RU2014115676A - Антитела против аффинного комплекса - Google Patents
Антитела против аффинного комплекса Download PDFInfo
- Publication number
- RU2014115676A RU2014115676A RU2014115676/10A RU2014115676A RU2014115676A RU 2014115676 A RU2014115676 A RU 2014115676A RU 2014115676/10 A RU2014115676/10 A RU 2014115676/10A RU 2014115676 A RU2014115676 A RU 2014115676A RU 2014115676 A RU2014115676 A RU 2014115676A
- Authority
- RU
- Russia
- Prior art keywords
- antibody
- affinity complex
- vitamin
- affinity
- estradiol
- Prior art date
Links
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 title 1
- 229960005309 estradiol Drugs 0.000 claims abstract 10
- -1 steroid compound Chemical class 0.000 claims abstract 8
- 239000000126 substance Substances 0.000 claims abstract 8
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 claims abstract 7
- 108090000623 proteins and genes Proteins 0.000 claims abstract 6
- 229940035722 triiodothyronine Drugs 0.000 claims abstract 6
- 229940088594 vitamin Drugs 0.000 claims abstract 5
- 239000011782 vitamin Substances 0.000 claims abstract 5
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims abstract 4
- JWUBBDSIWDLEOM-UHFFFAOYSA-N 25-Hydroxycholecalciferol Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CCC1=C JWUBBDSIWDLEOM-UHFFFAOYSA-N 0.000 claims abstract 4
- 108060003951 Immunoglobulin Proteins 0.000 claims abstract 4
- 229930003316 Vitamin D Natural products 0.000 claims abstract 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract 4
- 229930182833 estradiol Natural products 0.000 claims abstract 4
- 229940011871 estrogen Drugs 0.000 claims abstract 4
- 239000000262 estrogen Substances 0.000 claims abstract 4
- 102000018358 immunoglobulin Human genes 0.000 claims abstract 4
- 102000004169 proteins and genes Human genes 0.000 claims abstract 4
- 239000005495 thyroid hormone Substances 0.000 claims abstract 4
- 229940036555 thyroid hormone Drugs 0.000 claims abstract 4
- 229930003231 vitamin Natural products 0.000 claims abstract 4
- 235000013343 vitamin Nutrition 0.000 claims abstract 4
- 239000011710 vitamin D Substances 0.000 claims abstract 4
- 235000019166 vitamin D Nutrition 0.000 claims abstract 4
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract 4
- 229940046008 vitamin d Drugs 0.000 claims abstract 4
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 4
- KJKIIUAXZGLUND-QVKZFZTCSA-N (1s,3z)-3-[(2e)-2-[(1r,3as,7ar)-1-[(e,2r,5r)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)CCC1=C KJKIIUAXZGLUND-QVKZFZTCSA-N 0.000 claims 3
- 239000011647 vitamin D3 Substances 0.000 claims 3
- 229940021056 vitamin d3 Drugs 0.000 claims 3
- 102000015782 Electron Transport Complex III Human genes 0.000 claims 2
- 108010024882 Electron Transport Complex III Proteins 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims 1
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 claims 1
- ZHSOTLOTTDYIIK-ZDUSSCGKSA-N (2S)-2-amino-3-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]propanoic acid Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C=C1 ZHSOTLOTTDYIIK-ZDUSSCGKSA-N 0.000 claims 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims 1
- AXWYROHIFVWHMR-UGTOYMOASA-N [(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] n,n-bis(2-chloroethyl)carbamate Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AXWYROHIFVWHMR-UGTOYMOASA-N 0.000 claims 1
- 210000000628 antibody-producing cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229960002061 ergocalciferol Drugs 0.000 claims 1
- FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 claims 1
- 229960001842 estramustine Drugs 0.000 claims 1
- 229960001348 estriol Drugs 0.000 claims 1
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 claims 1
- 229960003399 estrone Drugs 0.000 claims 1
- 239000011653 vitamin D2 Substances 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011-206162 | 2011-09-21 | ||
| JP2011206162 | 2011-09-21 | ||
| JP2012006359 | 2012-01-16 | ||
| JP2012-006359 | 2012-01-16 | ||
| PCT/JP2012/067062 WO2013042426A1 (ja) | 2011-09-21 | 2012-07-04 | 親和性複合体に対する抗体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014115676A true RU2014115676A (ru) | 2015-10-27 |
Family
ID=47914207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014115676/10A RU2014115676A (ru) | 2011-09-21 | 2012-07-04 | Антитела против аффинного комплекса |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9599608B2 (enExample) |
| EP (1) | EP2759551B1 (enExample) |
| JP (1) | JP6156144B2 (enExample) |
| KR (1) | KR101720394B1 (enExample) |
