RU2018135371A - АНТИТЕЛА К ФАКТОРУ КОМПЛЕМЕНТА Bb - Google Patents
АНТИТЕЛА К ФАКТОРУ КОМПЛЕМЕНТА Bb Download PDFInfo
- Publication number
- RU2018135371A RU2018135371A RU2018135371A RU2018135371A RU2018135371A RU 2018135371 A RU2018135371 A RU 2018135371A RU 2018135371 A RU2018135371 A RU 2018135371A RU 2018135371 A RU2018135371 A RU 2018135371A RU 2018135371 A RU2018135371 A RU 2018135371A
- Authority
- RU
- Russia
- Prior art keywords
- seq
- antibody
- antibody according
- heavy chain
- amino acid
- Prior art date
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 230000001575 pathological effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 206010064930 age-related macular degeneration Diseases 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 102000003712 Complement factor B Human genes 0.000 claims 1
- 108090000056 Complement factor B Proteins 0.000 claims 1
- 206010018910 Haemolysis Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000008588 hemolysis Effects 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461945613P | 2014-02-27 | 2014-02-27 | |
| US61/945,613 | 2014-02-27 | ||
| US201461947880P | 2014-03-04 | 2014-03-04 | |
| US61/947,880 | 2014-03-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016137256A Division RU2673036C2 (ru) | 2014-02-27 | 2015-02-25 | АНТИТЕЛА К ФАКТОРУ КОМПЛЕМЕНТА Bb |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2018135371A true RU2018135371A (ru) | 2018-12-10 |
Family
ID=52629720
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018135371A RU2018135371A (ru) | 2014-02-27 | 2015-02-25 | АНТИТЕЛА К ФАКТОРУ КОМПЛЕМЕНТА Bb |
| RU2016137256A RU2673036C2 (ru) | 2014-02-27 | 2015-02-25 | АНТИТЕЛА К ФАКТОРУ КОМПЛЕМЕНТА Bb |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016137256A RU2673036C2 (ru) | 2014-02-27 | 2015-02-25 | АНТИТЕЛА К ФАКТОРУ КОМПЛЕМЕНТА Bb |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US9796776B2 (enExample) |
| EP (1) | EP3110845A1 (enExample) |
| JP (2) | JP6643244B2 (enExample) |
| KR (1) | KR20160126054A (enExample) |
| CN (2) | CN106232624B (enExample) |
| AU (2) | AU2015223056B2 (enExample) |
| BR (1) | BR112016019825A2 (enExample) |
| CA (1) | CA2939586A1 (enExample) |
| IL (1) | IL247322A0 (enExample) |
| RU (2) | RU2018135371A (enExample) |
| SG (2) | SG11201606983SA (enExample) |
| WO (1) | WO2015130826A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| CA2910766C (en) | 2013-04-30 | 2020-12-15 | Otitopic Inc. | Dry powder formulations and methods of use |
| KR20160126054A (ko) * | 2014-02-27 | 2016-11-01 | 알러간, 인코포레이티드 | 보체 인자 Bb 항체 |
| JP6920292B2 (ja) * | 2015-10-30 | 2021-08-18 | ジェネンテック， インコーポレイテッド | ヒンジが修飾された抗体断片及び作製方法 |
| CR20180529A (es) * | 2016-04-04 | 2019-03-21 | Bioverativ Usa Inc | Anticuerpos anti-factor bb del complemento y usos de estos referencia cruzada |
| US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
| WO2019059953A2 (en) | 2017-09-22 | 2019-03-28 | Otitopic Inc. | DRY POWDER COMPOSITIONS CONTAINING MAGNESIUM STEARATE |
| TWI823868B (zh) | 2017-10-11 | 2023-12-01 | 美商生物維瑞提夫美國公司 | 誘導補體活性之方法 |
| GB201821089D0 (en) * | 2018-12-21 | 2019-02-06 | Gyroscope Therapeutics Ltd | Codon-optimised complement factor I |
| CA3143995A1 (en) * | 2019-06-21 | 2020-12-24 | Single Cell Technology, Inc. | Anti-tigit antibodies |
| CN110951915A (zh) * | 2019-11-21 | 2020-04-03 | 南方医科大学南方医院 | 一种慢性乙型肝炎抗病毒治疗应答疗效预测的引物以及试剂盒 |
| JP7794758B2 (ja) | 2020-04-20 | 2026-01-06 | ジェンザイム・コーポレーション | ヒト化抗補体Ｂｂ因子抗体およびその使用 |
| JP7787164B2 (ja) | 2020-09-23 | 2025-12-16 | アキリオン ファーマシューティカルズ， インコーポレーテッド | 補体媒介性障害の治療のための医薬化合物 |
