RU2012115120A - Имплантируемые устройства, которые отличаются профилем высвобождения, и способы их изготовления и применения - Google Patents
Имплантируемые устройства, которые отличаются профилем высвобождения, и способы их изготовления и применения Download PDFInfo
- Publication number
- RU2012115120A RU2012115120A RU2012115120/15A RU2012115120A RU2012115120A RU 2012115120 A RU2012115120 A RU 2012115120A RU 2012115120/15 A RU2012115120/15 A RU 2012115120/15A RU 2012115120 A RU2012115120 A RU 2012115120A RU 2012115120 A RU2012115120 A RU 2012115120A
- Authority
- RU
- Russia
- Prior art keywords
- biologically active
- active agent
- subject
- parts
- release profile
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 26
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000013543 active substance Substances 0.000 claims abstract 38
- 229920000642 polymer Polymers 0.000 claims abstract 14
- 238000002347 injection Methods 0.000 claims abstract 5
- 239000007924 injection Substances 0.000 claims abstract 5
- 229920002988 biodegradable polymer Polymers 0.000 claims abstract 3
- 239000004621 biodegradable polymer Substances 0.000 claims abstract 3
- 230000000694 effects Effects 0.000 claims abstract 3
- 239000011258 core-shell material Substances 0.000 claims 6
- 230000001684 chronic effect Effects 0.000 claims 2
- 239000007943 implant Substances 0.000 claims 2
- 229920006237 degradable polymer Polymers 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24330309P | 2009-09-17 | 2009-09-17 | |
| US61/243,303 | 2009-09-17 | ||
| PCT/US2010/049104 WO2011035013A2 (en) | 2009-09-17 | 2010-09-16 | Implant devices that differ by release profile and methods of making and using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012115120A true RU2012115120A (ru) | 2013-10-27 |
Family
ID=43218276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012115120/15A RU2012115120A (ru) | 2009-09-17 | 2010-09-16 | Имплантируемые устройства, которые отличаются профилем высвобождения, и способы их изготовления и применения |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9399018B2 (enExample) |
| EP (1) | EP2477612A2 (enExample) |
| JP (1) | JP2013505251A (enExample) |
| KR (1) | KR20120102598A (enExample) |
| CN (1) | CN102917693B (enExample) |
| BR (1) | BR112012006103B8 (enExample) |
| CA (1) | CA2774495C (enExample) |
| IN (1) | IN2012DN02656A (enExample) |
| RU (1) | RU2012115120A (enExample) |
| WO (1) | WO2011035013A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005325213B2 (en) | 2004-08-04 | 2010-10-07 | Evonik Operations Gmbh | Methods for manufacturing delivery devices and devices thereof |
| JP5675820B2 (ja) * | 2009-09-22 | 2015-02-25 | エボニック コーポレイションＥｖｏｎｉｋ Ｃｏｒｐｏｒａｔｉｏｎ | 様々な生物活性剤担持構成を有するインプラントデバイス |
| US9980850B2 (en) | 2016-09-29 | 2018-05-29 | Gesea Biosciences, Inc. | Bioerodible contraceptive implant and methods of use thereof |
| KR102183669B1 (ko) * | 2019-03-26 | 2020-11-26 | 가톨릭대학교 산학협력단 | 이중 약물 방출을 위한 약물 전달체 |
| JP6905035B2 (ja) | 2019-11-29 | 2021-07-21 | Ｎｉｓｓｈａ株式会社 | 可食性フィルムの製造方法、フィルム製剤及び可食性フィルム |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6309669B1 (en) * | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
| US4720384A (en) * | 1985-05-03 | 1988-01-19 | E. I. Du Pont De Nemours And Company | Manufacture of hollow fine tubular drug delivery systems |
| US4976949A (en) * | 1985-10-25 | 1990-12-11 | The University Of Michigan | Controlled release dosage form |
| US4794001A (en) * | 1986-03-04 | 1988-12-27 | American Home Products Corporation | Formulations providing three distinct releases |
| JPS63203610A (ja) * | 1987-02-12 | 1988-08-23 | ヘキスト・アクチエンゲゼルシヤフト | 複数成分からなるインプラント用の持効性医薬製剤 |
| DE3710175A1 (de) * | 1987-02-12 | 1988-08-25 | Hoechst Ag | Mehrteilige implantierbare arzneizubereitung mit langzeitwirkung |
| US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| US5035891A (en) * | 1987-10-05 | 1991-07-30 | Syntex (U.S.A.) Inc. | Controlled release subcutaneous implant |
| JP2702729B2 (ja) * | 1988-02-24 | 1998-01-26 | エーザイ株式会社 | 徐放性埋込剤 |
| US5702716A (en) * | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| US5178874A (en) * | 1989-06-30 | 1993-01-12 | Smithkline Beechman Corporation | Intermittent release dosage form |
| US5153002A (en) * | 1991-03-04 | 1992-10-06 | University Of Montreal | Biocompatible gradient controlled release implant |
| JP3118009B2 (ja) | 1991-04-16 | 2000-12-18 | 住友製薬株式会社 | 多層構造を有するコラーゲンおよび／またはゼラチン製剤の製造方法 |
| US6013853A (en) * | 1992-02-14 | 2000-01-11 | The University Of Texas System | Continuous release polymeric implant carrier |
| US5876452A (en) * | 1992-02-14 | 1999-03-02 | Board Of Regents, University Of Texas System | Biodegradable implant |
