HRP20191029T1 - Derivati morfinana radi liječenja predoziranja lijekom - Google Patents
Derivati morfinana radi liječenja predoziranja lijekom Download PDFInfo
- Publication number
- HRP20191029T1 HRP20191029T1 HRP20191029TT HRP20191029T HRP20191029T1 HR P20191029 T1 HRP20191029 T1 HR P20191029T1 HR P20191029T T HRP20191029T T HR P20191029TT HR P20191029 T HRP20191029 T HR P20191029T HR P20191029 T1 HRP20191029 T1 HR P20191029T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- use according
- period
- overdose
- opioid
- Prior art date
Links
- 208000003870 Drug Overdose Diseases 0.000 title claims 5
- 206010033296 Overdoses Diseases 0.000 title claims 5
- 231100000725 drug overdose Toxicity 0.000 title claims 4
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 title 1
- 229940051807 opiod analgesics morphinan derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 27
- 206010070863 Toxicity to various agents Diseases 0.000 claims 6
- 208000024891 symptom Diseases 0.000 claims 5
- 208000012488 Opiate Overdose Diseases 0.000 claims 4
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical group O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims 4
- 229960004127 naloxone Drugs 0.000 claims 4
- 230000003247 decreasing effect Effects 0.000 claims 3
- 229940005483 opioid analgesics Drugs 0.000 claims 3
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 2
- 229940123257 Opioid receptor antagonist Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000003401 opiate antagonist Substances 0.000 claims 2
- 230000001988 toxicity Effects 0.000 claims 2
- 231100000419 toxicity Toxicity 0.000 claims 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical class OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- 206010010071 Coma Diseases 0.000 claims 1
- 206010012218 Delirium Diseases 0.000 claims 1
- 208000001953 Hypotension Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 206010046555 Urinary retention Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 208000008784 apnea Diseases 0.000 claims 1
- 230000036760 body temperature Effects 0.000 claims 1
- 230000036471 bradycardia Effects 0.000 claims 1
- 208000006218 bradycardia Diseases 0.000 claims 1
- 230000036543 hypotension Effects 0.000 claims 1
- 230000007954 hypoxia Effects 0.000 claims 1
- 230000004478 pupil constriction Effects 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 230000036387 respiratory rate Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Claims (21)
1. Spoj koji sadrži formulu:
za uporabu u postupku liječenja toksičnosti lijeka ili predoziranja lijekom kod subjekta kojem je nužno.
2. Spoj za uporabu sukladno patentnom zahtjevu 1, pri čemu navedena toksičnost ili predoziranje lijekom nastaje kao rezultat primjene opioida pacijentu koji nije ovisnik.
3. Spoj za uporabu sukladno patentnom zahtjevu 1 ili patentnom zahtjevu 2, pri čemu navedeni subjekt ima iskustvo s opioidom, a nije ovisnik o opoidima.
4. Spoj za uporabu sukladno patentnom zahtjevu 1, pri čemu se navedeni spoj primjenjuje u dnevnoj dozi od oko 3 do oko 20 mg/dnevno.
5. Spoj za uporabu sukladno patentnom zahtjevu 4, pri čemu je navedena dnevna doza oko 10 mg/dan.
6. Spoj za uporabu sukladno patentnom zahtjevu 1, pri čemu primjena spoja smanjuje simptome toksičnosti ili predoziranja lijekom tijekom perioda od najmanje 15 do oko 30 minuta.
7. Spoj za uporabu sukladno patentnom 6, pri čemu su simptomi predoziranja lijekom smanjeni za period od najmanje jednog sata, period od najmanje dva sata, period od najmanje tri sata, period od najmanje četiri sata ili period od najmanje osam sati.
8. Spoj za uporabu sukladno patentnom zahtjevu 6 ili patentnom zahtjevu 7, pri čemu navedena primjena sadrži oko 3 mg do oko 20 mg spoja.
9. Spoj za uporabu sukladno patentnom zahtjevu 6 ili patentnom zahtjevu 7, pri čemu su navedeni simptomi predoziranja odabrani iz smanjene brzine disanja, smanjene dubine disanja, apnee, komatoze, hipoksije, delirijske hipotenzije, bradikardije, smanjene temperature tijela, zadržavanja urina i suženja zjenica.
10. Spoj koji sadrži formulu:
za uporabu u postupku liječenja opioidne toksičnosti ili predoziranja kod subjekta kojem je potrebno sadrži isporuku prvog antagonista receptora opioida nakon čega slijedi taj spoj.
