RU2016132482A - Магнитные наночастицы, функционализированные пирокатехином, их получение и применение - Google Patents

Магнитные наночастицы, функционализированные пирокатехином, их получение и применение Download PDF

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RU2016132482A
RU2016132482A RU2016132482A RU2016132482A RU2016132482A RU 2016132482 A RU2016132482 A RU 2016132482A RU 2016132482 A RU2016132482 A RU 2016132482A RU 2016132482 A RU2016132482 A RU 2016132482A RU 2016132482 A RU2016132482 A RU 2016132482A
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Джованни БАЛДИ
Костанца РАВАЛЬИ
ФРАНКИНИ Мауро КОМЕС
Марио Милко Д'ЭЛЬОС
Мариса БЕНАДЖАНО
Марко БИТОССИ
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Колороббия Италия С.П.А.
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Claims (22)

1. Магнитные наночастицы, поверхность которых функционализирована пирокатехином, концевая часть молекулы которого не связана с поверхностью частицы и обеспечивает гидрофобную реакционноспособность, причем указанные магнитные частицы состоят из магнетитовых наночастиц.
2. Конструкция, содержащая множество наночастиц по п. 1, инкапсулированных в биологически совместимом полимерном матриксе, в котором необязательно диспергированы молекулы вещества, обладающего терапевтическим действием.
3. Конструкция по п. 2, дополнительно содержащая также множество золотых наностержней.
4. Конструкция по п. 2, в которой указанный биологически совместимый полимерный матрикс состоит из сополимеров, способных к биологической деградации.
5. Конструкция по п. 5, в которой указанные сополимеры, способные к биологической деградации, выбраны из способных к биологической деградации наномицелл, сложных полиэфиров, полиуретанов, поликарбонатов и поли(глутаминовой) кислоты, полиэфирамина и полибензилглутамата.
6. Конструкция по п. 5, в которой указанные способные к биологической деградации наномицеллы состоят из поли(молочной-со-гликолевой) кислоты и полиэтиленгликолькарбоксилата (PLGA-b-PEG-COOH), описываемого формулой (I)
Figure 00000001
где m=[117-330]; n=[117-330]; р=[60-100].
7. Конструкция по п. 2, в которой указанные вещества, обладающие терапевтическим действием, выбраны из противораковых агентов, скэвенджеров пероксинитрита; ингибиторов супероксиддисмутазы; ретиноидов; цитокинов; аспирина.
8. Конструкция по п. 6, в которой концевая карбоксильная группа фрагмента PEG-COOH в мицеллах дополнительно функционализирована моноклональными антителами, белками, пептидами или иными активными молекулами, представляющими интерес с точки зрения специфичного распознавания по чрезмерной экспрессии в клетках.
9. Конструкция по п. 8, в которой указанные антитела выбраны из hEGR, hEGFR, IgG, moAb.
10. Способ получения конструкции по п. 2, в котором
раствор полимера в органическом растворителе, смешанный с суспензией наночастиц, покрытых органическим связующим агентом, в том же растворителе, и
водный раствор Na2HPO4 (1 мМ)
смешивают в постоянном потоке в смесителе при периодическом или непрерывном синтезе.
11. Способ получения конструкций по п. 7, в котором концевую карбоксильную группу фрагмента PEG-COOH активируют, чтобы способствовать последующей реакции этерификации концевых аминогрупп.
12. Клетки иммунной системы человека, содержащие конструкции по п. 2.
13. Клетки по п. 12, в котором указанные клетки иммунной системы человека выбраны из Т-лимфоцитов, моноцитов, макрофагов, дендритных клеток, натуральных киллеров (NK-клеток), В-лимфоцитов, нейтрофильных гранулоцитов, эозинофильных гранулоцитов, базофильных гранулоцитов, гамма-дельта Т-лимфоцитов.
14. Применение наночастиц по п. 1 и конструкций по п. 2 для гипертермического лечения.
15. Применение клеток по п. 12 для диагностирования рака, дегенеративных заболеваний, заболеваний центральной нервной системы, сердечно-сосудистых заболеваний головного мозга, инфекционных и аутоиммунных заболеваний, и состояний, связанных с трансплантацией, а также для лечения опухолей, сердечно-сосудистых заболеваний головного мозга, дегенеративных заболеваний (например, болезни Альцгеймера), инфекционных заболеваний, состояний, связанных с трансплантацией, цирроза печени и других состояний, характеризующихся образованием и прорастанием соединительной ткани, расстройств, сопровождающихся повторными выкидышами, внутриутробной гибели плода, неонатальных заболеваний, врожденных и приобретенных расстройств свертывания крови, генетически обусловленных заболеваний, аутоиммунных заболеваний и, наконец, для облегчения боли.
16. Применение магнитных наночастиц по п. 1 в качестве средства для визуализации при магнитно-резонансной томографии.
17. Применение наночастиц по п. 3, содержащих наностержни, для диагностирования и лечения опухолевых заболеваний.
RU2016132482A 2014-01-07 2015-01-07 Магнитные наночастицы, функционализированные пирокатехином, их получение и применение RU2687497C2 (ru)

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