RU2012154447A - Гетероциклические сульфоновые аллостерические потенциаторы mglur4, композиции и способы лечения неврологических дисфункций - Google Patents
Гетероциклические сульфоновые аллостерические потенциаторы mglur4, композиции и способы лечения неврологических дисфункций Download PDFInfo
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- RU2012154447A RU2012154447A RU2012154447/04A RU2012154447A RU2012154447A RU 2012154447 A RU2012154447 A RU 2012154447A RU 2012154447/04 A RU2012154447/04 A RU 2012154447/04A RU 2012154447 A RU2012154447 A RU 2012154447A RU 2012154447 A RU2012154447 A RU 2012154447A
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- 238000000034 method Methods 0.000 title claims abstract 48
- 102100038354 Metabotropic glutamate receptor 4 Human genes 0.000 title claims abstract 40
- 230000004064 dysfunction Effects 0.000 title claims abstract 25
- 230000000926 neurological effect Effects 0.000 title claims 4
- 239000000203 mixture Substances 0.000 title claims 2
- 101150025480 Grm4 gene Proteins 0.000 title 1
- 230000003281 allosteric effect Effects 0.000 title 1
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 106
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 104
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 82
- 150000001875 compounds Chemical class 0.000 claims abstract 80
- 229910052799 carbon Inorganic materials 0.000 claims abstract 70
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims abstract 58
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims abstract 48
- 230000000694 effects Effects 0.000 claims abstract 42
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 39
- 108010038422 metabotropic glutamate receptor 4 Proteins 0.000 claims abstract 39
- 125000003118 aryl group Chemical group 0.000 claims abstract 36
- 241000124008 Mammalia Species 0.000 claims abstract 32
- 150000003839 salts Chemical class 0.000 claims abstract 13
- 230000005062 synaptic transmission Effects 0.000 claims abstract 9
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 66
- 229910052739 hydrogen Inorganic materials 0.000 claims 46
- 125000000217 alkyl group Chemical group 0.000 claims 44
- 229910052736 halogen Inorganic materials 0.000 claims 44
- 150000002367 halogens Chemical class 0.000 claims 44
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 29
- 208000035475 disorder Diseases 0.000 claims 21
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 125000003545 alkoxy group Chemical group 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 11
- 230000003389 potentiating effect Effects 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 9
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 208000020925 Bipolar disease Diseases 0.000 claims 5
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 claims 5
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 claims 5
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- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 claims 3
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims 3
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
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- 235000019441 ethanol Nutrition 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
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- 208000011580 syndromic disease Diseases 0.000 claims 1
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- 239000010802 sludge Substances 0.000 abstract 1
- 0 Cc(nc(NC(c1ncccc1)=O)[s]1)c1S(Cc1cc(*)ccc1*)(=O)=O Chemical compound Cc(nc(NC(c1ncccc1)=O)[s]1)c1S(Cc1cc(*)ccc1*)(=O)=O 0.000 description 2
- VYDJTWWECBUAEO-UHFFFAOYSA-N CC(C)c(nc(NC(c1ncccc1)=O)[s]1)c1S(C(C)c1ccccc1Cl)(=O)=O Chemical compound CC(C)c(nc(NC(c1ncccc1)=O)[s]1)c1S(C(C)c1ccccc1Cl)(=O)=O VYDJTWWECBUAEO-UHFFFAOYSA-N 0.000 description 1
- PGKLIZKBSJEMLX-UHFFFAOYSA-N CC(C)c1ccc(CS(c2c(C)nc(NC(c3ccccn3)=O)[s]2)(=O)=O)cc1 Chemical compound CC(C)c1ccc(CS(c2c(C)nc(NC(c3ccccn3)=O)[s]2)(=O)=O)cc1 PGKLIZKBSJEMLX-UHFFFAOYSA-N 0.000 description 1
