BR112018016983A2 - nova toxina e método de preparação de intermediário da mesma - Google Patents

nova toxina e método de preparação de intermediário da mesma

Info

Publication number
BR112018016983A2
BR112018016983A2 BR112018016983-8A BR112018016983A BR112018016983A2 BR 112018016983 A2 BR112018016983 A2 BR 112018016983A2 BR 112018016983 A BR112018016983 A BR 112018016983A BR 112018016983 A2 BR112018016983 A2 BR 112018016983A2
Authority
BR
Brazil
Prior art keywords
general formula
new toxin
preparing
present
same
Prior art date
Application number
BR112018016983-8A
Other languages
English (en)
Chinese (zh)
Inventor
Xu Jianyan
Zhang Ying
Qu Bolei
Jiang Guiyang
Original Assignee
Jiangsu Hengrui Medicine Co., Ltd.
Shanghai Hengrui Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd. filed Critical Jiangsu Hengrui Medicine Co., Ltd.
Publication of BR112018016983A2 publication Critical patent/BR112018016983A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

a presente invenção se refere a uma nova toxina e um método de preparação de um intermediário da mesma. em particular, a presente invenção se refere a uma nova toxina e um método de preparação de intermediários (iii) e (iv) da mesma, e um método de preparação para sintetizar o que é mostrado na fórmula geral (i). o método compreende submeter um composto quiral mostrado na fórmula geral (iii) a uma série de adição de grupo protetor, remoção de grupo protetor e amidação de modo a obter um composto conforme mostrado na fórmula geral (i). o presente método tem as vantagens de condição de reação suave, operação simples, pureza óptica alta e rendimento sintético alto e é adequado para produção em larga escala.
BR112018016983-8A 2016-02-26 2017-02-24 nova toxina e método de preparação de intermediário da mesma BR112018016983A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610107901 2016-02-26
CN201610107901.X 2016-02-26
PCT/CN2017/074756 WO2017144015A1 (zh) 2016-02-26 2017-02-24 一种新毒素及其中间体的制备方法

Publications (1)

Publication Number Publication Date
BR112018016983A2 true BR112018016983A2 (pt) 2018-12-26

Family

ID=59685835

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018016983-8A BR112018016983A2 (pt) 2016-02-26 2017-02-24 nova toxina e método de preparação de intermediário da mesma

Country Status (13)

Country Link
US (1) US10513510B2 (pt)
EP (1) EP3421463A4 (pt)
JP (1) JP2019510000A (pt)
KR (1) KR20180115743A (pt)
CN (1) CN107531680B (pt)
AU (1) AU2017223532A1 (pt)
BR (1) BR112018016983A2 (pt)
CA (1) CA3015098A1 (pt)
HK (1) HK1244805A1 (pt)
MX (1) MX2018010128A (pt)
RU (1) RU2018132749A (pt)
TW (1) TWI732826B (pt)
WO (1) WO2017144015A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201912626A (zh) * 2017-09-04 2019-04-01 大陸商江蘇恆瑞醫藥股份有限公司 一種新毒素及其中間體的製備方法
CN112390853A (zh) * 2019-08-11 2021-02-23 复旦大学 海兔毒素10类似物及其制备方法
BR112023001359A2 (pt) 2020-07-27 2023-02-14 Tuojie Biotech Shanghai Co Ltd Conjugado de anticorpo-fármaco anti-cd79b, método de preparação do mesmo e uso farmacêutico do mesmo

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861170B1 (fr) 2003-10-16 2006-01-20 Tijani Gharbi Dispositif optique pour determiner au moins une caracteristique dimensionnelle d'une goutte de liquide
SG195524A1 (en) * 2003-11-06 2013-12-30 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
SI1791565T1 (sl) * 2004-09-23 2016-08-31 Genentech, Inc. Cisteinsko konstruirana protitelesa in konjugati
TW200833328A (en) 2006-12-28 2008-08-16 Actelion Pharmaceuticals Ltd 2-aza-bicyclo[3.1.0]hexane derivatives
TWI476190B (zh) 2009-03-30 2015-03-11 必治妥美雅史谷比公司 Ｃ型肝炎病毒抑制劑
CN103826661B (zh) * 2011-04-21 2019-03-05 西雅图基因公司 新的结合剂-药物缀合物(adc)及其用途
SG11201401452PA (en) 2011-11-17 2014-06-27 Pfizer Cytotoxic peptides and antibody drug conjugates thereof
EP2790731A2 (de) * 2011-12-14 2014-10-22 Seattle Genetics, Inc. Fgfr-binder-wirkstoff konjugate und ihre verwendung
FR3005051A1 (fr) * 2013-04-25 2014-10-31 Pf Medicament Derives de la dolastatine 10 et d'auristatines
RU2685259C2 (ru) * 2014-04-25 2019-04-17 Пьер Фабр Медикамент Конъюгат антитела и лекарственного средства и его применение для лечения рака
AU2016218840A1 (en) 2015-02-15 2017-08-31 Jiangsu Hengrui Medicine Co., Ltd. Ligand-cytotoxicity drug conjugate, preparing method therefor, and application thereof
CN106188293A (zh) * 2015-04-17 2016-12-07 江苏恒瑞医药股份有限公司 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途

Also Published As

Publication number Publication date
CN107531680B (zh) 2020-09-11
HK1244805A1 (zh) 2018-08-17
US10513510B2 (en) 2019-12-24
CN107531680A (zh) 2018-01-02
TW201730185A (zh) 2017-09-01
JP2019510000A (ja) 2019-04-11
RU2018132749A (ru) 2020-03-26
AU2017223532A1 (en) 2018-08-30
WO2017144015A1 (zh) 2017-08-31
EP3421463A4 (en) 2019-10-23
CA3015098A1 (en) 2017-08-31
MX2018010128A (es) 2019-01-21
US20190055223A1 (en) 2019-02-21
TWI732826B (zh) 2021-07-11
RU2018132749A3 (pt) 2020-04-14
EP3421463A1 (en) 2019-01-02
KR20180115743A (ko) 2018-10-23

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2659 DE 21-12-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.