RU2016132687A - Способ изготовления таблеток с использованием радиочастотного излучения и частиц с поглощающим покрытием - Google Patents

Способ изготовления таблеток с использованием радиочастотного излучения и частиц с поглощающим покрытием Download PDF

Info

Publication number
RU2016132687A
RU2016132687A RU2016132687A RU2016132687A RU2016132687A RU 2016132687 A RU2016132687 A RU 2016132687A RU 2016132687 A RU2016132687 A RU 2016132687A RU 2016132687 A RU2016132687 A RU 2016132687A RU 2016132687 A RU2016132687 A RU 2016132687A
Authority
RU
Russia
Prior art keywords
value
substrate
activator
absorbent
tablet
Prior art date
Application number
RU2016132687A
Other languages
English (en)
Other versions
RU2712267C2 (ru
RU2016132687A3 (ru
Inventor
Кристофер И. ШИМЧАК
Вайпул ДЭЙВ
Джерард П. МАКНАЛЛИ
Дэвид Б. КОЧРАН
Грегори КОЛЛ
Стефен УЛЬРИХ
Original Assignee
Джонсон энд Джонсон Консьюмер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джонсон энд Джонсон Консьюмер Инк. filed Critical Джонсон энд Джонсон Консьюмер Инк.
Publication of RU2016132687A publication Critical patent/RU2016132687A/ru
Publication of RU2016132687A3 publication Critical patent/RU2016132687A3/ru
Application granted granted Critical
Publication of RU2712267C2 publication Critical patent/RU2712267C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/006—Coating of the granules without description of the process or the device by which the granules are obtained
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (22)

1. Способ изготовления таблетки, содержащей, по меньшей мере, один фармацевтически активный агент, содержащий этап, на котором на порошковую смесь воздействуют энергией радиочастотного излучения для спекания указанной порошковой смеси в указанную таблетку, при этом указанная порошковая смесь содержит частицы с поглощающим покрытием и указанный, по меньшей мере, один фармацевтически активный агент, причем указанные частицы с поглощающим покрытием содержат субстрат, который, по меньшей мере, частично покрыт поглощающим покрытием, содержащим, по меньшей мере, один активатор, при этом указанный субстрат имеет значение Q более 100, а указанный активатор имеет значение Q менее 75.
2. Способ по п. 1, в котором указанный активатор имеет значение Q менее 50.
3. Способ по п. 1, в котором указанный субстрат имеет значение Q более 200.
4. Способ по п. 2, в котором указанный субстрат имеет значение Q более 200.
5. Способ по п. 1, в котором указанные частицы с поглощающим покрытием имеют значение Q более 100.
6. Способ по п. 1, в котором указанная порошковая смесь имеет значение Q более 100.
7. Способ по п. 1, в котором указанная порошковая смесь содержит, по меньшей мере, 20 мас.% указанных частиц с поглощающим покрытием.
8. Способ по п. 1, в котором указанные частицы с поглощающим покрытием содержат от приблизительно 0,1 до приблизительно 2 мас.% указанного, по меньшей мере, одного активатора.
9. Способ по п. 1, в котором указанные частицы с поглощающим покрытием содержат от приблизительно 0,1 до приблизительно 3 мас.% воды.
10. Способ по п. 1, в котором рассасывание указанной таблетки во рту при помещении на язык занимает менее чем приблизительно 30 секунд.
11. Способ по п. 1, в котором указанная энергия радиочастотного излучения имеет частоту от приблизительно 13 МГц до приблизительно 40 МГц.
12. Способ по п. 1, в котором указанные таблетки формируют в таблеточной пресс-форме.
13. Способ по п. 1, в котором указанный активатор представляет собой полимер, который выбирают из группы, состоящей из целлюлоз, гидроколлоидов, полиметакрилатов, поливинилов, белков, полисахаридов и их сополимеров.
14. Способ по п. 1, в котором указанный активатор представляет собой гидроксипропилцеллюлозу или гидроксиэтилцеллюлозу.
15. Способ по п. 1, в котором указанный субстрат содержит крахмал, сахароспирт или сахар.
16. Способ по п. 1, в котором указанный субстрат содержит мальтит и маннит.
17. Способ по п. 1, в котором указанный субстрат содержит указанный фармацевтически активный агент.
18. Способ по п. 1, в котором хрупкость таблетки составляет менее чем приблизительно 5%.
19. Способ по п. 1, в котором указанная таблетка дополнительно содержит влагоудалитель.
20. Способ по п. 1, в котором указанная таблетка дополнительно содержит пластификатор.
21. Способ изготовления таблетки, содержащей, по меньшей мере, один фармацевтически активный агент, содержащий этап, на котором на порошковую смесь воздействуют энергией радиочастотного излучения для спекания указанной порошковой смеси в указанную таблетку, при этом указанная порошковая смесь содержит частицы с поглощающим покрытием и указанный, по меньшей мере, один фармацевтически активный агент, причем указанные частицы с поглощающим покрытием содержат субстрат, который, по меньшей мере, частично покрыт поглощающим покрытием, содержащим, по меньшей мере, один активатор, при этом значение Q активатора составляет менее половины значения Q субстрата.
22. Спекшаяся таблетка, содержащая частицы с поглощающим покрытием и, по меньшей мере, один фармацевтически активный агент, причем указанные частицы с поглощающим покрытием содержат субстрат, который, по меньшей мере, частично покрыт поглощающим покрытием, содержащим, по меньшей мере, один активатор, при этом указанный субстрат имеет значение Q более 100, а указанный активатор имеет значение Q менее 75.
RU2016132687A 2014-01-10 2015-01-08 Способ изготовления таблеток с использованием радиочастотного излучения и частиц с поглощающим покрытием RU2712267C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461925713P 2014-01-10 2014-01-10
US61/925,713 2014-01-10
PCT/US2015/010647 WO2015105992A1 (en) 2014-01-10 2015-01-08 Process for making tablet using radiofrequency and lossy coated particles

