RU2013132683A - Ингибиторы репликации вирусов гриппа - Google Patents
Ингибиторы репликации вирусов гриппа Download PDFInfo
- Publication number
- RU2013132683A RU2013132683A RU2013132683/04A RU2013132683A RU2013132683A RU 2013132683 A RU2013132683 A RU 2013132683A RU 2013132683/04 A RU2013132683/04 A RU 2013132683/04A RU 2013132683 A RU2013132683 A RU 2013132683A RU 2013132683 A RU2013132683 A RU 2013132683A
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- Russia
- Prior art keywords
- alkyl
- group
- independently
- optionally substituted
- optionally
- Prior art date
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- 241000712461 unidentified influenza virus Species 0.000 title claims 3
- 239000003112 inhibitor Substances 0.000 title 1
- 230000029812 viral genome replication Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 42
- 125000002837 carbocyclic group Chemical group 0.000 claims abstract 15
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 13
- 125000001931 aliphatic group Chemical group 0.000 claims abstract 10
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 8
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims abstract 8
- 150000003839 salts Chemical class 0.000 claims abstract 8
- 238000004177 carbon cycle Methods 0.000 claims abstract 5
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims abstract 4
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims abstract 3
- 125000003118 aryl group Chemical group 0.000 claims abstract 3
- 229910052736 halogen Inorganic materials 0.000 claims 39
- -1 cyano, hydroxy Chemical group 0.000 claims 31
- 125000004043 oxo group Chemical group O=* 0.000 claims 22
- 125000001424 substituent group Chemical group 0.000 claims 22
- 125000005843 halogen group Chemical group 0.000 claims 20
- 150000002367 halogens Chemical class 0.000 claims 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000001188 haloalkyl group Chemical group 0.000 claims 6
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 229940126062 Compound A Drugs 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001620 monocyclic carbocycle group Chemical group 0.000 claims 1
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 0 Cc1c(*)cnc(C)n1 Chemical compound Cc1c(*)cnc(C)n1 0.000 description 14
- BHFSMDPSSVQLOD-UHFFFAOYSA-N Cc(c(C#N)c1)nc(C)c1F Chemical compound Cc(c(C#N)c1)nc(C)c1F BHFSMDPSSVQLOD-UHFFFAOYSA-N 0.000 description 2
- HEMCGZPSGYRIOL-UHFFFAOYSA-N C(C1)C11CCCC1 Chemical compound C(C1)C11CCCC1 HEMCGZPSGYRIOL-UHFFFAOYSA-N 0.000 description 1
- GJJWOCIFFXEBPU-UHFFFAOYSA-N CC(C(CC12)CN=C1NCC2C1NC(NC2CCCCC2)NCC1(C)N)(F)F Chemical compound CC(C(CC12)CN=C1NCC2C1NC(NC2CCCCC2)NCC1(C)N)(F)F GJJWOCIFFXEBPU-UHFFFAOYSA-N 0.000 description 1
- CUMNGZMHERFBAQ-HMNKSOQGSA-N CCC(C(C1)[C@@H](C)NC=C1C(F)(F)F)c1nc(NC(CCCC2)[C@H]2C(O)=O)ncc1N Chemical compound CCC(C(C1)[C@@H](C)NC=C1C(F)(F)F)c1nc(NC(CCCC2)[C@H]2C(O)=O)ncc1N CUMNGZMHERFBAQ-HMNKSOQGSA-N 0.000 description 1
- PIIRZLZCOKFAAZ-MCZRRMNISA-N COC([C@@H](C1CCC2CC1)[C@H]2Nc1cc(-c2c[nH]c(nc3)c2cc3F)ncc1F)=O Chemical compound COC([C@@H](C1CCC2CC1)[C@H]2Nc1cc(-c2c[nH]c(nc3)c2cc3F)ncc1F)=O PIIRZLZCOKFAAZ-MCZRRMNISA-N 0.000 description 1
- QMCMZEDXEDPDTP-AMDVSUOASA-N COC([C@H]1C(CC2)CCC2C1)=O Chemical compound COC([C@H]1C(CC2)CCC2C1)=O QMCMZEDXEDPDTP-AMDVSUOASA-N 0.000 description 1
- YJXZVXMYASVALG-DRSMGJIXSA-N CO[IH]([C@@H](C1CCC2CC1)[C@H]2Nc(cc(-c1c[nH]c(nc2)c1cc2F)c(C#N)c1)c1F)=O Chemical compound CO[IH]([C@@H](C1CCC2CC1)[C@H]2Nc(cc(-c1c[nH]c(nc2)c1cc2F)c(C#N)c1)c1F)=O YJXZVXMYASVALG-DRSMGJIXSA-N 0.000 description 1
