JP2013504328A5 - - Google Patents
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- JP2013504328A5 JP2013504328A5 JP2012528940A JP2012528940A JP2013504328A5 JP 2013504328 A5 JP2013504328 A5 JP 2013504328A5 JP 2012528940 A JP2012528940 A JP 2012528940A JP 2012528940 A JP2012528940 A JP 2012528940A JP 2013504328 A5 JP2013504328 A5 JP 2013504328A5
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- JP
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- Prior art keywords
- seq
- antibody
- amino acid
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- acid residues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical group NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 30
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 24
- 125000000539 amino acid group Chemical group 0.000 claims 20
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical group OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 15
- 239000004471 Glycine Chemical group 0.000 claims 15
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Chemical group OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 15
- 235000004279 alanine Nutrition 0.000 claims 15
- 150000007523 nucleic acids Chemical class 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 230000008685 targeting Effects 0.000 claims 12
- 239000001132 aluminium potassium sulphate Substances 0.000 claims 10
- 239000001194 polyoxyethylene (40) stearate Substances 0.000 claims 10
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 9
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 108700033844 Pseudomonas aeruginosa toxA Proteins 0.000 claims 5
- 150000001413 amino acids Chemical group 0.000 claims 5
- 101100321445 Arabidopsis thaliana ZHD3 gene Proteins 0.000 claims 4
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 4
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 4
- -1 CD79b Proteins 0.000 claims 4
- 102000000905 Cadherin Human genes 0.000 claims 4
- 108050007957 Cadherin Proteins 0.000 claims 4
- 102100032768 Complement receptor type 2 Human genes 0.000 claims 4
- 102000004127 Cytokines Human genes 0.000 claims 4
- 108090000695 Cytokines Proteins 0.000 claims 4
- 102000001301 EGF receptor Human genes 0.000 claims 4
- 108060006698 EGF receptor Proteins 0.000 claims 4
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 4
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 4
- 101000941929 Homo sapiens Complement receptor type 2 Proteins 0.000 claims 4
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 4
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 4
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 4
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 4
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 4
- 102000003735 Mesothelin Human genes 0.000 claims 4
- 108090000015 Mesothelin Proteins 0.000 claims 4
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 4
- 101710160107 Outer membrane protein A Proteins 0.000 claims 4
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 4
- 108010033576 Transferrin Receptors Proteins 0.000 claims 4
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims 4
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 4
- 239000003102 growth factor Substances 0.000 claims 4
- 230000010261 cell growth Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24162009P | 2009-09-11 | 2009-09-11 | |
| US61/241,620 | 2009-09-11 | ||
| PCT/US2010/048504 WO2011032022A1 (en) | 2009-09-11 | 2010-09-10 | Improved pseudomonas exotoxin a with reduced immunogenicity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013504328A JP2013504328A (ja) | 2013-02-07 |
| JP2013504328A5 true JP2013504328A5 (enExample) | 2013-10-24 |
| JP5795765B2 JP5795765B2 (ja) | 2015-10-14 |
Family
ID=43446435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528940A Expired - Fee Related JP5795765B2 (ja) | 2009-09-11 | 2010-09-10 | 低減した免疫原性を有する改良型シュードモナス（Ｐｓｅｕｄｏｍｏｎａｓ）外毒素Ａ |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8936792B2 (enExample) |
| EP (1) | EP2475398B1 (enExample) |
| JP (1) | JP5795765B2 (enExample) |
| CN (1) | CN102655882B (enExample) |
| AU (1) | AU2010292069B2 (enExample) |
| CA (1) | CA2773665C (enExample) |
| ES (1) | ES2544805T3 (enExample) |
| RU (1) | RU2012114005A (enExample) |