Publications (3)

Publication Number Publication Date
RU2016132687A true RU2016132687A (ru) 2018-02-14
RU2016132687A3 RU2016132687A3 (ru) 2018-09-18
RU2712267C2 RU2712267C2 (ru) 2020-01-28

Family

ID=52432954

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2016132687A RU2712267C2 (ru) 2014-01-10 2015-01-08 Способ изготовления таблеток с использованием радиочастотного излучения и частиц с поглощающим покрытием

Country Status (13)

Country Link
US (2) US9789066B2 (ru)
EP (1) EP3091966B1 (ru)
JP (1) JP6505721B2 (ru)
KR (1) KR20160107254A (ru)
CN (1) CN106068120B (ru)
AU (2) AU2015204763A1 (ru)
BR (1) BR112016015944A8 (ru)
CA (1) CA2936216C (ru)
ES (1) ES2750323T3 (ru)
IL (1) IL246648B (ru)
MX (1) MX368159B (ru)
RU (1) RU2712267C2 (ru)
WO (1) WO2015105992A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9695165B2 (en) 2014-01-15 2017-07-04 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
KR20160138156A (ko) 2014-03-25 2016-12-02 스트라타시스 엘티디. 교차 계층 패턴의 제조 방법 및 시스템
KR20170130515A (ko) * 2015-03-25 2017-11-28 스트라타시스 엘티디. 전도성 잉크의 인 시츄 소결을 위한 방법 및 시스템
WO2018021264A1 (ja) * 2016-07-28 2018-02-01 沢井製薬株式会社 口腔内崩壊性を有する被検物の食感評価方法及び食感評価装置
RU2771159C2 (ru) * 2016-11-28 2022-04-27 Джонсон энд Джонсон Консьюмер Инк. Способ получения дозированной формы с покрытием
US10493026B2 (en) * 2017-03-20 2019-12-03 Johnson & Johnson Consumer Inc. Process for making tablet using radiofrequency and lossy coated particles
WO2024039897A2 (en) * 2022-08-19 2024-02-22 Mirati Therapeutics, Inc. Adagrasib solid pharmaceutical compositions

