CA2939979C - Drug delivery systems and methods for treatment of bladder cancer with gemcitabine - Google Patents

Drug delivery systems and methods for treatment of bladder cancer with gemcitabine Download PDF

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Publication number
CA2939979C
CA2939979C CA2939979A CA2939979A CA2939979C CA 2939979 C CA2939979 C CA 2939979C CA 2939979 A CA2939979 A CA 2939979A CA 2939979 A CA2939979 A CA 2939979A CA 2939979 C CA2939979 C CA 2939979C
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Prior art keywords
gemcitabine
bladder
day
medicament
patient
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Active
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CA2939979A
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English (en)
French (fr)
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CA2939979A1 (en
Inventor
Dennis GIESING
Heejin Lee
Karen Daniel
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Taris Biomedical LLC
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Taris Biomedical LLC
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Application filed by Taris Biomedical LLC filed Critical Taris Biomedical LLC
Publication of CA2939979A1 publication Critical patent/CA2939979A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Anesthesiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CA2939979A 2014-03-06 2015-03-06 Drug delivery systems and methods for treatment of bladder cancer with gemcitabine Active CA2939979C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461949215P 2014-03-06 2014-03-06
US61/949,215 2014-03-06
PCT/US2015/019262 WO2015134911A1 (en) 2014-03-06 2015-03-06 Drug delivery systems and methods for treatment of bladder cancer with gemcitabine

Publications (2)

Publication Number Publication Date
CA2939979A1 CA2939979A1 (en) 2015-09-11
CA2939979C true CA2939979C (en) 2023-03-21

Family

ID=52697553

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2939979A Active CA2939979C (en) 2014-03-06 2015-03-06 Drug delivery systems and methods for treatment of bladder cancer with gemcitabine

Country Status (24)

Country Link
US (4) US20150250717A1 (enExample)
EP (2) EP4124339B1 (enExample)
JP (5) JP6901858B2 (enExample)
KR (1) KR102338079B1 (enExample)
CN (2) CN106102751A (enExample)
AU (4) AU2015226901B2 (enExample)
BR (1) BR112016020381A8 (enExample)
CA (1) CA2939979C (enExample)
DK (2) DK4124339T3 (enExample)
ES (2) ES2930435T3 (enExample)
FI (1) FI4124339T3 (enExample)
HR (2) HRP20251264T1 (enExample)
HU (1) HUE060704T2 (enExample)
IL (2) IL247347B2 (enExample)
LT (2) LT4124339T (enExample)
MX (1) MX2016011333A (enExample)
PL (2) PL3113782T3 (enExample)
PT (2) PT4124339T (enExample)
RS (2) RS63675B1 (enExample)
RU (1) RU2694902C1 (enExample)
SG (2) SG10202101978SA (enExample)
SI (1) SI4124339T1 (enExample)
SM (2) SMT202200449T1 (enExample)
WO (1) WO2015134911A1 (enExample)

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JP7660066B2 (ja) * 2019-10-03 2025-04-10 生化学工業株式会社 膀胱の粘膜下組織への医薬品有効成分の経粘膜的送達システム
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JP7061595B2 (ja) 2022-04-28
PT3113782T (pt) 2023-01-05
AU2024259822A1 (en) 2024-11-28
AU2015226901A1 (en) 2016-09-01
NZ723303A (en) 2023-10-27
US20220117886A1 (en) 2022-04-21
MX2016011333A (es) 2016-12-07
HRP20251264T1 (hr) 2025-12-05
AU2020217383A1 (en) 2020-09-03
US12582599B2 (en) 2026-03-24
IL247347A0 (en) 2016-11-30
CA2939979A1 (en) 2015-09-11
JP2019218410A (ja) 2019-12-26
RU2694902C1 (ru) 2019-07-18
AU2020217383B2 (en) 2022-09-08
KR102338079B1 (ko) 2021-12-09
WO2015134911A1 (en) 2015-09-11
DK3113782T3 (da) 2022-10-17
CN106102751A (zh) 2016-11-09
SG11201607342QA (en) 2016-10-28
IL311410B1 (en) 2025-07-01
SI4124339T1 (sl) 2025-11-28
SMT202500385T1 (it) 2025-11-10
LT4124339T (lt) 2025-11-10
BR112016020381A2 (pt) 2017-08-15
EP4124339A1 (en) 2023-02-01
DK4124339T3 (da) 2025-10-13
ES3051417T3 (en) 2025-12-29
RS63675B1 (sr) 2022-11-30
BR112016020381A8 (pt) 2018-05-02
US20220347091A1 (en) 2022-11-03
IL311410A (en) 2024-05-01
AU2022215156A1 (en) 2022-09-01
JP2026062972A (ja) 2026-04-10
JP7802743B2 (ja) 2026-01-20
LT3113782T (lt) 2022-11-25
US20260183226A1 (en) 2026-07-02
SMT202200449T1 (it) 2023-01-13
KR20160124425A (ko) 2016-10-27
HRP20221252T1 (hr) 2022-12-09
JP7383681B2 (ja) 2023-11-20
IL247347B1 (en) 2024-11-01
JP6901858B2 (ja) 2021-07-14
SG10202101978SA (en) 2021-04-29
PL3113782T3 (pl) 2023-01-23
CN119950539A (zh) 2025-05-09
HUE060704T2 (hu) 2023-04-28
EP3113782B1 (en) 2022-09-28
ES2930435T3 (es) 2022-12-13
FI4124339T3 (fi) 2025-10-17
EP4124339B1 (en) 2025-09-10
IL247347B2 (en) 2025-03-01
JP2017508749A (ja) 2017-03-30
IL311410B2 (en) 2025-11-01
EP3113782A1 (en) 2017-01-11
JP2022022235A (ja) 2022-02-03
RS67337B1 (sr) 2025-11-28
PT4124339T (pt) 2025-11-04
AU2015226901B2 (en) 2020-05-14
US20150250717A1 (en) 2015-09-10
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