MA33835B1 - Sels de 4-[2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine - Google Patents
Sels de 4-[2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholineInfo
- Publication number
- MA33835B1 MA33835B1 MA34986A MA34986A MA33835B1 MA 33835 B1 MA33835 B1 MA 33835B1 MA 34986 A MA34986 A MA 34986A MA 34986 A MA34986 A MA 34986A MA 33835 B1 MA33835 B1 MA 33835B1
- Authority
- MA
- Morocco
- Prior art keywords
- naphthalenyl
- pyrazol
- oxy
- ethyl
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA PRÉSENTE INVENTION CONCERNE DES SELS DE 4-[-2-[[5-MÉTHYL-1 -(2-NAPHTALÉNYL)-1 H-PYRAZOL-3- YL]OXY]ÉTHYL]MORPHOLINE, SPÉCIFIQUEMENT DU CHLORHYDRATE, DES COMPOSITIONS PHARMACEUTIQUES LES COMPRENANT, ET LEUR UTILISATION EN TRAITEMENT ET/OU PROPHYLAXIE DES MALADIES ASSOCIÉES AU RÉCEPTEUR SIGMA.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09382261A EP2335688A1 (fr) | 2009-11-25 | 2009-11-25 | Compositions pharmaceutiques comprenant des ligands du récepteur sigma |
EP10382025A EP2361904A1 (fr) | 2010-02-04 | 2010-02-04 | Chlorhydrate de 4-[-2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine et formes cristallines correspondantes |
PCT/EP2010/068256 WO2011064315A1 (fr) | 2009-11-25 | 2010-11-25 | Sels de 4-[2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33835B1 true MA33835B1 (fr) | 2012-12-03 |
Family
ID=43629487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34986A MA33835B1 (fr) | 2009-11-25 | 2012-06-20 | Sels de 4-[2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine |
Country Status (32)
Country | Link |
---|---|
US (1) | US20130143884A1 (fr) |
EP (1) | EP2503993B1 (fr) |
JP (1) | JP5794999B2 (fr) |
KR (2) | KR20170096225A (fr) |
CN (2) | CN102753154A (fr) |
AR (1) | AR079198A1 (fr) |
AU (1) | AU2010323116B2 (fr) |
BR (1) | BR112012012456A2 (fr) |
CA (1) | CA2781744C (fr) |
CO (1) | CO6612255A2 (fr) |
CY (1) | CY1117962T1 (fr) |
DK (1) | DK2503993T3 (fr) |
EC (1) | ECSP12011959A (fr) |
ES (1) | ES2589045T3 (fr) |
HR (1) | HRP20161128T1 (fr) |
HU (1) | HUE029283T2 (fr) |
IL (1) | IL219997A (fr) |
LT (1) | LT2503993T (fr) |
MA (1) | MA33835B1 (fr) |
ME (1) | ME02481B (fr) |
MX (1) | MX339932B (fr) |
MY (1) | MY160018A (fr) |
NZ (1) | NZ600310A (fr) |
PT (1) | PT2503993T (fr) |
RS (1) | RS55099B1 (fr) |
RU (1) | RU2559325C2 (fr) |
SI (1) | SI2503993T1 (fr) |
SM (1) | SMT201600304B (fr) |
TN (1) | TN2012000247A1 (fr) |
TW (1) | TWI482767B (fr) |
WO (1) | WO2011064315A1 (fr) |
ZA (1) | ZA201203771B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2116539A1 (fr) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles en tant que ligands améliorant les effets analgésiques des opioïdes et réduisant leur dépendance |
EP2353598A1 (fr) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Ligands sigma pour utilisation dans la prévention et/ou le traitement de la douleur post-opératoire |
EP2353591A1 (fr) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Ligands sigma pour la potentialisation de l'effet analgésique d'opioïdes et d'opiacés dans la douleur post-opératoire et en atténuant la dépendance |
EP2388005A1 (fr) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Ligands sigma pour la prévention et/ou le traitement du vomissement induit par la chimiothérapie ou la radiothérapie |
