CN102655882B - 具有降低的免疫原性的改进的假单胞菌外毒素a - Google Patents

具有降低的免疫原性的改进的假单胞菌外毒素a Download PDF

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Publication number
CN102655882B
CN102655882B CN201080049559.3A CN201080049559A CN102655882B CN 102655882 B CN102655882 B CN 102655882B CN 201080049559 A CN201080049559 A CN 201080049559A CN 102655882 B CN102655882 B CN 102655882B
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seq
antibody
amino acid
targeting moiety
pseudomonas exotoxin
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CN102655882A (zh
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艾拉·H·帕斯坦
理查德·比尔斯
恩田正德
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Goverment Of United States, AS REPRESENTED BY SECRETARY D
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201080049559.3A 2009-09-11 2010-09-10 具有降低的免疫原性的改进的假单胞菌外毒素a Expired - Fee Related CN102655882B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24162009P 2009-09-11 2009-09-11
US61/241,620 2009-09-11
PCT/US2010/048504 WO2011032022A1 (en) 2009-09-11 2010-09-10 Improved pseudomonas exotoxin a with reduced immunogenicity

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CN102655882A CN102655882A (zh) 2012-09-05
CN102655882B true CN102655882B (zh) 2014-11-19

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US (1) US8936792B2 (enExample)
EP (1) EP2475398B1 (enExample)
JP (1) JP5795765B2 (enExample)
CN (1) CN102655882B (enExample)
AU (1) AU2010292069B2 (enExample)
CA (1) CA2773665C (enExample)
ES (1) ES2544805T3 (enExample)
RU (1) RU2012114005A (enExample)
WO (1) WO2011032022A1 (enExample)

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US8936792B2 (en) 2015-01-20
CA2773665C (en) 2018-02-20
JP5795765B2 (ja) 2015-10-14
CA2773665A1 (en) 2011-03-17
EP2475398B1 (en) 2015-05-20
WO2011032022A1 (en) 2011-03-17
JP2013504328A (ja) 2013-02-07
CN102655882A (zh) 2012-09-05
US20120263674A1 (en) 2012-10-18
AU2010292069A1 (en) 2012-04-05
ES2544805T3 (es) 2015-09-04
RU2012114005A (ru) 2013-10-20
AU2010292069B2 (en) 2015-08-13

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