Family Cites Families (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2183053A (en) 1936-12-03 1939-12-12 Atlantic Coast Fisheries Co Vitamin preparation and method of making same
BE536822A (ru) 1954-03-25
US2887437A (en) 1956-08-22 1959-05-19 Pfizer & Co C Palatable vitamin tablet containing an amino acid
US3071470A (en) 1959-12-24 1963-01-01 Bishop Lee Porter Method for preparing soluble coffee wafers
US3145146A (en) * 1961-10-31 1964-08-18 Warner Lambert Pharmaceutical Modified mannitol for pharmaceutical tablets
GB1097207A (en) 1964-08-24 1967-12-29 Collett & Co As Process for the preparation of sustained action tablets
NL6808619A (ru) 1968-06-19 1969-12-23
US3586066A (en) 1969-05-09 1971-06-22 Vogt Clarence W Method of filling flexible containers
DE2246013A1 (de) 1972-09-20 1974-03-28 Boehringer Mannheim Gmbh Verfahren zur herstellung von poroesen tabletten
US4230693A (en) 1975-04-21 1980-10-28 Armour-Dial, Inc. Antacid tablets and processes for their preparation
CA1063935A (en) 1975-04-21 1979-10-09 Frederick G. Wheeler Antacid tablets and processes for their preparation
US4158411A (en) 1976-05-10 1979-06-19 Hall Douglas C Dispensing package
DE2742572B1 (de) 1977-09-22 1979-03-29 Fette Wilhelm Gmbh Verfahren zum Herstellen von Tabletten und Tablettenpresse
US4268465A (en) 1978-01-27 1981-05-19 Massachusetts Institute Of Technology Method of accelerating the cooling of polymeric articles
US4268238A (en) 1978-03-13 1981-05-19 Clint, Inc. Flow molding
US4173626A (en) 1978-12-11 1979-11-06 Merck & Co., Inc. Sustained release indomethacin
US4260596A (en) 1979-08-13 1981-04-07 Bristol-Myers Company Edible unit dosage form consisting of outer mannitol shell and inner liquid or gel center and method for manufacturing the same
US4327076A (en) 1980-11-17 1982-04-27 Life Savers, Inc. Compressed chewable antacid tablet and method for forming same
EP0070127A3 (en) 1981-07-10 1983-08-17 Beecham Group Plc Tablets
US4398634A (en) 1981-11-12 1983-08-16 Wrapade Machine Company, Inc. Child-proof package system
US4994260A (en) 1982-05-28 1991-02-19 Astra Lakemedel Aktiebolag Pharmaceutical mixture
JPS5967006A (ja) 1982-10-08 1984-04-16 Hitachi Ltd タブレツト成形機
GB2137470B (en) 1983-04-08 1986-11-26 Meiji Seika Kaisha Fleecy confectionery producing machine
US4508740A (en) 1983-07-11 1985-04-02 General Foods Corporation Tabletted beverage composition containing dipeptide sweetener and process therefore
US4609543A (en) 1983-11-14 1986-09-02 Nabisco Brands, Inc. Soft homogeneous antacid tablet
US4758439A (en) 1984-06-11 1988-07-19 Godfrey Science & Design, Inc. Flavor of zinc supplements for oral use
US4590075A (en) 1984-08-27 1986-05-20 Warner-Lambert Company Elastomer encapsulation of flavors and sweeteners, long lasting flavored chewing gum compositions based thereon and process of preparation
US4684534A (en) 1985-02-19 1987-08-04 Dynagram Corporation Of America Quick-liquifying, chewable tablet
US4642903A (en) 1985-03-26 1987-02-17 R. P. Scherer Corporation Freeze-dried foam dosage form
US4832956A (en) 1985-09-25 1989-05-23 Gerhard Gergely Disintegrating tablet and process for its preparation
JPH0649482B2 (ja) 1985-12-12 1994-06-29 ポ−ラ化成工業株式会社 粉末充▲填▼方法及び装置
JPS62205009A (ja) 1986-03-05 1987-09-09 Kanebo Ltd 受皿入り多色固形化粧料の製造方法
IE58401B1 (en) 1986-06-20 1993-09-08 Elan Corp Plc Controlled absorption pharmaceutical composition
US4762719A (en) 1986-08-07 1988-08-09 Mark Forester Powder filled cough product
US4828845A (en) 1986-12-16 1989-05-09 Warner-Lambert Company Xylitol coated comestible and method of preparation
US4824681A (en) 1986-12-19 1989-04-25 Warner-Lambert Company Encapsulated sweetener composition for use with chewing gum and edible products
US4777050A (en) 1987-03-23 1988-10-11 Schering Corporation Controlled-release dosage form comprising acetaminophen, pseudoephedrine and dexbrompheniramine
US4851226A (en) 1987-11-16 1989-07-25 Mcneil Consumer Products Company Chewable medicament tablet containing means for taste masking
US4979720A (en) 1987-11-30 1990-12-25 Jeffrey Robinson Injection mold having interchangeable inscription plates
US4857331A (en) 1988-03-31 1989-08-15 Warner-Lambert Company Sugarless pectin delivery system
SU1632629A1 (ru) 1988-06-03 1991-03-07 Ереванский политехнический институт им.К.Маркса Пресс-форма дл прессовани заготовок из порошка
