MA33835B1 - Sels de 4-[2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine - Google Patents
Sels de 4-[2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholineInfo
- Publication number
- MA33835B1 MA33835B1 MA34986A MA34986A MA33835B1 MA 33835 B1 MA33835 B1 MA 33835B1 MA 34986 A MA34986 A MA 34986A MA 34986 A MA34986 A MA 34986A MA 33835 B1 MA33835 B1 MA 33835B1
- Authority
- MA
- Morocco
- Prior art keywords
- naphthalenyl
- pyrazol
- oxy
- ethyl
- methyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA PRÉSENTE INVENTION CONCERNE DES SELS DE 4-[-2-[[5-MÉTHYL-1 -(2-NAPHTALÉNYL)-1 H-PYRAZOL-3- YL]OXY]ÉTHYL]MORPHOLINE, SPÉCIFIQUEMENT DU CHLORHYDRATE, DES COMPOSITIONS PHARMACEUTIQUES LES COMPRENANT, ET LEUR UTILISATION EN TRAITEMENT ET/OU PROPHYLAXIE DES MALADIES ASSOCIÉES AU RÉCEPTEUR SIGMA.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09382261A EP2335688A1 (fr) | 2009-11-25 | 2009-11-25 | Compositions pharmaceutiques comprenant des ligands du récepteur sigma |
EP10382025A EP2361904A1 (fr) | 2010-02-04 | 2010-02-04 | Chlorhydrate de 4-[-2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine et formes cristallines correspondantes |
PCT/EP2010/068256 WO2011064315A1 (fr) | 2009-11-25 | 2010-11-25 | Sels de 4-[2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33835B1 true MA33835B1 (fr) | 2012-12-03 |
Family
ID=43629487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34986A MA33835B1 (fr) | 2009-11-25 | 2012-06-20 | Sels de 4-[2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine |
Country Status (32)
Country | Link |
---|---|
US (1) | US20130143884A1 (fr) |
EP (1) | EP2503993B1 (fr) |
JP (1) | JP5794999B2 (fr) |
KR (2) | KR20130004244A (fr) |
CN (2) | CN105859624A (fr) |
AR (1) | AR079198A1 (fr) |
AU (1) | AU2010323116B2 (fr) |
BR (1) | BR112012012456A2 (fr) |
CA (1) | CA2781744C (fr) |
CO (1) | CO6612255A2 (fr) |
CY (1) | CY1117962T1 (fr) |
DK (1) | DK2503993T3 (fr) |
EC (1) | ECSP12011959A (fr) |
ES (1) | ES2589045T3 (fr) |
HR (1) | HRP20161128T1 (fr) |
HU (1) | HUE029283T2 (fr) |
IL (1) | IL219997A (fr) |
LT (1) | LT2503993T (fr) |
MA (1) | MA33835B1 (fr) |
ME (1) | ME02481B (fr) |
MX (1) | MX339932B (fr) |
MY (1) | MY160018A (fr) |
NZ (1) | NZ600310A (fr) |
PT (1) | PT2503993T (fr) |
RS (1) | RS55099B1 (fr) |
RU (1) | RU2559325C2 (fr) |
SI (1) | SI2503993T1 (fr) |
SM (1) | SMT201600304B (fr) |
TN (1) | TN2012000247A1 (fr) |
TW (1) | TWI482767B (fr) |
WO (1) | WO2011064315A1 (fr) |
ZA (1) | ZA201203771B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2116539A1 (fr) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles en tant que ligands améliorant les effets analgésiques des opioïdes et réduisant leur dépendance |
EP2353591A1 (fr) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Ligands sigma pour la potentialisation de l'effet analgésique d'opioïdes et d'opiacés dans la douleur post-opératoire et en atténuant la dépendance |
EP2353598A1 (fr) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Ligands sigma pour utilisation dans la prévention et/ou le traitement de la douleur post-opératoire |
EP2388005A1 (fr) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Ligands sigma pour la prévention et/ou le traitement du vomissement induit par la chimiothérapie ou la radiothérapie |
