RU2015139562A - УСТРОЙСТВО ДЛЯ ОПРЕДЕЛЕНИЯ рН И СОСТАВ - Google Patents
УСТРОЙСТВО ДЛЯ ОПРЕДЕЛЕНИЯ рН И СОСТАВ Download PDFInfo
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- RU2015139562A RU2015139562A RU2015139562A RU2015139562A RU2015139562A RU 2015139562 A RU2015139562 A RU 2015139562A RU 2015139562 A RU2015139562 A RU 2015139562A RU 2015139562 A RU2015139562 A RU 2015139562A RU 2015139562 A RU2015139562 A RU 2015139562A
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- Prior art keywords
- fluid
- indicator
- phenylazo
- color
- gjm
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- 239000012530 fluid Substances 0.000 claims 29
- 239000007793 ph indicator Substances 0.000 claims 23
- -1 phenylazo compound Chemical class 0.000 claims 13
- BHQZFFNRGVOBNP-UHFFFAOYSA-N 2-[[2-(2-hydroxyethylsulfonyl)phenyl]diazenyl]-6-methoxyphenol Chemical compound OCCS(=O)(=O)C1=C(C=CC=C1)N=NC1=C(C(=CC=C1)OC)O BHQZFFNRGVOBNP-UHFFFAOYSA-N 0.000 claims 3
- NCFGIICRROZNFI-UHFFFAOYSA-N 2-fluoro-4-[[4-(2-hydroxyethylsulfonyl)phenyl]diazenyl]-6-methoxyphenol Chemical compound FC1=C(C(=CC(=C1)N=NC1=CC=C(C=C1)S(=O)(=O)CCO)OC)O NCFGIICRROZNFI-UHFFFAOYSA-N 0.000 claims 3
- JLXJVDXMEAFPED-UHFFFAOYSA-N 4-[[4-(2-hydroxyethylsulfonyl)phenyl]diazenyl]-2,6-dimethoxyphenol Chemical compound COc1cc(cc(OC)c1O)N=Nc1ccc(cc1)S(=O)(=O)CCO JLXJVDXMEAFPED-UHFFFAOYSA-N 0.000 claims 3
- RAKLVDUIHRTLLP-UHFFFAOYSA-N C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)ON=NC3=CC=CC=C3S(=O)(=O)CCO Chemical compound C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)ON=NC3=CC=CC=C3S(=O)(=O)CCO RAKLVDUIHRTLLP-UHFFFAOYSA-N 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 230000002093 peripheral effect Effects 0.000 claims 2
- 239000000463 material Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
- G01N31/221—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating pH value
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring pH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/42—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm
- A61F2013/427—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm pH indicator
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
- G01N21/80—Indicating pH value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/4163—Systems checking the operation of, or calibrating, the measuring apparatus
- G01N27/4165—Systems checking the operation of, or calibrating, the measuring apparatus for pH meters
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Claims (48)
1. Устройство для определения рН текучей среды, содержащее поверхность, контактирующую с текучей средой, содержащую рН-индикатор, ковалентно иммобилизованный на ней, причем рН-индикатор имеет первый цвет до контакта с текучей средой и изменяет цвет в зависимости от рН текучей среды.
2. Устройство по п. 1, отличающееся тем, что изменение цвета рН-индикатора можно обнаружить при изменении рН с интервалом 0,1 единицы.
3. Устройство по п. 2, отличающееся тем, что изменение цвета рН-индикатора можно обнаружить в диапазоне от рН приблизительно 5 до рН приблизительно 10.
4. Устройство по п. 3, отличающееся тем, что изменение цвета рН-индикатора можно обнаружить в диапазоне от рН приблизительно 5,5 до рН приблизительно 9,5.
5. Устройство по п. 3 или 4, отличающееся тем, что изменение цвета рН-индикатора можно обнаружить в диапазоне рН приблизительно от 6,5 до 9,5.
6. Устройство по любому из пп. 1-4, отличающееся тем, что рН-индикатор содержит фенилазо-соединение.
