CA3053275A1 (en) | 2018-08-16 |
| IL268574A (en) | 2019-09-26 |
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