- QFRNZEQLGXIDMF-UHFFFAOYSA-N Cc(nc(NC(c1ccccn1)=O)[s]1)c1S(Cc1ccc(C)cc1)(=O)=O Chemical compound Cc(nc(NC(c1ccccn1)=O)[s]1)c1S(Cc1ccc(C)cc1)(=O)=O QFRNZEQLGXIDMF-UHFFFAOYSA-N 0.000 description 1
- OCVRDYREJYODBM-UHFFFAOYSA-N Cc(nc(NC(c1ncccc1)=O)[s]1)c1S(Cc1ccccc1Cl)(=O)=O Chemical compound Cc(nc(NC(c1ncccc1)=O)[s]1)c1S(Cc1ccccc1Cl)(=O)=O OCVRDYREJYODBM-UHFFFAOYSA-N 0.000 description 1
- ZXIIVXBJJRPTOY-UHFFFAOYSA-N O=C(c1ccccn1)Nc([s]1)nnc1S(Cc1ccccc1)(=O)=O Chemical compound O=C(c1ccccn1)Nc([s]1)nnc1S(Cc1ccccc1)(=O)=O ZXIIVXBJJRPTOY-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
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- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33392610P | 2010-05-12 | 2010-05-12 | |
| US61/333,926 | 2010-05-12 | ||
| PCT/US2011/036308 WO2011143466A1 (en) | 2010-05-12 | 2011-05-12 | Heterocyclic sulfone mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012154447A true RU2012154447A (ru) | 2014-06-20 |
Family
ID=44914713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012154447/04A RU2012154447A (ru) | 2010-05-12 | 2011-05-12 | Гетероциклические сульфоновые аллостерические потенциаторы mglur4, композиции и способы лечения неврологических дисфункций |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9192603B2 (enExample) |
| EP (1) | EP2568809A4 (enExample) |
| JP (1) | JP2013526544A (enExample) |
| KR (1) | KR20130079429A (enExample) |
| CN (1) | CN102939006A (enExample) |
| AU (1) | AU2011252974A1 (enExample) |
| BR (1) | BR112012028894A2 (enExample) |
| CA (1) | CA2798514A1 (enExample) |
| IL (1) | IL222854A0 (enExample) |
| MX (1) | MX2012013031A (enExample) |
| RU (1) | RU2012154447A (enExample) |
| SG (1) | SG185414A1 (enExample) |
| WO (1) | WO2011143466A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2735521A1 (en) | 2008-09-04 | 2010-03-11 | Boehringer Ingelheim International Gmbh | Indolizine inhibitors of leukotriene production |
| WO2010088406A1 (en) | 2009-01-28 | 2010-08-05 | Vanderbilt University | Substituted 1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazoles as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US8759377B2 (en) | 2009-11-23 | 2014-06-24 | Vanderbilt University | Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| WO2011068821A1 (en) | 2009-12-04 | 2011-06-09 | Boehringer Ingelheim International Gmbh | Benzimidazole inhibitors of leukotriene production |
| WO2012024150A1 (en) | 2010-08-16 | 2012-02-23 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| JP5862669B2 (ja) | 2010-08-26 | 2016-02-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のオキサジアゾール阻害剤 |
| EP2619197B1 (en) | 2010-09-23 | 2015-08-05 | Boehringer Ingelheim International GmbH | Oxadiazole inhibitors of leukotriene production |
| WO2012040137A1 (en) | 2010-09-23 | 2012-03-29 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| EP2632915B1 (en) | 2010-10-29 | 2015-08-12 | Boehringer Ingelheim International GmbH | Benzimidazole inhibitors of leukotriene production |
| EP2635566B1 (en) | 2010-11-01 | 2018-05-16 | Boehringer Ingelheim International GmbH | Benzimidazole inhibitors of leukotriene production |
| EP2651930B1 (en) | 2010-12-16 | 2015-10-28 | Boehringer Ingelheim International GmbH | Biarylamide inhibitors of leukotriene production |
| AR089853A1 (es) | 2012-02-01 | 2014-09-24 | Boehringer Ingelheim Int | Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso |
| EP2863738A2 (en) | 2012-06-14 | 2015-04-29 | Basf Se | Pesticidal methods using substituted 3-pyridyl thiazole compounds and derivatives for combating animal pests |
| SI3049409T1 (sl) * | 2013-09-25 | 2017-08-31 | F. Hoffmann-La Roche Ag | Derivati etinila |
| WO2016115272A1 (en) | 2015-01-13 | 2016-07-21 | Vanderbilt University | Benzothiazole and benzisothiazole-substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| WO2016123627A1 (en) | 2015-01-30 | 2016-08-04 | Vanderbilt University | Isoquiniline and napthalene-substituted compounds as mglur4 allosteric potentiators, compounds, and methods of treating neurological dysfunction |