7. Устройство по п. 6, отличающееся тем, что фенилазо-соединение выбрано из группы, включающей 2-[4(2-гидроксиэтилсульфонил)-фенил]диазенил]-4-метилфенол (GJM-514),
1-гидрокси-4-[4[(гидроксиэтилсульфонил)-фенилазо]-нафталин-2-сульфонат (GJM-546),
2-фтор-4-[4[(2-гидроксиэтансульфонил)-фенилазо]-6-метоксифенол (GJM-492), 4-[4-(2-гидроксиэтилсульфонил)-фенилазо]-2,6-диметоксифенол (GJM-534).
8. Устройство по п. 7, отличающееся тем, что рН-индикатор содержит комбинацию фенилазо-соединений.
9. Устройство по любому из пп. 1-4, 7, 8, отличающееся тем, что оно содержит целлюлозный материал.
10. Устройство для определения рН текучей среды, содержащее
(а) поверхность, контактирующую с текучей средой,
(б) противолежащую поверхность, не контактирующую с текучей средой,
(в) область рН-индикации, содержащую рН-индикатор, ковалентно связанный в ней, который указывает рН текучей среды, причем цвет рН-индикатора изменяется в ответ на изменение рН текучей среды; и
(г) по меньшей мере один канал для направления текучей среды к области рН-индикации.
11. Устройство по п. 10, отличающееся тем, что оно содержит наружную поверхность, причем область рН-индикации находится на наружной поверхности или вблизи нее.
12. Устройство по п. 11, отличающееся тем, что устройство содержит периферийную краевую область, проходящую между поверхностью, контактирующей с текучей средой, и противолежащей поверхностью, не контактирующей с текучей средой, причем внешняя поверхность является периферийной краевой областью.
13. Устройство по любому из пп. 10-12, отличающееся тем, что по меньшей мере один канал направляет жидкость в латеральном направлении к области рН-индикации.
14. Устройство по любому из пп. 10-12, отличающееся тем, что изменение цвета рН-индикатора можно обнаружить при изменении рН с интервалом 0,1 единицы.
15. Устройство по п. 14, отличающееся тем, что изменение цвета рН-индикатора можно обнаружить в диапазоне от рН приблизительно 5 до рН приблизительно 10.
16. Устройство по п. 15, отличающееся тем, что изменение цвета рН-индикатора можно обнаружить в диапазоне от рН приблизительно 5,5 до рН приблизительно 9,5.
17. Устройство по п. 15 или 16, отличающееся тем, что изменение цвета рН-индикатора можно обнаружить в диапазоне от рН приблизительно 6,5 до рН приблизительно 9,5.
18. Повязка по любому из пп. 10-12, 15, 16, отличающаяся тем, что рН-индикатор содержит фенилазо-соединение.
19. Устройство по п. 18, отличающееся тем, что фенилазо-соединение выбрано из группы, включающей
2-[4(2-гидроксиэтилсульфонил)-фенил]диазенил]-4-метилфенол (GJM-514),
1-гидрокси-4-[4[(гидроксиэтилсульфонил)-фенилазо]-нафталин-2-сульфонат (GJM-546),
2-фтор-4-[4[(2-гидроксиэтансульфонил)-фенилазо]-6-метоксифенол (GJM-492), 4-[4-(2-гидроксиэтилсульфонил)-фенилазо]-2,6-диметоксифенол (GJM-534).
20. Устройство по п. 19, отличающееся тем, что рН-индикатор содержит комбинацию фенилазо-соединений.
21. Состав для рН-индикации текучей среды, содержащий краситель, включающий фенилазо-соединение, причем цвет фенилазо-соединения изменяется в ответ на изменение рН текучей среды.
