CO2021001857A2 - Preparación de intermedio útil para la síntesis de inhibidor de sglt - Google Patents

Preparación de intermedio útil para la síntesis de inhibidor de sglt

Info

Publication number
CO2021001857A2
CO2021001857A2 CONC2021/0001857A CO2021001857A CO2021001857A2 CO 2021001857 A2 CO2021001857 A2 CO 2021001857A2 CO 2021001857 A CO2021001857 A CO 2021001857A CO 2021001857 A2 CO2021001857 A2 CO 2021001857A2
Authority
CO
Colombia
Prior art keywords
synthesis
sglt inhibitor
preparation
useful intermediate
related substances
Prior art date
Application number
CONC2021/0001857A
Other languages
English (en)
Inventor
Qing Ri Li
Hee Kyoon Yoon
Original Assignee
Dae Woong Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dae Woong Pharma filed Critical Dae Woong Pharma
Publication of CO2021001857A2 publication Critical patent/CO2021001857A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Método de preparación de un producto intermedio útil para la síntesis de un derivado de difenilmetano que puede usarse como inhibidor de SGLT. Un método de síntesis de un compuesto de fórmula 7 según la presente invención puede solucionar problemas de los procedimientos de síntesis existentes de requerir procedimientos adicionales, debido a la síntesis del reactivo de Grignard, y al manejo de sustancias relacionadas. Además, el método según la presente invención puede minimizar la generación de sustancias relacionadas, y por tanto no requiere un reprocesamiento de los productos de reacción, pudiendo así simplificar el procedimiento. Por consiguiente, puede maximizarse el rendimiento de producción de un derivado de difenilmetano.
CONC2021/0001857A 2018-08-13 2021-02-16 Preparación de intermedio útil para la síntesis de inhibidor de sglt CO2021001857A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20180094261 2018-08-13
PCT/KR2019/010123 WO2020036382A1 (ko) 2018-08-13 2019-08-09 Sglt 저해제의 합성에 유용한 중간체의 제조

Publications (1)

Publication Number Publication Date
CO2021001857A2 true CO2021001857A2 (es) 2021-02-26

Family

ID=69525610

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2021/0001857A CO2021001857A2 (es) 2018-08-13 2021-02-16 Preparación de intermedio útil para la síntesis de inhibidor de sglt

Country Status (12)

Country Link
US (1) US11661406B2 (es)
EP (1) EP3838894B1 (es)
JP (1) JP7146067B2 (es)
KR (1) KR102307475B1 (es)
CN (1) CN112585124B (es)
BR (1) BR112021002523A2 (es)
CA (1) CA3109107C (es)
CO (1) CO2021001857A2 (es)
MX (1) MX2021001732A (es)
PE (1) PE20211206A1 (es)
PH (1) PH12021550297A1 (es)
WO (1) WO2020036382A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021225706A1 (en) * 2020-02-27 2022-09-01 Daewoong Pharmaceutical Co., Ltd. Intermediate useful for synthesis of SGLT inhibitor and method for preparing SGLT inhibitor using same
KR20230110001A (ko) * 2022-01-14 2023-07-21 주식회사 대웅제약 Ssglt 저해제의 합성에 유용한 중간체의 제조 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA107175C2 (uk) 2007-07-26 2014-12-10 Спосіб і сполука, призначені для одержання інгібіторів контранспортера натрій-глюкози 2 типу, варіанти
EP2714032B1 (en) 2011-06-01 2019-01-16 Green Cross Corporation Novel diphenylmethane derivatives as sglt2 inhibitors
US9340521B2 (en) * 2013-03-18 2016-05-17 Green Cross Corporation Method for dual inhibition of SGLT1 and SGLT2 using diphenylmethane derivatives
CA2923522C (en) * 2013-09-09 2018-11-06 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. C-aryl glucoside derivative, preparation method for same, and medical applications thereof
CN113651803B (zh) 2016-06-17 2022-10-28 株式会社大熊制药 用于制备二苯基甲烷衍生物的方法
KR101770302B1 (ko) * 2016-06-28 2017-08-22 주식회사 녹십자 다이페닐메탄 유도체의 제조방법
CN110337442B (zh) * 2017-02-24 2023-05-12 东亚St株式会社 作为2型钠依赖性葡萄糖转运蛋白抑制剂的新型葡萄糖衍生物

Also Published As

Publication number Publication date
JP7146067B2 (ja) 2022-10-03
MX2021001732A (es) 2021-06-23
PH12021550297A1 (en) 2021-10-11
CA3109107A1 (en) 2020-02-20
KR20200019092A (ko) 2020-02-21
EP3838894A4 (en) 2022-04-20
CA3109107C (en) 2023-04-25
KR102307475B1 (ko) 2021-09-30
US20210292291A1 (en) 2021-09-23
WO2020036382A1 (ko) 2020-02-20
BR112021002523A2 (pt) 2021-05-04
EP3838894A1 (en) 2021-06-23
JP2021534174A (ja) 2021-12-09
PE20211206A1 (es) 2021-07-05
US11661406B2 (en) 2023-05-30
EP3838894B1 (en) 2024-03-13
CN112585124A (zh) 2021-03-30
CN112585124B (zh) 2024-04-19

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