DK2732289T3 - ANTIBODIES, KIT AND IN VITRO METHOD FOR DETECTING BETA AMYLOID OLIGOMERS - Google Patents
ANTIBODIES, KIT AND IN VITRO METHOD FOR DETECTING BETA AMYLOID OLIGOMERS Download PDFInfo
- Publication number
- DK2732289T3 DK2732289T3 DK12737445.2T DK12737445T DK2732289T3 DK 2732289 T3 DK2732289 T3 DK 2732289T3 DK 12737445 T DK12737445 T DK 12737445T DK 2732289 T3 DK2732289 T3 DK 2732289T3
- Authority
- DK
- Denmark
- Prior art keywords
- ser
- gly
- antibody
- thr
- oligomers
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161507332P | 2011-07-13 | 2011-07-13 | |
| PCT/US2011/043866 WO2012009442A2 (en) | 2010-07-14 | 2011-07-13 | Anti-addl monoclonal antibody and uses thereof |
| PCT/US2012/045956 WO2013009703A2 (en) | 2011-07-13 | 2012-07-09 | Antibodies, kit and method for detecting amyloid beta oligomers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2732289T3 true DK2732289T3 (en) | 2018-05-22 |
Family
ID=47506433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12737445.2T DK2732289T3 (en) | 2011-07-13 | 2012-07-09 | ANTIBODIES, KIT AND IN VITRO METHOD FOR DETECTING BETA AMYLOID OLIGOMERS |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20130052670A1 (enExample) |
| EP (2) | EP2732286A4 (enExample) |
| JP (1) | JP2014521089A (enExample) |
| KR (1) | KR20140072019A (enExample) |
| CN (1) | CN103782171B (enExample) |
| AU (1) | AU2012282825B2 (enExample) |
| BR (1) | BR112014000671A2 (enExample) |
| CA (1) | CA2840976A1 (enExample) |
| DK (1) | DK2732289T3 (enExample) |
| ES (1) | ES2666840T3 (enExample) |
| MX (1) | MX2014000480A (enExample) |
| RU (1) | RU2014105172A (enExample) |
| WO (2) | WO2013009667A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220084437A (ko) | 2009-06-17 | 2022-06-21 | 바이오젠 엠에이 인코포레이티드 | 대상에게서 ｓｍｎ２ 스플라이싱을 조정하기 위한 조성물 및 방법 |
| US9320793B2 (en) * | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
| EP2943225A4 (en) | 2013-01-09 | 2016-07-13 | Ionis Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR MODULATING SMN2 DISTRIBUTION IN THE BODY OF A PATIENT |
| ES2874704T3 (es) * | 2013-11-20 | 2021-11-05 | Univ Iowa Res Found | Procedimiento para monitorizar la eficacia de un tratamiento de la enfermedad de Alzheimer con una isoforma de ApoE |
| US20170044538A1 (en) | 2014-04-17 | 2017-02-16 | Biogen Ma Inc. | Compositions and Methods for Modulation of SMN2 Splicing in a Subject |
| WO2015175769A1 (en) | 2014-05-15 | 2015-11-19 | Biogen Ma Inc. | Methods for the detection of amyloid beta oligomers in biological samples |
| WO2016040748A1 (en) * | 2014-09-12 | 2016-03-17 | Ionis Pharmaceuticals, Inc. | Compositions and methods for detection of smn protein in a subject and treatment of a subject |
| MA41480A (fr) * | 2014-10-17 | 2017-12-19 | Glenmark Pharmaceuticals Sa | Anticorps qui se lient au ccr6 et leurs utilisations |
| JP6989927B2 (ja) * | 2015-08-25 | 2022-02-03 | プロセナ バイオサイエンシーズ リミテッド | リン酸化アルファ－シヌクレインを検出するための方法 |
