RU2014101762A - Биорезорбируемый перевязочный материал для ран - Google Patents

Биорезорбируемый перевязочный материал для ран Download PDF

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RU2014101762A
RU2014101762A RU2014101762/15A RU2014101762A RU2014101762A RU 2014101762 A RU2014101762 A RU 2014101762A RU 2014101762/15 A RU2014101762/15 A RU 2014101762/15A RU 2014101762 A RU2014101762 A RU 2014101762A RU 2014101762 A RU2014101762 A RU 2014101762A
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material according
fibers
tissue
cystine
gdf
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RU2014101762/15A
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RU2577155C2 (ru
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Франк Плегер
Дени РЕБЕЛЬ
Дирк ГРАФАРЕНД
Даниэль НОЙМЮЛЛЕР
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Биофарм Гезелльшафт Цур Биотехнологишен Энтвиклунг Фон Фармака Мбх
Карл Фройденберг Кг
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Abstract

1. Нетканый материал, содержащий:волокна волокнистого сырьевого материала, содержащие биорезорбируемые и/или биосовместимые полимеры, причем эти волокна включают по меньшей мере одно биологически активное вещество, которое распределено в этих волокнах, где это биологически активное вещество является GDF-5-родственным белком, который является белком, содержащим цистин-узел-домен с идентичностью аминокислот по меньшей мере 60% относительно 102 аа-цистин-узел-домена GDF-5 человека, соответствующих аминокислотам 400-501 SEQ ID NO:2.2. Нетканый материал по п.1, где биологически активный белок дополнительно распределен на этих волокнах.3. Нетканый материал по п.2, где GDF-5-родственный белок является белком, содержащим цистин-узел-домен с идентичностью аминокислот по меньшей мере 70%, 80%, 90% или 95% относительно 102 aa-цистин-узел-домена GDF-5 человека.4. Нетканый материал по п.1, где волокнистый сырьевой материал выбран из группы, состоящей из природных полимеров, синтетических полимеров и полимеров, произведенных из консервативных сырьевых материалов, каждый из которых может быть модифицированным или немодифицированным, и их комбинаций.5. Нетканый материал по п.4, где природные полимеры выбраны из группы, состоящей из полипептидов, таких как коллаген, желатин, фибрин, казеин или полисахаридов, таких как декстран, целлюлоза, крахмал, хитин, хитозан, альгинат и гиалуроновая кислота, или полинуклеотидов, а также синтетических полимеров, таких как полилактид (PLA), полигликолид (PGA), поликапролактон (PCL), поливинилпирролидон (PVP), полиэтиленоксид (PEO), полиэтиленгликоль (PEG), полигидроксифиры, или их комбинаций.6. Нетканый материал по п.1, где данное вещест

Claims (15)

1. Нетканый материал, содержащий:
волокна волокнистого сырьевого материала, содержащие биорезорбируемые и/или биосовместимые полимеры, причем эти волокна включают по меньшей мере одно биологически активное вещество, которое распределено в этих волокнах, где это биологически активное вещество является GDF-5-родственным белком, который является белком, содержащим цистин-узел-домен с идентичностью аминокислот по меньшей мере 60% относительно 102 аа-цистин-узел-домена GDF-5 человека, соответствующих аминокислотам 400-501 SEQ ID NO:2.
2. Нетканый материал по п.1, где биологически активный белок дополнительно распределен на этих волокнах.
3. Нетканый материал по п.2, где GDF-5-родственный белок является белком, содержащим цистин-узел-домен с идентичностью аминокислот по меньшей мере 70%, 80%, 90% или 95% относительно 102 aa-цистин-узел-домена GDF-5 человека.
4. Нетканый материал по п.1, где волокнистый сырьевой материал выбран из группы, состоящей из природных полимеров, синтетических полимеров и полимеров, произведенных из консервативных сырьевых материалов, каждый из которых может быть модифицированным или немодифицированным, и их комбинаций.
5. Нетканый материал по п.4, где природные полимеры выбраны из группы, состоящей из полипептидов, таких как коллаген, желатин, фибрин, казеин или полисахаридов, таких как декстран, целлюлоза, крахмал, хитин, хитозан, альгинат и гиалуроновая кислота, или полинуклеотидов, а также синтетических полимеров, таких как полилактид (PLA), полигликолид (PGA), поликапролактон (PCL), поливинилпирролидон (PVP), полиэтиленоксид (PEO), полиэтиленгликоль (PEG), полигидроксифиры, или их комбинаций.
6. Нетканый материал по п.1, где данное вещество диспергировано в эти волокна.
7. Нетканый материал по п.6, где диспергируемое вещество выбрано из группы неорганических веществ, подобных гидроксилапатиту и/или β-трикальцийфосфату.
8. Нетканый материал по п.1, где нетканый материал является продуцируемым или продуцируется спин-вращательным способом.
9. Нетканый материал по п.1, где по меньшей мере некоторые из волокон являются скрученными друг с другом, переплетенными друг с другом и имеют скрученную структуру, предпочтительно, где по меньшей мере некоторые из этих волокон переплетены друг с другом и образуют по меньшей мере один пучок волокон.
10. Нетканый материал по п.1, где по меньшей мере некоторые из этих волокон являются нановолокнами.
11. Нетканый материал по любому из пп.1-10, где материал включает структуру открытых пор, имеющих воздухопроницаемость между 0,01 и 100 л/мин∙см2.
12. Нетканый материал по любому из пп.1-10, где по меньшей мере 10% биологически активного вещества элюируются в пределах 3-7 дней при физиологических условиях (ЗФР-буфер, 10% Фетальная Телячья Сыворотка, 37°C).
13. Нетканый материал по любому из пп.1-10, для улучшенного заживления ран, включающих диабетические и другие язвы, ожоги, кожные повреждения и/или кожные трансплантаты, для индукции роста нервов или предотвращения смерти нейронов, для содействия ангиогенезу, для индукции пролиферации клеток-предшественников и/или клеток костного мозга; для поддержания состояния пролиферации или дифференцировки для лечения или сохранения ткани или клеток для трансплантации органа или ткани; для лечения дегенеративных нарушений, касающихся суставов для скелетных элементов, и/или для репарации мениска и/или спинального/межпозвонкового диска.
14. Нетканый материал по любому из пп.1-10, для содействия регенерации ткани, причем указанная ткань выбрана из группы, состоящей из кожной ткани, соединительной ткани, кости, хряща, фиксации соединительной ткани, сухожилия, связки, спинального/межпозвонкового диска, мениска, зубной ткани, дентина, периодонтальной связки, волос, тканей сенсорной системы, печени, поджелудочной железы, сердечной ткани, кровеносного сосуда, почечной, маточной ткани и ткани щитовидной железы, слизистых мембран, эндотелия, эпителия или нервной ткани.
15. Повязка для ран, прокладка для ран или имплантат, содержащие нетканый материал по любому из пп.1-14.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9782511B2 (en) 2011-06-22 2017-10-10 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Bioresorbable wound dressing