EP2415471A1 (fr) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Utilisation de ligands sigma dans l'hyperalgie induite par opioïdes |
EP2426111A1 (fr) * | 2010-08-09 | 2012-03-07 | Laboratorios Del. Dr. Esteve, S.A. | Formes cristallines de chlorhydrate de 4-[-2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine |
EP2524694A1 (fr) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Utilisation de ligands sigma dans la douleur liée au diabète de type 2 |
EP2792352A1 (fr) | 2013-04-16 | 2014-10-22 | Laboratorios Del. Dr. Esteve, S.A. | Combinaisons comprenants un ligand de receptor Sigma et un ligand de réceptor adrénergic-alpha-2 |
WO2015091508A1 (fr) | 2013-12-17 | 2015-06-25 | Laboratorios Del Dr. Esteve, S.A. | Combinaisons d'inhibiteurs de la recapture de sérotonine-norépinéphrine (snri) et de ligands des récepteurs sigma |
AU2014364644A1 (en) | 2013-12-17 | 2016-06-23 | Laboratorios Del Dr. Esteve, S.A. | Gabapentinoids and Sigma receptor ligands combinations |
US10640468B2 (en) * | 2015-09-02 | 2020-05-05 | Esteve Pharmaceuticals, S.A. | 1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-Yl)methoxy)ethyl)piperazin-1- Yl)ethanone salts |
TW201808300A (zh) | 2016-06-06 | 2018-03-16 | 以斯提夫博士實驗室股份有限公司 | σ受體配體在癌症中的用途 |
WO2018059420A1 (fr) * | 2016-09-27 | 2018-04-05 | 苏州科睿思制药有限公司 | Forme h de cristal de sel d'hydrochlorure e52862 h et son procédé de préparation |
WO2019068771A1 (fr) | 2017-10-04 | 2019-04-11 | Esteve Pharmaceuticals, S.A. | Utilisation de ligands de récepteur sigma contre des troubles cognitifs liés à l'âge |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2347015C2 (de) * | 1973-09-14 | 1985-12-12 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue Pyrazolyloxyessigsäurederivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel |
PL1781618T3 (pl) * | 2004-08-27 | 2013-03-29 | Esteve Labor Dr | Inhibitory receptora sigma |
EP1634872A1 (fr) * | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Dérivés de pyrazole en tant qu'inhibiteurs des récepteurs sigma |
RU2417987C2 (ru) * | 2004-08-27 | 2011-05-10 | Лабораторьос Дель Др.Эстеве, С.А. | Ингибиторы сигма-рецептора |
EP2113501A1 (fr) * | 2008-04-25 | 2009-11-04 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazoles de 5-Methyl-1-(naphthalen-2-YL)-1H- utiles en tant qu'inhibiteurs de récepteur sigma |
EP2335688A1 (fr) * | 2009-11-25 | 2011-06-22 | Laboratorios Del. Dr. Esteve, S.A. | Compositions pharmaceutiques comprenant des ligands du récepteur sigma |
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2010
- 2010-11-25 SI SI201031267A patent/SI2503993T1/sl unknown
- 2010-11-25 LT LTEP10782303.1T patent/LT2503993T/lt unknown
- 2010-11-25 MY MYPI2012002317A patent/MY160018A/en unknown
- 2010-11-25 AR ARP100104368A patent/AR079198A1/es unknown
- 2010-11-25 RS RS20160716A patent/RS55099B1/sr unknown
- 2010-11-25 PT PT107823031T patent/PT2503993T/pt unknown
- 2010-11-25 BR BR112012012456-0A patent/BR112012012456A2/pt not_active IP Right Cessation
- 2010-11-25 CN CN201610172899.4A patent/CN105859624A/zh active Pending
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- 2010-11-25 WO PCT/EP2010/068256 patent/WO2011064315A1/fr active Application Filing
- 2010-11-25 EP EP10782303.1A patent/EP2503993B1/fr active Active
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