DE3822095A1 (de) 1988-06-30 1990-01-04 Klinge Co Chem Pharm Fab Neue arzneimittelformulierung sowie verfahren zu deren herstellung
US5073374A (en) 1988-11-30 1991-12-17 Schering Corporation Fast dissolving buccal tablet
US5112616A (en) 1988-11-30 1992-05-12 Schering Corporation Fast dissolving buccal tablet
US4906478A (en) 1988-12-12 1990-03-06 Valentine Enterprises, Inc. Simethicone/calcium silicate composition
US4984240A (en) 1988-12-22 1991-01-08 Codex Corporation Distributed switching architecture for communication module redundancy
US5082436A (en) 1989-07-14 1992-01-21 General Electric Company Apparatus for deforming thermoplastic material using RF heating
NZ234587A (en) 1989-08-04 1991-11-26 Mcneil Ppc Inc A chewable pharmaceutical tablet of compressed coated granules
US5139407A (en) 1989-09-01 1992-08-18 General Electric Company Apparatus for reducing thermoplastic material compression mold cycle time
EP0416791A2 (en) 1989-09-08 1991-03-13 General Motors Corporation Method and apparatus for compression moulding with dielectric heating
CA2024304C (en) 1989-09-15 1996-12-10 Norwin Ced Derby Vacuum fill system
US5223264A (en) 1989-10-02 1993-06-29 Cima Labs, Inc. Pediatric effervescent dosage form
US5178878A (en) 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
US5013557A (en) 1989-10-03 1991-05-07 Warner-Lambert Company Taste masking compositions comprising spray dried microcapsules containing sucralfate and methods for preparing same
US5106594A (en) 1990-03-30 1992-04-21 Stericycle, Inc. Apparatus for processing medical waste
US5275822A (en) 1989-10-19 1994-01-04 Valentine Enterprises, Inc. Defoaming composition
US5064656A (en) 1989-11-14 1991-11-12 Dr. Gergely & Co. Uncoated pharmaceutical reaction tablet
US5558880A (en) 1989-12-22 1996-09-24 Janssen Pharmaceutica Inc. Pharmaceutical and other dosage forms
US5215756A (en) 1989-12-22 1993-06-01 Gole Dilip J Preparation of pharmaceutical and other matrix systems by solid-state dissolution
DE4005328A1 (de) 1990-02-20 1991-08-22 Technics Plasma Gmbh Verfahren zur konditionierung eines pulvers und vorrichtung dafuer
US5075114A (en) 1990-05-23 1991-12-24 Mcneil-Ppc, Inc. Taste masking and sustained release coatings for pharmaceuticals
US5134260A (en) 1990-06-27 1992-07-28 Carnegie-Mellon University Method and apparatus for inductively heating powders or powder compacts for consolidation
SE9003296L (sv) 1990-10-16 1992-04-17 Kabi Pharmacia Ab Foerfarande foer att formulera laekemedel
US5046618A (en) 1990-11-19 1991-09-10 R. P. Scherer Corporation Child-resistant blister pack
US5126151A (en) 1991-01-24 1992-06-30 Warner-Lambert Company Encapsulation matrix
US5286497A (en) 1991-05-20 1994-02-15 Carderm Capital L.P. Diltiazem formulation
DK0587744T3 (da) 1991-05-28 2003-10-20 Mcneil Ppc Inc Tygbar sammensætning til frigørelse af et lægemiddel
CA2068402C (en) 1991-06-14 1998-09-22 Michael R. Hoy Taste mask coatings for preparation of chewable pharmaceutical tablets
US5464632C1 (en) 1991-07-22 2001-02-20 Prographarm Lab Rapidly disintegratable multiparticular tablet
US5326570A (en) 1991-07-23 1994-07-05 Pharmavene, Inc. Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine
US5236636A (en) 1991-10-07 1993-08-17 Ford Motor Company In-mold plasma treatment
US5262171A (en) 1991-11-25 1993-11-16 Isp Investments Inc. Pharmaceutical tablet with PVP having enhanced drug dissolution rate
US5304055A (en) 1991-11-27 1994-04-19 Nabisco, Inc. Apparatus and methods for the production of three-dimensional food products
JP2640570B2 (ja) 1992-01-13 1997-08-13 ファイザー インク． 強度が増加した錠剤の製造
MX9300110A (es) 1992-01-13 1994-07-29 Gerhard Gergely Preparacion farmaceutica en la forma de una tableta de efervescencia o de desintegracion o de un granulado de tipo instanteneo y procedimiento para su preparacion.
JP3069458B2 (ja) 1992-01-29 2000-07-24 武田薬品工業株式会社 口腔内崩壊型錠剤およびその製造法
US5654003A (en) 1992-03-05 1997-08-05 Fuisz Technologies Ltd. Process and apparatus for making tablets and tablets made therefrom
CA2095776C (en) 1992-05-12 2007-07-10 Richard C. Fuisz Rapidly dispersable compositions containing polydextrose
JPH0649482A (ja) 1992-08-04 1994-02-22 Lion Corp 液体洗浄剤組成物
IT1255522B (it) 1992-09-24 1995-11-09 Ubaldo Conte Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita'
