ES2930435T3 - Sistemas y métodos de administración de fármacos para el tratamiento del cáncer de vejiga con gemcitabina - Google Patents
Sistemas y métodos de administración de fármacos para el tratamiento del cáncer de vejiga con gemcitabina Download PDFInfo
- Publication number
- ES2930435T3 ES2930435T3 ES15711373T ES15711373T ES2930435T3 ES 2930435 T3 ES2930435 T3 ES 2930435T3 ES 15711373 T ES15711373 T ES 15711373T ES 15711373 T ES15711373 T ES 15711373T ES 2930435 T3 ES2930435 T3 ES 2930435T3
- Authority
- ES
- Spain
- Prior art keywords
- gemcitabine
- bladder
- day
- drug
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 title claims abstract description 151
- 229960005277 gemcitabine Drugs 0.000 title claims abstract description 147
- 238000012377 drug delivery Methods 0.000 title claims abstract description 37
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 title claims abstract description 25
- 206010005003 Bladder cancer Diseases 0.000 title claims abstract description 22
- 238000011282 treatment Methods 0.000 title claims abstract description 22
- 201000005112 urinary bladder cancer Diseases 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 title abstract description 13
- 230000002485 urinary effect Effects 0.000 claims abstract description 10
- 210000005068 bladder tissue Anatomy 0.000 claims abstract description 9
- 230000002459 sustained effect Effects 0.000 claims abstract description 7
- 239000003814 drug Substances 0.000 claims description 161
- 229940079593 drug Drugs 0.000 claims description 136
- 230000014759 maintenance of location Effects 0.000 claims description 46
- 210000002700 urine Anatomy 0.000 claims description 26
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 230000001225 therapeutic effect Effects 0.000 claims description 14
- 210000003708 urethra Anatomy 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- 230000002708 enhancing effect Effects 0.000 claims description 6
- 239000002357 osmotic agent Substances 0.000 claims description 6
- 238000002271 resection Methods 0.000 claims description 4
- 241001467552 Mycobacterium bovis BCG Species 0.000 claims description 3
- 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 claims description 3
- 210000003205 muscle Anatomy 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 239000012453 solvate Substances 0.000 claims description 3
- 210000003932 urinary bladder Anatomy 0.000 description 80
- 229920001296 polysiloxane Polymers 0.000 description 20
- 239000003826 tablet Substances 0.000 description 20
- 239000000463 material Substances 0.000 description 18
- 239000007787 solid Substances 0.000 description 16
- 239000011248 coating agent Substances 0.000 description 15
- 238000000576 coating method Methods 0.000 description 15
- 239000000126 substance Substances 0.000 description 14
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 11
- 239000004202 carbamide Substances 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 238000013461 design Methods 0.000 description 10
- 238000009792 diffusion process Methods 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 8
- 229940124597 therapeutic agent Drugs 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 238000001802 infusion Methods 0.000 description 7
- 238000001990 intravenous administration Methods 0.000 description 7
- 244000309715 mini pig Species 0.000 description 7
- 239000004433 Thermoplastic polyurethane Substances 0.000 description 6
- 239000013583 drug formulation Substances 0.000 description 6
- 238000000338 in vitro Methods 0.000 description 6
- 230000009885 systemic effect Effects 0.000 description 6
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 6
- 239000002246 antineoplastic agent Substances 0.000 description 5
- 229940127089 cytotoxic agent Drugs 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 230000003204 osmotic effect Effects 0.000 description 5
- 230000010412 perfusion Effects 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- FIRDBEQIJQERSE-QPPQHZFASA-N 2',2'-Difluorodeoxyuridine Chemical compound FC1(F)[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 FIRDBEQIJQERSE-QPPQHZFASA-N 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 238000002513 implantation Methods 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 230000009545 invasion Effects 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 230000002035 prolonged effect Effects 0.000 description 3
