JP6901858B2 - 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 - Google Patents

薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 Download PDF

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JP6901858B2
JP6901858B2 JP2016555554A JP2016555554A JP6901858B2 JP 6901858 B2 JP6901858 B2 JP 6901858B2 JP 2016555554 A JP2016555554 A JP 2016555554A JP 2016555554 A JP2016555554 A JP 2016555554A JP 6901858 B2 JP6901858 B2 JP 6901858B2
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gemcitabine
bladder
drug
day
patient
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JP2017508749A (ja
JP2017508749A5 (enExample
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ギーシング，デニス
イ，ヒジン
ダニエル，カレン
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タリス バイオメディカル エルエルシー
タリス バイオメディカル エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nanotechnology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
JP2016555554A 2014-03-06 2015-03-06 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 Active JP6901858B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461949215P 2014-03-06 2014-03-06
US61/949,215 2014-03-06
PCT/US2015/019262 WO2015134911A1 (en) 2014-03-06 2015-03-06 Drug delivery systems and methods for treatment of bladder cancer with gemcitabine

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JP2017508749A JP2017508749A (ja) 2017-03-30
JP2017508749A5 JP2017508749A5 (enExample) 2018-03-08
JP6901858B2 true JP6901858B2 (ja) 2021-07-14

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JP2016555554A Active JP6901858B2 (ja) 2014-03-06 2015-03-06 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法
JP2019184023A Active JP7061595B2 (ja) 2014-03-06 2019-10-04 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法
JP2021183995A Active JP7383681B2 (ja) 2014-03-06 2021-11-11 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法
JP2023190543A Pending JP2024009034A (ja) 2014-03-06 2023-11-08 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法

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JP2019184023A Active JP7061595B2 (ja) 2014-03-06 2019-10-04 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法
JP2021183995A Active JP7383681B2 (ja) 2014-03-06 2021-11-11 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法
JP2023190543A Pending JP2024009034A (ja) 2014-03-06 2023-11-08 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法

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US (3) US20150250717A1 (enExample)
EP (2) EP3113782B1 (enExample)
JP (4) JP6901858B2 (enExample)
KR (1) KR102338079B1 (enExample)
CN (2) CN106102751A (enExample)
AU (4) AU2015226901B2 (enExample)
BR (1) BR112016020381A8 (enExample)
CA (1) CA2939979C (enExample)
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ES (1) ES2930435T3 (enExample)
FI (1) FI4124339T3 (enExample)
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HU (1) HUE060704T2 (enExample)
IL (2) IL247347B2 (enExample)
LT (2) LT3113782T (enExample)
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PL (2) PL3113782T3 (enExample)
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RS (2) RS67337B1 (enExample)
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SG (2) SG11201607342QA (enExample)
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SM (2) SMT202200449T1 (enExample)
WO (1) WO2015134911A1 (enExample)

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KR102383496B1 (ko) 2012-08-31 2022-04-08 타리스 바이오메디컬 엘엘씨 젬시타빈을 포함하는 전립선 질환의 치료를 위한 약물 전달 시스템과 방법
WO2015026813A1 (en) 2013-08-19 2015-02-26 Taris Biomedical Llc Multi-unit drug delivery devices and methods
HRP20251264T1 (hr) * 2014-03-06 2025-12-05 Taris Biomedical Llc Sustavi za primjenu lijeka i metode za liječenje karcinoma mokraćnog mjehura gemcitabinom
ES2940227T3 (es) 2016-05-06 2023-05-04 Taris Biomedical Llc Método de tratamiento del cáncer urotelial del tracto inferior
WO2019023388A1 (en) * 2017-07-25 2019-01-31 Taris Biomedical Llc METHODS OF TREATING TUMOR METASTASIS
PE20210041A1 (es) * 2017-11-08 2021-01-08 Taris Biomedical Llc Metodos de tratamiento y terapia de mantenimiento para el cancer de vejiga con gemcitabina
CA3107461A1 (en) 2018-08-01 2020-02-06 Taris Biomedical Llc Methods of treating overactive bladder using trospium
JP7660066B2 (ja) * 2019-10-03 2025-04-10 生化学工業株式会社 膀胱の粘膜下組織への医薬品有効成分の経粘膜的送達システム
RU2713443C2 (ru) * 2019-11-01 2020-02-05 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) Способ комбинированного лечения мышечно-инвазивного рака мочевого пузыря т3-т4 n0-+m0
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CN112169066B (zh) * 2020-10-29 2023-05-12 安徽省立医院(中国科学技术大学附属第一医院) 具有控制器的连续缓释给药留置管
CN113616666A (zh) * 2021-08-24 2021-11-09 傅广波 膀胱黏膜下注射吉西他滨在治疗膀胱癌中的应用

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EP4124339B1 (en) 2025-09-10
WO2015134911A1 (en) 2015-09-11
CN106102751A (zh) 2016-11-09
RS67337B1 (sr) 2025-11-28
US20150250717A1 (en) 2015-09-10
LT4124339T (lt) 2025-11-10
AU2022215156A1 (en) 2022-09-01
AU2015226901A1 (en) 2016-09-01
JP2019218410A (ja) 2019-12-26
ES2930435T3 (es) 2022-12-13
JP2017508749A (ja) 2017-03-30
US20220347091A1 (en) 2022-11-03
JP2024009034A (ja) 2024-01-19
CA2939979C (en) 2023-03-21
PL4124339T3 (pl) 2025-11-17
KR20160124425A (ko) 2016-10-27
PL3113782T3 (pl) 2023-01-23
IL311410B1 (en) 2025-07-01
DK3113782T3 (da) 2022-10-17
HUE060704T2 (hu) 2023-04-28
PT4124339T (pt) 2025-11-04
SMT202200449T1 (it) 2023-01-13
PT3113782T (pt) 2023-01-05
KR102338079B1 (ko) 2021-12-09
CA2939979A1 (en) 2015-09-11
EP4124339A1 (en) 2023-02-01
EP3113782B1 (en) 2022-09-28
US20220117886A1 (en) 2022-04-21
BR112016020381A8 (pt) 2018-05-02
AU2020217383B2 (en) 2022-09-08
CN119950539A (zh) 2025-05-09
RS63675B1 (sr) 2022-11-30
HRP20251264T1 (hr) 2025-12-05
AU2024259822A1 (en) 2024-11-28
AU2020217383A1 (en) 2020-09-03
IL311410A (en) 2024-05-01
BR112016020381A2 (pt) 2017-08-15
MX2016011333A (es) 2016-12-07
SMT202500385T1 (it) 2025-11-10
JP7383681B2 (ja) 2023-11-20
SI4124339T1 (sl) 2025-11-28
JP2022022235A (ja) 2022-02-03
IL311410B2 (en) 2025-11-01
NZ723303A (en) 2023-10-27
IL247347B2 (en) 2025-03-01
EP3113782A1 (en) 2017-01-11
HRP20221252T1 (hr) 2022-12-09
AU2015226901B2 (en) 2020-05-14
SG10202101978SA (en) 2021-04-29
DK4124339T3 (da) 2025-10-13
IL247347B1 (en) 2024-11-01
FI4124339T3 (fi) 2025-10-17
RU2694902C1 (ru) 2019-07-18
LT3113782T (lt) 2022-11-25
SG11201607342QA (en) 2016-10-28
AU2022215156B2 (en) 2024-09-05
IL247347A0 (en) 2016-11-30
JP7061595B2 (ja) 2022-04-28

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