RU2013139682A - Способ улучшения роста волос - Google Patents
Способ улучшения роста волос Download PDFInfo
- Publication number
- RU2013139682A RU2013139682A RU2013139682/15A RU2013139682A RU2013139682A RU 2013139682 A RU2013139682 A RU 2013139682A RU 2013139682/15 A RU2013139682/15 A RU 2013139682/15A RU 2013139682 A RU2013139682 A RU 2013139682A RU 2013139682 A RU2013139682 A RU 2013139682A
- Authority
- RU
- Russia
- Prior art keywords
- weight
- composition
- minoxidil
- bimatoprost
- hair loss
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 13
- 230000003752 improving hair Effects 0.000 title claims abstract 3
- 239000000203 mixture Substances 0.000 claims abstract 43
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 claims abstract 27
- AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 claims abstract 27
- 229960002470 bimatoprost Drugs 0.000 claims abstract 27
- 229960003632 minoxidil Drugs 0.000 claims abstract 27
- 239000002904 solvent Substances 0.000 claims abstract 6
- 210000004761 scalp Anatomy 0.000 claims abstract 5
- 239000004094 surface-active agent Substances 0.000 claims abstract 5
- 239000006260 foam Substances 0.000 claims abstract 4
- 230000000699 topical effect Effects 0.000 claims abstract 4
- 241000124008 Mammalia Species 0.000 claims abstract 3
- 239000007788 liquid Substances 0.000 claims abstract 3
- 238000005187 foaming Methods 0.000 claims abstract 2
- 230000003779 hair growth Effects 0.000 claims abstract 2
- 239000003381 stabilizer Substances 0.000 claims abstract 2
- 201000004384 Alopecia Diseases 0.000 claims 16
- 230000003676 hair loss Effects 0.000 claims 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 9
- 208000024963 hair loss Diseases 0.000 claims 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 231100000360 alopecia Toxicity 0.000 claims 3
- 239000003021 water soluble solvent Substances 0.000 claims 3
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- 208000004631 alopecia areata Diseases 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 229940058015 1,3-butylene glycol Drugs 0.000 claims 1
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims 1
- 206010010356 Congenital anomaly Diseases 0.000 claims 1
- 208000003024 Diffuse alopecia Diseases 0.000 claims 1
- 206010020850 Hyperthyroidism Diseases 0.000 claims 1
- 201000009495 Hypotrichosis Diseases 0.000 claims 1
- 206010022971 Iron Deficiencies Diseases 0.000 claims 1
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 claims 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000002474 Tinea Diseases 0.000 claims 1
- 241000893966 Trichophyton verrucosum Species 0.000 claims 1
- 206010068168 androgenetic alopecia Diseases 0.000 claims 1
- 201000002996 androgenic alopecia Diseases 0.000 claims 1
- 235000019437 butane-1,3-diol Nutrition 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims 1
- 229940113120 dipropylene glycol Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000004709 eyebrow Anatomy 0.000 claims 1
- 210000000744 eyelid Anatomy 0.000 claims 1
- 210000004209 hair Anatomy 0.000 claims 1
- 229940051250 hexylene glycol Drugs 0.000 claims 1
- 230000003054 hormonal effect Effects 0.000 claims 1
- 208000003532 hypothyroidism Diseases 0.000 claims 1
- 230000002989 hypothyroidism Effects 0.000 claims 1