| CN (1) | CN103827145A (enExample) |
| AU (1) | AU2012310880B2 (enExample) |
| BR (1) | BR112014006405A2 (enExample) |
| CA (1) | CA2849274C (enExample) |
| IL (1) | IL231404A0 (enExample) |
| IN (1) | IN2014CN02113A (enExample) |
| RU (1) | RU2014115676A (enExample) |
| TW (1) | TW201313743A (enExample) |
| WO (1) | WO2013042426A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11261257B2 (en) | 2013-01-28 | 2022-03-01 | Diasorin S.P.A. | Methods for detecting 1,25-dihydroxyvitamin D and related antibodies |
| US10983136B2 (en) | 2013-01-28 | 2021-04-20 | Diasorin S.P.A. | Use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker |
| DK2759550T3 (en) | 2013-01-28 | 2018-11-26 | Diasorin S P A | Method and kit for detecting vitamin 1,25-dihydroxy-D and related antibodies |
| KR101840525B1 (ko) | 2013-02-06 | 2018-03-20 | 후지레비오 가부시키가이샤 | 비타민 d 의 측정 방법 및 측정용 키트 |
| WO2015129651A1 (ja) * | 2014-02-25 | 2015-09-03 | 富士レビオ株式会社 | 改変単量体ＩｇＭ |
| CN108779169B (zh) | 2015-12-21 | 2022-06-07 | 图尔库大学 | 针对包含蓝细菌环肽肝毒素的免疫复合物的抗体 |
| EP3405198B1 (en) | 2016-01-22 | 2021-08-04 | Affimedix, Inc. | Device for detection of vitamin d metabolites |
| CN106244562B (zh) * | 2016-05-20 | 2019-07-23 | 杭州奥泰生物技术股份有限公司 | 杂交瘤细胞株及其分泌的抗25羟基维生素d3单克隆抗体和应用 |
| JP7177767B2 (ja) * | 2016-07-29 | 2022-11-24 | ダイアザイム ラボラトリーズ， インコーポレイテッド | ビタミンｄをアッセイするための方法および組成物 |
| AU2018270515A1 (en) | 2017-05-19 | 2019-12-05 | The Regents Of The University Of California | Antibody chemically induced dimerizer (abCID) as molecular switches for regulating cellular therapies |
| WO2019131380A1 (ja) | 2017-12-25 | 2019-07-04 | 富士レビオ株式会社 | マクロライド系免疫抑制剤についての血液検査方法 |
| JP7434824B2 (ja) * | 2019-11-20 | 2024-02-21 | 東ソー株式会社 | 抗イムノコンプレックス抗体を用いた測定方法 |
| EP4063514A4 (en) * | 2019-11-20 | 2023-11-01 | Tosoh Corporation | MEASURING METHOD USING ANTI-IMMUNOCOMPLEX ANTIBODIES |
| JP7683188B2 (ja) * | 2019-11-29 | 2025-05-27 | 東ソー株式会社 | 抗イムノコンプレックス抗体を用いた測定法 |
| CN113125696B (zh) * | 2019-12-31 | 2024-03-26 | 科美博阳诊断技术(上海)有限公司 | 一种雌二醇均相化学发光检测试剂盒及其应用 |
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| JP4892717B2 (ja) | 2005-03-31 | 2012-03-07 | 国立大学法人広島大学 | ニワトリキメラ抗体およびその利用 |
| CA2624124A1 (en) * | 2005-09-29 | 2007-04-12 | F. Hoffmann-La Roche Ag | Antibodies against 25-hydroxyvitamin d |
| FI20075251A0 (fi) | 2007-04-13 | 2007-04-13 | Hytest Oy | Immunomääritys epästabiilien antigeenien määrittämiseksi |
| JP2009082033A (ja) | 2007-09-28 | 2009-04-23 | Kaneka Corp | 完全ヒト型抗体生産法 |
| FI20085579A0 (fi) * | 2008-06-12 | 2008-06-12 | Valtion Teknillinen | Kannabiskäytön toteaminen |
| US20110097733A1 (en) * | 2009-10-27 | 2011-04-28 | Michel Anciaux | Process for the production of a hybridoma and antibody obtained therefrom, able to recognize more than one vitamin d metabolite |
-
2012
- 2012-07-04 IN IN2113CHN2014 patent/IN2014CN02113A/en unknown
- 2012-07-04 CN CN201280045570.1A patent/CN103827145A/zh active Pending
- 2012-07-04 AU AU2012310880A patent/AU2012310880B2/en not_active Ceased
- 2012-07-04 BR BR112014006405A patent/BR112014006405A2/pt not_active IP Right Cessation
- 2012-07-04 EP EP12833103.0A patent/EP2759551B1/en active Active
- 2012-07-04 RU RU2014115676/10A patent/RU2014115676A/ru not_active Application Discontinuation
- 2012-07-04 WO PCT/JP2012/067062 patent/WO2013042426A1/ja not_active Ceased
- 2012-07-04 KR KR1020147006583A patent/KR101720394B1/ko not_active Expired - Fee Related
- 2012-07-04 CA CA2849274A patent/CA2849274C/en active Active
- 2012-07-04 JP JP2013534624A patent/JP6156144B2/ja active Active
- 2012-07-04 US US14/346,615 patent/US9599608B2/en active Active
- 2012-07-11 TW TW101124860A patent/TW201313743A/zh unknown
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2014
- 2014-03-06 IL IL231404A patent/IL231404A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012310880B2 (en) | 2015-12-03 |
| EP2759551A4 (en) | 2015-03-04 |
| US9599608B2 (en) | 2017-03-21 |
| KR101720394B1 (ko) | 2017-03-27 |
| TW201313743A (zh) | 2013-04-01 |
| IN2014CN02113A (enExample) | 2015-05-29 |
| KR20140044940A (ko) | 2014-04-15 |
| IL231404A0 (en) | 2014-04-30 |
| BR112014006405A2 (pt) | 2017-04-04 |
| EP2759551A1 (en) | 2014-07-30 |
| CN103827145A (zh) | 2014-05-28 |
| JPWO2013042426A1 (ja) | 2015-03-26 |
| JP6156144B2 (ja) | 2017-07-05 |
| US20150037813A1 (en) | 2015-02-05 |
| AU2012310880A1 (en) | 2014-04-10 |
| CA2849274C (en) | 2018-12-04 |
| CA2849274A1 (en) | 2013-03-28 |
| EP2759551B1 (en) | 2019-05-22 |
| WO2013042426A1 (ja) | 2013-03-28 |
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