HRP20220064T1 - Zglobno modificirani fragmenti protutijela i postupci za pripravu - Google Patents
Zglobno modificirani fragmenti protutijela i postupci za pripravu Download PDFInfo
- Publication number
- HRP20220064T1 HRP20220064T1 HRP20220064TT HRP20220064T HRP20220064T1 HR P20220064 T1 HRP20220064 T1 HR P20220064T1 HR P20220064T T HRP20220064T T HR P20220064TT HR P20220064 T HRP20220064 T HR P20220064T HR P20220064 T1 HRP20220064 T1 HR P20220064T1
- Authority
- HR
- Croatia
- Prior art keywords
- antibody fragment
- preparation
- preparation according
- fab
- making
- Prior art date
Links
- 102000008394 Immunoglobulin Fragments Human genes 0.000 title claims 6
- 108010021625 Immunoglobulin Fragments Proteins 0.000 title claims 6
- 238000000034 method Methods 0.000 title claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 1
- 101710099301 Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (9)
1. Pripravak koji sadržava izolirani fragment protutijela, naznačen time, da je fragment protutijela Fab izotipa IgG1 koji sadrži skraćenu zglobnu regiju koja završava ostatkom D221 (EU numeracija).
2. Pripravak prema patentnom zahtjevu 1, naznačen time, da Fab završava aminokiselinama koje sadrže aminokiselinsku sekvencu CD.
3. Pripravak prema patentnom zahtjevu 1, naznačen time, da Fab sadrži konstantnu regiju teškog lanca koja sadrži aminokiselinsku sekvencu odabranu iz skupine koju čine SEQ ID NO: 6 i njezine konzervativne modifikacije.
4. Pripravak prema patentnom zahtjevu 1, naznačen time, da izolirani fragment protutijela pokazuje smanjeno vezanje za FcγRIIIa, C1q ili njihovu kombinaciju.
5. Pripravak koji sadrži izoliranu nukleinsku kiselinu, naznačenu time, da kodira fragment protutijela prema patentnom zahtjevu 1.
6. Stanica domaćina, naznačena time, da sadrži pripravak prema patentnom zahtjevu 5.
7. Postupak za dobivanje protutijela, naznačen time, da obuhvaća kultiviranje stanice domaćina prema patentnom zahtjevu 6 na način da se proizvede fragment protutijela.
8. Farmaceutska formulacija, naznačena time, da sadrži protutijelo prema bilo kojem od patentnih zahtjeva 1–4 i farmaceutski prihvatljivi nosač.
9. Pripravak prema bilo kojem od patentnih zahtjeva 1–4 za uporabu kao lijek.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562248792P | 2015-10-30 | 2015-10-30 | |
US201662346905P | 2016-06-07 | 2016-06-07 | |
PCT/US2016/059137 WO2017075229A1 (en) | 2015-10-30 | 2016-10-27 | Hinge modified antibody fragments and methods of making |
EP16795192.0A EP3368579B1 (en) | 2015-10-30 | 2016-10-27 | Hinge modified antibody fragments and methods of making |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20220064T1 true HRP20220064T1 (hr) | 2022-04-15 |
Family
ID=57288500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20220064TT HRP20220064T1 (hr) | 2015-10-30 | 2016-10-27 | Zglobno modificirani fragmenti protutijela i postupci za pripravu |
Country Status (9)
Country | Link |
---|---|
US (2) | US10662254B2 (hr) |
EP (2) | EP3368579B1 (hr) |
JP (3) | JP6920292B2 (hr) |
CN (2) | CN115925962A (hr) |
ES (1) | ES2904553T3 (hr) |
HR (1) | HRP20220064T1 (hr) |
PL (1) | PL3368579T3 (hr) |
SI (1) | SI3368579T1 (hr) |
WO (1) | WO2017075229A1 (hr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11254734B2 (en) * | 2016-11-14 | 2022-02-22 | Morphosys Ag | Fab molecules with a rodent hinge region and a non-rodent CH1 region |
WO2023212906A1 (en) * | 2022-05-06 | 2023-11-09 | Wuxi Xdc (Shanghai) Co., Ltd. | Antibodis comprising engineered hinge and uses thereof |
CN115873833A (zh) * | 2022-11-08 | 2023-03-31 | 上海泰昶生物技术有限公司 | 生产免疫球蛋白g降解酶的工程菌株和工艺 |
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US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
EP0861893A3 (en) | 1991-09-19 | 1999-11-10 | Genentech, Inc. | High level expression of immunoglobulin polypeptides |
EP0752248B1 (en) | 1992-11-13 | 2000-09-27 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
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-
2016
- 2016-10-27 CN CN202210935154.4A patent/CN115925962A/zh active Pending
- 2016-10-27 SI SI201631449T patent/SI3368579T1/sl unknown
- 2016-10-27 JP JP2018521860A patent/JP6920292B2/ja active Active
- 2016-10-27 WO PCT/US2016/059137 patent/WO2017075229A1/en active Application Filing
- 2016-10-27 ES ES16795192T patent/ES2904553T3/es active Active
- 2016-10-27 PL PL16795192T patent/PL3368579T3/pl unknown
- 2016-10-27 CN CN201680077081.2A patent/CN109071674B/zh active Active
- 2016-10-27 EP EP16795192.0A patent/EP3368579B1/en active Active
- 2016-10-27 EP EP21207346.4A patent/EP4036120A1/en active Pending
- 2016-10-27 HR HRP20220064TT patent/HRP20220064T1/hr unknown
-
2018
- 2018-04-30 US US15/967,154 patent/US10662254B2/en active Active
-
2020
- 2020-04-17 US US16/852,136 patent/US20200308304A1/en active Pending
-
2021
- 2021-07-21 JP JP2021120669A patent/JP7413322B2/ja active Active
-
2023
- 2023-12-27 JP JP2023221318A patent/JP2024045138A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
SI3368579T1 (sl) | 2022-04-29 |
ES2904553T3 (es) | 2022-04-05 |
US20180305462A1 (en) | 2018-10-25 |
WO2017075229A1 (en) | 2017-05-04 |
CN115925962A (zh) | 2023-04-07 |
US10662254B2 (en) | 2020-05-26 |
JP6920292B2 (ja) | 2021-08-18 |
EP3368579A1 (en) | 2018-09-05 |
CN109071674A (zh) | 2018-12-21 |
US20200308304A1 (en) | 2020-10-01 |
CN109071674B (zh) | 2022-08-05 |
EP3368579B1 (en) | 2021-11-24 |
JP2021181452A (ja) | 2021-11-25 |
JP7413322B2 (ja) | 2024-01-15 |
EP4036120A1 (en) | 2022-08-03 |
JP2019504820A (ja) | 2019-02-21 |
PL3368579T3 (pl) | 2022-03-21 |
JP2024045138A (ja) | 2024-04-02 |
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