BR112012006103A2 - dispositivos de implante que diferem pelo perfil de liberação e métodos de fabricação e utilização dos mesmos - Google Patents
dispositivos de implante que diferem pelo perfil de liberação e métodos de fabricação e utilização dos mesmosInfo
- Publication number
- BR112012006103A2 BR112012006103A2 BR112012006103A BR112012006103A BR112012006103A2 BR 112012006103 A2 BR112012006103 A2 BR 112012006103A2 BR 112012006103 A BR112012006103 A BR 112012006103A BR 112012006103 A BR112012006103 A BR 112012006103A BR 112012006103 A2 BR112012006103 A2 BR 112012006103A2
- Authority
- BR
- Brazil
- Prior art keywords
- implant devices
- methods
- release profile
- manufacturing
- differ
- Prior art date
Links
- 239000007943 implant Substances 0.000 title abstract 9
- 238000000034 method Methods 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000012867 bioactive agent Substances 0.000 abstract 3
- 229920000642 polymer Polymers 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
dispositivos de implante que diferem pelo perfil de liberação e métodos de fabricação e utilização dos mesmos. a invenção se refere a dispositivos de implante, aos kits que compreendam os dispositivos de implante, e a métodos de fabricação e utilização dos dispositivos e kits. em um aspecto, uma pluralidade de dispositivos de implante compreende, pelo menos, dois implantes que apresentam um perfil de liberação diferente de um agente bioativo. em outro aspecto, o dispositivo de implante compreende um ou mais corpos de polímero unidos em que, pelo menos, dois dos corpos do polímero apresentam um perfil de liberação diferente de um agente bioativo. em outro aspecto, o kit compreende um ou mais dispositivos de implante apresentados. em outro aspecto, os métodos de administração de um agente bioativo em um paciente compreendem a administração no paciente de um ou mais dispositivos de implante apresentados.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24330309P | 2009-09-17 | 2009-09-17 | |
| US61/243,303 | 2009-09-17 | ||
| PCT/US2010/049104 WO2011035013A2 (en) | 2009-09-17 | 2010-09-16 | Implant devices that differ by release profile and methods of making and using same |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BR112012006103A2 true BR112012006103A2 (pt) | 2016-06-07 |
| BR112012006103A8 BR112012006103A8 (pt) | 2017-10-03 |
| BR112012006103B1 BR112012006103B1 (pt) | 2020-10-27 |
| BR112012006103B8 BR112012006103B8 (pt) | 2021-05-25 |
Family
ID=43218276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012006103A BR112012006103B8 (pt) | 2009-09-17 | 2010-09-16 | dispositivo de implante e kit |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9399018B2 (pt) |
| EP (1) | EP2477612A2 (pt) |
| JP (1) | JP2013505251A (pt) |
| KR (1) | KR20120102598A (pt) |
| CN (1) | CN102917693B (pt) |
| BR (1) | BR112012006103B8 (pt) |
| CA (1) | CA2774495C (pt) |
| IN (1) | IN2012DN02656A (pt) |
| RU (1) | RU2012115120A (pt) |
| WO (1) | WO2011035013A2 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006078320A2 (en) | 2004-08-04 | 2006-07-27 | Brookwood Pharmaceuticals, Inc. | Methods for manufacturing delivery devices and devices thereof |
| KR20120107070A (ko) * | 2009-09-22 | 2012-09-28 | 에보닉 데구사 코포레이션 | 다양한 생리활성 물질 로딩 구성을 갖는 임플란트 장치 |
| WO2018064544A1 (en) | 2016-09-29 | 2018-04-05 | Gesea Biosciences Inc. | Bioerodible contraceptive implant and methods of use thereof |
| KR102183669B1 (ko) * | 2019-03-26 | 2020-11-26 | 가톨릭대학교 산학협력단 | 이중 약물 방출을 위한 약물 전달체 |
