IT201700083637A1 - Nuovi anticorpi - Google Patents

Nuovi anticorpi

Info

Publication number
IT201700083637A1
IT201700083637A1 IT102017000083637A IT201700083637A IT201700083637A1 IT 201700083637 A1 IT201700083637 A1 IT 201700083637A1 IT 102017000083637 A IT102017000083637 A IT 102017000083637A IT 201700083637 A IT201700083637 A IT 201700083637A IT 201700083637 A1 IT201700083637 A1 IT 201700083637A1
Authority
IT
Italy
Prior art keywords
new antibodies
antibodies
new
Prior art date
Application number
IT102017000083637A
Other languages
English (en)
Inventor
Annarosa Arcangeli
Claudia Duranti
Laura Carraresi
Silvia Crescioli
Original Assignee
Univ Degli Studi Di Firenze
Di V A L Toscana S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Di Firenze, Di V A L Toscana S R L filed Critical Univ Degli Studi Di Firenze
Priority to IT102017000083637A priority Critical patent/IT201700083637A1/it
Priority to CA3070643A priority patent/CA3070643A1/en
Priority to US16/632,803 priority patent/US11572406B2/en
Priority to PCT/EP2018/067641 priority patent/WO2019015936A1/en
Priority to EA202090344A priority patent/EA202090344A1/ru
Priority to KR1020207005232A priority patent/KR20200104279A/ko
Priority to AU2018302356A priority patent/AU2018302356A1/en
Priority to EP18742941.0A priority patent/EP3655434A1/en
Priority to CN201880061398.6A priority patent/CN111479827B/zh
Priority to JP2020524672A priority patent/JP7378088B2/ja
Publication of IT201700083637A1 publication Critical patent/IT201700083637A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Urology & Nephrology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
IT102017000083637A 2017-07-21 2017-07-21 Nuovi anticorpi IT201700083637A1 (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT102017000083637A IT201700083637A1 (it) 2017-07-21 2017-07-21 Nuovi anticorpi
CA3070643A CA3070643A1 (en) 2017-07-21 2018-06-29 Mono and bispecific antibody binding to herg1 and herg1/integrin beta 1
US16/632,803 US11572406B2 (en) 2017-07-21 2018-06-29 Mono and bispecific antibody binding to hERG1 and hERG1/integrin beta 1
PCT/EP2018/067641 WO2019015936A1 (en) 2017-07-21 2018-06-29 MONO AND BISPECIFIC ANTIBODIES BINDING TO HERG1 AND HERG1 / INTEGRIN BETA 1
EA202090344A EA202090344A1 (ru) 2017-07-21 2018-06-29 МОНО- И БИСПЕЦИФИЧНЫЕ АНТИТЕЛА, СВЯЗЫВАЮЩИЕСЯ С hERG1 И hERG1/ИНТЕГРИНОМ БЕТА 1
KR1020207005232A KR20200104279A (ko) 2017-07-21 2018-06-29 Herg1 및 herg/인테그린 베타 1에 결합하는 동종 및 이중특이적 항체
AU2018302356A AU2018302356A1 (en) 2017-07-21 2018-06-29 Mono and bispecific antibody binding to hERG1 and hERG1/integrin beta 1
EP18742941.0A EP3655434A1 (en) 2017-07-21 2018-06-29 Mono and bispecific antibody binding to herg1 and herg1/integrin beta 1
CN201880061398.6A CN111479827B (zh) 2017-07-21 2018-06-29 结合hERG1和hERG1/整联蛋白β1的单特异性和双特异性抗体
JP2020524672A JP7378088B2 (ja) 2017-07-21 2018-06-29 ｈＥＲＧ１およびｈＥＲＧ１／インテグリンβ１に結合する単一特異性および二重特異性抗体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102017000083637A IT201700083637A1 (it) 2017-07-21 2017-07-21 Nuovi anticorpi

Publications (1)

Publication Number Publication Date
IT201700083637A1 true IT201700083637A1 (it) 2019-01-21

Family

ID=60570110

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102017000083637A IT201700083637A1 (it) 2017-07-21 2017-07-21 Nuovi anticorpi

Country Status (10)

Country Link
US (1) US11572406B2 (it)
EP (1) EP3655434A1 (it)
JP (1) JP7378088B2 (it)
KR (1) KR20200104279A (it)
CN (1) CN111479827B (it)
AU (1) AU2018302356A1 (it)
CA (1) CA3070643A1 (it)
EA (1) EA202090344A1 (it)
IT (1) IT201700083637A1 (it)
WO (1) WO2019015936A1 (it)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016020483A1 (en) * 2014-08-08 2016-02-11 Universita' Degli Studi Di Firenze Anti-herg1 antibodies

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120022116A1 (en) * 2010-07-20 2012-01-26 Huayun Deng Compositions and methods for the treatment of pathological condition(s) related to gpr35 and/or gpr35-herg complex
CN106068128B (zh) * 2014-01-07 2020-04-10 卡罗比亚意大利（共同）股份公司 用儿茶酚功能化的磁性纳米颗粒、其制备和用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016020483A1 (en) * 2014-08-08 2016-02-11 Universita' Degli Studi Di Firenze Anti-herg1 antibodies

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZANIERI ET AL.: "beta1integrin/hERG1 complex as a novel molecular target for antineoplastic therapy", ABCD CONGRESS 2011 RAVENNA, 8 September 2011 (2011-09-08), pages 58, XP002779496 *

Also Published As

Publication number Publication date
AU2018302356A1 (en) 2020-03-05
US11572406B2 (en) 2023-02-07
US20210147574A1 (en) 2021-05-20
EP3655434A1 (en) 2020-05-27
JP7378088B2 (ja) 2023-11-13
CA3070643A1 (en) 2019-01-24
JP2020534023A (ja) 2020-11-26
CN111479827A (zh) 2020-07-31
KR20200104279A (ko) 2020-09-03
EA202090344A1 (ru) 2020-06-08
CN111479827B (zh) 2024-03-05
WO2019015936A1 (en) 2019-01-24

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