| US20240401082A1 (en) * | 2023-03-16 | 2024-12-05 | Genzyme Corporation | Treatment of Dry Age-Related Macular Degeneration |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3691016A (en) | 1970-04-17 | 1972-09-12 | Monsanto Co | Process for the preparation of insoluble enzymes |
| CA1023287A (en) | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4195128A (en) | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
| US4330440A (en) | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
| CA1093991A (en) | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
| US4229537A (en) | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| EP0088046B1 (de) | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipide in wässriger Phase |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| DE3474511D1 (en) | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| JPS63502716A (ja) | 1986-03-07 | 1988-10-13 | マサチューセッツ・インステチュート・オブ・テクノロジー | 糖タンパク安定性の強化方法 |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| AU643427B2 (en) | 1988-10-31 | 1993-11-18 | Immunex Corporation | Interleukin-4 receptors |
| ATE102631T1 (de) | 1988-11-11 | 1994-03-15 | Medical Res Council | Klonierung von immunglobulin sequenzen aus den variabelen domaenen. |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| US5683888A (en) | 1989-07-22 | 1997-11-04 | University Of Wales College Of Medicine | Modified bioluminescent proteins and their use |
| US5292658A (en) | 1989-12-29 | 1994-03-08 | University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center | Cloning and expressions of Renilla luciferase |
| AU651596B2 (en) | 1990-06-05 | 1994-07-28 | Immunex Corporation | Type II interleukin-1 receptors |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| DK0575319T3 (da) | 1991-03-11 | 2000-07-10 | Univ Georgia Res Found | Kloning og ekspression af Renilla-luciferase |
| ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| DE69329974T2 (de) | 1992-12-04 | 2001-07-19 | Medical Research Council, London | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| JP3810791B2 (ja) | 1993-09-10 | 2006-08-16 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | 緑色蛍光タンパク質の使用 |
| US5679546A (en) | 1993-09-24 | 1997-10-21 | Cytomed, Inc. | Chimeric proteins which block complement activation |
| WO1995021191A1 (en) | 1994-02-04 | 1995-08-10 | William Ward | Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein |
| US5777079A (en) | 1994-11-10 | 1998-07-07 | The Regents Of The University Of California | Modified green fluorescent proteins |
| EP0831854A4 (en) | 1995-06-06 | 2001-01-24 | Isis Pharmaceuticals Inc | OLIGONUCLEOTIDS WITH PHOSPHOROTHIOATE BINDINGS OF HIGH CHIRAL PURITY |
| US5985662A (en) | 1995-07-13 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense inhibition of hepatitis B virus replication |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| US5804387A (en) | 1996-02-01 | 1998-09-08 | The Board Of Trustees Of The Leland Stanford Junior University | FACS-optimized mutants of the green fluorescent protein (GFP) |
| US5876995A (en) | 1996-02-06 | 1999-03-02 | Bryan; Bruce | Bioluminescent novelty items |
| US5925558A (en) | 1996-07-16 | 1999-07-20 | The Regents Of The University Of California | Assays for protein kinases using fluorescent protein substrates |
| US5976796A (en) | 1996-10-04 | 1999-11-02 | Loma Linda University | Construction and expression of renilla luciferase and green fluorescent protein fusion genes |
| JP3795533B2 (ja) | 1996-12-12 | 2006-07-12 | プロルーム・リミテツド | 感染性物質を検出及び同定するための方法及び装置 |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| JP2002507410A (ja) | 1998-03-27 | 2002-03-12 | プロルーム・リミテッド | ルシフェラーゼ、蛍光タンパク質、ルシフェラーゼおよび蛍光タンパク質をコードする核酸および、診断、高処理スクリーニングおよび新規アイテムにおけるその使用 |
