RU2012114005A - Усовершенствованный экзотоксин а pseudomonas со сниженной иммуногенностью - Google Patents
Усовершенствованный экзотоксин а pseudomonas со сниженной иммуногенностью Download PDFInfo
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- RU2012114005A RU2012114005A RU2012114005/10A RU2012114005A RU2012114005A RU 2012114005 A RU2012114005 A RU 2012114005A RU 2012114005/10 A RU2012114005/10 A RU 2012114005/10A RU 2012114005 A RU2012114005 A RU 2012114005A RU 2012114005 A RU2012114005 A RU 2012114005A
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- OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 title 1
- 241000589516 Pseudomonas Species 0.000 title 1
- 239000002095 exotoxin Substances 0.000 title 1
- 231100000776 exotoxin Toxicity 0.000 title 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract 28
- 125000000539 amino acid group Chemical group 0.000 claims abstract 28
- 239000004471 Glycine Substances 0.000 claims abstract 14
- 235000004279 alanine Nutrition 0.000 claims abstract 14
- 150000001413 amino acids Chemical group 0.000 claims abstract 14
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims abstract 13
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims abstract 11
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims abstract 9
- 108700033844 Pseudomonas aeruginosa toxA Proteins 0.000 claims abstract 7
- 239000001132 aluminium potassium sulphate Substances 0.000 claims abstract 7
- 239000001194 polyoxyethylene (40) stearate Substances 0.000 claims abstract 7
- 238000006467 substitution reaction Methods 0.000 claims abstract 6
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims abstract 2
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 238000000034 method Methods 0.000 claims 12
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 101100321445 Arabidopsis thaliana ZHD3 gene Proteins 0.000 claims 4
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 4
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 4
- -1 CD79b Proteins 0.000 claims 4
- 102000000905 Cadherin Human genes 0.000 claims 4
- 108050007957 Cadherin Proteins 0.000 claims 4
- 102100032768 Complement receptor type 2 Human genes 0.000 claims 4
- 102000004127 Cytokines Human genes 0.000 claims 4
- 108090000695 Cytokines Proteins 0.000 claims 4
- 102000001301 EGF receptor Human genes 0.000 claims 4
- 108060006698 EGF receptor Proteins 0.000 claims 4
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 4
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 4
- 101000941929 Homo sapiens Complement receptor type 2 Proteins 0.000 claims 4
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 4
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 4
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 4
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 4
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 4
- 102000003735 Mesothelin Human genes 0.000 claims 4
- 108090000015 Mesothelin Proteins 0.000 claims 4
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 4
- 101710160107 Outer membrane protein A Proteins 0.000 claims 4
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 4
- 108010033576 Transferrin Receptors Proteins 0.000 claims 4
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims 4
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 239000003102 growth factor Substances 0.000 claims 4
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24162009P | 2009-09-11 | 2009-09-11 | |
| US61/241,620 | 2009-09-11 | ||
| PCT/US2010/048504 WO2011032022A1 (en) | 2009-09-11 | 2010-09-10 | Improved pseudomonas exotoxin a with reduced immunogenicity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012114005A true RU2012114005A (ru) | 2013-10-20 |
Family
ID=43446435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012114005/10A RU2012114005A (ru) | 2009-09-11 | 2010-09-10 | Усовершенствованный экзотоксин а pseudomonas со сниженной иммуногенностью |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8936792B2 (enExample) |
| EP (1) | EP2475398B1 (enExample) |
| JP (1) | JP5795765B2 (enExample) |
| CN (1) | CN102655882B (enExample) |
| AU (1) | AU2010292069B2 (enExample) |
| CA (1) | CA2773665C (enExample) |
| ES (1) | ES2544805T3 (enExample) |
| RU (1) | RU2012114005A (enExample) |
| WO (1) | WO2011032022A1 (enExample) |
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| US9623117B2 (en) * | 2011-04-04 | 2017-04-18 | Wisconsin Alumni Research Foundation | Method for selective targeting and entry of bacterial toxins to cells |
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| CA2835070C (en) * | 2011-05-06 | 2021-07-06 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Recombinant immunotoxin targeting mesothelin |
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| US8932586B2 (en) | 2011-09-06 | 2015-01-13 | Intrexon Corporation | Modified forms of Pseudomonas exotoxin A |
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2010
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- 2010-09-10 AU AU2010292069A patent/AU2010292069B2/en active Active
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- 2010-09-10 CA CA2773665A patent/CA2773665C/en active Active
- 2010-09-10 RU RU2012114005/10A patent/RU2012114005A/ru not_active Application Discontinuation
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| EP2475398A1 (en) | 2012-07-18 |
| US8936792B2 (en) | 2015-01-20 |
| CN102655882B (zh) | 2014-11-19 |
| CA2773665C (en) | 2018-02-20 |
| JP5795765B2 (ja) | 2015-10-14 |
| CA2773665A1 (en) | 2011-03-17 |
| EP2475398B1 (en) | 2015-05-20 |
| WO2011032022A1 (en) | 2011-03-17 |
| JP2013504328A (ja) | 2013-02-07 |
| CN102655882A (zh) | 2012-09-05 |
| US20120263674A1 (en) | 2012-10-18 |
| AU2010292069A1 (en) | 2012-04-05 |
| ES2544805T3 (es) | 2015-09-04 |
| AU2010292069B2 (en) | 2015-08-13 |
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