11. Spoj za uporabu sukladno patentnom zahtjevu 10, pri čemu je prvi antagonist receptora opioida nalokson.
12. Spoj za uporabu sukladno patentnom zahtjevu 10 ili patentnom zahtjevu 11, pri čemu je navedeni subjekt korisnik opoida koji ima iskustvo s opioidom ali nije ovisnik.
13. Spoj za uporabu sukladno patentnom zahtjevu 11, pri čemu nabedenoj primjeni prethodi navedena primjena naloksona.
14. Spoj za uporabu sukladno patentnom zahtjevu 13, pri čemu navedena primjena naloksona smanjuje simptome predoziranja ili toksičnosti prije primjene spoja.
15. Spoj za uporabu sukladno patentnom zahtjevu 11, pri čemu se nalokson primjenjuje istodobno s tim spojem.
16. Spoj od formule:
za uporabu u postupku liječenja akutne opioidne toksičnosti ili predoziranja tijemom razdoblja od preko jednog sata sadrži jednokratnu primjenu navedenog spoja subjektu kojem je nužno.
17. Spoj za uporabu sukladno patentnom zahtjevu 16, pri čemu je navedeni subjekt opioidno iskusan pacijent koji nije ovisnik.
18. Spoj za uporabu sukladno patentnom zahtjevu 16, pri čemu su simptomi opioidne toksičnosti ili predoziranja smanjeni tijekom razdoblja od više od jednog sata, tijekom razdoblja od više od četiri sata, tijekom razdoblja od više od osam sati ili tijekom razdoblja od više od dvadeset četiri sata.
19. Spoj od formule:
radi uporabe u postupku za nekontrolirano liječenje opioidne toksičnosti ili predoziranja opioidom kod pacijenta kojem je nužno.
20. Spoj za uporabu sukladno patentnom zahtjevu 19, pri čemu je navedeno nekontrolirano liječenje djelotvorno tijekom razdoblja od preko jedog sata..
21. Sol L-malata koja sadrži formulu:
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26688109P | 2009-12-04 | 2009-12-04 | |
| PCT/US2010/052437 WO2011068594A1 (en) | 2009-12-04 | 2010-10-13 | Morphinan derivatives for the treatment of drug overdose |
| EP10834900.2A EP2506712B8 (en) | 2009-12-04 | 2010-10-13 | Morphinan derivatives for the treatment of drug overdose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191029T1 true HRP20191029T1 (hr) | 2019-09-20 |
Family
ID=44082631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191029TT HRP20191029T1 (hr) | 2009-12-04 | 2019-06-07 | Derivati morfinana radi liječenja predoziranja lijekom |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9119848B2 (hr) |
| EP (2) | EP3569234A1 (hr) |
| JP (2) | JP5691042B2 (hr) |
| AU (1) | AU2010326676B2 (hr) |
| CA (1) | CA2782529C (hr) |
| CY (1) | CY1121646T1 (hr) |
| DK (1) | DK2506712T3 (hr) |
| ES (1) | ES2729679T3 (hr) |
| HR (1) | HRP20191029T1 (hr) |
| HU (1) | HUE043963T2 (hr) |
| LT (1) | LT2506712T (hr) |
| ME (1) | ME03468B (hr) |
| NZ (1) | NZ600379A (hr) |
| PL (1) | PL2506712T3 (hr) |
| PT (1) | PT2506712T (hr) |
| RS (1) | RS58894B1 (hr) |
| SI (1) | SI2506712T1 (hr) |
| TR (1) | TR201908514T4 (hr) |
| WO (1) | WO2011068594A1 (hr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201118084A (en) * | 2009-09-18 | 2011-06-01 | Adolor Corp | The use of an opioid receptor antagonist for the treatment or prevention of gastrointestinal tract disorders |
| NZ600379A (en) * | 2009-12-04 | 2014-05-30 | Alkermes Pharma Ireland Ltd | Morphinan derivatives for the treatment of drug overdose |
| CA2807965C (en) | 2010-08-23 | 2016-03-15 | Alkermes Pharma Ireland Limited | Methods for treating antipsychotic-induced weight gain |
| US8627816B2 (en) * | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| US8939943B2 (en) | 2011-01-26 | 2015-01-27 | Kaleo, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| CA2858808C (en) * | 2011-12-15 | 2017-04-18 | Alkermes Pharma Ireland Limited | Samidorphan (alks 33) in combination with opioid agonists |
