JP2014522918A - 生体吸収性創傷被覆材 - Google Patents
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Abstract
Description
誤解及び多義性を回避するために、本明細書において頻繁に使用されるいくつかの用語を以下の通り定義し、例示する。
a)タンパク質の生物活性断片、少なくともシスチンノットドメインを含むことが好ましい。
b)アミノ酸置換を含有するタンパク質又は構成物の元の配列に対して、追加的な配列を過剰に含有する(生物学的機能の付加を伴う、又は伴わない)生物活性タンパク質構成物。
c)a)及びb)の任意の組み合わせ。
粘膜/上皮表面の完全性を保存するレチノイド(ビタミンA誘導体)。
表皮脱落を増強するヒドロキシ酸(アルファヒドロキシ酸(AHA)及びベータヒドロキシル酸(BHA)に更に分類される有機カルボン酸)、即ち、グリコール酸、乳酸、クエン酸、マンデル酸、リンゴ酸、及び酒石酸。
フリーラジカルの有害作用を打ち消す抗酸化剤、即ち、ビタミンC、ビタミンE、パンテノール、リポ酸、ユビキノン、ナイアシンアミド、ジメチルアミノエタノール、スピントラップ、メラトニン、カタラーゼ、グルタチオン、スーパーオキシドジスムターゼ、ペルオキシダーゼ、グルコピラノシド、ポリフェノール、システイン、アラントイン、フルフリルアデニン、尿酸、及びカルノシン。
色素沈着過度を緩和する色素脱失剤、即ち、N−アセチル−4−S−システアニミルフェノール、コウジ酸、アルブチン、アゼライン酸、カジノキ化合物、ケミカルピーリング剤(レゾルシノール、サリチル酸)、Kligman処方(Kligman’s formula)、Pathak処方(Pathak’s formula)、及びWesterhof処方(Westerhof’s formula)。
植物性薬品、即ち、カモミール、チョウセンニンジン、Gingkobiloba、クルクミン、グリチルリジン、カプサイシン、及びaloe vera。
表皮の再生を支持するグリコサミノグリカン、即ち、ヒアルロン酸;
脂肪分解を媒介する抗セルライト剤(Anticellulite)、即ち、ベータ−アドレナリン作動性刺激物質、例えば、テオブロミン、テオフィリン、アミノフィリン、カフェイン、エピネフリン等、及びアルファ1−アドレナリン作動性刺激物質、例えば、ヨヒンビン、ピペロキサン、及びフェントラミン等。
ホルモン、即ち、エストロゲン、プロゲステロン、テストステロン、及び成長ホルモン。
抗菌性剤、即ち、トリクロサン、クロルヘキシジン、ポピドンヨード、過酸化水素、フケ防止調合剤、ピリチオン亜鉛。
化学的UVフィルター、即ち、3−ベンジリデンカンファー(3−BC)又は4−メチルベンジリデンカンファー(4−MBC)。
更に緩衝液、安定剤、防腐剤、還元剤、抗酸化キレート化剤、等張性を改変する作用剤、脱臭剤、麻酔薬、アジュバント(免疫増強剤)及び溶解性増強添加物。
純粋なゼラチン、ゼラチンとヒアルロン酸、又はゼラチンとI型コラーゲンからなる、GDF−5速放性を示す不織物を以下の通り作製した。
ポリビニルピロリドン(A.)、ポリエチレンオキシド(B.)、又は、ゼラチンとヒドロキシルアパタイト(C.)からなり、GDF−5徐放性を示す不織物を以下の通り作製した。
(A.)ポリビニルピロリドン(Kollidon F 90、BASF AG.、Germany)40gをビーカーに満たし、磁気攪拌器及び水160gを加えた。その後、混合物を室温で24時間撹拌し、80℃まで加熱した。最後に溶液を1時間超音波処理した後、冷却して60℃とした。
Claims (16)
- 生体吸収性及び/又は生体適合性ポリマーを含む繊維原料からなり、繊維内に少なくとも1種の生物活性物質が分布した繊維を含み、前記生物活性物質はGDF−5関連タンパク質である不織布。
- 繊維上に、更に生物活性タンパク質が分布している請求項1に記載の不織布。
- GDF−5関連タンパク質が、配列番号2に示すヒトGDF−5のアミノ酸配列400位〜501位における、102のアミノ酸シスチンノットドメインに対して、少なくとも60%の同一性を有するアミノ酸配列のシスチンノットドメインを含むタンパク質である請求項1又は請求項2に記載の不織布。
- GDF−5関連タンパク質が、ヒトGDF−5における102のアミノ酸シスチンノットドメインに対して、少なくとも70%、少なくとも80%、少なくとも90%、又は少なくとも95%の同一性を有するアミノ酸配列のシスチンノットドメインを含む請求項3に記載の不織布。
- 繊維原料が、修飾され又は修飾されていない、天然ポリマー、合成ポリマー、及び化石原料由来ポリマー、並びにそれらの組み合わせからなる群から選択される請求項1〜請求項4のいずれかに記載の不織布。
- 天然ポリマーが、コラーゲン、ゼラチン、フィブリン、カゼインのようなポリペプチド、又はデキストラン、セルロース、デンプン、キチン、キトサン、アルギネートやヒアルロン酸のような多糖、又はポリヌクレオチド、又はそれらの組み合わせからなる群から選択され、