- 239000012678 infectious agent Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 229920000223 polyglycerol Polymers 0.000 claims 1
- 230000003658 preventing hair loss Effects 0.000 claims 1
- 229960004063 propylene glycol Drugs 0.000 claims 1
- 230000002269 spontaneous effect Effects 0.000 claims 1
- 208000006379 syphilis Diseases 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161437785P | 2011-01-31 | 2011-01-31 | |
| US61/437,785 | 2011-01-31 | ||
| PCT/US2012/023148 WO2012106249A2 (en) | 2011-01-31 | 2012-01-30 | Method of enhancing hair growth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013139682A true RU2013139682A (ru) | 2015-03-10 |
Family
ID=45688992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013139682/15A RU2013139682A (ru) | 2011-01-31 | 2012-01-30 | Способ улучшения роста волос |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8932567B2 (enExample) |
| EP (1) | EP2670488A2 (enExample) |
| JP (1) | JP6017455B2 (enExample) |
| KR (1) | KR20140020895A (enExample) |
| CN (1) | CN103747775A (enExample) |
| AU (2) | AU2012212481A1 (enExample) |
| BR (1) | BR112013019519A2 (enExample) |
| CA (1) | CA2826232C (enExample) |
| RU (1) | RU2013139682A (enExample) |
| WO (1) | WO2012106249A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8278757B2 (en) | 2008-02-05 | 2012-10-02 | Vorbeck Materials Corporation | Printed electronics |
| US8859616B2 (en) * | 2011-01-21 | 2014-10-14 | Allergan, Inc. | Compounds and methods for enhancing hair growth |
| CN103747775A (zh) | 2011-01-31 | 2014-04-23 | 阿勒根公司 | 促进毛发生长的方法 |
| RU2690183C2 (ru) * | 2013-09-26 | 2019-05-31 | Галдерма С.А. | Простагландин f2 альфа и его аналоги для лечения атрофического кожного рубцевания |
| WO2016159916A1 (en) * | 2015-03-31 | 2016-10-06 | Ogi̇g Sağlik Ürünleri̇ Ve Hi̇zmetleri̇ Sanayi̇ Ti̇caret Li̇mi̇ted Şi̇rketi̇ | A foamy pharmaceutical formulation used in dermatological diseases |
| MX2018001843A (es) * | 2015-08-13 | 2018-05-16 | River Town Therapeutics Inc | Composiciones y metodos para tratar alopecia. |
| JP7064820B2 (ja) * | 2016-03-31 | 2022-05-11 | ピアス株式会社 | 育毛剤、並びにε‐ポリリジンおよび／またはシャクヤク抽出物の使用 |
| KR102017796B1 (ko) * | 2016-07-28 | 2019-09-03 | 주식회사 큐어바이오 | 신규한 aimp1 단백질의 단편과 이를 유효성분으로 포함하는 발모 촉진용 조성물 |
| US10512670B2 (en) | 2016-08-08 | 2019-12-24 | Scm Lifescience Co., Ltd. | Pharmaceutical composition for preventing or treating hair loss comprising chemokine (C-X-C motif) ligand 1 (CXCL1) protein or CXCL1 protein and minoxidil as active ingredient |
| KR101849200B1 (ko) * | 2017-01-19 | 2018-04-16 | 주식회사 효성 | 충격강도가 개선된 폴리케톤 조성물 |
| KR101878795B1 (ko) * | 2017-03-22 | 2018-08-16 | 주식회사 효성 | 내열성이 개선된 폴리케톤 조성물 |
| KR102000217B1 (ko) * | 2017-08-08 | 2019-07-15 | 에스씨엠생명과학 주식회사 | Cxcl1 단백질 및 미녹시딜을 유효성분으로 포함하는 탈모 예방 또는 치료용 약학적 조성물 |
| EP3829607A4 (en) * | 2018-08-02 | 2022-06-01 | Histogen, Inc. | Conditioned medium and extracellular matrix compositions and uses thereof |
| US10987355B2 (en) * | 2019-08-07 | 2021-04-27 | Aneira Pharma, Inc. | Methods and compositions for the treatment of hair loss |
| CN110755286A (zh) * | 2019-11-18 | 2020-02-07 | 童婧 | 一种有助于生发的发际线填充组合物 |
| CN111110721A (zh) * | 2020-01-19 | 2020-05-08 | 朱炜 | 一种毛发防脱再生的复合制剂及其使用方法 |
| WO2021232054A1 (en) * | 2020-05-12 | 2021-11-18 | Chemistryrx | Compositions for treating hair loss |
