RU2012126105A - Соли 4-[2-[[5-метил-1-(2-нафталинил)-1н-пиразол-3-ил]окси]этил]морфолина - Google Patents

Соли 4-[2-[[5-метил-1-(2-нафталинил)-1н-пиразол-3-ил]окси]этил]морфолина Download PDF

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RU2012126105A
RU2012126105A RU2012126105/04A RU2012126105A RU2012126105A RU 2012126105 A RU2012126105 A RU 2012126105A RU 2012126105/04 A RU2012126105/04 A RU 2012126105/04A RU 2012126105 A RU2012126105 A RU 2012126105A RU 2012126105 A RU2012126105 A RU 2012126105A
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hydrochloride salt
pyrazol
oxy
morpholine
ethyl
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RU2012126105/04A
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RU2559325C2 (ru
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Мария Роса КУБЕРЕС-АЛТИСЕНТ
Льюис СОЛА-КАРАНДЕЛЬ
Урко ГАРСИЯ-КОУСЕЙРО
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Лабораторьос Дель Др. Эстеве, С.А.
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Priority claimed from EP09382261A external-priority patent/EP2335688A1/en
Priority claimed from EP10382025A external-priority patent/EP2361904A1/en
Application filed by Лабораторьос Дель Др. Эстеве, С.А. filed Critical Лабораторьос Дель Др. Эстеве, С.А.
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Abstract

1. Соль 4-[2-[[5-метил-1-(2-нафталинил)-1H-пиразол-3-ил]окси]этил]морфолина, выбранная из этансульфоната, фумарата, гидрохлорида, малата, малеата, малоната и метансульфоната.2. Соль 4-[2-[[5-метил-1-(2-нафталинил)-1H-пиразол-3-ил]окси]этил]морфолина по п.1, где указанная соль представляет собой гидрохлоридную соль 4-[2-[[5-метил-1-(2-нафталинил)-1H-пиразол-3-ил]окси]этил]морфолина.3. Способ получения гидрохлоридной соли по п.2, включающий:a) смешивание 4-[2-[[5-метил-1-(2-нафталинил)-1H-пиразол-3-ил]окси]этил]морфолина и раствора, содержащего хлористоводородную кислоту, иb) выделение полученной гидрохлоридной соли.4. Фармацевтическая композиция, включающая гидрохлоридную соль по п.2.5. Гидрохлоридная соль по п.2 для использования в качестве лекарственного средства.6. Гидрохлоридная соль по п.2, предназначенная для лечения и/или профилактики заболевания или состояния, опосредованного рецептором сигма.7. Гидрохлоридная соль по п.2, предназначенная для лечения и/или профилактики заболевания, выбранного из группы, состоящей из диареи; липопротеиновых нарушений; мигрени; ожирения; артрита; гипертензии; аритмии; язвы; дефицита обучаемости, памяти и внимания; нарушений познавательных способностей; нейродегенеративных заболеваний; демиенилизирующих заболеваний; зависимости от лекарств и химических веществ, включая кокаин, амфетамин, этанол и никотин; поздней дискинезии; ишемического удара; эпилепсии; удара; стресса; рака; психотических состояний, в частности депрессии, страхов или шизофрении; воспалений; или аутоиммунных заболеваний.

Claims (7)