| US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| KR101996108B1 (ko) * | 2011-12-15 | 2019-10-01 | 엘커메스 파마 아일랜드 리미티드 | 부프레놀핀 및 뮤-오피오이드 수용체 길항물질의 조성물 |
| US10195191B2 (en) | 2011-12-15 | 2019-02-05 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| CA2911231C (en) | 2013-05-24 | 2021-12-07 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
| US9656961B2 (en) | 2013-05-24 | 2017-05-23 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
| WO2015099863A1 (en) | 2013-12-27 | 2015-07-02 | Purdue Pharma L.P. | 6-substituted and 7-substituted morphinan analogs and the use thereof |
| WO2015192053A1 (en) * | 2014-06-13 | 2015-12-17 | Purdue Pharma L.P. | Azamophinan derivatives and use thereof |
| US9517307B2 (en) | 2014-07-18 | 2016-12-13 | Kaleo, Inc. | Devices and methods for delivering opioid antagonists including formulations for naloxone |
| US9763572B2 (en) * | 2015-02-17 | 2017-09-19 | Children's Hospital Medical Center | Quantitative pupillometry as a bedside predictor of postoperative respiratory depression |
| EP4243768A1 (en) | 2020-11-12 | 2023-09-20 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
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-
2010
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- 2010-10-13 ES ES10834900T patent/ES2729679T3/es active Active
- 2010-10-13 PT PT10834900T patent/PT2506712T/pt unknown
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- 2010-10-13 JP JP2012542008A patent/JP5691042B2/ja active Active
- 2010-10-13 CA CA2782529A patent/CA2782529C/en active Active
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- 2010-10-13 DK DK10834900.2T patent/DK2506712T3/da active
- 2010-10-13 ME MEP-2019-167A patent/ME03468B/me unknown
- 2010-10-13 HU HUE10834900A patent/HUE043963T2/hu unknown
- 2010-10-13 EP EP19164844.3A patent/EP3569234A1/en not_active Withdrawn
- 2010-10-13 EP EP10834900.2A patent/EP2506712B8/en active Active
- 2010-10-13 SI SI201031896T patent/SI2506712T1/sl unknown
- 2010-10-13 US US12/903,462 patent/US9119848B2/en active Active
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- 2010-10-13 TR TR2019/08514T patent/TR201908514T4/tr unknown
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2014
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2017
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2019
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Also Published As
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|---|---|
| CA2782529A1 (en) | 2011-06-09 |
| JP2013512901A (ja) | 2013-04-18 |
| SI2506712T1 (sl) | 2019-06-28 |
| NZ600379A (en) | 2014-05-30 |
| AU2010326676A1 (en) | 2012-06-21 |
| EP2506712A1 (en) | 2012-10-10 |
| US9119848B2 (en) | 2015-09-01 |
| PL2506712T3 (pl) | 2019-09-30 |
| JP2015038139A (ja) | 2015-02-26 |
| US20110136848A1 (en) | 2011-06-09 |
| AU2010326676A2 (en) | 2012-08-30 |
| US20160051535A1 (en) | 2016-02-25 |
| EP2506712A4 (en) | 2013-07-10 |
| ME03468B (me) | 2020-01-20 |
| JP5691042B2 (ja) | 2015-04-01 |
| TR201908514T4 (tr) | 2019-07-22 |
| CY1121646T1 (el) | 2020-07-31 |
| RS58894B1 (sr) | 2019-08-30 |
| JP6216305B2 (ja) | 2017-10-18 |
| DK2506712T3 (da) | 2019-06-03 |
| US20200345718A1 (en) | 2020-11-05 |
| EP2506712B8 (en) | 2019-06-19 |
| CA2782529C (en) | 2015-05-26 |
| LT2506712T (lt) | 2019-06-25 |
| US20170333422A1 (en) | 2017-11-23 |
| WO2011068594A1 (en) | 2011-06-09 |
| HUE043963T2 (hu) | 2019-09-30 |
| PT2506712T (pt) | 2019-05-31 |
| ES2729679T3 (es) | 2019-11-05 |
| AU2010326676B2 (en) | 2013-03-14 |
| EP3569234A1 (en) | 2019-11-20 |
| EP2506712B1 (en) | 2019-03-27 |
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