CN106188293A - 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途 - Google Patents

抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途 Download PDF

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Publication number
CN106188293A
CN106188293A CN201510300885.1A CN201510300885A CN106188293A CN 106188293 A CN106188293 A CN 106188293A CN 201510300885 A CN201510300885 A CN 201510300885A CN 106188293 A CN106188293 A CN 106188293A
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CN
China
Prior art keywords
antibody
sequence
seq
met
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510300885.1A
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English (en)
Chinese (zh)
Inventor
刘佳建
张连山
陶维康
付雅媛
张玲
马动
崔东冰
王亚里
许建烟
梁金栋
章瑛
蒋贵阳
邱均专
孙自勇
查济平
魏京平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Priority to BR112017021245-5A priority Critical patent/BR112017021245A2/pt
Priority to PCT/CN2016/078699 priority patent/WO2016165580A1/zh
Priority to EP16779555.8A priority patent/EP3284751A4/en
Priority to CN201910217709.XA priority patent/CN111196853A/zh
Priority to AU2016248357A priority patent/AU2016248357A1/en
Priority to RU2017135257A priority patent/RU2017135257A/ru
Priority to CN201680001857.2A priority patent/CN106687480B/zh
Priority to US15/565,928 priority patent/US10543284B2/en
Priority to KR1020177031260A priority patent/KR20170138451A/ko
Priority to CA2982777A priority patent/CA2982777A1/en
Priority to MX2017012965A priority patent/MX2017012965A/es
Priority to JP2017553320A priority patent/JP2018516539A/ja
Priority to TW105111792A priority patent/TWI731856B/zh
Publication of CN106188293A publication Critical patent/CN106188293A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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CN201510300885.1A 2015-04-17 2015-06-04 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途 Pending CN106188293A (zh)

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PCT/CN2016/078699 WO2016165580A1 (zh) 2015-04-17 2016-04-07 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途
EP16779555.8A EP3284751A4 (en) 2015-04-17 2016-04-07 Anti-c-met antibody and anti-c-met antibody-cytotoxic drug conjugate and pharmaceutical use thereof
CN201910217709.XA CN111196853A (zh) 2015-04-17 2016-04-07 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途
AU2016248357A AU2016248357A1 (en) 2015-04-17 2016-04-07 Anti-c-Met antibody and anti-c-Met antibody-cytotoxic drug conjugate and pharmaceutical use thereof
RU2017135257A RU2017135257A (ru) 2015-04-17 2016-04-07 Антитело к с-мет и конъюгат антитело к с-мет-цитотоксическое лекарственное средство, и их фармацевтическое применение
CN201680001857.2A CN106687480B (zh) 2015-04-17 2016-04-07 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途
US15/565,928 US10543284B2 (en) 2015-04-17 2016-04-07 Anti-c-Met antibody and anti-c-Met antibody-cytotoxic drug conjugate and pharmaceutical use thereof
KR1020177031260A KR20170138451A (ko) 2015-04-17 2016-04-07 항-ｃ-ｍｅｔ 항체 및 항-ｃ-ｍｅｔ 항체-세포독성 약물 컨쥬게이트 및 이의 약학적 용도
CA2982777A CA2982777A1 (en) 2015-04-17 2016-04-07 Anti-c-met antibody and anti-c-met antibody-cytotoxic drug conjugate and pharmaceutical use thereof
MX2017012965A MX2017012965A (es) 2015-04-17 2016-04-07 Anticuerpo anti-c-met y conjugado de farmaco citotoxico de anticuerpo anti-c-met y uso farmaceutico del mismo.
JP2017553320A JP2018516539A (ja) 2015-04-17 2016-04-07 抗ｃ−Ｍｅｔ抗体および抗ｃ−Ｍｅｔ抗体−細胞毒性薬物複合体ならびにそれらの医薬用途
TW105111792A TWI731856B (zh) 2015-04-17 2016-04-15 抗c-Met抗體和抗c-Met抗體-細胞毒性藥物偶聯物及其醫藥用途

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WO2018223958A1 (zh) * 2017-06-06 2018-12-13 江苏恒瑞医药股份有限公司 一种含c-Met抗体药物偶联物的药物组合物及其用途
WO2019034176A1 (zh) * 2017-08-18 2019-02-21 四川百利药业有限责任公司 一种喜树碱-抗体偶联物
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WO2019242505A1 (zh) 2018-06-17 2019-12-26 上海健信生物医药科技有限公司 靶向cldn18.2的抗体、双特异性抗体、adc和car及其应用
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CN112543771A (zh) * 2018-09-30 2021-03-23 江苏恒瑞医药股份有限公司 抗b7h3抗体-依喜替康类似物偶联物及其医药用途
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WO2021190602A1 (zh) * 2020-03-25 2021-09-30 江苏恒瑞医药股份有限公司 一种抗体药物偶联物的制备方法
WO2022078279A1 (zh) * 2020-10-12 2022-04-21 昆山新蕴达生物科技有限公司 抗体-药物偶联物及其应用
WO2022205316A1 (en) * 2021-04-01 2022-10-06 Shanghai Allygen Biologics Co., Ltd. Targeting conjugates comprising effector molecules and uses thereof
CN115297889A (zh) * 2020-09-01 2022-11-04 荣昌生物制药(烟台)股份有限公司 抗c-Met抗体药物偶联物及其应用
CN115963233A (zh) * 2022-03-17 2023-04-14 南京美新诺医药科技有限公司 一种评估抗体偶联药物稳定性的方法
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WO2024109914A1 (zh) * 2022-11-24 2024-05-30 江苏恒瑞医药股份有限公司 一种包含特异性结合hgfr和egfr的双特异性抗体的药物组合物
WO2024131949A1 (zh) * 2022-12-23 2024-06-27 苏州宜联生物医药有限公司 Anti-cMet抗体、抗体药物偶联物及其制备方法和用途
WO2025021151A1 (zh) * 2023-07-25 2025-01-30 江苏恒瑞医药股份有限公司 靶向c-Met的抗体-药物偶联物及其医药用途
WO2025060962A1 (en) * 2023-09-21 2025-03-27 Beijing Neox Biotech Limited Multi-specific antibodies and uses thereof
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JP2019510000A (ja) * 2016-02-26 2019-04-11 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． 新規トキシン及びその中間体の製造方法
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TW201825515A (zh) * 2017-01-04 2018-07-16 美商伊繆諾金公司 Ｍｅｔ抗體以及其免疫結合物及用途
KR102221755B1 (ko) * 2018-05-02 2021-03-02 (주)에임드바이오 c-Met에 특이적으로 결합하는 항체 및 그의 용도
AU2020288275A1 (en) * 2019-06-06 2022-02-03 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Anti-B7-H4 antibody–drug conjugate and medicinal use thereof
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WO2021190564A1 (zh) * 2020-03-26 2021-09-30 上海翰森生物医药科技有限公司 抗体药物偶联物及其医药用途
JP2023527962A (ja) * 2020-05-03 2023-07-03 レヴィーナ （スジョウ） バイオファーマ カンパニー， リミテッド 抗ｔｒｏｐ２抗体を含む抗体薬物複合体（ａｄｃ）、かかるａｄｃを含む組成物、ならびにそれらを作製および使用する方法
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