- 210000002307 prostate Anatomy 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- 210000003741 urothelium Anatomy 0.000 description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000009102 absorption Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 210000003484 anatomy Anatomy 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000013270 controlled release Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000013536 elastomeric material Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- 230000003232 mucoadhesive effect Effects 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 230000004118 muscle contraction Effects 0.000 description 2
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 2
- 229910001000 nickel titanium Inorganic materials 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 229920000570 polyether Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 235000012434 pretzels Nutrition 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 239000007916 tablet composition Substances 0.000 description 2
- 229920002725 thermoplastic elastomer Polymers 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 206010051779 Bone marrow toxicity Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 206010016322 Feeling abnormal Diseases 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229920007269 Pebax® MV 1074 SA 01 MED Polymers 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 229920002614 Polyether block amide Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 208000007660 Residual Neoplasm Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000008135 aqueous vehicle Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 231100000366 bone marrow toxicity Toxicity 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 230000000349 chemoimmunotherapeutic effect Effects 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 201000003146 cystitis Diseases 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000009513 drug distribution Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 229920005570 flexible polymer Polymers 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 230000001024 immunotherapeutic effect Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000008185 minitablet Substances 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 150000003230 pyrimidines Chemical class 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000013464 silicone adhesive Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 208000014794 superficial urinary bladder carcinoma Diseases 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 231100000057 systemic toxicity Toxicity 0.000 description 1
- -1 systems Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 206010044412 transitional cell carcinoma Diseases 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 210000002229 urogenital system Anatomy 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Nanotechnology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461949215P | 2014-03-06 | 2014-03-06 | |
| PCT/US2015/019262 WO2015134911A1 (en) | 2014-03-06 | 2015-03-06 | Drug delivery systems and methods for treatment of bladder cancer with gemcitabine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2930435T3 true ES2930435T3 (es) | 2022-12-13 |
Family
ID=52697553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15711373T Active ES2930435T3 (es) | 2014-03-06 | 2015-03-06 | Sistemas y métodos de administración de fármacos para el tratamiento del cáncer de vejiga con gemcitabina |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US20150250717A1 (enExample) |
| EP (2) | EP3113782B1 (enExample) |
| JP (4) | JP6901858B2 (enExample) |
| KR (1) | KR102338079B1 (enExample) |
| CN (2) | CN106102751A (enExample) |
| AU (4) | AU2015226901B2 (enExample) |
| BR (1) | BR112016020381A8 (enExample) |
| CA (1) | CA2939979C (enExample) |
| DK (2) | DK4124339T3 (enExample) |
| ES (1) | ES2930435T3 (enExample) |
| FI (1) | FI4124339T3 (enExample) |
| HR (2) | HRP20251264T1 (enExample) |
| HU (1) | HUE060704T2 (enExample) |
