RU2012147590A - Пептиды cdca5 и содержащие их вакцины - Google Patents
Пептиды cdca5 и содержащие их вакцины Download PDFInfo
- Publication number
- RU2012147590A RU2012147590A RU2012147590/10A RU2012147590A RU2012147590A RU 2012147590 A RU2012147590 A RU 2012147590A RU 2012147590/10 A RU2012147590/10 A RU 2012147590/10A RU 2012147590 A RU2012147590 A RU 2012147590A RU 2012147590 A RU2012147590 A RU 2012147590A
- Authority
- RU
- Russia
- Prior art keywords
- peptide
- amino acid
- group
- ctl
- seq
- Prior art date
Links
- 101000980900 Homo sapiens Sororin Proteins 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 47
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims abstract 17
- 150000001413 amino acids Chemical group 0.000 claims abstract 16
- 239000000427 antigen Substances 0.000 claims abstract 12
- 108091007433 antigens Proteins 0.000 claims abstract 12
- 102000036639 antigens Human genes 0.000 claims abstract 12
- 239000000203 mixture Substances 0.000 claims abstract 8
- 239000012634 fragment Substances 0.000 claims abstract 7
- 239000002157 polynucleotide Substances 0.000 claims abstract 7
- 102000040430 polynucleotide Human genes 0.000 claims abstract 7
- 108091033319 polynucleotide Proteins 0.000 claims abstract 7
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims abstract 4
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims abstract 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims abstract 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims abstract 4
- 230000001939 inductive effect Effects 0.000 claims abstract 4
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims abstract 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims abstract 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims abstract 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims abstract 2
- 229930182817 methionine Natural products 0.000 claims abstract 2
- 108091005601 modified peptides Proteins 0.000 claims abstract 2
- 239000004474 valine Substances 0.000 claims abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 238000000034 method Methods 0.000 claims 5
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000001808 exosome Anatomy 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32267610P | 2010-04-09 | 2010-04-09 | |
| US61/322,676 | 2010-04-09 | ||
| PCT/JP2011/002078 WO2011125334A1 (en) | 2010-04-09 | 2011-04-07 | Cdca5 peptides and vaccines including the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012147590A true RU2012147590A (ru) | 2014-05-20 |
Family
ID=44762304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012147590/10A RU2012147590A (ru) | 2010-04-09 | 2011-04-07 | Пептиды cdca5 и содержащие их вакцины |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20130108664A1 (enExample) |
| EP (1) | EP2556084A4 (enExample) |
| JP (1) | JP2013523084A (enExample) |
| KR (1) | KR20130043627A (enExample) |
| CN (1) | CN102947325B (enExample) |
| AU (1) | AU2011236397A1 (enExample) |
| BR (1) | BR112012025567A2 (enExample) |
| CA (1) | CA2795534A1 (enExample) |
| MX (1) | MX2012011668A (enExample) |
| RU (1) | RU2012147590A (enExample) |
| SG (2) | SG10201502791YA (enExample) |
| TW (1) | TW201138806A (enExample) |
| WO (1) | WO2011125334A1 (enExample) |
