RU2013145283A - Новые антагонисты рецептора интерлейкина-1 - Google Patents
Новые антагонисты рецептора интерлейкина-1 Download PDFInfo
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- RU2013145283A RU2013145283A RU2013145283/10A RU2013145283A RU2013145283A RU 2013145283 A RU2013145283 A RU 2013145283A RU 2013145283/10 A RU2013145283/10 A RU 2013145283/10A RU 2013145283 A RU2013145283 A RU 2013145283A RU 2013145283 A RU2013145283 A RU 2013145283A
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- 229940119178 Interleukin 1 receptor antagonist Drugs 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 69
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 32
- 150000001413 amino acids Chemical group 0.000 claims abstract 30
- 101710144554 Interleukin-1 receptor antagonist protein Proteins 0.000 claims abstract 27
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 claims abstract 21
- 239000003407 interleukin 1 receptor blocking agent Substances 0.000 claims abstract 21
- 239000012634 fragment Substances 0.000 claims abstract 15
- 102100026018 Interleukin-1 receptor antagonist protein Human genes 0.000 claims abstract 14
- 125000000539 amino acid group Chemical group 0.000 claims abstract 8
- 102000005962 receptors Human genes 0.000 claims abstract 8
- 108020003175 receptors Proteins 0.000 claims abstract 8
- 150000001875 compounds Chemical class 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 208000027866 inflammatory disease Diseases 0.000 claims 7
- 208000015122 neurodegenerative disease Diseases 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 206010052779 Transplant rejections Diseases 0.000 claims 3
- 208000010668 atopic eczema Diseases 0.000 claims 3
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- 230000002401 inhibitory effect Effects 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 206010002198 Anaphylactic reaction Diseases 0.000 claims 2
- 208000009137 Behcet syndrome Diseases 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims 2
- 201000005569 Gout Diseases 0.000 claims 2
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 2
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- 239000000412 dendrimer Substances 0.000 claims 2
- 229920000736 dendritic polymer Polymers 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
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- 208000027930 type IV hypersensitivity disease Diseases 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
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- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
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Classifications
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| DKPA201170120 | 2011-03-14 | ||
| DKPA201170120 | 2011-03-14 | ||
| PCT/DK2012/000022 WO2012122985A1 (en) | 2011-03-14 | 2012-03-14 | Antagonists of the interleukin- 1 receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013145283A true RU2013145283A (ru) | 2015-04-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| RU2013145283/10A RU2013145283A (ru) | 2011-03-14 | 2012-03-14 | Новые антагонисты рецептора интерлейкина-1 |
Country Status (13)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20230776T1 (hr) | 2010-07-29 | 2023-10-27 | Buzzard Pharmaceuticals AB | Himerni antagonisti receptora il-1 tipa i |
