JP2017508749A5 - - Google Patents
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- Publication number
- JP2017508749A5 JP2017508749A5 JP2016555554A JP2016555554A JP2017508749A5 JP 2017508749 A5 JP2017508749 A5 JP 2017508749A5 JP 2016555554 A JP2016555554 A JP 2016555554A JP 2016555554 A JP2016555554 A JP 2016555554A JP 2017508749 A5 JP2017508749 A5 JP 2017508749A5
- Authority
- JP
- Japan
- Prior art keywords
- bladder
- gemcitabine
- patient
- day
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 34
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 32
- 229960005277 gemcitabine Drugs 0.000 claims 32
- 229940079593 drug Drugs 0.000 claims 13
- 238000011200 topical administration Methods 0.000 claims 6
- 238000012377 drug delivery Methods 0.000 claims 5
- 210000002700 urine Anatomy 0.000 claims 5
- 230000002459 sustained effect Effects 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 239000002357 osmotic agent Substances 0.000 claims 3
- 239000002562 thickening agent Substances 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 210000005068 bladder tissue Anatomy 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000003232 mucoadhesive effect Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000005086 pumping Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000005063 solubilization Methods 0.000 claims 1
- 230000007928 solubilization Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 210000003708 urethra Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461949215P | 2014-03-06 | 2014-03-06 | |
| US61/949,215 | 2014-03-06 | ||
| PCT/US2015/019262 WO2015134911A1 (en) | 2014-03-06 | 2015-03-06 | Drug delivery systems and methods for treatment of bladder cancer with gemcitabine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019184023A Division JP7061595B2 (ja) | 2014-03-06 | 2019-10-04 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017508749A JP2017508749A (ja) | 2017-03-30 |
| JP2017508749A5 true JP2017508749A5 (enExample) | 2018-03-08 |
| JP6901858B2 JP6901858B2 (ja) | 2021-07-14 |
Family
ID=52697553
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555554A Active JP6901858B2 (ja) | 2014-03-06 | 2015-03-06 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2019184023A Active JP7061595B2 (ja) | 2014-03-06 | 2019-10-04 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2021183995A Active JP7383681B2 (ja) | 2014-03-06 | 2021-11-11 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2023190543A Active JP7802743B2 (ja) | 2014-03-06 | 2023-11-08 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2026001498A Pending JP2026062972A (ja) | 2014-03-06 | 2026-01-07 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019184023A Active JP7061595B2 (ja) | 2014-03-06 | 2019-10-04 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2021183995A Active JP7383681B2 (ja) | 2014-03-06 | 2021-11-11 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2023190543A Active JP7802743B2 (ja) | 2014-03-06 | 2023-11-08 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2026001498A Pending JP2026062972A (ja) | 2014-03-06 | 2026-01-07 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US20150250717A1 (enExample) |
| EP (2) | EP4124339B1 (enExample) |
| JP (5) | JP6901858B2 (enExample) |
| KR (1) | KR102338079B1 (enExample) |