| ZA (1) | ZA201207416B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015012234A2 (pt) * | 2012-12-04 | 2017-08-15 | Oncotherapy Science Inc | Peptídios sema5b e vacinas contendo os mesmos |
| WO2014106886A1 (en) * | 2013-01-07 | 2014-07-10 | Oncotherapy Science, Inc. | Cdca5 peptides and vaccines containing the same |
| TW201636358A (zh) * | 2014-12-09 | 2016-10-16 | 腫瘤療法 科學股份有限公司 | 對於ｔｈ１細胞之ｇｐｃ３抗原決定位胜肽及含此之疫苗 |
| CN107619835A (zh) * | 2017-05-11 | 2018-01-23 | 广东医科大学 | Cdca5在胃癌中的表达载体及其构建方法及cdca5在胃癌中特异干扰片段 |
| IL271966B2 (en) * | 2017-07-12 | 2025-01-01 | Nouscom Ag | A universal vaccine based on shared neoantigens for the prevention and treatment of cancer (MICRO SATELLITE INSTABLE (MSI)) |
| CN109355394A (zh) * | 2018-12-28 | 2019-02-19 | 江苏省人民医院（南京医科大学第附属医院） | 癌-睾丸抗原cdca5作为食管鳞癌预后标志物及治疗靶点 |
| PL3840767T3 (pl) * | 2019-05-29 | 2024-03-04 | Hubro Therapeutics As | Peptydy |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050069878A1 (en) * | 2001-06-15 | 2005-03-31 | Henry Yue | Proteins associated with cell growth, differentiation, and death |
| JP2003135075A (ja) * | 2001-11-05 | 2003-05-13 | Research Association For Biotechnology | 新規な全長ｃＤＮＡ |
| CN103073620B (zh) * | 2002-09-12 | 2014-12-10 | 肿瘤疗法科学股份有限公司 | Kdr肽和包括该肽的疫苗 |
| TW201425333A (zh) * | 2007-04-11 | 2014-07-01 | Oncotherapy Science Inc | 腫瘤血管內皮標誌８胜肽及包含此胜肽之疫苗 |
| US20110160280A1 (en) * | 2007-08-24 | 2011-06-30 | Oncotherapy Science, Inc. | Cancer-related genes, cdca5, epha7, stk31 and wdhd1 |
| TW200932260A (en) * | 2007-11-28 | 2009-08-01 | Oncotherapy Science Inc | STAT3 epitope peptides |
-
2011
- 2011-04-07 JP JP2012546271A patent/JP2013523084A/ja not_active Withdrawn
- 2011-04-07 CA CA2795534A patent/CA2795534A1/en not_active Abandoned
- 2011-04-07 KR KR1020127028423A patent/KR20130043627A/ko not_active Withdrawn
- 2011-04-07 SG SG10201502791YA patent/SG10201502791YA/en unknown
- 2011-04-07 MX MX2012011668A patent/MX2012011668A/es not_active Application Discontinuation
- 2011-04-07 BR BR112012025567A patent/BR112012025567A2/pt not_active IP Right Cessation
- 2011-04-07 RU RU2012147590/10A patent/RU2012147590A/ru not_active Application Discontinuation
- 2011-04-07 CN CN201180028644.6A patent/CN102947325B/zh not_active Expired - Fee Related
- 2011-04-07 AU AU2011236397A patent/AU2011236397A1/en not_active Abandoned
- 2011-04-07 WO PCT/JP2011/002078 patent/WO2011125334A1/en not_active Ceased
- 2011-04-07 EP EP11765236.2A patent/EP2556084A4/en not_active Withdrawn
- 2011-04-07 SG SG2012066221A patent/SG183945A1/en unknown
- 2011-04-07 US US13/639,935 patent/US20130108664A1/en not_active Abandoned
- 2011-04-08 TW TW100112188A patent/TW201138806A/zh unknown
-
2012
- 2012-10-03 ZA ZA2012/07416A patent/ZA201207416B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012025567A2 (pt) | 2019-09-24 |
| CN102947325A (zh) | 2013-02-27 |
| JP2013523084A (ja) | 2013-06-17 |
| SG10201502791YA (en) | 2015-05-28 |
| AU2011236397A1 (en) | 2012-11-01 |
| CA2795534A1 (en) | 2011-10-13 |
| WO2011125334A1 (en) | 2011-10-13 |
| KR20130043627A (ko) | 2013-04-30 |
| TW201138806A (en) | 2011-11-16 |
| SG183945A1 (en) | 2012-10-30 |
| CN102947325B (zh) | 2015-04-01 |
| US20130108664A1 (en) | 2013-05-02 |
| ZA201207416B (en) | 2013-06-26 |
| EP2556084A1 (en) | 2013-02-13 |
| MX2012011668A (es) | 2012-12-17 |
| EP2556084A4 (en) | 2013-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20151125 |