22. Состав по п. 21, отличающийся тем, что фенилазо-соединение выбрано из группы, включающей
2-[4(2-гидроксиэтилсульфонил)-фенил]диазенил]-4-метилфенол (GJM-514),
1-гидрокси-4-[4[(гидроксиэтилсульфонил)-фенилазо]-нафталин-2-сульфонат (GJM-546),
2-фтор-4-[4[(2-гидроксиэтансульфонил)-фенилазо]-6-метоксифенол (GJM-492), 4-[4-(2-гидроксиэтилсульфонил)-фенилазо]-2,6-диметоксифенол (GJM-534).
23. Состав по п. 21 или 22, отличающийся тем, что краситель содержит комбинацию фенилазо-соединений.
24. Состав по п. 21 или 22, отличающийся тем, что изменение цвета рН-индикатора можно обнаружить при изменении рН с интервалом 0,1 единицы.
25. Состав по п. 24, отличающийся тем, что изменение цвета рН-индикатора можно обнаружить в диапазоне от рН приблизительно 5 до рН приблизительно 10.
26. Состав по п. 25, отличающийся тем, что изменение цвета рН-индикатора можно обнаружить в диапазоне от рН приблизительно 5 до рН приблизительно 9,5.
27. Состав по п. 25 или 26, отличающийся тем, что изменение цвета рН-индикатора можно обнаружить в диапазоне от рН приблизительно 6,5 до рН приблизительно 9,5.
28. Способ мониторинга рН текучей среды, включающий этапы
(а) получение устройства, содержащего поверхность, предназначенную для контакта с текучей средой, причем указанная поверхность содержит рН-индикатор, ковалентно иммобилизованный на ней, где рН-индикатор имеет первый цвет до контакта с текучей средой и изменяет цвет в зависимости от рН текучей среды;
(б) приведение устройства в контакт с текучей средой; и
(в) оценку цвета рН-индикатора.
29. Устройство для определения рН текучей среды, содержащее поверхность, контактирующую с текучей средой, содержащую средство рН-индикации, ковалентно иммобилизованное на ней, причем средство рН-индикации имеет первый цвет до контакта с текучей средой и изменяет цвет в зависимости от рН текучей среды.
30. Устройство для определения рН текучей среды, содержащее
(а) средство рН-индикации, имеющее первый цвет до контакта с текучей средой и изменяющее цвет в зависимости от рН текучей среды; и
(б) проводящую часть для направления текучей среды к средству рН-индикации.
31. Система для обнаружения рН текучей среды, содержащая по меньшей мере одно из группы, включающей устройство по любому из пп. 1-4, 7, 8, 10-12, 15, 16, 19, 20 и состав по любому из пп. 21, 22, 25, 26.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1317746.4A GB201317746D0 (en) | 2013-10-08 | 2013-10-08 | PH indicator |
| GB1317746.4 | 2013-10-08 | ||
| PCT/EP2014/071520 WO2015052225A1 (en) | 2013-10-08 | 2014-10-08 | Ph indicator device and formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015139562A true RU2015139562A (ru) | 2017-11-16 |
| RU2015139562A3 RU2015139562A3 (ru) | 2018-06-27 |
Family
ID=49630330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015139562A RU2015139562A (ru) | 2013-10-08 | 2014-10-08 | УСТРОЙСТВО ДЛЯ ОПРЕДЕЛЕНИЯ рН И СОСТАВ |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9829471B2 (ru) |
| EP (1) | EP3055689B1 (ru) |
| JP (1) | JP6396481B2 (ru) |
| CN (2) | CN108204972A (ru) |
| AU (1) | AU2014333841B2 (ru) |
| BR (1) | BR112015015287A2 (ru) |
| CA (1) | CA2895628A1 (ru) |
| GB (1) | GB201317746D0 (ru) |
| RU (1) | RU2015139562A (ru) |
| WO (1) | WO2015052225A1 (ru) |
| ZA (1) | ZA201503770B (ru) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0224986D0 (en) | 2002-10-28 | 2002-12-04 | Smith & Nephew | Apparatus |