| JP6905035B2 (ja) * | 2019-11-29 | 2021-07-21 | Ｎｉｓｓｈａ株式会社 | 可食性フィルムの製造方法、フィルム製剤及び可食性フィルム |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6309669B1 (en) * | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
| US4720384A (en) * | 1985-05-03 | 1988-01-19 | E. I. Du Pont De Nemours And Company | Manufacture of hollow fine tubular drug delivery systems |
| US4976949A (en) * | 1985-10-25 | 1990-12-11 | The University Of Michigan | Controlled release dosage form |
| US4794001A (en) * | 1986-03-04 | 1988-12-27 | American Home Products Corporation | Formulations providing three distinct releases |
| JPS63203610A (ja) * | 1987-02-12 | 1988-08-23 | ヘキスト・アクチエンゲゼルシヤフト | 複数成分からなるインプラント用の持効性医薬製剤 |
| DE3710175A1 (de) * | 1987-02-12 | 1988-08-25 | Hoechst Ag | Mehrteilige implantierbare arzneizubereitung mit langzeitwirkung |
| US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| US5035891A (en) * | 1987-10-05 | 1991-07-30 | Syntex (U.S.A.) Inc. | Controlled release subcutaneous implant |
| JP2702729B2 (ja) | 1988-02-24 | 1998-01-26 | エーザイ株式会社 | 徐放性埋込剤 |
| US5702716A (en) * | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| US5178874A (en) * | 1989-06-30 | 1993-01-12 | Smithkline Beechman Corporation | Intermittent release dosage form |
| US5153002A (en) * | 1991-03-04 | 1992-10-06 | University Of Montreal | Biocompatible gradient controlled release implant |
| JP3118009B2 (ja) | 1991-04-16 | 2000-12-18 | 住友製薬株式会社 | 多層構造を有するコラーゲンおよび／またはゼラチン製剤の製造方法 |
| US6013853A (en) * | 1992-02-14 | 2000-01-11 | The University Of Texas System | Continuous release polymeric implant carrier |
| US5876452A (en) * | 1992-02-14 | 1999-03-02 | Board Of Regents, University Of Texas System | Biodegradable implant |
| US5429822A (en) * | 1992-03-13 | 1995-07-04 | Cambridge Scientific, Inc. | Biodegradable bursting release system |
| GB9223144D0 (en) * | 1992-11-05 | 1992-12-16 | Scherer Corp R P | Controlled release device |
| US5456917A (en) * | 1993-04-12 | 1995-10-10 | Cambridge Scientific, Inc. | Method for making a bioerodible material for the sustained release of a medicament and the material made from the method |
| US6447796B1 (en) * | 1994-05-16 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
| US6855331B2 (en) * | 1994-05-16 | 2005-02-15 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
| US5958458A (en) * | 1994-06-15 | 1999-09-28 | Dumex-Alpharma A/S | Pharmaceutical multiple unit particulate formulation in the form of coated cores |
| US6902743B1 (en) * | 1995-05-22 | 2005-06-07 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix |
| US5705191A (en) * | 1995-08-18 | 1998-01-06 | The United States Of America As Represented By The Secretary Of The Navy | Sustained delivery of active compounds from tubules, with rational control |
| CA2291659A1 (fr) * | 1997-06-04 | 1998-12-10 | Debio Recherche Pharmaceutique S.A. | Implants pour la liberation controlee de principes pharmaceutiquement actifs et procede pour leur fabrication |
| JP2001515854A (ja) * | 1997-09-11 | 2001-09-25 | ニュコメデ ダンマルク アクティーゼルスカブ | 非ステロイド性抗炎症薬物質（ＮＳＡＩＤｓ）の改良された開放性多重−単位組成物 |
| US6296831B1 (en) * | 1998-04-10 | 2001-10-02 | Battelle Memorial Institute | Stimulus sensitive gel with radioisotope and methods of making |
| ATE428371T1 (de) * | 1998-07-17 | 2009-05-15 | Pacira Pharmaceuticals Inc | Biologisch abbaubare anordnungen zur kontrollierten freigabe eingeschlossener substanzen |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| WO2001007079A1 (en) * | 1999-07-26 | 2001-02-01 | Bomac Laboratories Limited | Improvements in dispensing vaccines |
