CN102939006A - 杂环砜基代谢型谷氨酸受体第4亚型(mglur4)变构增效剂，组合物，以及用以治疗神经性障碍的方法 - Google Patents

杂环砜基代谢型谷氨酸受体第4亚型(mglur4)变构增效剂，组合物，以及用以治疗神经性障碍的方法 Download PDF

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CN102939006A
CN102939006A CN201180029055XA CN201180029055A CN102939006A CN 102939006 A CN102939006 A CN 102939006A CN 201180029055X A CN201180029055X A CN 201180029055XA CN 201180029055 A CN201180029055 A CN 201180029055A CN 102939006 A CN102939006 A CN 102939006A
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P·J·康那
C·W·林斯利
C·R·霍普金斯
C·D·韦乌尔
C·M·尼斯温德
R·D·高格廖蒂
张耀延
J·M·萨洛维奇
D·W·恩格尔斯
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Vanderbilt University
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201180029055XA 2010-05-12 2011-05-12 杂环砜基代谢型谷氨酸受体第4亚型(mglur4)变构增效剂，组合物，以及用以治疗神经性障碍的方法 Pending CN102939006A (zh)

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Application Number Priority Date Filing Date Title
US33392610P 2010-05-12 2010-05-12
US61/333,926 2010-05-12
PCT/US2011/036308 WO2011143466A1 (en) 2010-05-12 2011-05-12 Heterocyclic sulfone mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

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US (1) US9192603B2 (enExample)
EP (1) EP2568809A4 (enExample)
JP (1) JP2013526544A (enExample)
KR (1) KR20130079429A (enExample)
CN (1) CN102939006A (enExample)
AU (1) AU2011252974A1 (enExample)
BR (1) BR112012028894A2 (enExample)
CA (1) CA2798514A1 (enExample)
IL (1) IL222854A0 (enExample)
MX (1) MX2012013031A (enExample)
RU (1) RU2012154447A (enExample)
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Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8618300B2 (en) 2008-09-04 2013-12-31 Boehringer Ingelheim International Gmbh Indolizine inhibitors of leukotriene production
US8658650B2 (en) 2009-01-28 2014-02-25 Vanderbilt University Substituted 1,1,3,1-tetraoxidobenzo[D][1,3,2]dithiazoles as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US8759377B2 (en) 2009-11-23 2014-06-24 Vanderbilt University Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US8420655B2 (en) 2009-12-04 2013-04-16 Boehringer Ingelheim International Gmbh Benzimidazole inhibitors of leukotriene production
BR112013003439A2 (pt) 2010-08-16 2019-09-24 Boehringer Ingelheim Int "inibidores de oxadiazol de produção de leucotrieno"
EP2609092B1 (en) 2010-08-26 2015-04-01 Boehringer Ingelheim International GmbH Oxadiazole inhibitors of leukotriene production
JP5828188B2 (ja) 2010-09-23 2015-12-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン産生のオキサジアゾール阻害剤
EP2619197B1 (en) 2010-09-23 2015-08-05 Boehringer Ingelheim International GmbH Oxadiazole inhibitors of leukotriene production
US8829200B2 (en) 2010-10-29 2014-09-09 Boehringer Ingelheim International Gmbh Benzimidazole inhibitors of leukotriene production
JP5789888B2 (ja) 2010-11-01 2015-10-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成のベンゾイミダゾールインヒビター
JP6097998B2 (ja) 2010-12-16 2017-03-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成のビアリールアミドインヒビター
AR089853A1 (es) 2012-02-01 2014-09-24 Boehringer Ingelheim Int Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso
EP2863738A2 (en) 2012-06-14 2015-04-29 Basf Se Pesticidal methods using substituted 3-pyridyl thiazole compounds and derivatives for combating animal pests
WO2015044075A1 (en) * 2013-09-25 2015-04-02 F. Hoffmann-La Roche Ag Ethynyl derivatives
US10221172B2 (en) 2015-01-13 2019-03-05 Vanderbilt University Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
WO2016123627A1 (en) 2015-01-30 2016-08-04 Vanderbilt University Isoquiniline and napthalene-substituted compounds as mglur4 allosteric potentiators, compounds, and methods of treating neurological dysfunction
US10526323B2 (en) 2015-01-30 2020-01-07 Vanderbilt University Indazole and azaindazole substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US9987242B2 (en) 2015-05-05 2018-06-05 Northwestern University Treatment of Levodopa-induced Dyskinesias
WO2016202935A1 (en) 2015-06-19 2016-12-22 Bayer Pharma Aktiengesellschaft Glucose transport inhibitors
US10710997B2 (en) 2016-09-01 2020-07-14 Vanderbilt University Isoquinoline amide and isoquinoline amide-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US10294222B2 (en) 2016-09-01 2019-05-21 Vanderbilt University Benzomorpholine and benzomorpholine-substituted compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US10968227B2 (en) 2016-11-08 2021-04-06 Vanderbilt University Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
WO2018089544A1 (en) 2016-11-08 2018-05-17 Vanderbilt University Isoquinoline amine compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
TW201837026A (zh) 2017-01-10 2018-10-16 德商拜耳廠股份有限公司 作為除害劑之雜環衍生物（二）
UY37556A (es) 2017-01-10 2018-07-31 Bayer Ag Derivados heterocíclicos como pesticidas
US11319304B2 (en) 2017-06-28 2022-05-03 Vanderbilt University Pyridine quinoline compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
PE20200756A1 (es) 2017-08-16 2020-07-27 Univ Vanderbilt Compuestos de indazol como potenciadores alostericos mglur4, composiciones y metodos de tratamiento de la disfuncion neurologica
MY196582A (en) 2018-02-13 2023-04-19 Gilead Sciences Inc PD-1/PD-L1 Inhibitors
US11724997B2 (en) 2018-03-01 2023-08-15 Annapurna Bio, Inc. Compounds and compositions for treating conditions associated with APJ receptor activity
WO2019204609A1 (en) 2018-04-19 2019-10-24 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
PT3820572T (pt) 2018-07-13 2023-11-10 Gilead Sciences Inc Inibidores pd-1/pd-l1
EP3870566A1 (en) 2018-10-24 2021-09-01 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
CN121108034A (zh) 2019-04-03 2025-12-12 阿里戈斯治疗公司 吡咯化合物
BR112022011917A2 (pt) 2019-12-20 2022-09-06 Tenaya Therapeutics Inc Fluoroalquil-oxadiazois e seus usos
US20230247994A1 (en) 2020-07-02 2023-08-10 Bayer Aktiengesellschaft Heterocyclene derivatives as pest control agents
MX2023012875A (es) 2021-05-04 2024-01-12 Tenaya Therapeutics Inc Inhibidores 2-fluoro alquil-l,3,4-oxadiazol-5-il-tiazol de hdac6 para su uso en el tratamiento de enfermedades metabólicas y hfpef.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009010454A2 (en) * 2007-07-13 2009-01-22 Addex Pharma S.A. Amido derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors
CN101384554A (zh) * 2006-02-17 2009-03-11 弗·哈夫曼-拉罗切有限公司 吡啶-2-甲酰胺衍生物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE21393T1 (de) 1982-01-22 1986-08-15 Basf Ag Thiadiazolderivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses.
US6040321A (en) 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6262096B1 (en) 1997-11-12 2001-07-17 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6162791A (en) 1998-03-02 2000-12-19 Apotex Inc. Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes
US6468977B1 (en) 1998-03-02 2002-10-22 Apotex Inc. Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes
DK1064273T3 (da) 1998-03-19 2003-03-31 Upjohn Co 1,3,4-Thiadiazoler, som er nyttige til behandling af CMV-infektioner
DE60117605T2 (de) 2000-12-21 2006-12-07 Bristol-Myers Squibb Co. Thiazolyl-inhibitoren von tyrosinkinasen der tec-familie
EP1646377A4 (en) * 2003-07-11 2009-09-09 Merck & Co Inc TREATMENT OF MOVEMENT DISORDERS WITH METABOTROPIC GLUTAMATE 4 RECEPTOR POSITIVE ALLOSTERIC MODULATOR
JP2009524677A (ja) 2006-01-25 2009-07-02 シンタ ファーマシューティカルズ コーポレーション 炎症および免疫関連使用用のチアゾールおよびチアジアゾール化合物
CA2657247A1 (en) 2006-07-28 2008-01-31 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
US7928123B2 (en) 2006-09-25 2011-04-19 Boehringer Ingelheim International Gmbh Compounds which modulate the CB2 receptor
US20100029685A1 (en) 2006-10-25 2010-02-04 Neurosearch A/S Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators
GB0622202D0 (en) 2006-11-07 2006-12-20 Addex Pharmaceuticals Sa Novel compounds
EP2334183A4 (en) 2008-09-16 2012-06-06 Merck Sharp & Dohme METABOTROPE GLUTAMATE R4 LIGANDS FROM SULFONAMIDE

