CN110724691A - 补体因子Bb抗体 - Google Patents

补体因子Bb抗体 Download PDF

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Publication number
CN110724691A
CN110724691A CN201911079865.0A CN201911079865A CN110724691A CN 110724691 A CN110724691 A CN 110724691A CN 201911079865 A CN201911079865 A CN 201911079865A CN 110724691 A CN110724691 A CN 110724691A
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CN
China
Prior art keywords
seq
ser
antibody
gly
val
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Pending
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CN201911079865.0A
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English (en)
Chinese (zh)
Inventor
Y·梁
C·李
I·李
V·M·古兹曼
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Allergan Inc
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Allergan Inc
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Publication of CN110724691A publication Critical patent/CN110724691A/zh
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Endocrinology (AREA)
CN201911079865.0A 2014-02-27 2015-02-25 补体因子Bb抗体 Pending CN110724691A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461945613P 2014-02-27 2014-02-27
US61/945,613 2014-02-27
US201461947880P 2014-03-04 2014-03-04
US61/947,880 2014-03-04
CN201580019612.8A CN106232624B (zh) 2014-02-27 2015-02-25 补体因子Bb抗体

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201580019612.8A Division CN106232624B (zh) 2014-02-27 2015-02-25 补体因子Bb抗体

Publications (1)

Publication Number Publication Date
CN110724691A true CN110724691A (zh) 2020-01-24

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Family Applications (2)

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CN201911079865.0A Pending CN110724691A (zh) 2014-02-27 2015-02-25 补体因子Bb抗体
CN201580019612.8A Expired - Fee Related CN106232624B (zh) 2014-02-27 2015-02-25 补体因子Bb抗体

Family Applications After (1)

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CN201580019612.8A Expired - Fee Related CN106232624B (zh) 2014-02-27 2015-02-25 补体因子Bb抗体

Country Status (12)

Country Link
US (5) US9796776B2 (enExample)
EP (1) EP3110845A1 (enExample)
JP (2) JP6643244B2 (enExample)
KR (1) KR20160126054A (enExample)
CN (2) CN110724691A (enExample)
AU (2) AU2015223056B2 (enExample)
BR (1) BR112016019825A2 (enExample)
CA (1) CA2939586A1 (enExample)
IL (1) IL247322A0 (enExample)
RU (2) RU2673036C2 (enExample)
SG (2) SG10202104175YA (enExample)
WO (1) WO2015130826A1 (enExample)

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US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US10149823B2 (en) 2013-04-30 2018-12-11 Otitopic Inc. Dry powder formulations and methods of use
SG10202104175YA (en) * 2014-02-27 2021-06-29 Allergan Inc COMPLEMENT FACTOR Bb ANTIBODIES
HRP20220064T1 (hr) * 2015-10-30 2022-04-15 F. Hoffmann - La Roche Ag Zglobno modificirani fragmenti protutijela i postupci za pripravu
WO2017176651A1 (en) * 2016-04-04 2017-10-12 True North Therapeutics, Inc. Anti-complement factor bb antibodies and uses thereof
CN115919780A (zh) 2017-09-22 2023-04-07 维克图拉公司 含有硬脂酸镁的干粉组合物
US10786456B2 (en) 2017-09-22 2020-09-29 Otitopic Inc. Inhaled aspirin and magnesium to treat inflammation
JP7369121B2 (ja) * 2017-10-11 2023-10-25 バイオベラティブ・ユーエスエイ・インコーポレイテッド 補体活性を誘発する方法
GB201821089D0 (en) * 2018-12-21 2019-02-06 Gyroscope Therapeutics Ltd Codon-optimised complement factor I
AU2020298324A1 (en) * 2019-06-21 2022-01-27 Single Cell Technology, Inc. Anti-TIGIT antibodies
CN110951915A (zh) * 2019-11-21 2020-04-03 南方医科大学南方医院 一种慢性乙型肝炎抗病毒治疗应答疗效预测的引物以及试剂盒
CA3173325A1 (en) * 2020-04-20 2021-10-28 Graham Parry Humanized anti-complement factor bb antibodies and uses thereof
CN116437913A (zh) 2020-09-23 2023-07-14 艾其林医药公司 用于治疗补体介导的病症的药物化合物
KR20250158063A (ko) * 2023-03-16 2025-11-05 젠자임 코포레이션 건식 연령-관련 황반 변성의 치료

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Also Published As

Publication number Publication date
SG10202104175YA (en) 2021-06-29
KR20160126054A (ko) 2016-11-01
AU2021200012A1 (en) 2021-02-11
US10604563B2 (en) 2020-03-31
JP2017507657A (ja) 2017-03-23
US20190071492A1 (en) 2019-03-07
EP3110845A1 (en) 2017-01-04
US10093724B2 (en) 2018-10-09
US20200317762A1 (en) 2020-10-08
IL247322A0 (en) 2016-09-29
RU2016137256A3 (enExample) 2018-03-30
RU2018135371A (ru) 2018-12-10
RU2673036C2 (ru) 2018-11-21
RU2016137256A (ru) 2018-03-30
JP6643244B2 (ja) 2020-02-12
US20180057576A1 (en) 2018-03-01
AU2015223056B2 (en) 2020-10-01
WO2015130826A1 (en) 2015-09-03
US9796776B2 (en) 2017-10-24
AU2015223056A1 (en) 2016-09-15
US20150239987A1 (en) 2015-08-27
JP2020078304A (ja) 2020-05-28
CN106232624B (zh) 2020-01-21
US20230124150A1 (en) 2023-04-20
CN106232624A (zh) 2016-12-14
CA2939586A1 (en) 2015-09-03
SG11201606983SA (en) 2016-09-29
BR112016019825A2 (pt) 2017-10-17

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