EP2415471A1 (fr) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Utilisation de ligands sigma dans l'hyperalgie induite par opioïdes |
EP2426111A1 (fr) * | 2010-08-09 | 2012-03-07 | Laboratorios Del. Dr. Esteve, S.A. | Formes cristallines de chlorhydrate de 4-[-2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine |
EP2524694A1 (fr) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Utilisation de ligands sigma dans la douleur liée au diabète de type 2 |
EP2792352A1 (fr) | 2013-04-16 | 2014-10-22 | Laboratorios Del. Dr. Esteve, S.A. | Combinaisons comprenants un ligand de receptor Sigma et un ligand de réceptor adrénergic-alpha-2 |
KR20160097366A (ko) | 2013-12-17 | 2016-08-17 | 라보라토리오스 델 드라. 에스테브.에스.에이. | 세로토닌-노르에피네프린 재흡수 억제제들(SNRIs) 및 시그마 리셉터 리간드들 조합 |
WO2015091505A1 (fr) | 2013-12-17 | 2015-06-25 | Laboratorios Del Dr. Esteve, S.A. | Combinaisons de gabapentanoïdes et de ligands des récepteurs sigma |
KR20180048923A (ko) * | 2015-09-02 | 2018-05-10 | 라보라토리오스 델 드라. 에스테브.에스.에이. | 1-(4-(2-((1-(3,4-디플루오로페닐)-1h-피라졸-3-일)메톡시)에틸)피페라진-1- 일)에타논 염들 |
JP7094231B2 (ja) | 2016-06-06 | 2022-07-01 | エスティーブ ファーマシューティカルズ エス エイ | がんにおけるシグマ受容体リガンドの使用 |
WO2018059420A1 (fr) * | 2016-09-27 | 2018-04-05 | 苏州科睿思制药有限公司 | Forme h de cristal de sel d'hydrochlorure e52862 h et son procédé de préparation |
WO2019068771A1 (fr) | 2017-10-04 | 2019-04-11 | Esteve Pharmaceuticals, S.A. | Utilisation de ligands de récepteur sigma contre des troubles cognitifs liés à l'âge |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2347015C2 (de) * | 1973-09-14 | 1985-12-12 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue Pyrazolyloxyessigsäurederivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel |
MX2007002341A (es) * | 2004-08-27 | 2007-09-25 | Esteve Labor Dr | Inhibidores del receptor sigma. |
BRPI0514692A (pt) * | 2004-08-27 | 2008-06-17 | Esteve Labor Dr | inibidores do receptor sigma |
EP1634872A1 (fr) * | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Dérivés de pyrazole en tant qu'inhibiteurs des récepteurs sigma |
EP2113501A1 (fr) * | 2008-04-25 | 2009-11-04 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazoles de 5-Methyl-1-(naphthalen-2-YL)-1H- utiles en tant qu'inhibiteurs de récepteur sigma |
EP2335688A1 (fr) * | 2009-11-25 | 2011-06-22 | Laboratorios Del. Dr. Esteve, S.A. | Compositions pharmaceutiques comprenant des ligands du récepteur sigma |
-
2010
- 2010-11-25 MX MX2012006108A patent/MX339932B/es active IP Right Grant
- 2010-11-25 ME MEP-2016-173A patent/ME02481B/fr unknown
- 2010-11-25 NZ NZ600310A patent/NZ600310A/xx not_active IP Right Cessation
- 2010-11-25 DK DK10782303.1T patent/DK2503993T3/en active
- 2010-11-25 CN CN2010800608479A patent/CN102753154A/zh active Pending
- 2010-11-25 AR ARP100104368A patent/AR079198A1/es unknown
- 2010-11-25 PT PT107823031T patent/PT2503993T/pt unknown
- 2010-11-25 ES ES10782303.1T patent/ES2589045T3/es active Active
- 2010-11-25 CN CN201610172899.4A patent/CN105859624A/zh active Pending
- 2010-11-25 TW TW099140791A patent/TWI482767B/zh not_active IP Right Cessation
- 2010-11-25 BR BR112012012456-0A patent/BR112012012456A2/pt not_active IP Right Cessation
- 2010-11-25 WO PCT/EP2010/068256 patent/WO2011064315A1/fr active Application Filing