| CN (2) | CN106102751A (enExample) |
| AU (4) | AU2015226901B2 (enExample) |
| BR (1) | BR112016020381A8 (enExample) |
| CA (1) | CA2939979C (enExample) |
| DK (2) | DK4124339T3 (enExample) |
| ES (2) | ES2930435T3 (enExample) |
| FI (1) | FI4124339T3 (enExample) |
| HR (2) | HRP20251264T1 (enExample) |
| HU (1) | HUE060704T2 (enExample) |
| IL (2) | IL247347B2 (enExample) |
| LT (2) | LT4124339T (enExample) |
| MX (1) | MX2016011333A (enExample) |
| PL (2) | PL3113782T3 (enExample) |
| PT (2) | PT4124339T (enExample) |
| RS (2) | RS63675B1 (enExample) |
| RU (1) | RU2694902C1 (enExample) |
| SG (2) | SG10202101978SA (enExample) |
| SI (1) | SI4124339T1 (enExample) |
| SM (2) | SMT202200449T1 (enExample) |
| WO (1) | WO2015134911A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015004110A2 (pt) | 2012-08-31 | 2017-07-04 | Taris Biomedical Llc | sistemas e métodos de distribuição de drogas para tratamento de próstata |
| ES2956840T3 (es) | 2013-08-19 | 2023-12-29 | Taris Biomedical Llc | Dispositivos de administración de fármacos de múltiples unidades |
| US20150250717A1 (en) * | 2014-03-06 | 2015-09-10 | Taris Biomedical Llc | Drug delivery systems and methods for treatment of bladder cancer with gemcitabine |
| SMT202300047T1 (it) * | 2016-05-06 | 2023-03-17 | Taris Biomedical Llc | Metodo di trattamento del cancro uroteliale del tratto inferiore |
| US10857173B2 (en) * | 2017-07-25 | 2020-12-08 | Taris Biomedical Llc | Methods of treating tumor metastasis |
| JOP20200124A1 (ar) | 2017-11-08 | 2020-05-20 | Taris Biomedical Llc | طُرق لعلاج سرطان المثانة باستخدام جيمسيتابين وعلاج مدوامة لذلك |
| KR20210039403A (ko) | 2018-08-01 | 2021-04-09 | 타리스 바이오메디컬 엘엘씨 | 트로스피움을 사용한 과민성 방광의 치료 방법 |
| JP7660066B2 (ja) * | 2019-10-03 | 2025-04-10 | 生化学工業株式会社 | 膀胱の粘膜下組織への医薬品有効成分の経粘膜的送達システム |
| RU2713443C2 (ru) * | 2019-11-01 | 2020-02-05 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Способ комбинированного лечения мышечно-инвазивного рака мочевого пузыря т3-т4 n0-+m0 |
| EP4096686A4 (en) * | 2020-01-27 | 2024-01-10 | Isola Therapeutics, Inc. | TISSUE DOSAGE FOR LOCAL INTRALUMINAL DRUG ADMINISTRATION |
| CN112169066B (zh) * | 2020-10-29 | 2023-05-12 | 安徽省立医院(中国科学技术大学附属第一医院) | 具有控制器的连续缓释给药留置管 |
| CN113616666A (zh) * | 2021-08-24 | 2021-11-09 | 傅广波 | 膀胱黏膜下注射吉西他滨在治疗膀胱癌中的应用 |
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| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4111203A (en) * | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system with means for improving delivery kinetics of system |
| US6171298B1 (en) | 1996-05-03 | 2001-01-09 | Situs Corporation | Intravesical infuser |
| DE60219607T2 (de) | 2001-01-09 | 2007-12-27 | Microchips, Inc., Bedford | Flexible mikrochip-vorrichtungen zur ophthalmologischen und anderen applikation |
| WO2004026281A2 (en) * | 2002-09-23 | 2004-04-01 | Microchips, Inc. | Micro-reservoir osmotic release systems and microtube array device |
| US20040260272A1 (en) | 2002-10-22 | 2004-12-23 | Friedman Craig D. | Method and system for intravesicular delivery of therapeutic agents |
| US7207982B2 (en) * | 2003-03-31 | 2007-04-24 | Alza Corporation | Osmotic pump with means for dissipating internal pressure |
| US8361490B2 (en) | 2004-09-16 | 2013-01-29 | Theracoat Ltd. | Biocompatible drug delivery apparatus and methods |