US5503846A (en) 1993-03-17 1996-04-02 Cima Labs, Inc. Base coated acid particles and effervescent formulation incorporating same
AU691195B2 (en) 1993-07-09 1998-05-14 R.P. Scherer Corporation Method for making freeze dried drug dosage forms
ZA945944B (en) 1993-08-13 1996-02-08 Eurand America Inc Procedure for encapsulating nsaids
US5895664A (en) 1993-09-10 1999-04-20 Fuisz Technologies Ltd. Process for forming quickly dispersing comestible unit and product therefrom
US5622719A (en) 1993-09-10 1997-04-22 Fuisz Technologies Ltd. Process and apparatus for making rapidly dissolving dosage units and product therefrom
US5662849A (en) 1993-09-10 1997-09-02 Fulsz Technologies Ltd. Method and apparatus for forming compression dosage units within the product package
WO1995009044A1 (en) 1993-09-29 1995-04-06 E.I. Du Pont De Nemours And Company Melt granulation with dielectric heating
NL9400040A (nl) 1994-01-10 1995-08-01 Suiker Unie Werkwijze voor het bereiden van polysaccharidederivaten.
US5635210A (en) 1994-02-03 1997-06-03 The Board Of Regents Of The University Of Oklahoma Method of making a rapidly dissolving tablet
JPH1133084A (ja) 1994-02-10 1999-02-09 Yamanouchi Pharmaceut Co Ltd 口腔内溶解型錠剤およびその製造方法
TW466119B (en) 1994-02-28 2001-12-01 Janssen Pharmaceutica Nv Film coated tablet of paracetamol and domperidone
US5672364A (en) 1994-07-07 1997-09-30 Sankyo Seisakusho Co. & Eisai Co., Ltd. Apparatus for manufacturing tablets
CA2134611C (en) 1994-10-28 2002-12-24 Richard John Yarwood Process for preparing solid pharmaceutical dosage forms
US5607697A (en) 1995-06-07 1997-03-04 Cima Labs, Incorporated Taste masking microparticles for oral dosage forms
KR19990077340A (ko) 1996-01-25 1999-10-25 한스 크리스토프 빌크, 미하엘 베르크만 수성 바인더 시스템의 제조를 위한 다공성 성형품
AU2636797A (en) 1996-04-16 1997-11-07 Novartis Consumer Health S.A. Fast disintegrating oral dosage form
PL188231B1 (pl) 1996-06-17 2004-12-31 Janssen Pharmaceutica Nv Sposób wytwarzania stałej, szybko rozpadającej się postaci dawkowania, stała, szybko rozpadająca się postać dawkowania oraz arkusz wykonany z folii ztworzywa sztucznego albo z metalu
US6491900B2 (en) 1996-08-20 2002-12-10 American Dental Association Health Foundation Anti-carious candies and confections
IT1286212B1 (it) 1996-09-11 1998-07-08 Mg 2 Spa Metodo e macchina per la produzione di pastiglie di polvere medicinale
US5891474A (en) 1997-01-29 1999-04-06 Poli Industria Chimica, S.P.A. Time-specific controlled release dosage formulations and method of preparing same
US6024981A (en) 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
US5939091A (en) 1997-05-20 1999-08-17 Warner Lambert Company Method for making fast-melt tablets
ATE288742T1 (de) 1997-07-10 2005-02-15 Gergely Dr & Co Lösliche, gummihaltige, dragierte kautablette
US5976577A (en) 1997-07-11 1999-11-02 Rp Scherer Corporation Process for preparing fast dispersing solid oral dosage form
US6103260A (en) 1997-07-17 2000-08-15 Mcneil-Ppc, Inc. Simethicone/anhydrous calcium phosphate compositions
US5886081A (en) 1997-08-05 1999-03-23 Rockwell Science Center, Inc. Efficient dielectrically heatable compound and method
WO1999017771A1 (en) 1997-10-02 1999-04-15 H. Lundbeck A/S Granular preparations of 5-(2-ethyl- 2h-tetrazol- 5-yl)-1-methyl-1, 2,3,6-tetrahydropyridine
US6612826B1 (en) 1997-10-15 2003-09-02 Iap Research, Inc. System for consolidating powders
AU741992B2 (en) 1998-03-06 2001-12-13 Adare Pharmaceuticals S.R.L. Fast disintegrating tablets
US6287826B1 (en) 1998-03-09 2001-09-11 Novo Nordisk A/S Enzymatic preparation of glucose syrup from starch
KR100655627B1 (ko) 1998-03-16 2006-12-12 아스텔라스세이야쿠 가부시키가이샤 구강 내에서 급속히 붕괴되는 정제
ES2274625T3 (es) 1998-05-18 2007-05-16 Takeda Pharmaceutical Company Limited Comprimidos desintegrables en la boca que comprenden un bencimidazol.
DE19831520A1 (de) 1998-07-14 2000-01-20 Schaeffler Waelzlager Ohg Elektromagnetischer Ventiltrieb
BR9906712A (pt) * 1998-07-17 2000-10-10 Janssen Pharmaceutica Nv Péletes que apresentam um núcleo revestido com um antifúngico e um polìmero
US6358060B2 (en) 1998-09-03 2002-03-19 Jsr Llc Two-stage transmucosal medicine delivery system for symptom relief
US5997905A (en) 1998-09-04 1999-12-07 Mcneil-Ppc Preparation of pharmaceutically active particles
JP2000095674A (ja) 1998-09-22 2000-04-04 Sato Pharmaceutical Co Ltd 口腔内崩壊時間短縮化錠剤の製造方法及び装置