- 2010-11-25 SI SI201031267A patent/SI2503993T1/sl unknown
- 2010-11-25 CA CA2781744A patent/CA2781744C/fr not_active Expired - Fee Related
- 2010-11-25 KR KR1020177022538A patent/KR20170096225A/ko not_active Application Discontinuation
- 2010-11-25 KR KR1020127016392A patent/KR20130004244A/ko not_active Application Discontinuation
- 2010-11-25 AU AU2010323116A patent/AU2010323116B2/en not_active Ceased
- 2010-11-25 RS RS20160716A patent/RS55099B1/sr unknown
- 2010-11-25 RU RU2012126105/04A patent/RU2559325C2/ru not_active IP Right Cessation
- 2010-11-25 EP EP10782303.1A patent/EP2503993B1/fr active Active
- 2010-11-25 JP JP2012540438A patent/JP5794999B2/ja active Active
- 2010-11-25 US US13/511,715 patent/US20130143884A1/en not_active Abandoned
- 2010-11-25 MY MYPI2012002317A patent/MY160018A/en unknown
- 2010-11-25 LT LTEP10782303.1T patent/LT2503993T/lt unknown
- 2010-11-25 HU HUE10782303A patent/HUE029283T2/en unknown
-
2012
- 2012-05-22 TN TNP2012000247A patent/TN2012000247A1/en unknown
- 2012-05-23 ZA ZA2012/03771A patent/ZA201203771B/en unknown
- 2012-05-24 IL IL219997A patent/IL219997A/en not_active IP Right Cessation
- 2012-06-08 EC ECSP12011959 patent/ECSP12011959A/es unknown
- 2012-06-20 MA MA34986A patent/MA33835B1/fr unknown
- 2012-06-25 CO CO12106023A patent/CO6612255A2/es not_active Application Discontinuation
-
2016
- 2016-09-02 HR HRP20161128TT patent/HRP20161128T1/hr unknown
- 2016-09-02 CY CY20161100867T patent/CY1117962T1/el unknown
- 2016-09-07 SM SM201600304T patent/SMT201600304B/it unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA33835B1 (fr) | Sels de 4-[2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine | |
PL2503993T3 (pl) | Chlorowodorek 4-[2-[[5-metylo-1-(2-naftalenylo)-1H-pirazol-3-ilo]oksy]etylo]morfoliny | |
BRPI1009112A2 (pt) | inibidores de tirosina quinase de bruton | |
ES2590905T8 (es) | Inhibidores de la tirosina quinasa de Bruton | |
BRPI0920135A2 (pt) | imidazopiridazinacarbonitrilos úteis como inibidores de quinase | |
BRPI0913879A2 (pt) | fenilpirazinonas como inibidores de quinase | |
FIC20230025I1 (fi) | neratinibi | |
BRPI0922880A2 (pt) | compostos inibidores de quinase | |
FI20085782L (fi) | Kartonkikone | |
IL221277A (en) | Polymorphs and solvates of 4 - [2 - [[5 - methyl - 1 - (2 - naphthalenyl) -1H - pyrazole - 3 - yl] oxy] ethyl] morpholine hydrochloride | |
BRPI0909829A2 (pt) | composições aperfeiçoadas de abrilhantamento óptico | |
BRPI1010858A2 (pt) | cassetes de expressão derivados de milho | |
BRPI0912475A8 (pt) | compostos como inibidores de quinase | |
BRPI0912301A2 (pt) | pedaço bruto de caixa de dobrar | |
DK2285784T3 (da) | 2-methyl-1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-benzimidazol som 5-hydroxytryptamin-6-ligand | |
NO20082548L (no) | Teine | |
IT1395913B1 (it) | Erogatore di fogli di carta tissue | |
IT1391450B1 (it) | Impianto di macinazione | |
TH0801005303A (th) | สารยับยั้ง c-fms ไคเนส | |
TH110117B (th) | ที่ใส่กระดาษทิชชู่ | |
ES1068186Y (es) | Servilletero | |
TH99111B (th) | หลอดใส่ทิชชูแบบม้วน | |
TN2013000027A1 (en) | - 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms | |
IT1394771B1 (it) | Bara di cartone | |
UA17755S (uk) | Упаковка для носових хусточок |