MX2018010128A - Toxina nueva y metodo de preparacion de un intermediario de la misma. - Google Patents

Toxina nueva y metodo de preparacion de un intermediario de la misma.

Info

Publication number
MX2018010128A
MX2018010128A MX2018010128A MX2018010128A MX2018010128A MX 2018010128 A MX2018010128 A MX 2018010128A MX 2018010128 A MX2018010128 A MX 2018010128A MX 2018010128 A MX2018010128 A MX 2018010128A MX 2018010128 A MX2018010128 A MX 2018010128A
Authority
MX
Mexico
Prior art keywords
general formula
new toxin
present
preparing
iii
Prior art date
Application number
MX2018010128A
Other languages
English (en)
Inventor
Xu Jianyan
Zhang Ying
Qu Bolei
Jiang Guiyang
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of MX2018010128A publication Critical patent/MX2018010128A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

La presente invención se refiere a una toxina nueva y a un método para preparar un intermediario de la misma. En particular, la presente invención se refiere a una toxina nueva y a un método para preparar los compuestos intermediarios (III) y (IV) de la misma y a un método de preparación para sintetizar lo que se muestra en la fórmula general (I). El método comprende someter un compuesto quiral, mostrado en la fórmula general (III), a una serie de adición de grupo protector, eliminación de grupo protector y amidación para obtener un compuesto como se muestra en la fórmula general (I). El presente método tiene las ventajas de una condición de reacción suave, operación simple, pureza óptica alta y rendimiento sintético alto, y es adecuado para producción a gran escala. (ver fórmulas).
MX2018010128A 2016-02-26 2017-02-24 Toxina nueva y metodo de preparacion de un intermediario de la misma. MX2018010128A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610107901 2016-02-26
PCT/CN2017/074756 WO2017144015A1 (zh) 2016-02-26 2017-02-24 一种新毒素及其中间体的制备方法

Publications (1)

Publication Number Publication Date
MX2018010128A true MX2018010128A (es) 2019-01-21

Family

ID=59685835

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018010128A MX2018010128A (es) 2016-02-26 2017-02-24 Toxina nueva y metodo de preparacion de un intermediario de la misma.

Country Status (13)

Country Link
US (1) US10513510B2 (es)
EP (1) EP3421463A4 (es)
JP (1) JP2019510000A (es)
KR (1) KR20180115743A (es)
CN (1) CN107531680B (es)
AU (1) AU2017223532A1 (es)
BR (1) BR112018016983A2 (es)
CA (1) CA3015098A1 (es)
HK (1) HK1244805A1 (es)
MX (1) MX2018010128A (es)
RU (1) RU2018132749A (es)
TW (1) TWI732826B (es)
WO (1) WO2017144015A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109963835B (zh) * 2017-09-04 2022-10-21 江苏恒瑞医药股份有限公司 一种新毒素及其中间体的制备方法
CN112390853A (zh) * 2019-08-11 2021-02-23 复旦大学 海兔毒素10类似物及其制备方法
KR20230044275A (ko) 2020-07-27 2023-04-03 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 항-cd79b 항체-약물 접합체, 및 이의 제조 방법 및 이의 약학적 용도

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861170B1 (fr) 2003-10-16 2006-01-20 Tijani Gharbi Dispositif optique pour determiner au moins une caracteristique dimensionnelle d'une goutte de liquide
BR122018071808B8 (pt) * 2003-11-06 2020-06-30 Seattle Genetics Inc conjugado
RU2412947C2 (ru) * 2004-09-23 2011-02-27 Дженентек, Инк. Антитела, сконструированные на основе цистеинов, и их конъюгаты
CL2007003827A1 (es) * 2006-12-28 2008-09-26 Actelion Pharmaceuticals Ltd Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras.
TWI476190B (zh) * 2009-03-30 2015-03-11 必治妥美雅史谷比公司 Ｃ型肝炎病毒抑制劑
CA2833477A1 (en) * 2011-04-21 2012-10-26 Seattle Genetics, Inc. Novel binder-drug conjugates (adcs) and their use
KR101733853B1 (ko) 2011-11-17 2017-05-08 화이자 인코포레이티드 세포독성 펩티드 및 그의 항체 약물 접합체
CA2859255A1 (en) 2011-12-14 2013-06-20 Seattle Genetics, Inc. New antibody drug conjugates (adcs) and the use thereof
FR3005051A1 (fr) * 2013-04-25 2014-10-31 Pf Medicament Derives de la dolastatine 10 et d'auristatines
KR102459647B1 (ko) * 2014-04-25 2022-10-26 피에르 파브르 메디카먼트 항체-약물-결합체 및 암의 치료를 위한 그의 용도
JP2018512377A (ja) 2015-02-15 2018-05-17 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． リガンド‐細胞傷害性薬物複合体、その製造方法、及びその使用
CN106188293A (zh) * 2015-04-17 2016-12-07 江苏恒瑞医药股份有限公司 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途

Also Published As

Publication number Publication date
EP3421463A4 (en) 2019-10-23
KR20180115743A (ko) 2018-10-23
CN107531680B (zh) 2020-09-11
AU2017223532A1 (en) 2018-08-30
TW201730185A (zh) 2017-09-01
EP3421463A1 (en) 2019-01-02
US20190055223A1 (en) 2019-02-21
JP2019510000A (ja) 2019-04-11
RU2018132749A (ru) 2020-03-26
CA3015098A1 (en) 2017-08-31
BR112018016983A2 (pt) 2018-12-26
CN107531680A (zh) 2018-01-02
US10513510B2 (en) 2019-12-24
RU2018132749A3 (es) 2020-04-14
TWI732826B (zh) 2021-07-11
WO2017144015A1 (zh) 2017-08-31
HK1244805A1 (zh) 2018-08-17

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