| CN108603880B (zh) | 2016-02-08 | 2021-01-05 | 希森美康株式会社 | 受试物质的检测方法及受试物质的检测用试剂盒 |
| US11198867B2 (en) | 2016-06-16 | 2021-12-14 | Ionis Pharmaceuticals, Inc. | Combinations for the modulation of SMN expression |
| WO2021005857A1 (ja) * | 2019-07-05 | 2021-01-14 | 株式会社 島津製作所 | アミロイドベータに対するモノクローナル抗体、及びその抗体を用いるアミロイドベータ関連ペプチドの測定方法 |
| AU2021225957A1 (en) | 2020-02-28 | 2022-09-08 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating SMN2 |
| US20260202426A1 (en) * | 2021-06-25 | 2026-07-16 | Jae Won Chang | Early diagnosis system utilizing standard deviation and autocorrelation of dynamic fluorescent or x-ray |
| WO2023034324A2 (en) * | 2021-08-30 | 2023-03-09 | The Brigham And Women’S Hospital, Inc. | Methods and materials to treat neurodegenerative disease |
| EP4562427A4 (en) * | 2022-07-27 | 2026-07-15 | Durin Life Sciences Inc | EARLY DETECTION AND MONITORING OF NEURODEGENERATIVE DISEASES USING A MULTI-DISEASE DIAGNOSTIC PLATFORM |
| CN117589996A (zh) * | 2022-08-09 | 2024-02-23 | 深圳智源生物医药有限公司 | 强毒性淀粉样蛋白寡聚体的诊断用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4665024A (en) | 1984-10-01 | 1987-05-12 | Becton, Dickinson And Company | Fluorescent gram stain |
| US6218506B1 (en) | 1997-02-05 | 2001-04-17 | Northwestern University | Amyloid β protein (globular assembly and uses thereof) |
| US6082205A (en) | 1998-02-06 | 2000-07-04 | Ohio State University | System and device for determining particle characteristics |
| ATE283285T1 (de) | 1999-08-04 | 2004-12-15 | Univ Southern California | Globularer aufbau vom amyloid-beta- protein und deren verwendungen |
| CN1871517A (zh) * | 2002-02-19 | 2006-11-29 | 免疫公司 | 快速有效分离循环癌细胞的方法和试剂 |
| US7807157B2 (en) | 2004-02-20 | 2010-10-05 | Intellect Neurosciences Inc. | Monoclonal antibodies and use thereof |
| CA2561532A1 (en) * | 2004-04-02 | 2005-10-20 | Merck & Co., Inc. | Methods for detecting substances which bind to the amyloid precursor protein or beta amyloid fragments, and binding compounds |
| US7572640B2 (en) | 2004-09-28 | 2009-08-11 | Singulex, Inc. | Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties |
| KR20070094890A (ko) | 2004-10-25 | 2007-09-27 | 머크 앤드 캄파니 인코포레이티드 | 안티 ａｄｄｌ 항체 및 그 용도 |
| US7731962B2 (en) | 2005-02-14 | 2010-06-08 | Merck & Co., Inc. | Anti-ADDL monoclonal antibody and use thereof |
| AU2006306553B9 (en) * | 2005-10-21 | 2011-09-29 | Merck Sharp & Dohme Corp. | Anti-ADDL monoclonal antibody and use thereof |
| US20090181359A1 (en) * | 2007-10-25 | 2009-07-16 | Lou Sheng C | Method of performing ultra-sensitive immunoassays |
| JP2013511734A (ja) * | 2009-11-24 | 2013-04-04 | プロビオドルグ エージー | アルツハイマー病又は軽度認知障害の診断のための新規診断方法 |
| US8795664B2 (en) * | 2010-06-04 | 2014-08-05 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Monoclonal antibodies targeting amyloid beta oligomers |
| US20130115227A1 (en) * | 2010-07-14 | 2013-05-09 | Renee C. Gaspar | Anti-addl monoclonal antibody and uses thereof |
| US9320793B2 (en) * | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
-
2012