| WO2016123629A1 (en) | 2015-01-30 | 2016-08-04 | Vanderbilt University | Indazole and azaindazole substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| WO2016179351A1 (en) | 2015-05-05 | 2016-11-10 | Northwestern University | Treatment of levodopa-induced dyskinesias |
| WO2016202935A1 (en) | 2015-06-19 | 2016-12-22 | Bayer Pharma Aktiengesellschaft | Glucose transport inhibitors |
| US10710997B2 (en) | 2016-09-01 | 2020-07-14 | Vanderbilt University | Isoquinoline amide and isoquinoline amide-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US10294222B2 (en) | 2016-09-01 | 2019-05-21 | Vanderbilt University | Benzomorpholine and benzomorpholine-substituted compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US10968227B2 (en) | 2016-11-08 | 2021-04-06 | Vanderbilt University | Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US11242342B2 (en) | 2016-11-08 | 2022-02-08 | Vanderbilt University | Isoquinoline amine compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
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| DE3272640D1 (en) | 1982-01-22 | 1986-09-18 | Basf Ag | Thiadiazole derivatives, process for their preparation, and their use in combatting unwanted plant growth |
| US6262096B1 (en) | 1997-11-12 | 2001-07-17 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
| US6040321A (en) | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
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| WO1999047507A2 (en) | 1998-03-19 | 1999-09-23 | Pharmacia & Upjohn Company | 1,3,4-thiadiazoles useful for the treatment of cmv infections |
| DK1347971T3 (da) | 2000-12-21 | 2006-05-15 | Bristol Myers Squibb Co | Thiazolylinhibitorer af tyrosinkinaser fra Tec-familien |
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| JP5448164B2 (ja) | 2006-07-28 | 2014-03-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を変調する化合物 |
| EP2074084B1 (en) | 2006-09-25 | 2013-08-28 | Boehringer Ingelheim International GmbH | Compounds which modulate the cb2 receptor |
| MX2009003892A (es) * | 2006-10-25 | 2009-04-23 | Neurosearch As | Compuestos de oxadiazol y tiadiazol y su uso como moduladores del receptor de acetilcolina nicotinico. |
| GB0622202D0 (en) | 2006-11-07 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel compounds |
| GB0713686D0 (en) * | 2007-07-13 | 2007-08-22 | Addex Pharmaceuticals Sa | New compounds 2 |
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- 2011-05-12 KR KR1020127032242A patent/KR20130079429A/ko not_active Withdrawn
- 2011-05-12 CN CN201180029055XA patent/CN102939006A/zh active Pending
- 2011-05-12 US US13/697,783 patent/US9192603B2/en active Active
- 2011-05-12 MX MX2012013031A patent/MX2012013031A/es not_active Application Discontinuation
- 2011-05-12 RU RU2012154447/04A patent/RU2012154447A/ru not_active Application Discontinuation
- 2011-05-12 SG SG2012081162A patent/SG185414A1/en unknown
- 2011-05-12 CA CA2798514A patent/CA2798514A1/en not_active Abandoned
- 2011-05-12 BR BR112012028894A patent/BR112012028894A2/pt not_active IP Right Cessation
- 2011-05-12 WO PCT/US2011/036308 patent/WO2011143466A1/en not_active Ceased
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- 2011-05-12 EP EP11781297.4A patent/EP2568809A4/en not_active Withdrawn
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| MX2012013031A (es) | 2012-12-17 |
| CA2798514A1 (en) | 2011-11-17 |
| KR20130079429A (ko) | 2013-07-10 |
| US9192603B2 (en) | 2015-11-24 |
| US20130158078A1 (en) | 2013-06-20 |
| IL222854A0 (en) | 2012-12-31 |
| AU2011252974A1 (en) | 2012-12-13 |
| CN102939006A (zh) | 2013-02-20 |
| EP2568809A1 (en) | 2013-03-20 |
| WO2011143466A1 (en) | 2011-11-17 |
| BR112012028894A2 (pt) | 2019-09-24 |
| EP2568809A4 (en) | 2013-11-06 |
| JP2013526544A (ja) | 2013-06-24 |
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