JP2018516539A - 抗ｃ−Ｍｅｔ抗体および抗ｃ−Ｍｅｔ抗体−細胞毒性薬物複合体ならびにそれらの医薬用途 - Google Patents

抗ｃ−Ｍｅｔ抗体および抗ｃ−Ｍｅｔ抗体−細胞毒性薬物複合体ならびにそれらの医薬用途 Download PDF

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Publication number
JP2018516539A
JP2018516539A JP2017553320A JP2017553320A JP2018516539A JP 2018516539 A JP2018516539 A JP 2018516539A JP 2017553320 A JP2017553320 A JP 2017553320A JP 2017553320 A JP2017553320 A JP 2017553320A JP 2018516539 A JP2018516539 A JP 2018516539A
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Japan
Prior art keywords
antibody
group
seq
met
antigen
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Pending
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JP2017553320A
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English (en)
Japanese (ja)
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JP2018516539A5 (enExample
Inventor
リュウ、ジアジエン
ジャン、リエンシャン
タオ、ウェイカン
フー、ヤユエン
ジャン、リン
マ、ドン
ツェイ、ドンビン
ワン、ヤリ
シュ、ジエンヤン
リアン、ジンドン
ジャン、イン
ジアン、グェイヤン
チユ、ジュンジュアン
スン、ヅヨン
ジャ、ジピン
ウェイ、ジンピン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Publication date
Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Priority claimed from PCT/CN2016/078699 external-priority patent/WO2016165580A1/zh
Publication of JP2018516539A publication Critical patent/JP2018516539A/ja
Publication of JP2018516539A5 publication Critical patent/JP2018516539A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022535858A (ja) * 2019-06-06 2022-08-10 上▲海▼翰森生物医▲薬▼科技有限公司 抗ｂ７－ｈ４抗体－薬物コンジュゲート及びその医薬的使用
JP2023524678A (ja) * 2020-09-01 2023-06-13 レメゲン シーオー．，エルティーディー． 抗ｃ－Ｍｅｔ抗体薬物複合体及びその応用
JP2023527962A (ja) * 2020-05-03 2023-07-03 レヴィーナ （スジョウ） バイオファーマ カンパニー， リミテッド 抗ｔｒｏｐ２抗体を含む抗体薬物複合体（ａｄｃ）、かかるａｄｃを含む組成物、ならびにそれらを作製および使用する方法
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Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2708461C2 (ru) * 2015-02-15 2019-12-09 Цзянсу Хэнжуй Медсин Ко., Лтд. Конъюгат лиганда с цитотоксическим лекарственным средством, способ его получения и применение
BR112018016983A2 (pt) * 2016-02-26 2018-12-26 Jiangsu Hengrui Medicine Co., Ltd. nova toxina e método de preparação de intermediário da mesma
RU2740996C2 (ru) * 2016-05-17 2021-01-22 Эббви Байотерапьютикс Инк. КОНЪЮГАТЫ АНТИТЕЛА К cMet И ЛЕКАРСТВЕННОГО СРЕДСТВА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
US20180230218A1 (en) * 2017-01-04 2018-08-16 Immunogen, Inc. Met antibodies and immunoconjugates and uses thereof
AU2018241654A1 (en) 2017-03-30 2019-11-07 Jiangsu Hengrui Medicine Co., Ltd. Method for preparing antibody-drug conjugate
WO2018223958A1 (zh) * 2017-06-06 2018-12-13 江苏恒瑞医药股份有限公司 一种含c-Met抗体药物偶联物的药物组合物及其用途
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KR102221755B1 (ko) * 2018-05-02 2021-03-02 (주)에임드바이오 c-Met에 특이적으로 결합하는 항체 및 그의 용도
WO2019242505A1 (zh) 2018-06-17 2019-12-26 上海健信生物医药科技有限公司 靶向cldn18.2的抗体、双特异性抗体、adc和car及其应用
KR20210068457A (ko) * 2018-09-30 2021-06-09 지앙수 헨그루이 메디슨 컴퍼니 리미티드 항-b7h3 항체-엑사테칸 유사체 접합체 및 이의 의약 용도
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MX2022002886A (es) 2019-09-16 2022-04-06 Regeneron Pharma Proteinas de union met radiomarcadas para la obtencion de imagenes por inmuno-pet.
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MX2022011769A (es) * 2020-03-25 2022-10-18 Jiangsu Hengrui Pharmaceuticals Co Ltd Metodo de preparacion de medicamento de conjugado de anticuerpo.
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WO2022205316A1 (en) * 2021-04-01 2022-10-06 Shanghai Allygen Biologics Co., Ltd. Targeting conjugates comprising effector molecules and uses thereof
AU2022227708A1 (en) * 2021-02-25 2023-10-12 Allygen Group Targeting conjugates comprising effector molecules and uses thereof
UY39743A (es) * 2021-04-29 2022-11-30 Abbvie Inc Conjugados de anticuerpo anti-c-met y fármaco
MX2024000501A (es) * 2021-07-14 2024-01-31 Jiangsu Hengrui Pharmaceuticals Co Ltd Molecula de union a antigeno que se une especificamente a hgfr y egfr, y su uso farmaceutico.
CN115975030B (zh) * 2021-09-30 2023-09-26 杭州邦顺制药有限公司 抗cd39抗体-药物偶联物及其用途
WO2023078393A1 (zh) * 2021-11-05 2023-05-11 正大天晴药业集团股份有限公司 抗c-Met抗体及其应用
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KR20250110257A (ko) * 2022-11-24 2025-07-18 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 Hgfr 및 egfr에 특이적으로 결합하는 이중특이성 항체를 포함하는 약학적 조성물
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WO2025021151A1 (zh) * 2023-07-25 2025-01-30 江苏恒瑞医药股份有限公司 靶向c-Met的抗体-药物偶联物及其医药用途
WO2025060962A1 (en) * 2023-09-21 2025-03-27 Beijing Neox Biotech Limited Multi-specific antibodies and uses thereof
WO2025108427A1 (zh) * 2023-11-23 2025-05-30 橙帆生物医药公司 结合分子及抗体药物偶联物和用途
WO2025146620A1 (ko) * 2024-01-02 2025-07-10 주식회사 종근당 항 c-met 항체를 포함하는 항암 조합물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004010957A2 (en) * 2002-07-31 2004-02-05 Seattle Genetics, Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
WO2005081711A2 (en) * 2003-11-06 2005-09-09 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation to ligands
US7750116B1 (en) * 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
WO2014178791A1 (en) * 2013-04-30 2014-11-06 Agency For Science, Technology And Research Mab 2 anti-met antibody