- VWUNZXFNDJUNMT-CCOGEBNFSA-N C[C@@H](C1CCC2CC1)C2Nc(nc1)nc(-c(c2c3)c[nH]c2ncc3F)c1F Chemical compound C[C@@H](C1CCC2CC1)C2Nc(nc1)nc(-c(c2c3)c[nH]c2ncc3F)c1F VWUNZXFNDJUNMT-CCOGEBNFSA-N 0.000 description 1
- LGODIPGSIRJWMT-UHFFFAOYSA-N Cc(c(F)c1)nc(C)c1F Chemical compound Cc(c(F)c1)nc(C)c1F LGODIPGSIRJWMT-UHFFFAOYSA-N 0.000 description 1
- SSYHSUNUQGJTDK-UHFFFAOYSA-N Cc(nc1C)ccc1F Chemical compound Cc(nc1C)ccc1F SSYHSUNUQGJTDK-UHFFFAOYSA-N 0.000 description 1
- VXROUMWEJBCDBZ-UHFFFAOYSA-N Cc1nc(C)cc(C(F)(F)F)c1 Chemical compound Cc1nc(C)cc(C(F)(F)F)c1 VXROUMWEJBCDBZ-UHFFFAOYSA-N 0.000 description 1
- VFMCCTVTAZJFQA-AKPINYAASA-N OC([C@@H](C1CCC2CC1)[C@H]2Nc1cc(-c2c[nH]c(nc3)c2cc3F)ncc1F)=O Chemical compound OC([C@@H](C1CCC2CC1)[C@H]2Nc1cc(-c2c[nH]c(nc3)c2cc3F)ncc1F)=O VFMCCTVTAZJFQA-AKPINYAASA-N 0.000 description 1
- IQJOXHUMARIQTH-QPGDOINGSA-N OC([C@H](C1CCC2CC1)[C@@H]2Nc(nc1)nc(-c2c[nH]c(nc3)c2cc3F)c1F)=O Chemical compound OC([C@H](C1CCC2CC1)[C@@H]2Nc(nc1)nc(-c2c[nH]c(nc3)c2cc3F)c1F)=O IQJOXHUMARIQTH-QPGDOINGSA-N 0.000 description 1
- VFMCCTVTAZJFQA-PEOAOIFPSA-N OC([C@H](C1CCC2CC1)[C@@H]2Nc1cc(-c2c[nH]c(nc3)c2cc3F)ncc1F)=O Chemical compound OC([C@H](C1CCC2CC1)[C@@H]2Nc1cc(-c2c[nH]c(nc3)c2cc3F)ncc1F)=O VFMCCTVTAZJFQA-PEOAOIFPSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42393310P | 2010-12-16 | 2010-12-16 | |
| US61/423,933 | 2010-12-16 | ||
| US201161527277P | 2011-08-25 | 2011-08-25 | |
| US61/527,277 | 2011-08-25 | ||
| PCT/US2011/065389 WO2012083122A1 (en) | 2010-12-16 | 2011-12-16 | Inhibitors of influenza viruses replication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013132683A true RU2013132683A (ru) | 2015-01-27 |
Family
ID=45464909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013132683/04A RU2013132683A (ru) | 2010-12-16 | 2011-12-16 | Ингибиторы репликации вирусов гриппа |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20130345218A1 (OSRAM) |
| EP (1) | EP2651938A1 (OSRAM) |
| JP (1) | JP2013545818A (OSRAM) |
| KR (1) | KR20130128435A (OSRAM) |
| CN (1) | CN103562205A (OSRAM) |
| AU (1) | AU2011343647A1 (OSRAM) |
| CA (1) | CA2822062A1 (OSRAM) |
| MX (1) | MX2013006840A (OSRAM) |
| RU (1) | RU2013132683A (OSRAM) |
| WO (1) | WO2012083122A1 (OSRAM) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8921376B2 (en) * | 2005-05-20 | 2014-12-30 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| SG10201405826RA (en) | 2009-06-17 | 2014-12-30 | Vertex Pharma | Inhibitors of influenza viruses replication |
| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| WO2015073481A1 (en) | 2013-11-13 | 2015-05-21 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| PT3068776T (pt) | 2013-11-13 | 2019-08-26 | Vertex Pharma | Inibidores da replicação de vírus da gripe |
| ES2812605T3 (es) * | 2013-12-20 | 2021-03-17 | Signal Pharm Llc | Compuestos de diaminopirimidilo sustituidos, composiciones de los mismos y procedimientos de tratamiento con ellos |
| CN106573920B (zh) | 2014-08-08 | 2020-11-10 | 爱尔兰詹森科学公司 | 用于在流感病毒感染中使用的吲哚 |
| AU2015314394A1 (en) * | 2014-09-08 | 2017-03-02 | Janssen Sciences Ireland Uc | Pyrrolopyrimidines for use in influenza virus infection |
| EP3277811B1 (en) | 2015-04-03 | 2020-12-23 | University of Massachusetts | Fully stabilized asymmetric sirna |
| JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤を調製する方法 |
| EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| CA2995110A1 (en) | 2015-08-14 | 2017-02-23 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| KR20180087290A (ko) * | 2015-11-27 | 2018-08-01 | 얀센 사이언시즈 아일랜드 유씨 | 인플루엔자 바이러스 감염에서 사용하기 위한 복소환식 인돌 |