| AU2001261103B2 (en) | 2000-04-29 | 2007-08-23 | University Of Iowa Research Foundation | Diagnostics and therapeutics for macular degeneration-related disorders |
| US7172874B2 (en) | 2001-04-30 | 2007-02-06 | The Cleveland Clinic Foundation | Diagnostic methods for age related macular degeneration |
| JP4303105B2 (ja) | 2001-06-28 | 2009-07-29 | ドマンティス リミテッド | 二重特異性リガンドとその利用 |
| WO2004003019A2 (en) | 2002-06-28 | 2004-01-08 | Domantis Limited | Immunoglobin single variant antigen-binding domains and dual-specific constructs |
| AU2003217912A1 (en) * | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| AU2003290330A1 (en) | 2002-12-27 | 2004-07-22 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| US7959919B2 (en) * | 2003-11-19 | 2011-06-14 | Novelmed Therapeutics, Inc. | Method of inhibiting factor B-mediated complement activation |
| JP5137053B2 (ja) | 2004-02-10 | 2013-02-06 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイト | 抗ｂ因子抗体もしくはその抗原結合性フラグメント、それを含む組成物、抗原結合性ポリペプチド、および治療薬 |
| AU2005229009A1 (en) * | 2004-03-23 | 2005-10-13 | Amgen, Inc. | Monoclonal antibodies specific for human OX40L (CD 134L) |
| KR20130137716A (ko) * | 2005-11-04 | 2013-12-17 | 제넨테크, 인크. | 안질환 치료를 위한 보체 경로 억제제의 용도 |
| ES2507542T3 (es) | 2007-03-14 | 2014-10-15 | Alexion Cambridge Corporation | Anticuerpo anti-factor B humanizado |
| US9745367B2 (en) * | 2007-03-23 | 2017-08-29 | Novelmed Theraputics, Inc. | Alternative pathway specific antibodies for treating arthritis |
| MX2009013082A (es) | 2007-06-07 | 2010-01-15 | Genentech Inc | Anticuerpos contra c3b y metodos para la prevencion y el tratamiento de trastornos asociados con el complemento. |
| AU2008293487A1 (en) * | 2007-08-27 | 2009-03-05 | Novelmed Therapeutics, Inc. | Method of inhibiting complement activation with factor Bb specific antibodies |
| PL2262831T3 (pl) * | 2008-03-03 | 2015-08-31 | Novelmed Therapeutics Inc | Przeciwciała przeciwko properdynie |
| GB0816702D0 (en) | 2008-09-12 | 2008-10-22 | Trinity College Dublin | Complement proteins |
| US20100291106A1 (en) * | 2009-05-06 | 2010-11-18 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c3b |
| EP2646821A4 (en) | 2010-11-29 | 2015-09-23 | Novelmed Therapeutics Inc | NEOANTIC BODY FOR THE DIAGNOSIS OF TISSUE INJURY |
| JP6244350B2 (ja) * | 2012-04-03 | 2017-12-06 | ノーベルメッド セラピューティクス インコーポレイテッド． | ヒト化およびキメラ抗因子Ｂｂ抗体、ならびにその使用 |
| EP2855529A4 (en) * | 2012-05-24 | 2015-12-09 | Alexion Pharma Inc | HUMANIZED ANTI-FACTOR B ANTIBODIES |
| US9401875B2 (en) | 2012-06-01 | 2016-07-26 | Nippon Telegraph And Telephone Corporation | Packet transfer processing method and packet transfer processing device |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
| KR20160126054A (ko) * | 2014-02-27 | 2016-11-01 | 알러간, 인코포레이티드 | 보체 인자 Bb 항체 |
| US9300829B2 (en) | 2014-04-04 | 2016-03-29 | Canon Kabushiki Kaisha | Image reading apparatus and correction method thereof |
-
2015
- 2015-02-25 KR KR1020167026580A patent/KR20160126054A/ko not_active Ceased
- 2015-02-25 JP JP2016554488A patent/JP6643244B2/ja not_active Expired - Fee Related
- 2015-02-25 SG SG11201606983SA patent/SG11201606983SA/en unknown
- 2015-02-25 US US14/631,057 patent/US9796776B2/en active Active
- 2015-02-25 SG SG10202104175YA patent/SG10202104175YA/en unknown
- 2015-02-25 WO PCT/US2015/017578 patent/WO2015130826A1/en not_active Ceased
- 2015-02-25 CN CN201580019612.8A patent/CN106232624B/zh not_active Expired - Fee Related
- 2015-02-25 EP EP15708422.9A patent/EP3110845A1/en not_active Withdrawn
