IN2012DN02656A - - Google Patents

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Publication number
IN2012DN02656A
IN2012DN02656A IN2656DEN2012A IN2012DN02656A IN 2012DN02656 A IN2012DN02656 A IN 2012DN02656A IN 2656DEN2012 A IN2656DEN2012 A IN 2656DEN2012A IN 2012DN02656 A IN2012DN02656 A IN 2012DN02656A
Authority
IN
India
Prior art keywords
implant devices
another aspect
bioactive agent
devices
implant
Prior art date
Application number
Inventor
Bruce W Hudson
Peter Markland
Original Assignee
Evonik Degussa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Degussa Corp filed Critical Evonik Degussa Corp
Publication of IN2012DN02656A publication Critical patent/IN2012DN02656A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Described herein are implant devices, kits comprising the implant devices, and methods of making and using the devices and kits. In one aspect, a plurality implant devices comprises at least two implants that exhibit a different release profile of a bioactive agent. In another aspect, an implant device comprises one or more adjoined polymer bodies, wherein at least two of the polymer bodies provide a different release profile of a bioactive agent. In another aspect, a kit comprises one or more disclosed implant devices. In another aspect, methods of delivering a bioactive agent to a subject comprise administering to the subject one or more disclosed implant devices.
IN2656DEN2012 2009-09-17 2010-09-16 IN2012DN02656A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24330309P 2009-09-17 2009-09-17
PCT/US2010/049104 WO2011035013A2 (en) 2009-09-17 2010-09-16 Implant devices that differ by release profile and methods of making and using same

Publications (1)

Publication Number Publication Date
IN2012DN02656A true IN2012DN02656A (en) 2015-09-11

Family

ID=43218276

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2656DEN2012 IN2012DN02656A (en) 2009-09-17 2010-09-16

Country Status (10)

Country Link
US (1) US9399018B2 (en)
EP (1) EP2477612A2 (en)
JP (1) JP2013505251A (en)
KR (1) KR20120102598A (en)
CN (1) CN102917693B (en)
BR (1) BR112012006103B8 (en)
CA (1) CA2774495C (en)
IN (1) IN2012DN02656A (en)
RU (1) RU2012115120A (en)
WO (1) WO2011035013A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005325213B2 (en) 2004-08-04 2010-10-07 Evonik Corporation Methods for manufacturing delivery devices and devices thereof
CA2775077C (en) * 2009-09-22 2018-05-01 Evonik Degussa Corporation Implant devices having varying bioactive agent loading configurations
US9980850B2 (en) 2016-09-29 2018-05-29 Gesea Biosciences, Inc. Bioerodible contraceptive implant and methods of use thereof
KR102183669B1 (en) * 2019-03-26 2020-11-26 가톨릭대학교 산학협력단 Drug delivery carrier for dual drug release
JP6905035B2 (en) * 2019-11-29 2021-07-21 Ｎｉｓｓｈａ株式会社 Manufacturing method of edible film, film preparation and edible film