| KR102017026B1 (ko) * | 2013-01-10 | 2019-09-02 | (주) 수파드엘릭사 | 염증 또는 알러지의 예방 또는 치료용 약학 조성물 및 염증 또는 알러지 개선용 화장료 조성물 |
| JP6450364B2 (ja) | 2013-03-13 | 2019-01-09 | セセン バイオ， インコーポレイテッド | 眼送達のためのキメラサイトカイン製剤 |
| CA2911547A1 (en) * | 2013-05-31 | 2014-12-04 | Regeneron Pharmaceuticals, Inc. | Methods of using il-1 antagonists to treat alzheimer's disease |
| CN104711214B (zh) * | 2015-04-09 | 2019-02-12 | 武汉联程生物科技有限公司 | 一种大肠杆菌bbm2015001菌株及其用途 |
| WO2017063657A1 (en) | 2015-10-14 | 2017-04-20 | Phlogo Aps | Il1ra-derived peptide antagonist |
| JP7145162B2 (ja) * | 2017-02-16 | 2022-09-30 | ヤンセン バイオテク，インコーポレイテッド | 化膿性汗腺炎の処置 |
| EP3773678A4 (en) | 2018-04-12 | 2022-05-04 | Mayo Foundation for Medical Education and Research | PROCEDURES FOR GUIDING TREATMENT DECISIONS IN USE |
| KR102022118B1 (ko) * | 2019-01-07 | 2019-09-18 | 주식회사 아스트로젠 | 중추신경계 질환의 예방 또는 치료용 세린 유도체 화합물 |
| AU2021455992A1 (en) * | 2021-07-13 | 2024-01-18 | Serodus Aps | Il1ra derived peptides for treatment of diabetic nephropathy |
| CN114177295B (zh) * | 2021-12-16 | 2023-09-19 | 上海市第五人民医院 | 白细胞介素1受体拮抗剂治疗非酒精性脂肪性肝病的应用 |
| CN116144668A (zh) * | 2023-02-13 | 2023-05-23 | 杭州吉倍思生物制药有限公司 | 人il-1r1基因、蛋白、同源二聚体蛋白质与用途 |
| JP2025179043A (ja) * | 2023-04-14 | 2025-12-09 | メルク・シャープ・アンド・ドーム・エルエルシー | インターロイキン－１ベータを捕捉するための環状ペプチド |
| EP4695271A2 (en) | 2023-04-14 | 2026-02-18 | Merck Sharp & Dohme LLC | A cyclic peptide for trapping interleukin-1 beta |
| WO2025101453A1 (en) * | 2023-11-07 | 2025-05-15 | University Of Washington | De novo design of potent minibinder antagonists of il-6r, gp130, and il1-r1 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858409B1 (en) | 1988-05-27 | 2005-02-22 | Amgen Inc. | Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors |
| US5075222A (en) | 1988-05-27 | 1991-12-24 | Synergen, Inc. | Interleukin-1 inhibitors |
| WO1989011540A1 (en) | 1988-05-27 | 1989-11-30 | Synergen, Inc. | Interleukin-1 inhibitors |
| US6159460A (en) | 1988-05-27 | 2000-12-12 | Amgen Inc. | Method for treating interleukin-1 mediated diseases |
| MX9606537A (es) * | 1994-07-05 | 1997-12-31 | Steeno Res Group As | Inmunomoduladores. |
| IT1269989B (it) | 1994-09-21 | 1997-04-16 | Dompe Spa | Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria |
| IT1270662B (it) | 1994-10-13 | 1997-05-07 | Applied Research Systems | Antagonista della interleuchina-1 |
| DE19919148A1 (de) * | 1999-04-27 | 2000-11-16 | Wieser Raimund J | Von Interleukin 12 abgeleitete Peptid-Homodimere und Peptid-Heterodimere |
| HUP0400698A3 (en) * | 2001-02-06 | 2006-01-30 | Merck Patent Gmbh | Modified interleukin-1 receptor antagonist (il-1ra) with reduced immunogenicity |
| JP4279554B2 (ja) * | 2001-02-19 | 2009-06-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｔ細胞エピトープの識別方法および低減された免疫原性を有する分子の製造方法 |
| WO2003022213A2 (en) | 2001-09-06 | 2003-03-20 | Board Of Regents, The University Of Texas System | Therapeutic treatments for spinal cord injury via blockade of interleukin-1 receptor |
| KR20050042082A (ko) * | 2002-05-31 | 2005-05-04 | 시젠 피티와이 리미티드 | 막 투과 서열로부터 유도된 자가 융합 또는 자가 응집단백질 |
| US20050159590A1 (en) | 2003-08-25 | 2005-07-21 | Galit Rotman | Variants of interleukin-1 receptor antagonist: compositions and uses thereof |