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101384554A (zh) * 2006-02-17 2009-03-11 弗·哈夫曼-拉罗切有限公司 吡啶-2-甲酰胺衍生物
WO2009010454A2 (en) * 2007-07-13 2009-01-22 Addex Pharma S.A. Amido derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS SERVICE: "RN:1001577-48-5", 《STN REGISTRY数据库》 *
CHEMICAL ABSTRACTS SERVICE: "RN:1095371-08-6", 《STN REGISTRY数据库》 *
CHEMICAL ABSTRACTS SERVICE: "RN:57352-58-6", 《STN REGISTRY数据库》 *
CHEMICAL ABSTRACTS SERVICE: "RN:784157-87-5", 《STN REGISTRY数据库》 *
CHEMICAL ABSTRACTS SERVICE: "RN:784170-41-8;784158-06-1", 《STN REGISTRY数据库》 *
CHEMICAL ABSTRACTS SERVICE: "RN:790287-98-8", 《STN REGISTRY数据库》 *
CHEMICAL ABSTRACTS SERVICE: "RN:847933-12-4", 《STN REGISTRY数据库》 *
CHEMICAL ABSTRACTS SERVICE: "RN:848619-06-7", 《STN REGISTRY数据库》 *
CHEMICAL ABSTRACTS SERVICE: "RN:869867-72-1", 《STN REGISTRY数据库》 *
CHEMICAL ABSTRACTS SERVICE: "RN:926445-74-1", 《STN REGISTRY数据库》 *
FRANCESCA CLERICI等: "Synthesis of 2-Amino-5-sulfanyl-1,3,4-thiadiazole Derivatives and Evaluation of Their Antidepressant and Anxiolytic Activity", 《J. MED. CHEM.》 *
MARCO RADI等: "Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *
O.H. RIZK 等: "Synthesis of Some New Antimicrobial Thiadiazolyl and Oxadiazolyl Quinoline Derivatives", 《MEDICINAL CHEMISTRY RESEARCH》 *

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EP2568809A1 (en) 2013-03-20
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KR20130079429A (ko) 2013-07-10
JP2013526544A (ja) 2013-06-24
RU2012154447A (ru) 2014-06-20
CA2798514A1 (en) 2011-11-17
WO2011143466A1 (en) 2011-11-17
MX2012013031A (es) 2012-12-17
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EP2568809A4 (en) 2013-11-06
US20130158078A1 (en) 2013-06-20

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