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US4720384A (en) 1985-05-03 1988-01-19 E. I. Du Pont De Nemours And Company Manufacture of hollow fine tubular drug delivery systems
US4976949A (en) 1985-10-25 1990-12-11 The University Of Michigan Controlled release dosage form
US4794001A (en) 1986-03-04 1988-12-27 American Home Products Corporation Formulations providing three distinct releases
JPS63203610A (en) * 1987-02-12 1988-08-23 ヘキスト・アクチエンゲゼルシヤフト Long life medicine comprising plural components for implant
DE3710175A1 (en) 1987-02-12 1988-08-25 Hoechst Ag MULTI-PIECE IMPLANTABLE MEDICINE PREPARATION WITH LONG-TERM EFFECT
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
US5035891A (en) 1987-10-05 1991-07-30 Syntex (U.S.A.) Inc. Controlled release subcutaneous implant
JP2702729B2 (en) * 1988-02-24 1998-01-26 エーザイ株式会社 Sustained release implant
US5702716A (en) 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US5178874A (en) 1989-06-30 1993-01-12 Smithkline Beechman Corporation Intermittent release dosage form
US5153002A (en) 1991-03-04 1992-10-06 University Of Montreal Biocompatible gradient controlled release implant
JP3118009B2 (en) 1991-04-16 2000-12-18 住友製薬株式会社 Method for producing collagen and / or gelatin preparation having multilayer structure
US6013853A (en) 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US5429822A (en) 1992-03-13 1995-07-04 Cambridge Scientific, Inc. Biodegradable bursting release system
GB9223144D0 (en) 1992-11-05 1992-12-16 Scherer Corp R P Controlled release device
US5456917A (en) 1993-04-12 1995-10-10 Cambridge Scientific, Inc. Method for making a bioerodible material for the sustained release of a medicament and the material made from the method
US6855331B2 (en) 1994-05-16 2005-02-15 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US6447796B1 (en) 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US5958458A (en) 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
US6902743B1 (en) 1995-05-22 2005-06-07 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
US5705191A (en) 1995-08-18 1998-01-06 The United States Of America As Represented By The Secretary Of The Navy Sustained delivery of active compounds from tubules, with rational control
ATE316779T1 (en) 1997-06-04 2006-02-15 Debio Rech Pharma Sa IMPLANTS FOR THE CONTROLLED RELEASE OF PHARMACEUTICAL ACTIVE INGREDIENTS AND METHOD FOR THE PRODUCTION
EA002806B1 (en) 1997-09-11 2002-10-31 Нюкомед Данмарк А/С Modified release multiple-units compositions of non-steroid anti-inflammatory drug substances (nsaid)
US6296831B1 (en) 1998-04-10 2001-10-02 Battelle Memorial Institute Stimulus sensitive gel with radioisotope and methods of making
NZ509186A (en) 1998-07-17 2005-01-28 Skyepharma Inc Biodegradable compositions for the controlled release of encapsulated substances
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
WO2001007079A1 (en) * 1999-07-26 2001-02-01 Bomac Laboratories Limited Improvements in dispensing vaccines
US20020131988A1 (en) 1999-12-16 2002-09-19 Foster Todd P. Pharmaceutical implant containing immediate-release and sustained-release components and method of administration
US6702803B2 (en) 2000-01-20 2004-03-09 Delsys Pharmaceutical Corporation Multi-step drug dosage forms
US6479065B2 (en) 2000-08-10 2002-11-12 Alkermes Controlled Therapeutics, Inc. Process for the preparation of polymer-based sustained release compositions
US20030055075A1 (en) 2001-07-13 2003-03-20 Rubsamen Reid M. Programmable controlled release injectable opioid formulation
NZ519363A (en) 2002-06-05 2004-02-27 Agres Ltd A novel drug dosing regimen
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US7220433B2 (en) 2003-06-27 2007-05-22 Ethicon, Inc. Compositions for parenteral administration and sustained-release of therapeutic agents
US8329203B2 (en) 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8685435B2 (en) * 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
WO2005107715A1 (en) * 2004-05-11 2005-11-17 Debio Recherche Pharmaceutique S.A. Implantable composition
AU2005325213B2 (en) 2004-08-04 2010-10-07 Evonik Corporation Methods for manufacturing delivery devices and devices thereof
EP1835885A1 (en) * 2004-12-23 2007-09-26 Durect Corporation Polymeric implants, preferably containing a mixture of peg and plg, for controlled release of a gnrh
US8969415B2 (en) * 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems

Also Published As

Publication number Publication date
CN102917693B (en) 2015-05-20
CN102917693A (en) 2013-02-06
BR112012006103B8 (en) 2021-05-25
EP2477612A2 (en) 2012-07-25
CA2774495C (en) 2017-09-26
JP2013505251A (en) 2013-02-14
US20110142906A1 (en) 2011-06-16
US9399018B2 (en) 2016-07-26
BR112012006103A2 (en) 2016-06-07
KR20120102598A (en) 2012-09-18
CA2774495A1 (en) 2011-03-24
RU2012115120A (en) 2013-10-27
BR112012006103B1 (en) 2020-10-27
WO2011035013A2 (en) 2011-03-24
WO2011035013A3 (en) 2011-12-29
BR112012006103A8 (en) 2017-10-03

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