US6060078A (en) 1998-09-28 2000-05-09 Sae Han Pharm Co., Ltd. Chewable tablet and process for preparation thereof
US20010055613A1 (en) 1998-10-21 2001-12-27 Beth A. Burnside Oral pulsed dose drug delivery system
US7815937B2 (en) 1998-10-27 2010-10-19 Biovail Laboratories International Srl Quick dissolve compositions and tablets based thereon
CA2348871C (en) 1998-11-02 2009-04-14 John G. Devane Multiparticulate modified release composition
US6270805B1 (en) 1998-11-06 2001-08-07 Andrx Pharmaceuticals, Inc. Two pellet controlled release formulation for water soluble drugs which contains an alkaline metal stearate
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20030161879A1 (en) 1999-06-29 2003-08-28 Shinji Ohmori Tablets quickly disintegrating in mouth
US6284270B1 (en) 1999-08-04 2001-09-04 Drugtech Corporation Means for creating a mass having structural integrity
US6649888B2 (en) 1999-09-23 2003-11-18 Codaco, Inc. Radio frequency (RF) heating system
US6277409B1 (en) 2000-02-11 2001-08-21 Mcneil-Ppc, Inc. Protective coating for tablet
US6258381B1 (en) 2000-02-11 2001-07-10 Mcneil-Ppc, Inc. Tablet and process for making the same
US6499984B1 (en) 2000-05-22 2002-12-31 Warner-Lambert Company Continuous production of pharmaceutical granulation
DE10029201A1 (de) 2000-06-19 2001-12-20 Basf Ag Verfahren zur Herstellung fester oraler Darreichungsformen mit retardierender Wirkstoffreisetzung
WO2002024193A1 (en) 2000-09-20 2002-03-28 Skyepharma Canada Inc. Stabilised fibrate microparticles
CA2824077C (en) 2000-09-22 2016-01-26 Dainippon Sumitomo Pharma Co., Ltd. Oral preparations with favorable disintegration characteristics
IN192750B (ru) 2000-12-15 2004-05-15 Ranbaxy Lab Ltd
US6814978B2 (en) 2000-12-29 2004-11-09 Mcneil-Ppc, Inc. Process for preparing a soft tablet
CN100506060C (zh) 2001-03-23 2009-07-01 古木林科有限公司 口香糖的一步制造方法
GB0110846D0 (en) 2001-05-02 2001-06-27 Phoqus Ltd Tablets with coloured patterns
US6509040B1 (en) 2001-06-22 2003-01-21 R.P. Scherer Corporation Fast dispersing dosage forms essentially free of mammalian gelatin
US20030114527A1 (en) * 2001-08-31 2003-06-19 Karnachi Anees Abdulquadar Pharmaceutical composition
EP1437116B1 (en) 2001-09-26 2008-12-31 Sanwa Kagaku Kenkyusho Co., Ltd. Method of producing a multi-core molding article, and device for producing the same
ATE376826T1 (de) 2001-09-28 2007-11-15 Mcneil Ppc Inc Darreichungsformen zur modifizierten freisetzung
US20030228368A1 (en) 2001-09-28 2003-12-11 David Wynn Edible solid composition and dosage form
US7323192B2 (en) 2001-09-28 2008-01-29 Mcneil-Ppc, Inc. Immediate release tablet
US6767200B2 (en) 2001-09-28 2004-07-27 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
US6837696B2 (en) 2001-09-28 2005-01-04 Mcneil-Ppc, Inc. Apparatus for manufacturing dosage forms
ATE380547T1 (de) 2002-01-16 2007-12-15 Boehringer Ingelheim Pharma Zweischichtige pharmazeutische tablette enthaltend telmisartan und hydrochlorothiazid
WO2003061399A1 (en) 2002-01-25 2003-07-31 De Abhijit Chewing gum composition and a process for preparing the same
CN100556762C (zh) 2002-02-13 2009-11-04 迈克尔K·韦伯尔 药物剂型及其制造方法
US6753009B2 (en) 2002-03-13 2004-06-22 Mcneil-Ppc, Inc. Soft tablet containing high molecular weight polyethylene oxide
GB0208587D0 (en) 2002-04-13 2002-05-22 Stanelco Fibre Optics Ltd Capsules
WO2003101431A1 (en) 2002-06-04 2003-12-11 J.B. Chemicals & Pharmaceuticals Ltd. Pharmaceutical composition for controlled drug delivery system
US7070825B2 (en) 2002-09-10 2006-07-04 Abbott Laboratories Infant formula
US7807197B2 (en) 2002-09-28 2010-10-05 Mcneil-Ppc, Inc. Composite dosage forms having an inlaid portion
DE10253479A1 (de) 2002-11-16 2004-06-03 Henkel Kgaa Befüllte Muldentabletten und Verfahren zu ihrer Herstellung II
US20060134195A1 (en) 2002-11-25 2006-06-22 Yourong Fu Mannose-based fast dissolving tablets
ES2414084T3 (es) 2003-02-24 2013-07-18 Pharmaceutical Productions Inc. Sistema de administración de fármacos por vía transmucosa
JP4551627B2 (ja) * 2003-02-28 2010-09-29 東和薬品株式会社 口腔内崩壊錠剤の製造方法
US7749533B2 (en) * 2003-05-07 2010-07-06 Akina, Inc. Highly plastic granules for making fast melting tablets
JP5062871B2 (ja) * 2003-05-13 2012-10-31 東和薬品株式会社 苦味を低減した口腔内崩壊錠剤
KR100473422B1 (ko) 2003-06-12 2005-03-14 박원봉 렉틴 함유 천연물의 장용성 코팅용 조성물
GB0322358D0 (en) 2003-09-24 2003-10-22 Bioprogress Technology Ltd Improvements in powder compaction and enrobing