| IL (2) | IL247347B2 (enExample) |
| LT (2) | LT3113782T (enExample) |
| MX (1) | MX2016011333A (enExample) |
| PL (2) | PL3113782T3 (enExample) |
| PT (2) | PT3113782T (enExample) |
| RS (2) | RS67337B1 (enExample) |
| RU (1) | RU2694902C1 (enExample) |
| SG (2) | SG11201607342QA (enExample) |
| SI (1) | SI4124339T1 (enExample) |
| SM (2) | SMT202200449T1 (enExample) |
| WO (1) | WO2015134911A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102383496B1 (ko) | 2012-08-31 | 2022-04-08 | 타리스 바이오메디컬 엘엘씨 | 젬시타빈을 포함하는 전립선 질환의 치료를 위한 약물 전달 시스템과 방법 |
| WO2015026813A1 (en) | 2013-08-19 | 2015-02-26 | Taris Biomedical Llc | Multi-unit drug delivery devices and methods |
| HRP20251264T1 (hr) * | 2014-03-06 | 2025-12-05 | Taris Biomedical Llc | Sustavi za primjenu lijeka i metode za liječenje karcinoma mokraćnog mjehura gemcitabinom |
| ES2940227T3 (es) | 2016-05-06 | 2023-05-04 | Taris Biomedical Llc | Método de tratamiento del cáncer urotelial del tracto inferior |
| WO2019023388A1 (en) * | 2017-07-25 | 2019-01-31 | Taris Biomedical Llc | METHODS OF TREATING TUMOR METASTASIS |
| PE20210041A1 (es) * | 2017-11-08 | 2021-01-08 | Taris Biomedical Llc | Metodos de tratamiento y terapia de mantenimiento para el cancer de vejiga con gemcitabina |
| CA3107461A1 (en) | 2018-08-01 | 2020-02-06 | Taris Biomedical Llc | Methods of treating overactive bladder using trospium |
| JP7660066B2 (ja) * | 2019-10-03 | 2025-04-10 | 生化学工業株式会社 | 膀胱の粘膜下組織への医薬品有効成分の経粘膜的送達システム |
| RU2713443C2 (ru) * | 2019-11-01 | 2020-02-05 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Способ комбинированного лечения мышечно-инвазивного рака мочевого пузыря т3-т4 n0-+m0 |
| US20230073301A1 (en) * | 2020-01-27 | 2023-03-09 | Isola Therapeutics, Inc. | Tissue dosing for intraluminal local drug delivery |
| CN112169066B (zh) * | 2020-10-29 | 2023-05-12 | 安徽省立医院(中国科学技术大学附属第一医院) | 具有控制器的连续缓释给药留置管 |
| CN113616666A (zh) * | 2021-08-24 | 2021-11-09 | 傅广波 | 膀胱黏膜下注射吉西他滨在治疗膀胱癌中的应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4111203A (en) * | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system with means for improving delivery kinetics of system |
| WO2004026281A2 (en) * | 2002-09-23 | 2004-04-01 | Microchips, Inc. | Micro-reservoir osmotic release systems and microtube array device |
| EP1613389B8 (en) * | 2003-03-31 | 2008-05-07 | Intarcia Therapeutics, Inc. | Osmotic pump with means for dissipating internal pressure |
| US8361490B2 (en) * | 2004-09-16 | 2013-01-29 | Theracoat Ltd. | Biocompatible drug delivery apparatus and methods |
| DK1933810T3 (da) | 2005-08-11 | 2013-01-28 | Childrens Medical Center | Intravesikal lægemiddelafgivelsesindretning og fremgangsmåde |
| US20100003297A1 (en) | 2005-08-11 | 2010-01-07 | Massachusetts Institute Of Technology | Implantable Drug Delivery Device and Methods of Treating Male Genitourinary and Surrounding Tissues |
| EP2049139A4 (en) * | 2006-04-24 | 2009-06-24 | Gloucester Pharmaceuticals Inc | TREATMENT OF TUMORS EXPRESSING RAS |
| DK2231254T3 (da) | 2007-12-11 | 2014-07-21 | Massachusetts Inst Technology | Implanterbar lægemiddelafgivelsesindretning |
| US8343516B2 (en) | 2009-06-26 | 2013-01-01 | Taris Biomedical, Inc. | Solid drug tablets for implantable drug delivery devices |
| US9017312B2 (en) | 2009-09-10 | 2015-04-28 | Taris Biomedical Llc | Implantable device for controlled drug delivery |
| US8721621B2 (en) | 2009-09-10 | 2014-05-13 | Taris Biomedical, Inc. | Systems and methods for deploying devices to genitourinary sites |
| US8679094B2 (en) | 2009-12-17 | 2014-03-25 | Taris Biomedical, Inc. | Implantable device with intravesical tolerability and methods of treatment |
| ES2732150T3 (es) * | 2010-01-20 | 2019-11-20 | Urogen Pharma Ltd | Material y método para tratar cavidades internas |
| US20110218488A1 (en) | 2010-03-05 | 2011-09-08 | Taris Biomedical, Inc. | Systems and Methods for Implanting Devices in the Bladder and Other Genitourinary Sites |
| US9457176B2 (en) | 2010-10-06 | 2016-10-04 | Taris Biomedical Llc | Implantable drug delivery device with bladder retention feature |
| US8690840B2 (en) | 2010-10-06 | 2014-04-08 | Taris Biomedical, Inc. | Time-selective bioresorbable or collapsible drug delivery systems and methods |