| GB0325129D0 (en) | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus in situ |
| US10058642B2 (en) | 2004-04-05 | 2018-08-28 | Bluesky Medical Group Incorporated | Reduced pressure treatment system |
| JP2009506878A (ja) | 2005-09-07 | 2009-02-19 | タイコ ヘルスケア グループ リミテッド パートナーシップ | マイクロポンプを有する自蔵創傷手当て |
| US7779625B2 (en) | 2006-05-11 | 2010-08-24 | Kalypto Medical, Inc. | Device and method for wound therapy |
| WO2009066105A1 (en) | 2007-11-21 | 2009-05-28 | Smith & Nephew Plc | Wound dressing |
| GB0722820D0 (en) | 2007-11-21 | 2008-01-02 | Smith & Nephew | Vacuum assisted wound dressing |
| US9199012B2 (en) | 2008-03-13 | 2015-12-01 | Smith & Nephew, Inc. | Shear resistant wound dressing for use in vacuum wound therapy |
| GB201108229D0 (en) | 2011-05-17 | 2011-06-29 | Smith & Nephew | Tissue healing |
| AU2013237095B2 (en) | 2012-03-20 | 2017-10-05 | Smith & Nephew Plc | Controlling operation of a reduced pressure therapy system based on dynamic duty cycle threshold determination |
| GB201317746D0 (en) * | 2013-10-08 | 2013-11-20 | Smith & Nephew | PH indicator |
| US10695226B2 (en) | 2013-03-15 | 2020-06-30 | Smith & Nephew Plc | Wound dressing and method of treatment |
| US10493184B2 (en) | 2013-03-15 | 2019-12-03 | Smith & Nephew Plc | Wound dressing and method of treatment |
| US20160120706A1 (en) | 2013-03-15 | 2016-05-05 | Smith & Nephew Plc | Wound dressing sealant and use thereof |
| US10073069B2 (en) | 2013-04-23 | 2018-09-11 | Cordant Research Solutions, Llc | Systems and methods to determine body drug concentration from an oral fluid |
| CA2952284C (en) | 2014-06-18 | 2023-03-28 | Smith & Nephew Plc | Wound dressing |
| EP3167007A1 (en) | 2014-07-10 | 2017-05-17 | Smith & Nephew PLC | Improvements in and relating to polymer materials |
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| CA3009878A1 (en) | 2015-12-30 | 2017-07-06 | Smith & Nephew Plc | Negative pressure wound therapy apparatus |
| GB201600746D0 (en) | 2016-01-14 | 2016-03-02 | Smith & Nephew | Improvements in and relating to polymer materials |
| GB201600747D0 (en) | 2016-01-14 | 2016-03-02 | Smith & Nephew | Improvements in and relating to devices |
| WO2017142813A1 (en) * | 2016-02-16 | 2017-08-24 | Cordant Research Solutions, Llc | Systems and methods to determine body drug concentration from an oral fluid |
| JP1586115S (ru) | 2016-02-29 | 2017-09-19 | ||
| USD796735S1 (en) | 2016-02-29 | 2017-09-05 | Smith & Nephew Plc | Mount apparatus for portable negative pressure apparatus |
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| AU2014333841B2 (en) | 2019-05-02 |
| US20180196021A1 (en) | 2018-07-12 |
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| CN105593679B (zh) | 2018-03-06 |
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| US10288590B2 (en) | 2019-05-14 |
| CN105593679A (zh) | 2016-05-18 |
| US9829471B2 (en) | 2017-11-28 |
| CN108204972A (zh) | 2018-06-26 |
| JP6396481B2 (ja) | 2018-09-26 |
| EP3055689B1 (en) | 2022-04-13 |
| EP3055689A1 (en) | 2016-08-17 |
| RU2015139562A3 (ru) | 2018-06-27 |
| WO2015052225A1 (en) | 2015-04-16 |
| US20150308994A1 (en) | 2015-10-29 |
| CA2895628A1 (en) | 2015-04-16 |
| AU2014333841A1 (en) | 2015-06-18 |
| BR112015015287A2 (pt) | 2017-07-11 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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