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9999702B2 (en) * 2010-04-09 2018-06-19 Kci Licensing Inc. Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds
US11173227B2 (en) 2013-05-22 2021-11-16 The Penn State Research Foundation Wound dressings and applications thereof
DK3427726T3 (da) * 2016-03-07 2023-05-15 Univ Osaka Ark med vedvarende lægemiddelfrigvelse til behandling af nerveskade
FR3058041B1 (fr) 2016-10-28 2021-06-04 Centre Hospitalier Regional Univ Lille Dispositif apte a etre implante dans le corps d'un sujet pour former un implant - masse tissulaire et procede associes.
AU2018266546B2 (en) 2017-05-07 2024-06-13 Locus Ip Company, Llc Cosmetic compositions for skin health and methods of using same
EP3703633B2 (en) 2017-11-03 2024-06-26 3M Innovative Properties Company Extended wear-time dressing
CN108210979B (zh) * 2018-01-28 2020-09-29 山东东贝医药科技有限公司 一种医用杀菌纤维敷料
CN108286132B (zh) * 2018-03-27 2020-06-23 界首市圣通无纺布有限公司 一种具有抗菌功能的易降解无纺布加工方法
CA3107300A1 (en) 2018-05-25 2019-11-28 Locus Ip Company, Llc Therapeutic compositions for enhanced healing of wounds and scars
CN108893792B (zh) * 2018-07-13 2020-11-03 深圳大学 生物活性纤维及其制备方法、应用和制备系统
BR112021024419A2 (pt) * 2019-06-03 2022-01-18 Convatec Ltd Métodos e dispositivos para desfazer e confinar patógenos
US20220409769A1 (en) * 2019-09-17 2022-12-29 Mayo Foundation For Medical Education And Research Methods and materials for treating fistulas
WO2022138206A1 (ja) * 2020-12-22 2022-06-30 日本毛織株式会社 創傷被覆材
US20240091404A1 (en) * 2021-02-09 2024-03-21 Shin-Etsu Chemical Co., Ltd. Gelatin-containing device