| AU2016368317B2 (en) | 2015-12-09 | 2019-05-23 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication, application methods and uses thereof |
| JP6989509B2 (ja) | 2016-01-20 | 2022-01-05 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | インフルエンザウイルス感染における使用のためのアリール置換ピリミジン |
| WO2017132669A1 (en) | 2016-01-31 | 2017-08-03 | University Of Massachusetts | Branched oligonucleotides |
| WO2017133667A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | Pyrimidine and pyridine derivatives and use in treatment, amelioration or prevention of influenza thereof |
| WO2017133664A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | Bicyclic pyridine and pyrimidine derivatives and their use in the treatment， amelioration or prevention of influenza |
| WO2017133658A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | 4, 7-diazaindole and 4, 7-diazaindazole derivatives and their use in the treatment, amelioration or prevention of influenza |
| WO2017133670A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza |
| WO2017133665A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | 6,7-diazaindazole and 6,7-diazaindole derivatives and use in treatment, amelioration or prevention of influenza thereof |
| WO2017133657A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza |
| CN107759571B (zh) | 2016-08-16 | 2021-03-02 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其使用方法和用途 |
| CN109641868B (zh) * | 2016-08-30 | 2021-12-03 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其使用方法和用途 |
| US10987354B2 (en) | 2016-12-15 | 2021-04-27 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
| WO2018127096A1 (en) | 2017-01-05 | 2018-07-12 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
| CN110446711B (zh) | 2017-03-02 | 2022-02-15 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其用途 |
| CN108727369B (zh) * | 2017-04-25 | 2023-06-09 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其用途 |
| CA3064590A1 (en) | 2017-06-23 | 2018-12-27 | University Of Massachusetts | Two-tailed self-delivering sirna and related methods |
| KR102813547B1 (ko) | 2018-07-27 | 2025-05-27 | 코크리스탈 파마, 아이엔씨. | 인플루엔자바이러스 복제 억제제로서의 피롤로[2,3-b]피리딘 유도체 |
| JP7627042B2 (ja) | 2018-08-23 | 2025-02-05 | ユニバーシティー オブ マサチューセッツ | Ｏ－メチルリッチ完全安定化オリゴヌクレオチド |
| CN109678738B (zh) * | 2018-12-26 | 2021-11-30 | 深圳市华先医药科技有限公司 | 一种合成(2s,3s)-3-氨基-二环[2.2.2]辛烷-2-甲酸酯的方法 |
| CN113614232A (zh) | 2019-01-18 | 2021-11-05 | 马萨诸塞大学 | 动态药代动力学修饰锚 |
| JP2022528840A (ja) | 2019-03-26 | 2022-06-16 | ユニバーシティ・オブ・マサチューセッツ | 安定性が増加した修飾オリゴヌクレオチド |
| US12024706B2 (en) | 2019-08-09 | 2024-07-02 | University Of Massachusetts | Modified oligonucleotides targeting SNPs |
| US12365894B2 (en) | 2019-09-16 | 2025-07-22 | University Of Massachusetts | Branched lipid conjugates of siRNA for specific tissue delivery |
| EP4126070A4 (en) | 2020-03-26 | 2024-07-24 | University Of Massachusetts | Synthesis of modified oligonucleotides with increased stability |
| BR112022019557A2 (pt) * | 2020-04-10 | 2022-12-06 | Cocrystal Pharma Inc | Inibidores de replicação de norovírus e coronavírus |
| CN112063726A (zh) * | 2020-09-21 | 2020-12-11 | 杭州市疾病预防控制中心 | 一种用于检测奥司他韦耐药突变的引物、探针及检测方法 |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2420210A1 (en) | 2000-09-22 | 2002-03-28 | Michael Edward Kobierski | Stereoselective process for preparing cyclohexyl amine derivatives |