| US20020131988A1 (en) * | 1999-12-16 | 2002-09-19 | Foster Todd P. | Pharmaceutical implant containing immediate-release and sustained-release components and method of administration |
| CA2395974A1 (en) * | 2000-01-20 | 2001-07-26 | Suggy S. Chrai | Multi-step drug dosage forms |
| US6479065B2 (en) * | 2000-08-10 | 2002-11-12 | Alkermes Controlled Therapeutics, Inc. | Process for the preparation of polymer-based sustained release compositions |
| US20030055075A1 (en) | 2001-07-13 | 2003-03-20 | Rubsamen Reid M. | Programmable controlled release injectable opioid formulation |
| NZ519363A (en) * | 2002-06-05 | 2004-02-27 | Agres Ltd | A novel drug dosing regimen |
| US7101566B2 (en) | 2002-06-28 | 2006-09-05 | Ethicon, Inc. | Polymer coated microparticles for sustained release |
| US7220433B2 (en) * | 2003-06-27 | 2007-05-22 | Ethicon, Inc. | Compositions for parenteral administration and sustained-release of therapeutic agents |
| US8329203B2 (en) * | 2004-01-12 | 2012-12-11 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
| US8685435B2 (en) * | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
| WO2005107715A1 (en) | 2004-05-11 | 2005-11-17 | Debio Recherche Pharmaceutique S.A. | Implantable composition |
| WO2006078320A2 (en) * | 2004-08-04 | 2006-07-27 | Brookwood Pharmaceuticals, Inc. | Methods for manufacturing delivery devices and devices thereof |
| JP2008525436A (ja) * | 2004-12-23 | 2008-07-17 | デュレクト コーポレーション | 放出制御組成物 |
| US8969415B2 (en) * | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
-
2010
- 2010-09-16 BR BR112012006103A patent/BR112012006103B8/pt active IP Right Grant
- 2010-09-16 RU RU2012115120/15A patent/RU2012115120A/ru not_active Application Discontinuation
- 2010-09-16 CN CN201080050895.XA patent/CN102917693B/zh active Active
- 2010-09-16 JP JP2012529897A patent/JP2013505251A/ja active Pending
- 2010-09-16 WO PCT/US2010/049104 patent/WO2011035013A2/en active Application Filing
- 2010-09-16 EP EP10760527A patent/EP2477612A2/en not_active Withdrawn
- 2010-09-16 CA CA2774495A patent/CA2774495C/en active Active
- 2010-09-16 US US12/883,415 patent/US9399018B2/en active Active
- 2010-09-16 KR KR1020127009806A patent/KR20120102598A/ko not_active Application Discontinuation
- 2010-09-16 IN IN2656DEN2012 patent/IN2012DN02656A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2774495C (en) | 2017-09-26 |
| CN102917693B (zh) | 2015-05-20 |
| WO2011035013A3 (en) | 2011-12-29 |
| BR112012006103B1 (pt) | 2020-10-27 |
| WO2011035013A2 (en) | 2011-03-24 |
| CA2774495A1 (en) | 2011-03-24 |
| IN2012DN02656A (pt) | 2015-09-11 |
| EP2477612A2 (en) | 2012-07-25 |
| US20110142906A1 (en) | 2011-06-16 |
| US9399018B2 (en) | 2016-07-26 |
| BR112012006103A8 (pt) | 2017-10-03 |
| CN102917693A (zh) | 2013-02-06 |
| RU2012115120A (ru) | 2013-10-27 |
| BR112012006103B8 (pt) | 2021-05-25 |
| KR20120102598A (ko) | 2012-09-18 |
| JP2013505251A (ja) | 2013-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: EVONIK CORPORATION (US) |
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| B25K | Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: republication |
Owner name: EVONIK CORPORATION (US) |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 27/10/2020, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/09/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B25G | Requested change of headquarter approved |
Owner name: EVONIK CORPORATION (US) |