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19525416A1 (de) 1995-07-12 1997-01-16 Bioph Biotech Entw Pharm Gmbh Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems
JP3193050B2 (ja) 1992-02-12 2001-07-30 ビオファルム ゲゼルシャフト ツア ビオテヒノロ ギッシェン エントヴィックルング フォン ファル マカ ミット ベシュレンクテル ハフツング 新規の増殖／分化因子をコード化するｄｎａ配列
WO1994015949A1 (en) 1993-01-12 1994-07-21 Johns Hopkins University School Of Medicine Growth differentiation factor-5
IL110589A0 (en) 1993-08-10 1994-11-11 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF- beta family
ES2255059T3 (es) 1993-12-07 2006-06-16 Genetics Institute, Llc Bmp-12, bmp-13 y composiciones suyas inductoras de tendon.
AU1120295A (en) 1994-11-07 1996-05-31 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Cartilage-derived morphogenetic proteins
JPH08209435A (ja) * 1995-01-30 1996-08-13 Sangi Co Ltd 生体適合糸
PL186518B1 (pl) 1995-04-19 2004-01-30 Bioph Biotech Entw Pharm Gmbh Białko, kompozycja farmaceutyczna i sposób wytwarzania białka
PT831884E (pt) 1995-06-05 2003-11-28 New York Society Uso de proteinas morfogeneticas do caso para cicatrizacao e reparacao da ligacao do tecido conjuntivo
JPH0931098A (ja) 1995-07-24 1997-02-04 Hoechst Japan Ltd 新規なタンパク質ｈｍｗヒトｍｐ５２
ZA966489B (en) 1995-08-03 1997-02-26 Bioph Biotech Entw Pharm Gmbh New protein human MP52 Arg.
DE19647853A1 (de) * 1996-11-19 1998-05-20 Bioph Biotech Entw Pharm Gmbh Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender Aktivität
JPH11335398A (ja) 1998-05-22 1999-12-07 Hoechst Marion Roussel Kk 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬
EP1074620A1 (en) 1999-08-06 2001-02-07 HyGene AG Monomeric protein of the TGF-beta family
CA2301693A1 (en) 1997-09-19 1999-04-01 Klaus Unsicker Cytokines having neurotrophic activity
US6992066B2 (en) * 1998-10-16 2006-01-31 Zimmer Orthobiologics, Inc. Povidone-containing carriers for polypeptide growth factors
US7020845B1 (en) * 1999-11-15 2006-03-28 Gottfurcht Elliot A Navigating internet content on a television using a simplified interface and a remote control
EP1372698A2 (en) 2001-03-23 2004-01-02 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Use of cytokines of the tgf-beta superfamily for the treatment and diagnosis of skin related disorders
WO2004000915A2 (en) * 2002-06-24 2003-12-31 Tufts University Silk biomaterials and methods of use thereof
TW200410714A (en) 2002-08-07 2004-07-01 Smithkline Beecham Corp Electrospun amorphous pharmaceutical compositions
EP1462126A1 (en) 2003-03-28 2004-09-29 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Improved Osteoinductive Materials
JP2005005144A (ja) * 2003-06-12 2005-01-06 Nemoto:Kk スイッチカバー
US7704740B2 (en) * 2003-11-05 2010-04-27 Michigan State University Nanofibrillar structure and applications including cell and tissue culture
JP4618997B2 (ja) * 2003-12-09 2011-01-26 テルモ株式会社 ステントおよびその製造方法
US8221780B2 (en) * 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
EP1698691A1 (en) * 2005-03-04 2006-09-06 Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH Growth factor mutants with improved biological activity
JP2006254722A (ja) * 2005-03-15 2006-09-28 Toray Ind Inc 細胞足場材料
DE102005048939A1 (de) 2005-07-01 2007-01-11 Carl Freudenberg Kg Vorrichtung, Anordnung und Verfahren zur Herstellung von Fasern und eine solche Fasern umfassende Anordnung
US20100303881A1 (en) 2006-02-02 2010-12-02 The John Hopkins University Therapeutic Electrospun Fiber Compositions
EP1880731A1 (en) 2006-07-18 2008-01-23 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Human growth and differentiation factor GDF-5
WO2008093341A2 (en) * 2007-01-31 2008-08-07 Technion Research & Development Foundation Ltd. Electrospun scaffolds and methods of generating and using same
DE102007011606A1 (de) * 2007-03-02 2008-09-04 Carl Freudenberg Kg Faser-Wirrgelege
KR101538981B1 (ko) 2007-09-13 2015-07-23 드레징 인터내셔널 엔. 브이. 준설을 최적화하기 위한 시스템 및 방법
DE102007044648B4 (de) * 2007-09-18 2020-11-26 Carl Freudenberg Kg Bioresorbierbarer Gelatinevliesstoff
US20090163936A1 (en) 2007-12-21 2009-06-25 Chunlin Yang Coated Tissue Engineering Scaffold
US20100002151A1 (en) * 2008-07-01 2010-01-07 Yang Pan Handheld media and communication device with a detachable projector
US7644955B1 (en) * 2008-07-03 2010-01-12 Naris Komolrochanaporn Quick coupling type fitting
US8557271B2 (en) * 2008-07-16 2013-10-15 Warsaw Orthopedic, Inc. Drug depot implantable within a joint
TWM370392U (en) * 2009-06-19 2009-12-11 zhi-sheng Chen Curative ventilating dressing
EP2598177B1 (en) * 2010-07-30 2015-06-17 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Drug delivery devices and growth factor formulations for accelerated wound healing
EP2537538A1 (en) 2011-06-22 2012-12-26 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Bioresorbable Wound Dressing

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9782511B2 (en) 2011-06-22 2017-10-10 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Bioresorbable wound dressing

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