| BR0211900A (pt) | 2001-08-14 | 2004-08-24 | Toyama Chemical Co Ltd | Método para inibição do desenvolvimento de vìrus e/ou virucida, análogos de nucleotìdeo de pirazina e de nucleosìdeo de pirazina, precursor do inibidor da polimerase de rna, inibidor da polimerase de rna, método para tratar pacientes infectados por vìrus, e, usos de um análogo de nucleotìdeo de pirazina ou um sal deste e de um análogo de nucleosìdeo de pirazina ou um sal deste |
| TWI339206B (en) * | 2003-09-04 | 2011-03-21 | Vertex Pharma | Compositions useful as inhibitors of protein kinases |
| DE602005027825D1 (de) * | 2004-03-30 | 2011-06-16 | Vertex Pharma | Als inhibitoren von jak und anderen proteinkinasen geeignete azaindole |
| UA87494C2 (en) * | 2004-03-30 | 2009-07-27 | Вертекс Фармасьютикалс Инкорпорейтед | Azaindoles useful as inhibitors of jak and other protein kinases |
| US20060161001A1 (en) * | 2004-12-20 | 2006-07-20 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| US20080300267A1 (en) * | 2005-05-16 | 2008-12-04 | Barun Okram | Compounds and Compositions as Protein Kinase Inhibitors |
| KR20080063809A (ko) * | 2005-09-30 | 2008-07-07 | 버텍스 파마슈티칼스 인코포레이티드 | 야누스 키나아제의 억제제로서 유용한 데아자퓨린 |
| EP2537849A3 (en) | 2006-01-17 | 2013-04-03 | Vertex Pharmaceuticals, Inc. | Azaindoles useful as inhibitors of janus kinases |
| NZ577798A (en) * | 2006-12-21 | 2012-04-27 | Vertex Pharma | 5-cyano-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
| CN101903384A (zh) | 2007-11-02 | 2010-12-01 | 沃泰克斯药物股份有限公司 | 作为蛋白激酶Cθ抑制剂的[1H-吡唑并[3,4-B]吡啶-4-基]-苯基或-吡啶-2-基衍生物 |
| WO2010011768A1 (en) | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| AU2009274027A1 (en) | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| MX2011000839A (es) | 2008-07-23 | 2011-04-05 | Vertex Pharma | Inhibidores de pirazolpiridina cinasa. |
| US20100038988A1 (en) | 2008-08-12 | 2010-02-18 | Gannon Ramy | Stator and Method of Making the Same |
| SG10201405826RA (en) * | 2009-06-17 | 2014-12-30 | Vertex Pharma | Inhibitors of influenza viruses replication |
| CN102471339A (zh) * | 2009-07-15 | 2012-05-23 | 雅培制药有限公司 | 激酶的吡咯并吡啶抑制剂 |
-
2011
- 2011-12-16 CA CA2822062A patent/CA2822062A1/en not_active Abandoned
- 2011-12-16 CN CN201180066551.2A patent/CN103562205A/zh active Pending
- 2011-12-16 JP JP2013544810A patent/JP2013545818A/ja active Pending
- 2011-12-16 WO PCT/US2011/065389 patent/WO2012083122A1/en not_active Ceased
- 2011-12-16 KR KR1020137018522A patent/KR20130128435A/ko not_active Withdrawn
- 2011-12-16 MX MX2013006840A patent/MX2013006840A/es not_active Application Discontinuation
- 2011-12-16 RU RU2013132683/04A patent/RU2013132683A/ru not_active Application Discontinuation
- 2011-12-16 EP EP11806096.1A patent/EP2651938A1/en not_active Withdrawn
- 2011-12-16 AU AU2011343647A patent/AU2011343647A1/en not_active Abandoned
-
2013
- 2013-06-14 US US13/918,115 patent/US20130345218A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2651938A1 (en) | 2013-10-23 |
| WO2012083122A8 (en) | 2013-12-05 |
| KR20130128435A (ko) | 2013-11-26 |
| US20130345218A1 (en) | 2013-12-26 |
| WO2012083122A1 (en) | 2012-06-21 |
| CA2822062A1 (en) | 2012-06-21 |
| CN103562205A (zh) | 2014-02-05 |
| AU2011343647A1 (en) | 2013-05-02 |
| MX2013006840A (es) | 2014-01-31 |
| JP2013545818A (ja) | 2013-12-26 |
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| Date | Code | Title | Description |
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| FA93 | Acknowledgement of application withdrawn (no request for examination) |
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