| JP5265359B2 (ja) | 2005-08-11 | 2013-08-14 | マサチューセッツ インスティテュート オブ テクノロジー | 膀胱内薬物送達デバイスおよび方法 |
| US9539303B2 (en) * | 2006-04-24 | 2017-01-10 | Celgene Corporation | Treatment of Ras-expressing tumors |
| EP1913962A1 (en) | 2006-10-22 | 2008-04-23 | Ophir Perelson | Expandable medical device for the treatment and prevention of cardiovascular diseases |
| US9586035B2 (en) | 2007-12-11 | 2017-03-07 | Massachusetts Institute Of Technology | Implantable drug delivery device and methods for treatment of the bladder and other body vesicles or lumens |
| BRPI0911098A2 (pt) | 2008-04-04 | 2015-10-06 | Lipella Pharmaceuticals Inc | formulação lipossomal e método para tratamento de bexiga hiperativa. |
| WO2010009335A1 (en) | 2008-07-17 | 2010-01-21 | Micell Technologies, Inc. | Drug delivery medical device |
| EA201170297A1 (ru) | 2008-08-09 | 2011-08-30 | Массачусетс Инститьют Оф Текнолоджи | Имплантируемое устройство для доставки лекарственных средств и способ лечения мужской мочеполовой системы и окружающих тканей |
| AU2010265863C1 (en) | 2009-06-26 | 2012-11-01 | Taris Biomedical Llc | Implantable drug delivery devices and methods of making the same |
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| DE212011100034U1 (de) * | 2010-01-20 | 2012-07-04 | Theracoat Ltd. | Material zur Behandlung von inneren Hohlräumen |
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| CN103221042B (zh) | 2010-06-02 | 2016-02-10 | 阿布拉科斯生物科学有限公司 | 治疗膀胱癌的方法 |
| SMT202000670T1 (it) | 2010-08-05 | 2021-01-05 | Taris Biomedical Llc | Dispositivo e kit di somministrazione di farmaci per stent ureterale |
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| SI2890384T1 (sl) | 2012-08-31 | 2022-02-28 | Taris Biomedical Llc | Sistemi za dostavo zdravila in postopki za zdravljenje raka sečnega mehurja, ki obsegajo oksaliplatin |
| BR112015004110A2 (pt) * | 2012-08-31 | 2017-07-04 | Taris Biomedical Llc | sistemas e métodos de distribuição de drogas para tratamento de próstata |
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| HUE072250T2 (hu) | 2013-03-15 | 2025-11-28 | Taris Biomedical Llc | Gyógyszeradagoló eszközök gyógyszeráteresztõ résszel |
| CA2944480C (en) | 2013-04-10 | 2021-05-18 | Massachusetts Institute Of Technology | Local drug delivery devices and methods for treating cancer |
| ES2956840T3 (es) | 2013-08-19 | 2023-12-29 | Taris Biomedical Llc | Dispositivos de administración de fármacos de múltiples unidades |
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| US20150250717A1 (en) | 2014-03-06 | 2015-09-10 | Taris Biomedical Llc | Drug delivery systems and methods for treatment of bladder cancer with gemcitabine |
| RU2591946C2 (ru) | 2014-06-24 | 2016-07-20 | Владимир Эдуардович Анников | Способ изготовления гелеобразного водосодержащего взрывчатого состава |
| US10737078B2 (en) | 2014-06-26 | 2020-08-11 | Taris Biomedical Llc | Intravesical drug delivery devices and methods including elastic polymer-drug matrix systems |
| KR102658706B1 (ko) | 2015-04-23 | 2024-04-17 | 타리스 바이오메디컬 엘엘씨 | 약물-투과성 성분을 구비한 약물 전달 장치 및 방법 |
| SMT202300047T1 (it) | 2016-05-06 | 2023-03-17 | Taris Biomedical Llc | Metodo di trattamento del cancro uroteliale del tratto inferiore |
| US10857173B2 (en) | 2017-07-25 | 2020-12-08 | Taris Biomedical Llc | Methods of treating tumor metastasis |
