MX2017012965A - Anticuerpo anti-c-met y conjugado de farmaco citotoxico de anticuerpo anti-c-met y uso farmaceutico del mismo. - Google Patents

Anticuerpo anti-c-met y conjugado de farmaco citotoxico de anticuerpo anti-c-met y uso farmaceutico del mismo.

Info

Publication number
MX2017012965A
MX2017012965A MX2017012965A MX2017012965A MX2017012965A MX 2017012965 A MX2017012965 A MX 2017012965A MX 2017012965 A MX2017012965 A MX 2017012965A MX 2017012965 A MX2017012965 A MX 2017012965A MX 2017012965 A MX2017012965 A MX 2017012965A
Authority
MX
Mexico
Prior art keywords
met antibody
antibody
drug conjugate
cytotoxic drug
pharmaceutical use
Prior art date
Application number
MX2017012965A
Other languages
English (en)
Inventor
Zhang Ying
Zhang Lianshan
Liu Jiajian
Wang Yali
Zhang Ling
Tao Weikang
Liang Jindong
Qiu Junzhuan
Xu Jianyan
Jiang Guiyang
Fu Yayuan
Cui Dongbing
Ma Dong
Sun Ziyong
Zha Jiping
Wei Jingping
Original Assignee
Suzhou Suncadia Biopharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suzhou Suncadia Biopharmaceuticals Co Ltd filed Critical Suzhou Suncadia Biopharmaceuticals Co Ltd
Priority claimed from PCT/CN2016/078699 external-priority patent/WO2016165580A1/zh
Publication of MX2017012965A publication Critical patent/MX2017012965A/es

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Classifications

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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2510/00—Genetically modified cells

Abstract

Se proporciona un anticuerpo anti-c-Met o un fragmento de unión al antígeno, y un conjugado de anticuerpo-citotóxico anti-c-Met, en el que el anticuerpo o fragmento de unión al antígeno es un anticuerpo quimérico o un anticuerpo humanizado. También se proporciona una composición farmacéutica que contiene un anticuerpo anti-c-Met humanizado o un fragmento de unión al antígeno, conjugado de fármaco citotóxico de anticuerpo, o una sal o compuesto solvente farmacéuticamente aceptable del mismo, aplicado en el tratamiento del cáncer.
MX2017012965A 2015-04-17 2016-04-07 Anticuerpo anti-c-met y conjugado de farmaco citotoxico de anticuerpo anti-c-met y uso farmaceutico del mismo. MX2017012965A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510185602 2015-04-17
CN201510300885.1A CN106188293A (zh) 2015-04-17 2015-06-04 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途
PCT/CN2016/078699 WO2016165580A1 (zh) 2015-04-17 2016-04-07 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途

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AU (1) AU2016248357A1 (es)
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BR112017021245A2 (pt) 2018-06-26
KR20170138451A (ko) 2017-12-15
RU2017135257A3 (es) 2019-09-24
US20180110875A1 (en) 2018-04-26
TWI731856B (zh) 2021-07-01
EP3284751A1 (en) 2018-02-21
CN111196853A (zh) 2020-05-26
TW201638108A (zh) 2016-11-01
CA2982777A1 (en) 2016-10-20
US10543284B2 (en) 2020-01-28
AU2016248357A1 (en) 2017-10-26
RU2017135257A (ru) 2019-05-17
EP3284751A4 (en) 2018-12-05
CN106188293A (zh) 2016-12-07
CN106687480A (zh) 2017-05-17
CN106687480B (zh) 2019-04-19
JP2018516539A (ja) 2018-06-28

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