| US5429822A (en) * | 1992-03-13 | 1995-07-04 | Cambridge Scientific, Inc. | Biodegradable bursting release system |
| GB9223144D0 (en) * | 1992-11-05 | 1992-12-16 | Scherer Corp R P | Controlled release device |
| US5456917A (en) * | 1993-04-12 | 1995-10-10 | Cambridge Scientific, Inc. | Method for making a bioerodible material for the sustained release of a medicament and the material made from the method |
| US6447796B1 (en) * | 1994-05-16 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
| US6855331B2 (en) * | 1994-05-16 | 2005-02-15 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
| US5958458A (en) * | 1994-06-15 | 1999-09-28 | Dumex-Alpharma A/S | Pharmaceutical multiple unit particulate formulation in the form of coated cores |
| US6902743B1 (en) * | 1995-05-22 | 2005-06-07 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix |
| US5705191A (en) * | 1995-08-18 | 1998-01-06 | The United States Of America As Represented By The Secretary Of The Navy | Sustained delivery of active compounds from tubules, with rational control |
| JP2002511075A (ja) * | 1997-06-04 | 2002-04-09 | デビオ ルシェルシュ ファルマスティク ソシエテ アノニム | 薬学的活性成分の制御放出のためのインプラント及びその製造方法 |
| JP2001515854A (ja) * | 1997-09-11 | 2001-09-25 | ニュコメデ ダンマルク アクティーゼルスカブ | 非ステロイド性抗炎症薬物質（ＮＳＡＩＤｓ）の改良された開放性多重−単位組成物 |
| US6296831B1 (en) * | 1998-04-10 | 2001-10-02 | Battelle Memorial Institute | Stimulus sensitive gel with radioisotope and methods of making |
| WO2000003660A1 (en) * | 1998-07-17 | 2000-01-27 | Skyepharma, Inc. | Biodegradable compositions for the controlled release of encapsulated substances |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| WO2001007079A1 (en) * | 1999-07-26 | 2001-02-01 | Bomac Laboratories Limited | Improvements in dispensing vaccines |
| US20020131988A1 (en) * | 1999-12-16 | 2002-09-19 | Foster Todd P. | Pharmaceutical implant containing immediate-release and sustained-release components and method of administration |
| IL150657A0 (en) * | 2000-01-20 | 2003-02-12 | Delsys Pharmaceutical Corp | Multi-step drug dosage forms |
| US6479065B2 (en) * | 2000-08-10 | 2002-11-12 | Alkermes Controlled Therapeutics, Inc. | Process for the preparation of polymer-based sustained release compositions |
| US20030055075A1 (en) | 2001-07-13 | 2003-03-20 | Rubsamen Reid M. | Programmable controlled release injectable opioid formulation |
| NZ519363A (en) * | 2002-06-05 | 2004-02-27 | Agres Ltd | A novel drug dosing regimen |
| US7101566B2 (en) | 2002-06-28 | 2006-09-05 | Ethicon, Inc. | Polymer coated microparticles for sustained release |
| US7220433B2 (en) * | 2003-06-27 | 2007-05-22 | Ethicon, Inc. | Compositions for parenteral administration and sustained-release of therapeutic agents |
| US8329203B2 (en) * | 2004-01-12 | 2012-12-11 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
| US8685435B2 (en) * | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
| WO2005107715A1 (en) * | 2004-05-11 | 2005-11-17 | Debio Recherche Pharmaceutique S.A. | Implantable composition |
| AU2005325213B2 (en) * | 2004-08-04 | 2010-10-07 | Evonik Operations Gmbh | Methods for manufacturing delivery devices and devices thereof |
| CN101163464A (zh) * | 2004-12-23 | 2008-04-16 | 杜雷科特公司 | 优选含有PEG和PLG混合物的控制释放GnRH的聚合物植入物 |
| US8969415B2 (en) * | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
-
2010
- 2010-09-16 CN CN201080050895.XA patent/CN102917693B/zh active Active
- 2010-09-16 JP JP2012529897A patent/JP2013505251A/ja active Pending
- 2010-09-16 CA CA2774495A patent/CA2774495C/en active Active
- 2010-09-16 RU RU2012115120/15A patent/RU2012115120A/ru not_active Application Discontinuation
- 2010-09-16 KR KR1020127009806A patent/KR20120102598A/ko not_active Ceased
- 2010-09-16 WO PCT/US2010/049104 patent/WO2011035013A2/en not_active Ceased
- 2010-09-16 BR BR112012006103A patent/BR112012006103B8/pt active IP Right Grant
- 2010-09-16 EP EP10760527A patent/EP2477612A2/en not_active Withdrawn
- 2010-09-16 IN IN2656DEN2012 patent/IN2012DN02656A/en unknown
- 2010-09-16 US US12/883,415 patent/US9399018B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012006103A2 (pt) | 2016-06-07 |
| US9399018B2 (en) | 2016-07-26 |
| BR112012006103B8 (pt) | 2021-05-25 |
| WO2011035013A3 (en) | 2011-12-29 |
| US20110142906A1 (en) | 2011-06-16 |
| BR112012006103A8 (pt) | 2017-10-03 |
| KR20120102598A (ko) | 2012-09-18 |
| EP2477612A2 (en) | 2012-07-25 |
| CA2774495C (en) | 2017-09-26 |
| CN102917693B (zh) | 2015-05-20 |
| IN2012DN02656A (enExample) | 2015-09-11 |
| WO2011035013A2 (en) | 2011-03-24 |
| BR112012006103B1 (pt) | 2020-10-27 |
| CA2774495A1 (en) | 2011-03-24 |
| CN102917693A (zh) | 2013-02-06 |
| JP2013505251A (ja) | 2013-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20160630 |