RU2014105172A - Способ обнаружения олигомеров бета-амилоида в образце жидкости организма и варианты его применения - Google Patents
Способ обнаружения олигомеров бета-амилоида в образце жидкости организма и варианты его применения Download PDFInfo
- Publication number
- RU2014105172A RU2014105172A RU2014105172/15A RU2014105172A RU2014105172A RU 2014105172 A RU2014105172 A RU 2014105172A RU 2014105172/15 A RU2014105172/15 A RU 2014105172/15A RU 2014105172 A RU2014105172 A RU 2014105172A RU 2014105172 A RU2014105172 A RU 2014105172A
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- Prior art keywords
- ndpoi
- antibody
- complex
- biological sample
- capture antibody
- Prior art date
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161507332P | 2011-07-13 | 2011-07-13 | |
| US61/507,332 | 2011-07-13 | ||
| PCT/US2012/045886 WO2013009667A1 (en) | 2011-07-13 | 2012-07-09 | Method for detection of amyloid beta oligomers in a fluid sample and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014105172A true RU2014105172A (ru) | 2015-08-20 |
Family
ID=47506433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014105172/15A RU2014105172A (ru) | 2011-07-13 | 2012-07-09 | Способ обнаружения олигомеров бета-амилоида в образце жидкости организма и варианты его применения |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20130052670A1 (enExample) |
| EP (2) | EP2732289B1 (enExample) |
| JP (1) | JP2014521089A (enExample) |
| KR (1) | KR20140072019A (enExample) |
| CN (1) | CN103782171B (enExample) |
| AU (1) | AU2012282825B2 (enExample) |
| BR (1) | BR112014000671A2 (enExample) |
| CA (1) | CA2840976A1 (enExample) |
| DK (1) | DK2732289T3 (enExample) |
| ES (1) | ES2666840T3 (enExample) |
| MX (1) | MX2014000480A (enExample) |
| RU (1) | RU2014105172A (enExample) |
| WO (2) | WO2013009667A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3449926T (pt) | 2009-06-17 | 2019-11-12 | Cold Spring Harbor Laboratory | Composições e métodos de modulação de excisões de smn2 em um sujeito |
| US9320793B2 (en) * | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
| WO2014110291A1 (en) | 2013-01-09 | 2014-07-17 | Isis Pharmaceuticals, Inc. | Compositions and methods for modulation of smn2 splicing in a subject |
| ES2874704T3 (es) * | 2013-11-20 | 2021-11-05 | Univ Iowa Res Found | Procedimiento para monitorizar la eficacia de un tratamiento de la enfermedad de Alzheimer con una isoforma de ApoE |
| MA39835A (fr) | 2014-04-17 | 2017-02-22 | Biogen Ma Inc | Compositions et procédés de modulation de l'épissage du smn2 chez un patient |
| WO2015175769A1 (en) | 2014-05-15 | 2015-11-19 | Biogen Ma Inc. | Methods for the detection of amyloid beta oligomers in biological samples |
| US10436802B2 (en) | 2014-09-12 | 2019-10-08 | Biogen Ma Inc. | Methods for treating spinal muscular atrophy |
| MA41480A (fr) * | 2014-10-17 | 2017-12-19 | Glenmark Pharmaceuticals Sa | Anticorps qui se lient au ccr6 et leurs utilisations |
| DK3341725T3 (da) * | 2015-08-25 | 2021-09-06 | Prothena Biosciences Ltd | Fremgangsmåder til detektering af phosphoryleret alpha-synuklein |
| EP3415912B1 (en) | 2016-02-08 | 2023-03-29 | Sysmex Corporation | Analyte detection method and reagent kit for detecting analyte |
| US11198867B2 (en) | 2016-06-16 | 2021-12-14 | Ionis Pharmaceuticals, Inc. | Combinations for the modulation of SMN expression |
| CN114026109A (zh) * | 2019-07-05 | 2022-02-08 | 株式会社岛津制作所 | β淀粉样蛋白的单克隆抗体、和使用该抗体的β淀粉样蛋白相关肽的测定方法 |
| CN120505310A (zh) | 2020-02-28 | 2025-08-19 | Ionis制药公司 | 用于调节smn2的化合物和方法 |
| WO2022270901A1 (ko) * | 2021-06-25 | 2022-12-29 | 장재원 | 동적 형광 또는 x-선의 표준편차와 자기상관을 활용한 조기 진단 시스템 |
| WO2023034324A2 (en) * | 2021-08-30 | 2023-03-09 | The Brigham And Women’S Hospital, Inc. | Methods and materials to treat neurodegenerative disease |
| WO2024026413A2 (en) * | 2022-07-27 | 2024-02-01 | Durin Technologies, Inc. | Early detection and monitoring of neurodegenerative diseases using a multi-disease diagnostic platform |
| CN117589996A (zh) * | 2022-08-09 | 2024-02-23 | 深圳智源生物医药有限公司 | 强毒性淀粉样蛋白寡聚体的诊断用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4665024A (en) | 1984-10-01 | 1987-05-12 | Becton, Dickinson And Company | Fluorescent gram stain |