| WO2005086695A2 (en) | 2004-03-04 | 2005-09-22 | The University Of Tennessee Research Foundation | Intracellular interleukin-1 receptor antagonist and uses thereof |
| US7674464B2 (en) * | 2004-03-04 | 2010-03-09 | The University Of Tennessee Research Foundation | Intracellular interleukin-1 receptor antagonists |
| PL1729810T3 (pl) | 2004-04-02 | 2019-02-28 | Swedish Orphan Biovitrum Ab (Publ) | Sposoby agregacji IL-1ra |
| EP1751175B1 (en) | 2004-05-05 | 2012-07-25 | VALORISATION-RECHERCHE, Société en Commandite | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
| US8618054B2 (en) | 2004-05-05 | 2013-12-31 | Valorisation-Rechereche Société en Commandite | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
| AU2006264567A1 (en) | 2005-05-05 | 2007-01-11 | Valorisation Hsj, Societe En Commandite | Cytokine receptor modulators and uses thereof |
| US7736860B2 (en) | 2006-11-09 | 2010-06-15 | Univeristy Of Massachusetts | Methods of identifying compounds for the treatment of sterile inflammation |
| EP2187900B1 (en) | 2007-08-16 | 2016-11-09 | The Schepens Eye Research Institute, Inc. | Therapeutic compositions for treatment of inflammation of ocular and adnexal tissues |
| CN101889022A (zh) * | 2007-10-08 | 2010-11-17 | 阿纳福公司 | 三聚IL-1Ra |
| CN101255197B (zh) * | 2008-03-28 | 2012-01-25 | 浙江海正药业股份有限公司 | 血清白蛋白与白介素1受体拮抗剂的融合蛋白及应用 |
| DK3178835T3 (da) * | 2009-02-03 | 2019-06-24 | Amunix Pharmaceuticals Inc | Forlængede rekombinante polypeptider og sammensætninger omfattende samme |
-
2012
- 2012-03-14 EP EP12710122.8A patent/EP2686431B1/en active Active
- 2012-03-14 ES ES12710122.8T patent/ES2600616T3/es active Active
- 2012-03-14 RU RU2013145283/10A patent/RU2013145283A/ru not_active Application Discontinuation
- 2012-03-14 WO PCT/DK2012/000022 patent/WO2012122985A1/en not_active Ceased
- 2012-03-14 AU AU2012228769A patent/AU2012228769B2/en not_active Ceased
- 2012-03-14 JP JP2013558307A patent/JP6120782B2/ja active Active
- 2012-03-14 CA CA2828504A patent/CA2828504A1/en not_active Abandoned
- 2012-03-14 KR KR1020137026679A patent/KR20140012127A/ko not_active Withdrawn
- 2012-03-14 BR BR112013023309A patent/BR112013023309A2/pt not_active IP Right Cessation
- 2012-03-14 MX MX2013010171A patent/MX2013010171A/es not_active Application Discontinuation
- 2012-03-14 CN CN201280013172.1A patent/CN103476933B/zh not_active Expired - Fee Related
- 2012-03-14 US US14/003,824 patent/US9359405B2/en active Active
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2013
- 2013-09-09 ZA ZA2013/06744A patent/ZA201306744B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ615710A (en) | 2015-10-30 |
| US20140073556A1 (en) | 2014-03-13 |
| JP2014510082A (ja) | 2014-04-24 |
| AU2012228769A1 (en) | 2013-10-10 |
| ZA201306744B (en) | 2014-11-26 |
| CA2828504A1 (en) | 2012-09-20 |
| WO2012122985A1 (en) | 2012-09-20 |
| MX2013010171A (es) | 2013-11-20 |
| EP2686431A1 (en) | 2014-01-22 |
| US9359405B2 (en) | 2016-06-07 |
| AU2012228769B2 (en) | 2016-09-08 |
| ES2600616T3 (es) | 2017-02-10 |
| CN103476933B (zh) | 2016-04-13 |
| JP6120782B2 (ja) | 2017-04-26 |
| BR112013023309A2 (pt) | 2017-09-19 |
| CN103476933A (zh) | 2013-12-25 |
| EP2686431B1 (en) | 2016-08-03 |
| KR20140012127A (ko) | 2014-01-29 |
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Legal Events
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20161206 |