DE102004008804A1 (de) 2004-02-20 2005-09-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Mehrschichttablette
US20070196477A1 (en) 2004-04-30 2007-08-23 Withiam Michael C Rapidly dissolving tablets comprising low surface area calcium phosphates
JP2008509144A (ja) 2004-08-04 2008-03-27 アルザ・コーポレーシヨン 上昇するゼロ次放出パターンを示す持続薬剤放出組成物、そのような組成物を製造する方法
EP1632135A1 (en) 2004-08-18 2006-03-08 Nestec S.A. Inert, glassy matrices for the stabilization of aroma in soluble coffee
DE102004052308B4 (de) 2004-10-12 2013-04-04 Divapharma-Knufinke Arzneimittelwerk Gmbh Octenidinhaltige Lutschtabletten gegen entzündliche Erkrankungen des Mund- und Rachenraums
TWI354559B (en) 2004-12-27 2011-12-21 Yaizu Suisankagaku Ind Co Ltd Oral disintegrative n-acetylglucosamine tablet and
EP1895992A4 (en) 2005-05-23 2012-03-28 Kraft Foods Global Brands Llc PHARMACEUTICAL SYSTEMS COMPRISING COMPRESSIBLE KAUGUMMIBASIS FOR INGREDIENT RELIEF
CN101282735A (zh) 2005-10-11 2008-10-08 拜耳消费者保健股份公司 掩蔽金属味道的铁盐和铜盐混合物
US20070184111A1 (en) 2006-02-03 2007-08-09 Pharmavite Llc Hybrid tablet
US20100061940A1 (en) 2006-03-16 2010-03-11 Niconovum Ab Chewing Gum Compositions Providing Rapid Release of Nicotine
WO2007126136A2 (en) * 2006-04-27 2007-11-08 Takeda Pharmaceutical Company Limited Mask- tasting solid preparation of pioglitazone
CN101437546A (zh) 2006-05-02 2009-05-20 万能药生物有限公司 经粘膜组合物
US20070286900A1 (en) 2006-06-09 2007-12-13 Catherine Herry Low dose tablets of opioid analgesics and preparation process
US20080008742A1 (en) 2006-06-29 2008-01-10 Capricorn Pharma, Inc. Chewy products and methods for making the same
ATE462416T1 (de) 2006-08-04 2010-04-15 Ethypharm Sa Mehrschichtige im mund zerfallende tablette
US20080286340A1 (en) 2007-05-16 2008-11-20 Sven-Borje Andersson Buffered nicotine containing products
CN101686942B (zh) 2007-06-27 2012-09-26 韩美药品株式会社 用于快速制备用于口服的崩解剂的方法及其产品
TWI547282B (zh) 2007-07-02 2016-09-01 愛戴爾製藥股份有限公司 樂命達之口服分解錠劑組合物
WO2009022670A1 (ja) * 2007-08-10 2009-02-19 Takeda Pharmaceutical Company Limited 速崩壊性錠剤
US20090060983A1 (en) 2007-08-30 2009-03-05 Bunick Frank J Method And Composition For Making An Orally Disintegrating Dosage Form
DE602007012241D1 (de) 2007-08-31 2011-03-10 Gm Global Tech Operations Inc Kraftfahrzeug mit verbessertem Bremssystem
BRPI0816890A2 (pt) 2007-09-18 2015-03-24 Niconovum Ab Composição de goma de mascar, uso de uma combinação de nicotina-celulose, maltitol e uma base de goma, e, método para a preparação de uma composição de goma de mascar
CA2704209C (en) 2007-10-31 2017-02-28 Mcneil-Ppc, Inc. Orally disintegrative dosage form
DK2229158T3 (en) 2007-12-20 2016-12-12 Fertin Pharma As Compressed chewing gum tablet
EP2233129B1 (en) * 2007-12-28 2014-05-07 Sawai Pharmaceutical Co., Ltd. Oral cavity disintegrating tablet and method of producing the same
GB0821186D0 (en) 2008-11-19 2008-12-24 Intrinsiq Materials Global Ltd Gum compositions
JP5517327B2 (ja) * 2008-12-16 2014-06-11 日医工株式会社 口腔内崩壊錠用組成物
US9610224B2 (en) 2009-09-24 2017-04-04 Johnson & Johnson Consumer Inc. Manufacture of tablet in a die utilizing powder blend containing water-containing material
US20110070286A1 (en) 2009-09-24 2011-03-24 Andreas Hugerth Process for the manufacture of nicotine-comprising chewing gum and nicotine-comprising chewing gum manufactured according to said process
US8858210B2 (en) 2009-09-24 2014-10-14 Mcneil-Ppc, Inc. Manufacture of variable density dosage forms utilizing radiofrequency energy
US8313768B2 (en) 2009-09-24 2012-11-20 Mcneil-Ppc, Inc. Manufacture of tablet having immediate release region and sustained release region
WO2012039788A1 (en) 2010-09-22 2012-03-29 Mcneil-Ppc, Inc. Multi-layered orally disintegrating tablet and the manufacture thereof
US20110319492A1 (en) * 2010-06-24 2011-12-29 Luber Joseph R Manufacture of tablets from energy-applied powder blend
CN103124552A (zh) * 2010-09-22 2013-05-29 麦克内尔-Ppc股份有限公司 由施以能量的粉末共混物制造片剂
US9445971B2 (en) 2012-05-01 2016-09-20 Johnson & Johnson Consumer Inc. Method of manufacturing solid dosage form
US20130295174A1 (en) 2012-05-01 2013-11-07 Mcneil-Ppc, Inc. Tablet comprising a first and second region
US9233491B2 (en) 2012-05-01 2016-01-12 Johnson & Johnson Consumer Inc. Machine for production of solid dosage forms
US9511028B2 (en) 2012-05-01 2016-12-06 Johnson & Johnson Consumer Inc. Orally disintegrating tablet

