RU2018131123A - Антитела к tgf-бета2 - Google Patents

Антитела к tgf-бета2 Download PDF

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Publication number
RU2018131123A
RU2018131123A RU2018131123A RU2018131123A RU2018131123A RU 2018131123 A RU2018131123 A RU 2018131123A RU 2018131123 A RU2018131123 A RU 2018131123A RU 2018131123 A RU2018131123 A RU 2018131123A RU 2018131123 A RU2018131123 A RU 2018131123A
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RU
Russia
Prior art keywords
seq
heavy chain
light chain
sequence
variable
Prior art date
Application number
RU2018131123A
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English (en)
Russian (ru)
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RU2018131123A3 (cg-RX-API-DMAC10.html
Inventor
Чиквенду Ибебунджо
Карстен Якоби
Ангелика Мейер
Эвелине Шаадт
Анне-Ульрике Тренделенбург
Ольга Владимировна Митина
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58191507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2018131123(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2018131123A publication Critical patent/RU2018131123A/ru
Publication of RU2018131123A3 publication Critical patent/RU2018131123A3/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU2018131123A 2016-02-17 2017-02-17 Антитела к tgf-бета2 RU2018131123A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662296282P 2016-02-17 2016-02-17
US62/296,282 2016-02-17
PCT/IB2017/050917 WO2017141208A1 (en) 2016-02-17 2017-02-17 Tgfbeta 2 antibodies

Publications (2)

Publication Number Publication Date
RU2018131123A true RU2018131123A (ru) 2020-03-17
RU2018131123A3 RU2018131123A3 (cg-RX-API-DMAC10.html) 2020-07-09

Family

ID=58191507

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018131123A RU2018131123A (ru) 2016-02-17 2017-02-17 Антитела к tgf-бета2

Country Status (22)

Country Link
US (1) US11180546B2 (cg-RX-API-DMAC10.html)
EP (1) EP3416982A1 (cg-RX-API-DMAC10.html)
JP (1) JP2019511911A (cg-RX-API-DMAC10.html)
KR (1) KR20180107151A (cg-RX-API-DMAC10.html)
CN (1) CN108699142A (cg-RX-API-DMAC10.html)
AU (1) AU2017219254B2 (cg-RX-API-DMAC10.html)
BR (1) BR112018015690A2 (cg-RX-API-DMAC10.html)
CA (1) CA3012294A1 (cg-RX-API-DMAC10.html)
CL (1) CL2018001941A1 (cg-RX-API-DMAC10.html)
CO (1) CO2018008590A2 (cg-RX-API-DMAC10.html)
CU (1) CU20180088A7 (cg-RX-API-DMAC10.html)
EA (1) EA201891724A1 (cg-RX-API-DMAC10.html)
EC (1) ECSP18064646A (cg-RX-API-DMAC10.html)
HK (1) HK1257455A1 (cg-RX-API-DMAC10.html)
IL (1) IL261065A (cg-RX-API-DMAC10.html)
MA (1) MA44236A (cg-RX-API-DMAC10.html)
MX (1) MX2018010021A (cg-RX-API-DMAC10.html)
PE (1) PE20181634A1 (cg-RX-API-DMAC10.html)
PH (1) PH12018501525A1 (cg-RX-API-DMAC10.html)
RU (1) RU2018131123A (cg-RX-API-DMAC10.html)
SG (1) SG11201805941WA (cg-RX-API-DMAC10.html)
WO (1) WO2017141208A1 (cg-RX-API-DMAC10.html)

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WO2020047333A1 (en) 2018-08-30 2020-03-05 HCW Biologics, Inc. Single-chain chimeric polypeptides and uses thereof
CN112996805A (zh) 2018-08-30 2021-06-18 Hcw生物科技公司 多链嵌合多肽和其用途
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CA3152371A1 (en) 2019-08-01 2021-02-04 Vaccinex, Inc. Combined inhibition of semaphorin-4d and tgf.beta. and compositions therefor
CA3169243A1 (en) 2020-02-11 2021-08-19 HCW Biologics, Inc. Methods of activating regulatory t cells
CN116670163A (zh) 2020-02-11 2023-08-29 Hcw生物科技公司 治疗年龄相关疾病和炎性疾病的方法
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CN112940119B (zh) * 2021-04-26 2022-05-20 北京芳渟阳生生物科技有限公司 一种单克隆抗体及其与间充质干细胞外泌体的联合应用
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US20250282874A1 (en) 2022-05-17 2025-09-11 Suzhou Transcenta Therapeutics Co., Ltd. Bifunctional protein, and preparation thereof and use thereof

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Also Published As

Publication number Publication date
PH12018501525A1 (en) 2019-03-18
US20190092846A1 (en) 2019-03-28
MX2018010021A (es) 2018-11-09
CN108699142A (zh) 2018-10-23
HK1257455A1 (zh) 2019-10-18
CA3012294A1 (en) 2017-08-24
AU2017219254A1 (en) 2018-08-02
RU2018131123A3 (cg-RX-API-DMAC10.html) 2020-07-09
PE20181634A1 (es) 2018-10-11
MA44236A (fr) 2018-12-26
KR20180107151A (ko) 2018-10-01
ECSP18064646A (es) 2018-09-30
EA201891724A1 (ru) 2019-01-31
BR112018015690A2 (en) 2018-12-26
AU2017219254B2 (en) 2019-12-12
WO2017141208A1 (en) 2017-08-24
IL261065A (en) 2018-10-31
CL2018001941A1 (es) 2018-09-07
SG11201805941WA (en) 2018-09-27
CO2018008590A2 (es) 2018-08-21
US11180546B2 (en) 2021-11-23
CU20180088A7 (es) 2019-05-03
JP2019511911A (ja) 2019-05-09
EP3416982A1 (en) 2018-12-26

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