- 2015-02-25 RU RU2018135371A patent/RU2018135371A/ru not_active Application Discontinuation
- 2015-02-25 CN CN201911079865.0A patent/CN110724691A/zh active Pending
- 2015-02-25 RU RU2016137256A patent/RU2673036C2/ru active
- 2015-02-25 AU AU2015223056A patent/AU2015223056B2/en not_active Ceased
- 2015-02-25 BR BR112016019825A patent/BR112016019825A2/pt not_active IP Right Cessation
- 2015-02-25 CA CA2939586A patent/CA2939586A1/en not_active Abandoned
-
2016
- 2016-08-17 IL IL247322A patent/IL247322A0/en unknown
-
2017
- 2017-10-23 US US15/790,759 patent/US10093724B2/en active Active
-
2018
- 2018-09-26 US US16/142,421 patent/US10604563B2/en active Active
-
2020
- 2020-01-06 JP JP2020000258A patent/JP2020078304A/ja not_active Withdrawn
- 2020-03-27 US US16/832,469 patent/US20200317762A1/en not_active Abandoned
-
2021
- 2021-01-04 AU AU2021200012A patent/AU2021200012A1/en not_active Abandoned
-
2022
- 2022-08-12 US US17/887,377 patent/US20230124150A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US10093724B2 (en) | 2018-10-09 |
| US20190071492A1 (en) | 2019-03-07 |
| IL247322A0 (en) | 2016-09-29 |
| US20150239987A1 (en) | 2015-08-27 |
| WO2015130826A1 (en) | 2015-09-03 |
| AU2021200012A1 (en) | 2021-02-11 |
| US20200317762A1 (en) | 2020-10-08 |
| BR112016019825A2 (pt) | 2017-10-17 |
| AU2015223056B2 (en) | 2020-10-01 |
| SG11201606983SA (en) | 2016-09-29 |
| CN106232624B (zh) | 2020-01-21 |
| RU2016137256A3 (enExample) | 2018-03-30 |
| AU2015223056A1 (en) | 2016-09-15 |
| JP2020078304A (ja) | 2020-05-28 |
| JP6643244B2 (ja) | 2020-02-12 |
| JP2017507657A (ja) | 2017-03-23 |
| CA2939586A1 (en) | 2015-09-03 |
| EP3110845A1 (en) | 2017-01-04 |
| SG10202104175YA (en) | 2021-06-29 |
| US20230124150A1 (en) | 2023-04-20 |
| KR20160126054A (ko) | 2016-11-01 |
| US10604563B2 (en) | 2020-03-31 |
| RU2016137256A (ru) | 2018-03-30 |
| US9796776B2 (en) | 2017-10-24 |
| CN106232624A (zh) | 2016-12-14 |
| US20180057576A1 (en) | 2018-03-01 |
| RU2673036C2 (ru) | 2018-11-21 |
| CN110724691A (zh) | 2020-01-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2018135371A (ru) | АНТИТЕЛА К ФАКТОРУ КОМПЛЕМЕНТА Bb | |
| RU2016137110A (ru) | Антитела к компоненту комплемента с5 | |
| RU2015143886A (ru) | Антитела к тау и способы применения | |
| JP2017507657A5 (enExample) | ||
| RU2015144105A (ru) | Антитела к гепсидину и их применения | |
| RU2020124153A (ru) | Гуманизированные антитела к cd19 человека и способы их применения | |
| JP2014519317A5 (enExample) | ||
| JP2017536354A5 (enExample) | ||
| JP2018517431A5 (enExample) | ||
| RU2017125758A (ru) | Антитела к с5 и способы их применения | |
| JP2017514461A5 (enExample) | ||
| JP2016526878A5 (enExample) | ||
| JP2014522843A5 (enExample) | ||
| JP2014158469A5 (enExample) | ||
| JP2018502840A5 (enExample) | ||
| RU2016100892A (ru) | Антитела против tweakr и их применение | |
| RU2021117293A (ru) | АНТИТЕЛА ПРОТИВ HtrA1 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ | |
| RU2014146503A (ru) | Белки, связывающие антиген - лиганд cd30 человека | |
| JP2015503909A5 (enExample) | ||
| JP2015504421A5 (enExample) | ||
| RU2019121086A (ru) | Иммунотерапия с применением антител, связывающих лиганд 1 белка программируемой смерти клеток (PD-L1) | |
| RU2014122990A (ru) | Способы комбинированной терапии с применением молекул, связывающихся с psl и pcrv pseudomonas | |
| JP2016538876A5 (enExample) | ||
| RU2018100824A (ru) | Антитела, которые связываются с сортилином и подавляют связывание програнулина | |
| RU2017120358A (ru) | Анти-il-1-бета антитела и способы их применения |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20180226 |