| BR102021003531A2 (pt) | 2021-02-24 | 2022-08-30 | Eurofarma Laboratorios S.A. | Composição farmacêutica tópica espumável |
| KR102482658B1 (ko) * | 2021-12-07 | 2022-12-29 | 주식회사 바이오빌리프 | 비마토프로스트를 포함하는 국소 투여용 약학 조성물 |
| WO2025069091A1 (en) * | 2023-09-29 | 2025-04-03 | Pdfe Pharma Innovations - Fzco | Novel topical pharmaceutical composition for prevention and treatment of hair loss |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4139619A (en) | 1976-05-24 | 1979-02-13 | The Upjohn Company | 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth |
| US4968812A (en) | 1989-06-23 | 1990-11-06 | Shell Oil Company | Spirolactonelactams |
| US5352708A (en) | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| ATE306888T1 (de) * | 2000-04-07 | 2005-11-15 | Taisho Pharmaceutical Co Ltd | Haarwachstumstimulierende mittel mit verlängerter wirkung |
| US7351404B2 (en) * | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
| MX2010004834A (es) * | 2007-10-31 | 2010-10-20 | Pamela Lipkin | Composiciones de analogos de prostaglandina y metodos para tratar las condiciones relacionadas al epitelio. |
| US20080275118A1 (en) * | 2008-06-12 | 2008-11-06 | Shaw Mari M | Health and cosmetic composition and regime for stimulating hair growth and thickening on the head, including the scalp, eyelashes, and eyebrows, and which discourages hair loss |
| US8470833B2 (en) * | 2009-12-15 | 2013-06-25 | Mcneil-Ppc, Inc. | Hair growth and/or regrowth compositions |
| CN103747775A (zh) | 2011-01-31 | 2014-04-23 | 阿勒根公司 | 促进毛发生长的方法 |
-
2012
- 2012-01-30 CN CN201280016300.8A patent/CN103747775A/zh active Pending
- 2012-01-30 CA CA2826232A patent/CA2826232C/en active Active
- 2012-01-30 EP EP12704965.8A patent/EP2670488A2/en not_active Ceased
- 2012-01-30 AU AU2012212481A patent/AU2012212481A1/en not_active Abandoned
- 2012-01-30 KR KR1020137022980A patent/KR20140020895A/ko not_active Withdrawn
- 2012-01-30 BR BR112013019519A patent/BR112013019519A2/pt not_active IP Right Cessation
- 2012-01-30 RU RU2013139682/15A patent/RU2013139682A/ru not_active Application Discontinuation
- 2012-01-30 WO PCT/US2012/023148 patent/WO2012106249A2/en not_active Ceased
- 2012-01-30 JP JP2013551414A patent/JP6017455B2/ja not_active Expired - Fee Related
- 2012-01-30 US US13/361,615 patent/US8932567B2/en active Active
-
2014
- 2014-12-05 US US14/561,561 patent/US9700503B2/en active Active
-
2017
- 2017-04-21 AU AU2017202667A patent/AU2017202667B2/en not_active Ceased
- 2017-06-08 US US15/617,739 patent/US20180110711A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20120302588A1 (en) | 2012-11-29 |
| EP2670488A2 (en) | 2013-12-11 |
| US20150290104A1 (en) | 2015-10-15 |
| CA2826232A1 (en) | 2012-08-09 |
| CA2826232C (en) | 2019-09-17 |
| JP6017455B2 (ja) | 2016-11-02 |
| WO2012106249A2 (en) | 2012-08-09 |
| AU2017202667B2 (en) | 2019-02-21 |
| AU2012212481A1 (en) | 2013-08-22 |
| AU2017202667A1 (en) | 2017-05-11 |
| KR20140020895A (ko) | 2014-02-19 |
| CN103747775A (zh) | 2014-04-23 |
| US20180110711A1 (en) | 2018-04-26 |
| US8932567B2 (en) | 2015-01-13 |
| US9700503B2 (en) | 2017-07-11 |
| WO2012106249A3 (en) | 2014-02-27 |
| BR112013019519A2 (pt) | 2016-08-09 |
| JP2014510042A (ja) | 2014-04-24 |
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