| US6218506B1 (en) | 1997-02-05 | 2001-04-17 | Northwestern University | Amyloid β protein (globular assembly and uses thereof) |
| US6082205A (en) | 1998-02-06 | 2000-07-04 | Ohio State University | System and device for determining particle characteristics |
| DE60043165D1 (de) | 1999-08-04 | 2009-11-26 | Univ Southern California | Globularer Aufbau vom Amyloid-beta- protein und deren Verwendungen |
| CN1871517A (zh) * | 2002-02-19 | 2006-11-29 | 免疫公司 | 快速有效分离循环癌细胞的方法和试剂 |
| US7807157B2 (en) | 2004-02-20 | 2010-10-05 | Intellect Neurosciences Inc. | Monoclonal antibodies and use thereof |
| CA2561532A1 (en) * | 2004-04-02 | 2005-10-20 | Merck & Co., Inc. | Methods for detecting substances which bind to the amyloid precursor protein or beta amyloid fragments, and binding compounds |
| US7572640B2 (en) | 2004-09-28 | 2009-08-11 | Singulex, Inc. | Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties |
| NZ554725A (en) * | 2004-10-25 | 2009-10-30 | Merck & Co Inc | Anti-ADDL antibodies and uses thereof |
| US7731962B2 (en) | 2005-02-14 | 2010-06-08 | Merck & Co., Inc. | Anti-ADDL monoclonal antibody and use thereof |
| JP5289963B2 (ja) * | 2005-10-21 | 2013-09-11 | メルク・シャープ・アンド・ドーム・コーポレーション | 抗ａｄｄｌモノクローナル抗体およびその使用 |
| US20090181359A1 (en) * | 2007-10-25 | 2009-07-16 | Lou Sheng C | Method of performing ultra-sensitive immunoassays |
| CN102666577A (zh) * | 2009-11-24 | 2012-09-12 | 前体生物药物股份公司 | 诊断阿尔茨海默病或轻度认知损害的新的诊断方法 |
| WO2011151076A2 (en) * | 2010-06-04 | 2011-12-08 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | MONOCLONAL ANTIBODIES TARGETING Αβ OLIGOMERS |
| US9320793B2 (en) * | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
| BR112013000796B1 (pt) * | 2010-07-14 | 2021-08-31 | Merck Sharp & Dohme Corp | Anticorpo isolado ou um fragmento de ligação ao antígeno, composição farmacêutica, métodos para inibir a montagem de ligantes difusíveis derivados de ß-amiloide, para inibir a fosforilação de proteína tau em ser202/thr205, para identificar um suposto agente terapêutico, para detectar ligantes difusíveis derivados de ß-amiloide e para diagnosticar uma doença associada aos ligantes difusíveis derivados de ß-amiloide, e, kit para detectar ligantes difusíveis derivados de ß-amiloide |
-
2012
- 2012-07-09 US US13/544,554 patent/US20130052670A1/en not_active Abandoned
- 2012-07-09 RU RU2014105172/15A patent/RU2014105172A/ru not_active Application Discontinuation
- 2012-07-09 EP EP12737445.2A patent/EP2732289B1/en active Active
- 2012-07-09 ES ES12737445.2T patent/ES2666840T3/es active Active
- 2012-07-09 WO PCT/US2012/045886 patent/WO2013009667A1/en not_active Ceased
- 2012-07-09 CA CA2840976A patent/CA2840976A1/en not_active Abandoned
- 2012-07-09 DK DK12737445.2T patent/DK2732289T3/en active
- 2012-07-09 KR KR1020147003386A patent/KR20140072019A/ko not_active Withdrawn
- 2012-07-09 AU AU2012282825A patent/AU2012282825B2/en active Active
- 2012-07-09 EP EP12811245.5A patent/EP2732286A4/en not_active Withdrawn
- 2012-07-09 CN CN201280044598.3A patent/CN103782171B/zh active Active
- 2012-07-09 JP JP2014520229A patent/JP2014521089A/ja active Pending
- 2012-07-09 MX MX2014000480A patent/MX2014000480A/es not_active Application Discontinuation
- 2012-07-09 WO PCT/US2012/045956 patent/WO2013009703A2/en not_active Ceased
- 2012-07-09 BR BR112014000671A patent/BR112014000671A2/pt not_active IP Right Cessation
-
2013
- 2013-12-20 US US14/137,351 patent/US20140120037A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012282825A1 (en) | 2014-01-16 |
| EP2732289B1 (en) | 2018-04-11 |
| WO2013009667A1 (en) | 2013-01-17 |
| US20140120037A1 (en) | 2014-05-01 |
| ES2666840T3 (es) | 2018-05-08 |
| CN103782171A (zh) | 2014-05-07 |
| EP2732286A4 (en) | 2015-02-25 |
| AU2012282825B2 (en) | 2016-05-26 |
| WO2013009703A3 (en) | 2013-03-21 |
| WO2013009703A2 (en) | 2013-01-17 |
| JP2014521089A (ja) | 2014-08-25 |
| KR20140072019A (ko) | 2014-06-12 |
| CN103782171B (zh) | 2016-12-14 |
| BR112014000671A2 (pt) | 2017-02-14 |
| DK2732289T3 (en) | 2018-05-22 |
| EP2732286A1 (en) | 2014-05-21 |
| WO2013009703A8 (en) | 2014-01-23 |
| CA2840976A1 (en) | 2013-01-17 |
| EP2732289A2 (en) | 2014-05-21 |
| MX2014000480A (es) | 2014-06-23 |
| US20130052670A1 (en) | 2013-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20170417 |