合成ポリマーが、ポリ乳酸(PLA)、ポリグリコリド(PGA)、ポリカプロラクトン(PCL)、ポリビニルピロリドン(PVP)、ポリエチレンオキシド(PEO)、ポリエチレングリコール(PEG)、ポリヒドロキシエステル、又はそれらの組み合わせからなる群から選択される請求項5に記載の不織布。 - 物質がフィラメント中に分散している請求項1〜請求項6のいずれかに記載の不織布。
- 分散している物質が、ヒドロキシルアパタイト及び/又はβ−リン酸三カルシウムのような無機物質の群から選択される請求項7に記載の不織布。
- 回転紡糸方法によって作製し、又は作製される請求項1〜請求項8のいずれかに記載の不織布。
- 繊維の少なくともいくつかが互いに撚り合わされ、又は、互いに絡み合わされたものであり、撚り合わさった構造を有し、繊維の少なくともいくつかが互いに絡み合っており、少なくとも1つの繊維束を形成している請求項1〜請求項9のいずれかに記載の不織布。
- 繊維の少なくともいくつかがナノ繊維である請求項1〜請求項10のいずれかに記載の不織布。
- 0.01〜100L/min・cm2の通気性を有する開いた細孔構造を含む請求項1〜請求項11のいずれかに記載の不織布。
- 生理的条件下(PBS緩衝液、10%ウシ胎仔血清、37℃)で、生物活性物質の少なくとも10%が3〜7日以内に放出する請求項1〜請求項12のいずれかに記載の不織布。
- 糖尿病性潰瘍及び他の潰瘍、熱傷、皮膚傷害及び/若しくは皮膚グラフトを含めた創傷の治癒の改善、神経成長を誘導する若しくは神経細胞死の予防、血管新生の促進、又は、前駆細胞及び/若しくは骨髄細胞の増殖の誘導のため、又は、
臓器若しくは組織を移植するための組織若しくは細胞の処理若しくは保存、増殖若しくは分化の状態を維持するため、又は、
骨格要素に対する関節に係わる変性障害の治療、並びに/又は半月板及び/若しくは脊椎/椎間板の修復のために用いられる請求項1〜請求項13のいずれかに記載の不織布。 - 皮膚組織、結合組織、骨、軟骨、結合組織性付着、腱、靭帯、脊椎/椎間板、半月板、歯の組織、象牙質、歯根膜、毛髪、感覚系の組織、肝臓組織、膵臓組織、心臓組織、血管組織、腎臓組織、子宮組織、甲状腺組織、粘膜、内皮、上皮又は神経組織からなる群から選択される組織の再生を促進するために用いられる請求項1〜請求項14のいずれかに記載の不織布。
- 請求項1〜請求項15のいずれかに記載の不織布を含む創傷被覆材、創傷パッド又はインプラント。
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PCT/EP2012/061965 WO2012175611A1 (en) | 2011-06-22 | 2012-06-21 | Bioresorbable wound dressing |
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JP2020169201A (ja) * | 2016-03-07 | 2020-10-15 | 国立大学法人大阪大学 | 神経損傷治療用薬剤徐放シート |
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RU2014101762A (ru) | 2015-07-27 |
KR20140146035A (ko) | 2014-12-24 |
ES2539405T3 (es) | 2015-06-30 |
US20180008743A1 (en) | 2018-01-11 |
WO2012175611A1 (en) | 2012-12-27 |
CN103874516A (zh) | 2014-06-18 |
EP2723408B1 (en) | 2015-04-15 |
US9278156B2 (en) | 2016-03-08 |
EP2537538A1 (en) | 2012-12-26 |
JP6138773B2 (ja) | 2017-05-31 |
RU2577155C2 (ru) | 2016-03-10 |
AU2012274046B2 (en) | 2016-02-18 |
BR112013032714A2 (pt) | 2017-01-24 |
AU2012274046C1 (en) | 2016-07-14 |
US20160199530A1 (en) | 2016-07-14 |
US9782511B2 (en) | 2017-10-10 |
TWI572336B (zh) | 2017-03-01 |
TW201302170A (zh) | 2013-01-16 |
CN103874516B (zh) | 2016-06-01 |
KR101964482B1 (ko) | 2019-04-01 |
ZA201309341B (en) | 2015-11-25 |
CA2839142C (en) | 2019-04-16 |
CA2839142A1 (en) | 2012-12-27 |
AU2012274046A1 (en) | 2014-01-23 |
EP2723408A1 (en) | 2014-04-30 |
US20140141050A1 (en) | 2014-05-22 |
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