| JOP20200124A1 (ar) | 2017-11-08 | 2020-05-20 | Taris Biomedical Llc | طُرق لعلاج سرطان المثانة باستخدام جيمسيتابين وعلاج مدوامة لذلك |
| KR20210039403A (ko) | 2018-08-01 | 2021-04-09 | 타리스 바이오메디컬 엘엘씨 | 트로스피움을 사용한 과민성 방광의 치료 방법 |
-
2015
- 2015-03-06 US US14/641,009 patent/US20150250717A1/en not_active Abandoned
- 2015-03-06 LT LTEP22196596.5T patent/LT4124339T/lt unknown
- 2015-03-06 HU HUE15711373A patent/HUE060704T2/hu unknown
- 2015-03-06 PT PT221965965T patent/PT4124339T/pt unknown
- 2015-03-06 CN CN201580011259.9A patent/CN106102751A/zh active Pending
- 2015-03-06 DK DK22196596.5T patent/DK4124339T3/da active
- 2015-03-06 IL IL247347A patent/IL247347B2/en unknown
- 2015-03-06 HR HRP20251264TT patent/HRP20251264T1/hr unknown
- 2015-03-06 SM SM20220449T patent/SMT202200449T1/it unknown
- 2015-03-06 BR BR112016020381A patent/BR112016020381A8/pt not_active Application Discontinuation
- 2015-03-06 RS RS20220937A patent/RS63675B1/sr unknown
- 2015-03-06 HR HRP20221252TT patent/HRP20221252T1/hr unknown
- 2015-03-06 KR KR1020167027303A patent/KR102338079B1/ko active Active
- 2015-03-06 LT LTEPPCT/US2015/019262T patent/LT3113782T/lt unknown
- 2015-03-06 PL PL15711373.9T patent/PL3113782T3/pl unknown
- 2015-03-06 RS RS20251017A patent/RS67337B1/sr unknown
- 2015-03-06 AU AU2015226901A patent/AU2015226901B2/en active Active
- 2015-03-06 CA CA2939979A patent/CA2939979C/en active Active
- 2015-03-06 SM SM20250385T patent/SMT202500385T1/it unknown
- 2015-03-06 MX MX2016011333A patent/MX2016011333A/es unknown
- 2015-03-06 SG SG10202101978SA patent/SG10202101978SA/en unknown
- 2015-03-06 IL IL311410A patent/IL311410B2/en unknown
- 2015-03-06 ES ES15711373T patent/ES2930435T3/es active Active
- 2015-03-06 PL PL22196596.5T patent/PL4124339T3/pl unknown
- 2015-03-06 WO PCT/US2015/019262 patent/WO2015134911A1/en not_active Ceased
- 2015-03-06 EP EP22196596.5A patent/EP4124339B1/en active Active
- 2015-03-06 FI FIEP22196596.5T patent/FI4124339T3/fi active
- 2015-03-06 CN CN202510128139.2A patent/CN119950539A/zh active Pending
- 2015-03-06 EP EP15711373.9A patent/EP3113782B1/en active Active
- 2015-03-06 RU RU2016136103A patent/RU2694902C1/ru active
- 2015-03-06 SG SG11201607342QA patent/SG11201607342QA/en unknown
- 2015-03-06 PT PT157113739T patent/PT3113782T/pt unknown
- 2015-03-06 DK DK15711373.9T patent/DK3113782T3/da active
- 2015-03-06 ES ES22196596T patent/ES3051417T3/es active Active
- 2015-03-06 SI SI201532080T patent/SI4124339T1/sl unknown
- 2015-03-06 JP JP2016555554A patent/JP6901858B2/ja active Active
-
2019
- 2019-10-04 JP JP2019184023A patent/JP7061595B2/ja active Active
-
2020
- 2020-08-12 AU AU2020217383A patent/AU2020217383B2/en active Active
-
2021
- 2021-11-11 JP JP2021183995A patent/JP7383681B2/ja active Active
- 2021-12-23 US US17/561,540 patent/US20220117886A1/en not_active Abandoned
-
2022
- 2022-07-07 US US17/811,296 patent/US12582599B2/en active Active
- 2022-08-08 AU AU2022215156A patent/AU2022215156B2/en active Active
-
2023
- 2023-11-08 JP JP2023190543A patent/JP7802743B2/ja active Active
-
2024
- 2024-11-08 AU AU2024259822A patent/AU2024259822A1/en active Pending
-
2026
- 2026-01-07 JP JP2026001498A patent/JP2026062972A/ja active Pending
- 2026-02-20 US US19/545,868 patent/US20260183226A1/en active Pending
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