RU2017135257A - Антитело к с-мет и конъюгат антитело к с-мет-цитотоксическое лекарственное средство, и их фармацевтическое применение - Google Patents

Антитело к с-мет и конъюгат антитело к с-мет-цитотоксическое лекарственное средство, и их фармацевтическое применение Download PDF

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Publication number
RU2017135257A
RU2017135257A RU2017135257A RU2017135257A RU2017135257A RU 2017135257 A RU2017135257 A RU 2017135257A RU 2017135257 A RU2017135257 A RU 2017135257A RU 2017135257 A RU2017135257 A RU 2017135257A RU 2017135257 A RU2017135257 A RU 2017135257A
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Russia
Prior art keywords
antibody
seq
sequence
antigen
binding fragment
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RU2017135257A
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English (en)
Russian (ru)
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RU2017135257A3 (enExample
Inventor
Цзяцзянь ЛЮ
Ляньшань Чжан
Вэйкан ТАО
Яюань ФУ
Лин ЧЖАН
Дун МА
Дунбин ЦУЙ
Яли ВАН
Цзяньянь СЮЙ
Цзиньдун ЛИАН
Ин Чжан
Гуйян ЦЗЯН
Цзюньчжуань ЦЮ
Цзыюн СУНЬ
Цзипин ЧЖА
Цзинпин ВЭЙ
Original Assignee
Сучжоу Санкэйдиа Биофармасьютикалз Ко., Лтд.
Цзянсу Хэнжуй Медсин Ко., Лтд.
Шанхай Хэнжуй Фармасьютикал Ко., Лтд.
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Application filed by Сучжоу Санкэйдиа Биофармасьютикалз Ко., Лтд., Цзянсу Хэнжуй Медсин Ко., Лтд., Шанхай Хэнжуй Фармасьютикал Ко., Лтд. filed Critical Сучжоу Санкэйдиа Биофармасьютикалз Ко., Лтд.
Priority claimed from PCT/CN2016/078699 external-priority patent/WO2016165580A1/zh
Publication of RU2017135257A publication Critical patent/RU2017135257A/ru
Publication of RU2017135257A3 publication Critical patent/RU2017135257A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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RU2017135257A 2015-04-17 2016-04-07 Антитело к с-мет и конъюгат антитело к с-мет-цитотоксическое лекарственное средство, и их фармацевтическое применение RU2017135257A (ru)

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