Also Published As

Publication number Publication date
AU2015204763A1 (en) 2016-07-21
WO2015105992A1 (en) 2015-07-16
ES2750323T3 (es) 2020-03-25
CA2936216A1 (en) 2015-07-16
JP2017502060A (ja) 2017-01-19
BR112016015944A2 (pt) 2017-08-08
RU2712267C2 (ru) 2020-01-28
CN106068120A (zh) 2016-11-02
CA2936216C (en) 2021-10-26
AU2020201762A1 (en) 2020-03-26
IL246648A0 (en) 2016-08-31
IL246648B (en) 2020-06-30
BR112016015944A8 (pt) 2020-06-09
EP3091966A1 (en) 2016-11-16
KR20160107254A (ko) 2016-09-13
US9789066B2 (en) 2017-10-17
US20150196493A1 (en) 2015-07-16
RU2016132687A3 (ru) 2018-09-18
MX2016009065A (es) 2017-01-23
MX368159B (es) 2019-09-20
US20170354606A1 (en) 2017-12-14
CN106068120B (zh) 2021-03-23
EP3091966B1 (en) 2019-07-31
JP6505721B2 (ja) 2019-04-24

Similar Documents

Publication Publication Date Title
RU2016132687A (ru) Способ изготовления таблеток с использованием радиочастотного излучения и частиц с поглощающим покрытием
RU2015122406A (ru) Продукты с капсулами, их применение и изготовление
JP2014024874A5 (ru)
RU2007137434A (ru) Таблетированный препарат с замедленным высвобождением для вертиго
JP2010540547A5 (ru)
RU2017134394A (ru) Диспергируемая дозированная форма
MX348866B (es) Producto de bicarbonato de sodio.
RU2016102605A (ru) Фармацевтический комбинированный состав капсулы, содержащий тадалафил и тамсулозин
RU2011102923A (ru) Препарат в форме пленки
WO2011056775A3 (en) Microcrystalline cellulose and calcium phosphate compositions useful as pharmaceutical excipients
RU2013130309A (ru) Твердая молекулярная дисперсия
RU2013125503A (ru) Прессуемый, высоковязкий порошок на основе полисахарида и полиола
MX2021001562A (es) Excipiente de alto rendimiento que comprende celulosa microcristalina co-procesada y carbonato de calcio reaccionado en superficie.
CN104523638A (zh) 含有草酸艾司西酞普兰的片剂及其制备方法
NZ629598A (en) Stable bioactive substances and methods of making
RU2009110638A (ru) Способ получения пористого титана
RU2008137778A (ru) Лекарственная форма с модифицированным высвобождением 6-метил-2-этил-3-гидроксипиридина сукцината
WO2016013001A3 (en) An "on-demand" self-degrading polymer composition and method thereof
JP2015521522A5 (ru)
CN202653155U (zh) 烟灰缸
CN106106552A (zh) 一种蚊香及其制备方法
CN104799432A (zh) 一种滤棒胶囊的防潮处理方法
TH164760B (th) เม็ด n-อะซีติลซิสเทอีนที่สามารถกลืนได้
TH164760A (th) เม็ด n-อะซีติลซิสเทอีนที่สามารถกลืนได้
WO2015086918A9 (fr) Nouveau procédé de fabrication de formulations pharmaceutiques transmuqueuses et formulations ainsi obtenues