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005267720B2 (en) 2004-08-05 2012-02-23 Genentech, Inc. Humanized anti-cmet antagonists
TW201116297A (en) * 2009-10-02 2011-05-16 Sanofi Aventis Antibodies that specifically bind to the EphA2 receptor
KR20130037153A (ko) * 2011-10-05 2013-04-15 삼성전자주식회사 항 ｃ-Ｍｅｔ 항체 및 그의 용도
AR090549A1 (es) * 2012-03-30 2014-11-19 Genentech Inc Anticuerpos anti-lgr5 e inmunoconjugados

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004010957A2 (en) * 2002-07-31 2004-02-05 Seattle Genetics, Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
WO2005081711A2 (en) * 2003-11-06 2005-09-09 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation to ligands
US20050238649A1 (en) * 2003-11-06 2005-10-27 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation to ligands
JP2007514652A (ja) * 2003-11-06 2007-06-07 シアトル ジェネティックス， インコーポレイテッド リガンドに結合体化可能なモノメチルバリン化合物
US7750116B1 (en) * 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
WO2014178791A1 (en) * 2013-04-30 2014-11-06 Agency For Science, Technology And Research Mab 2 anti-met antibody

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MOL. CELLS, vol. 34, JPN6020015906, 2012, pages 523 - 529, ISSN: 0004411376 *

Cited By (6)

* Cited by examiner, † Cited by third party
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JP2022535858A (ja) * 2019-06-06 2022-08-10 上▲海▼翰森生物医▲薬▼科技有限公司 抗ｂ７－ｈ４抗体－薬物コンジュゲート及びその医薬的使用
JP7641919B2 (ja) 2019-06-06 2025-03-07 上▲海▼翰森生物医▲薬▼科技有限公司 抗ｂ７－ｈ４抗体－薬物コンジュゲート及びその医薬的使用
JP2023527962A (ja) * 2020-05-03 2023-07-03 レヴィーナ （スジョウ） バイオファーマ カンパニー， リミテッド 抗ｔｒｏｐ２抗体を含む抗体薬物複合体（ａｄｃ）、かかるａｄｃを含む組成物、ならびにそれらを作製および使用する方法
JP2023524678A (ja) * 2020-09-01 2023-06-13 レメゲン シーオー．，エルティーディー． 抗ｃ－Ｍｅｔ抗体薬物複合体及びその応用
JP7510518B2 (ja) 2020-09-01 2024-07-03 レメゲン シーオー．，エルティーディー． 抗ｃ－Ｍｅｔ抗体薬物複合体及びその応用
JP2025517053A (ja) * 2022-12-23 2025-06-03 メディリンク セラピューティクス（スーチョウ）カンパニー，リミティド 抗ｃＭｅｔ抗体、抗体薬物複合体、及びその調製方法と使用

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