| WO2012106714A1 (en) * | 2011-02-04 | 2012-08-09 | Taris Biomedical, Inc. | Implantable device for controlled release of low solubility drug |
| KR102383496B1 (ko) * | 2012-08-31 | 2022-04-08 | 타리스 바이오메디컬 엘엘씨 | 젬시타빈을 포함하는 전립선 질환의 치료를 위한 약물 전달 시스템과 방법 |
| EP2968120A1 (en) | 2013-03-15 | 2016-01-20 | TARIS Biomedical LLC | Drug delivery devices and methods for drug delivery |
| SG11201507294WA (en) | 2013-03-15 | 2015-10-29 | Taris Biomedical Llc | Drug delivery devices with drug-permeable component and methods |
| WO2015026813A1 (en) * | 2013-08-19 | 2015-02-26 | Taris Biomedical Llc | Multi-unit drug delivery devices and methods |
| KR20160083061A (ko) * | 2013-11-05 | 2016-07-11 | 타리스 바이오메디컬 엘엘씨 | 삼투 약물 전달 디바이스들, 키트, 및 방법들 |
| HRP20251264T1 (hr) * | 2014-03-06 | 2025-12-05 | Taris Biomedical Llc | Sustavi za primjenu lijeka i metode za liječenje karcinoma mokraćnog mjehura gemcitabinom |
-
2015
- 2015-03-06 HR HRP20251264TT patent/HRP20251264T1/hr unknown
- 2015-03-06 CN CN201580011259.9A patent/CN106102751A/zh active Pending
- 2015-03-06 RU RU2016136103A patent/RU2694902C1/ru active
- 2015-03-06 SG SG11201607342QA patent/SG11201607342QA/en unknown
- 2015-03-06 EP EP15711373.9A patent/EP3113782B1/en active Active
- 2015-03-06 ES ES15711373T patent/ES2930435T3/es active Active
- 2015-03-06 RS RS20251017A patent/RS67337B1/sr unknown
- 2015-03-06 RS RS20220937A patent/RS63675B1/sr unknown
- 2015-03-06 SI SI201532080T patent/SI4124339T1/sl unknown
- 2015-03-06 HR HRP20221252TT patent/HRP20221252T1/hr unknown
- 2015-03-06 BR BR112016020381A patent/BR112016020381A8/pt not_active Application Discontinuation
- 2015-03-06 HU HUE15711373A patent/HUE060704T2/hu unknown
- 2015-03-06 SG SG10202101978SA patent/SG10202101978SA/en unknown
- 2015-03-06 PL PL15711373.9T patent/PL3113782T3/pl unknown
- 2015-03-06 DK DK22196596.5T patent/DK4124339T3/da active
- 2015-03-06 CN CN202510128139.2A patent/CN119950539A/zh active Pending
- 2015-03-06 WO PCT/US2015/019262 patent/WO2015134911A1/en not_active Ceased
- 2015-03-06 SM SM20220449T patent/SMT202200449T1/it unknown
- 2015-03-06 PL PL22196596.5T patent/PL4124339T3/pl unknown
- 2015-03-06 LT LTEPPCT/US2015/019262T patent/LT3113782T/lt unknown
- 2015-03-06 US US14/641,009 patent/US20150250717A1/en not_active Abandoned
- 2015-03-06 PT PT157113739T patent/PT3113782T/pt unknown
- 2015-03-06 PT PT221965965T patent/PT4124339T/pt unknown
- 2015-03-06 IL IL247347A patent/IL247347B2/en unknown
- 2015-03-06 MX MX2016011333A patent/MX2016011333A/es unknown
- 2015-03-06 KR KR1020167027303A patent/KR102338079B1/ko active Active
- 2015-03-06 DK DK15711373.9T patent/DK3113782T3/da active
- 2015-03-06 LT LTEP22196596.5T patent/LT4124339T/lt unknown
- 2015-03-06 FI FIEP22196596.5T patent/FI4124339T3/fi active
- 2015-03-06 JP JP2016555554A patent/JP6901858B2/ja active Active
- 2015-03-06 EP EP22196596.5A patent/EP4124339B1/en active Active
- 2015-03-06 CA CA2939979A patent/CA2939979C/en active Active
- 2015-03-06 SM SM20250385T patent/SMT202500385T1/it unknown
- 2015-03-06 AU AU2015226901A patent/AU2015226901B2/en active Active
-
2019
- 2019-10-04 JP JP2019184023A patent/JP7061595B2/ja active Active
-
2020
- 2020-08-12 AU AU2020217383A patent/AU2020217383B2/en active Active
-
2021
- 2021-11-11 JP JP2021183995A patent/JP7383681B2/ja active Active
- 2021-12-23 US US17/561,540 patent/US20220117886A1/en not_active Abandoned
-
2022
- 2022-07-07 US US17/811,296 patent/US20220347091A1/en active Pending
- 2022-08-08 AU AU2022215156A patent/AU2022215156B2/en active Active
-
2023
- 2023-11-08 JP JP2023190543A patent/JP2024009034A/ja active Pending
-
2024
- 2024-03-11 IL IL311410A patent/IL311410B2/en unknown
- 2024-11-08 AU AU2024259822A patent/AU2024259822A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2930435T3 (es) | Sistemas y métodos de administración de fármacos para el tratamiento del cáncer de vejiga con gemcitabina | |
| US10406335B2 (en) | Drug delivery systems and methods for treatment of prostate | |
| HK40088274A (en) | Drug delivery systems and methods for treatment of bladder cancer with gemcitabine | |
| NZ723303B2 (en) | Drug delivery systems and methods for treatment of bladder cancer with gemcitabine | |
| HK40042011A (en) | Drug delivery systems and methods for treatment of prostate |