1. Соль 4-[2-[[5-метил-1-(2-нафталинил)-1H-пиразол-3-ил]окси]этил]морфолина, выбранная из этансульфоната, фумарата, гидрохлорида, малата, малеата, малоната и метансульфоната.
2. Соль 4-[2-[[5-метил-1-(2-нафталинил)-1H-пиразол-3-ил]окси]этил]морфолина по п.1, где указанная соль представляет собой гидрохлоридную соль 4-[2-[[5-метил-1-(2-нафталинил)-1H-пиразол-3-ил]окси]этил]морфолина.
3. Способ получения гидрохлоридной соли по п.2, включающий:
a) смешивание 4-[2-[[5-метил-1-(2-нафталинил)-1H-пиразол-3-ил]окси]этил]морфолина и раствора, содержащего хлористоводородную кислоту, и
b) выделение полученной гидрохлоридной соли.
4. Фармацевтическая композиция, включающая гидрохлоридную соль по п.2.
5. Гидрохлоридная соль по п.2 для использования в качестве лекарственного средства.
6. Гидрохлоридная соль по п.2, предназначенная для лечения и/или профилактики заболевания или состояния, опосредованного рецептором сигма.
7. Гидрохлоридная соль по п.2, предназначенная для лечения и/или профилактики заболевания, выбранного из группы, состоящей из диареи; липопротеиновых нарушений; мигрени; ожирения; артрита; гипертензии; аритмии; язвы; дефицита обучаемости, памяти и внимания; нарушений познавательных способностей; нейродегенеративных заболеваний; демиенилизирующих заболеваний; зависимости от лекарств и химических веществ, включая кокаин, амфетамин, этанол и никотин; поздней дискинезии; ишемического удара; эпилепсии; удара; стресса; рака; психотических состояний, в частности депрессии, страхов или шизофрении; воспалений; или аутоиммунных заболеваний.
RU2012126105/04A 2009-11-25 2010-11-25 Соли 4-[2-[[5-метил-1-(2-нафталинил)-1н-пиразол-3-ил]окси]этил]морфолина RU2559325C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP09382261.7 2009-11-25
EP09382261A EP2335688A1 (en) 2009-11-25 2009-11-25 Pharmaceutical compositions comprising sigma receptor ligands
EP10382025.4 2010-02-04
EP10382025A EP2361904A1 (en) 2010-02-04 2010-02-04 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride and crystalline forms thereof
PCT/EP2010/068256 WO2011064315A1 (en) 2009-11-25 2010-11-25 4-[2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine salts

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RU2012126105A true RU2012126105A (ru) 2013-12-27
RU2559325C2 RU2559325C2 (ru) 2015-08-10

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US (1) US20130143884A1 (ru)
EP (1) EP2503993B1 (ru)
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EP2353598A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for use in the prevention and/or treatment of postoperative pain
EP2353591A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof
EP2388005A1 (en) 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
EP2415471A1 (en) 2010-08-03 2012-02-08 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in opioid-induced hyperalgesia
EP2426111A1 (en) * 2010-08-09 2012-03-07 Laboratorios Del. Dr. Esteve, S.A. 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms
EP2524694A1 (en) 2011-05-19 2012-11-21 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain
EP2792352A1 (en) 2013-04-16 2014-10-22 Laboratorios Del. Dr. Esteve, S.A. Alpha-2 adrenoreceptor and sigma receptor ligand combinations
KR20160097366A (ko) 2013-12-17 2016-08-17 라보라토리오스 델 드라. 에스테브.에스.에이. 세로토닌-노르에피네프린 재흡수 억제제들(SNRIs) 및 시그마 리셉터 리간드들 조합
WO2015091505A1 (en) 2013-12-17 2015-06-25 Laboratorios Del Dr. Esteve, S.A. Gabapentinoids and sigma receptor ligands combinations
KR20180048923A (ko) * 2015-09-02 2018-05-10 라보라토리오스 델 드라. 에스테브.에스.에이. 1-(4-(2-((1-(3,4-디플루오로페닐)-1h-피라졸-3-일)메톡시)에틸)피페라진-1- 일)에타논 염들
JP7094231B2 (ja) 2016-06-06 2022-07-01 エスティーブ ファーマシューティカルズ エス エイ がんにおけるシグマ受容体リガンドの使用
WO2018059420A1 (zh) * 2016-09-27 2018-04-05 苏州科睿思制药有限公司 E52862盐酸盐晶型h及其制备方法
WO2019068771A1 (en) 2017-10-04 2019-04-11 Esteve Pharmaceuticals, S.A. USE OF SIGMA RECEPTOR LIGANDS AGAINST AGE-RELATED COGNITIVE DISORDERS

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MX2007002341A (es) * 2004-08-27 2007-09-25 Esteve Labor Dr Inhibidores del receptor sigma.
BRPI0514692A (pt) * 2004-08-27 2008-06-17 Esteve Labor Dr inibidores do receptor sigma
EP1634872A1 (en) * 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Pyrazole derivatives as sigma receptor inhibitors
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AR079198A1 (es) 2012-01-04
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