RU2012103753A - Способ синтеза (2s, 3ar, 7as)-октагидро-1н-индол-карбоновой кислоты в качестве промежуточного соединения для получения трандолаприла - Google Patents

Способ синтеза (2s, 3ar, 7as)-октагидро-1н-индол-карбоновой кислоты в качестве промежуточного соединения для получения трандолаприла Download PDF

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Publication number
RU2012103753A
RU2012103753A RU2012103753/04A RU2012103753A RU2012103753A RU 2012103753 A RU2012103753 A RU 2012103753A RU 2012103753/04 A RU2012103753/04 A RU 2012103753/04A RU 2012103753 A RU2012103753 A RU 2012103753A RU 2012103753 A RU2012103753 A RU 2012103753A
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RU
Russia
Prior art keywords
ethyl
phenylethylamino
compound
formula
indole
Prior art date
Application number
RU2012103753/04A
Other languages
English (en)
Russian (ru)
Inventor
Санджай Р. Чембуркар
Раджаратнам И. РЕДДИ
Дуглас М. РИМЕР
Джон Т. ПАВЛИНА
Стефен С. УЛРЕЙ
Брайен Дж. КОТЕЦКИ
Original Assignee
Эбботт Лабораториз
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эбботт Лабораториз filed Critical Эбботт Лабораториз
Publication of RU2012103753A publication Critical patent/RU2012103753A/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2012103753/04A 2009-07-16 2010-07-16 Способ синтеза (2s, 3ar, 7as)-октагидро-1н-индол-карбоновой кислоты в качестве промежуточного соединения для получения трандолаприла RU2012103753A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22603009P 2009-07-16 2009-07-16
US61/226,030 2009-07-16
PCT/US2010/042219 WO2011009021A1 (en) 2009-07-16 2010-07-16 Processes for the synthesis of (2s, 3ar, 7as)-octahydro-1h-indole carboxylic acid as an intermediate for trandolapril

Publications (1)

Publication Number Publication Date
RU2012103753A true RU2012103753A (ru) 2013-08-27

Family

ID=42585097

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2012103753/04A RU2012103753A (ru) 2009-07-16 2010-07-16 Способ синтеза (2s, 3ar, 7as)-октагидро-1н-индол-карбоновой кислоты в качестве промежуточного соединения для получения трандолаприла

Country Status (10)

Country Link
US (1) US8288565B2 (enExample)
EP (1) EP2454235A1 (enExample)
JP (1) JP2012533563A (enExample)
CN (1) CN102498098A (enExample)
AU (1) AU2010273259B2 (enExample)
CA (1) CA2768239A1 (enExample)
CO (1) CO6491043A2 (enExample)
IN (1) IN2012DN00453A (enExample)
RU (1) RU2012103753A (enExample)
WO (1) WO2011009021A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111620788B (zh) * 2020-04-20 2022-09-30 广东莱佛士制药技术有限公司 一种制备(2s,3s)-3-氨基-二环[2.2.2]辛烷-2-甲酸酯的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US487932A (en) 1892-12-13 George b
US4350704A (en) 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
GR78413B (enExample) * 1981-12-29 1984-09-27 Hoechst Ag
US4490386A (en) 1982-09-23 1984-12-25 Warner-Lambert Company Phosphate salts of 1-[2-[(1-alkoxycarbonyl-3-aralkyl)-amino]-1-oxoalkyl]octahydro-1H-indole-2-carboxylic acids, preparation of, and medical compositions thereof
US4556655A (en) 1984-09-24 1985-12-03 Schering Corporation Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activity
FR2605630B1 (fr) 1986-10-22 1989-06-30 Roussel Uclaf Procede de preparation de derives de l'octahydroindole et intermediaires de preparation
DE19900205A1 (de) 1999-01-07 2000-07-13 Basf Ag Verfahren zur Herstellung von (2S,4R,9S)-Octahydro-1H-indol-2-carbonsäure und Zwischenprodukte dafür
JPWO2004065368A1 (ja) 2003-01-21 2006-05-18 大原薬品工業株式会社 トランドラプリル合成中間体の製造方法
DK1354874T3 (da) * 2003-04-15 2005-03-14 Servier Lab Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og estere heraf og anvendelse heraf ved syntese af perindopril
SI21507A (sl) 2003-05-16 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo spojin z ace inhibitornim delovanjem
US20070225505A1 (en) * 2003-11-25 2007-09-27 Pau Cid Method for the Preparation of (2S, 3AR, 7AS)-Octahydro-III-Indole-2-Carboxylic Acid as Key Intermediate in the Preparation of Trandolapril by Reacting a Cyclohexyl Aziridine with a Dialkyl Malonate
WO2005051909A1 (de) 2003-11-28 2005-06-09 Azad Pharmaceuticals Ingredients Ag Verfahren zur herstellung von {n-[1-(s)-carbalkoxy-3-phenylpropyl]-s-alanyl-2s, 3ar, 7as-octahydroindol-2-carbonsäure}verbindungen
WO2006014916A2 (en) 2004-07-26 2006-02-09 Dr. Reddy's Laboratories Ltd. Preparation of trandolapril
US20080171885A1 (en) 2005-02-14 2008-07-17 Lupin Limited Process for Preparation of Highly Pure Trandolapril
DE602005004897D1 (de) 2005-05-06 2008-04-03 Sochinaz Sa Verfahren zur Herstellung von i(2S, 3aR, 7aS)-octahydroindole-2-Carbonsäure und Umwandlung zum Trandolapril
WO2007003947A2 (en) 2005-07-05 2007-01-11 Cipla Limited Process for the synthesis of the ace inhibitor trandolapril
CN101808990B (zh) 2007-07-24 2012-09-05 百时美施贵宝公司 作为趋化因子受体活性调节剂的哌啶衍生物
CN101423490B (zh) * 2008-06-16 2012-07-18 重庆南松医药科技股份有限公司 群多普利关键中间体（2S,3aR,7as）-八氢－1H－吲哚－2－羧酸的合成方法

Also Published As

Publication number Publication date
EP2454235A1 (en) 2012-05-23
CO6491043A2 (es) 2012-07-31
WO2011009021A1 (en) 2011-01-20
US20110065930A1 (en) 2011-03-17
US8288565B2 (en) 2012-10-16
IN2012DN00453A (enExample) 2015-05-15
AU2010273259B2 (en) 2013-03-07
JP2012533563A (ja) 2012-12-27
CA2768239A1 (en) 2011-01-20
AU2010273259A1 (en) 2012-02-09
CN102498098A (zh) 2012-06-13

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Effective date: 20140901