- 2012-07-09 CN CN201280044598.3A patent/CN103782171B/zh active Active
- 2012-07-09 JP JP2014520229A patent/JP2014521089A/ja active Pending
- 2012-07-09 US US13/544,554 patent/US20130052670A1/en not_active Abandoned
- 2012-07-09 BR BR112014000671A patent/BR112014000671A2/pt not_active IP Right Cessation
- 2012-07-09 DK DK12737445.2T patent/DK2732289T3/en active
- 2012-07-09 AU AU2012282825A patent/AU2012282825B2/en active Active
- 2012-07-09 EP EP12811245.5A patent/EP2732286A4/en not_active Withdrawn
- 2012-07-09 KR KR1020147003386A patent/KR20140072019A/ko not_active Withdrawn
- 2012-07-09 WO PCT/US2012/045886 patent/WO2013009667A1/en not_active Ceased
- 2012-07-09 CA CA2840976A patent/CA2840976A1/en not_active Abandoned
- 2012-07-09 EP EP12737445.2A patent/EP2732289B1/en active Active
- 2012-07-09 MX MX2014000480A patent/MX2014000480A/es not_active Application Discontinuation
- 2012-07-09 WO PCT/US2012/045956 patent/WO2013009703A2/en not_active Ceased
- 2012-07-09 RU RU2014105172/15A patent/RU2014105172A/ru not_active Application Discontinuation
- 2012-07-09 ES ES12737445.2T patent/ES2666840T3/es active Active
-
2013
- 2013-12-20 US US14/137,351 patent/US20140120037A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013009703A3 (en) | 2013-03-21 |
| JP2014521089A (ja) | 2014-08-25 |
| AU2012282825A1 (en) | 2014-01-16 |
| EP2732289A2 (en) | 2014-05-21 |
| EP2732286A1 (en) | 2014-05-21 |
| US20140120037A1 (en) | 2014-05-01 |
| EP2732289B1 (en) | 2018-04-11 |
| MX2014000480A (es) | 2014-06-23 |
| CN103782171A (zh) | 2014-05-07 |
| KR20140072019A (ko) | 2014-06-12 |
| BR112014000671A2 (pt) | 2017-02-14 |
| AU2012282825B2 (en) | 2016-05-26 |
| US20130052670A1 (en) | 2013-02-28 |
| CA2840976A1 (en) | 2013-01-17 |
| WO2013009703A8 (en) | 2014-01-23 |
| CN103782171B (zh) | 2016-12-14 |
| WO2013009667A1 (en) | 2013-01-17 |
| RU2014105172A (ru) | 2015-08-20 |
| WO2013009703A2 (en) | 2013-01-17 |
| ES2666840T3 (es) | 2018-05-08 |
| EP2732286A4 (en) | 2015-02-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2732289B1 (en) | ANTIBODIES, KIT AND in vitro METHOD FOR DETECTING AMYLOID BETA OLIGOMERS | |
| KR102716144B1 (ko) | 신경퇴행을 검출하기 위한 분석 | |
| EP2731969B1 (en) | Antibodies to phosphorylated tau aggregates | |
| CA2584859C (en) | Anti-addl antibodies and uses thereof | |
| US9310383B2 (en) | Antibodies, kit and method for detecting amyloid beta oligomers | |
| EP2593475A2 (en) | Anti-addl monoclonal antibody and uses thereof | |
| US12509505B2 (en) | Anti Tau SVQIVYKPV epitope single domain antibody | |
| CA3207924A1 (en) | Methods for detecting neurofilament light chain in plasma and cerebrospinal fluid | |
| KR20210068408A (ko) | 가용성 bcma에 대한 항체 | |
| WO2025137532A1 (en) | Method for quantifying amyloid beta protofibril | |
| WO2025260029A1 (en) | Method for quantifying amyloid beta protofibril | |
| WO2021032966A1 (en) | Detection of a-beta oligomers | |
| EA051573B1 (ru) | АНТИТЕЛА К ПИРОГЛУТАМАТ-β-АМИЛОИДУ И ИХ ПРИМЕНЕНИЕ |