| WO (1) | WO2011032022A1 (enExample) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2332970B1 (en) * | 2005-07-29 | 2015-12-23 | The Government of the United States of America, as represented by the Secretary of Health and Human Services | Mutated pseudomonas exotoxins with reduced antigenicity |
| US9623117B2 (en) * | 2011-04-04 | 2017-04-18 | Wisconsin Alumni Research Foundation | Method for selective targeting and entry of bacterial toxins to cells |
| EP2998320B1 (en) | 2011-04-19 | 2018-07-18 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Human monoclonal antibodies specific for glypican-3 and use thereof |
| CA2835070C (en) * | 2011-05-06 | 2021-07-06 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Recombinant immunotoxin targeting mesothelin |
| KR20140033391A (ko) * | 2011-06-09 | 2014-03-18 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 면역원성이 보다 낮은 t 세포 및/또는 b 세포 에피토프를 갖는 슈도모나스 외독소 a |
| US8932586B2 (en) | 2011-09-06 | 2015-01-13 | Intrexon Corporation | Modified forms of Pseudomonas exotoxin A |
| WO2013039916A1 (en) | 2011-09-12 | 2013-03-21 | The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services | Compositions for and methods of treatment and enhanced detection of non-pituitary tumors |
| HK1198170A1 (en) | 2011-09-16 | 2015-03-13 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Pseudomonas exotoxin a with less immunogenic b cell epitopes |
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| KR102159773B1 (ko) | 2012-06-01 | 2020-09-28 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 글리피칸-3에 대한 고친화력 단클론 항체 및 이의 용도 |
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| JP2002501488A (ja) | 1997-03-20 | 2002-01-15 | アメリカ合衆国 | Ｃｄ２２を保有する細胞および腫瘍へ標的化された、組換え抗体および免疫複合体 |
| AU7071598A (en) | 1997-04-10 | 1998-10-30 | Erasmus University Rotterdam | Diagnosis method and reagents |
| US6809184B1 (en) | 1997-12-01 | 2004-10-26 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use |
| US6296843B1 (en) | 1998-04-03 | 2001-10-02 | The Penn State Research Foundation | Mutagenized IL 13-based chimeric molecules |
| CA2374398C (en) | 1999-05-27 | 2011-03-15 | Ira Pastan | Immunoconjugates having high binding affinity |
| AU1599301A (en) | 1999-11-11 | 2001-06-06 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Modulating IL-13 activity using mutated IL-13 molecules that are antagonists or agonists of IL-13 |
| WO2002040545A2 (en) | 2000-11-17 | 2002-05-23 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services | Reduction of the nonspecific animal toxicity of immunotoxins by mutating the framework regions of the fv to lower the isoelectric point |
| ES2342929T3 (es) | 2001-09-26 | 2010-07-19 | The Government of the United States of America as represented by the Secretary of Health and Human | Anticuerpos anti-cd22 con afinidad aumentada por las celulas leucemicas que expresan cd22. |
| JP2005508375A (ja) | 2001-11-09 | 2005-03-31 | ネオファーム、インコーポレイティッド | Ｉｌ−１３を発現する腫瘍の選択的治療 |
| AU2003239248A1 (en) | 2002-06-07 | 2003-12-22 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And | Anti-cd30 stalk and anti-cd30 antibodies suitable for use in immunotoxins |
| AU2004293471C1 (en) | 2003-11-25 | 2011-02-24 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services | Mutated anti-CD22 antibodies and immunoconjugates |
| EP2332970B1 (en) | 2005-07-29 | 2015-12-23 | The Government of the United States of America, as represented by the Secretary of Health and Human Services | Mutated pseudomonas exotoxins with reduced antigenicity |
| PT2197903E (pt) * | 2007-09-04 | 2015-01-02 | Us Gov Health & Human Serv | Delecções no domínio ii da exotoxina a de pseudomonas que reduzem toxicidade não específica |
-
2010
- 2010-09-10 WO PCT/US2010/048504 patent/WO2011032022A1/en not_active Ceased
- 2010-09-10 AU AU2010292069A patent/AU2010292069B2/en active Active
- 2010-09-10 ES ES10755283.8T patent/ES2544805T3/es active Active
- 2010-09-10 US US13/395,422 patent/US8936792B2/en active Active
- 2010-09-10 EP EP20100755283 patent/EP2475398B1/en active Active
- 2010-09-10 JP JP2012528940A patent/JP5795765B2/ja not_active Expired - Fee Related
- 2010-09-10 CN CN201080049559.3A patent/CN102655882B/zh not_active Expired - Fee Related
- 2010-09-10 CA CA2773665A patent/CA2773665C/en active Active
- 2010-09-10 RU RU2012114005/10A patent/RU2012114005A/ru not_active Application Discontinuation
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