IN2012DN00453A - - Google Patents
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- Publication number
- IN2012DN00453A IN2012DN00453A IN453DEN2012A IN2012DN00453A IN 2012DN00453 A IN2012DN00453 A IN 2012DN00453A IN 453DEN2012 A IN453DEN2012 A IN 453DEN2012A IN 2012DN00453 A IN2012DN00453 A IN 2012DN00453A
- Authority
- IN
- India
- Prior art keywords
- octahydro
- indole
- preparation
- acid hydrochloride
- hydrochloride
- Prior art date
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22603009P | 2009-07-16 | 2009-07-16 | |
| PCT/US2010/042219 WO2011009021A1 (en) | 2009-07-16 | 2010-07-16 | Processes for the synthesis of (2s, 3ar, 7as)-octahydro-1h-indole carboxylic acid as an intermediate for trandolapril |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN00453A true IN2012DN00453A (enExample) | 2015-05-15 |
Family
ID=42585097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN453DEN2012 IN2012DN00453A (enExample) | 2009-07-16 | 2010-07-16 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8288565B2 (enExample) |
| EP (1) | EP2454235A1 (enExample) |
| JP (1) | JP2012533563A (enExample) |
| CN (1) | CN102498098A (enExample) |
| AU (1) | AU2010273259B2 (enExample) |
| CA (1) | CA2768239A1 (enExample) |
| CO (1) | CO6491043A2 (enExample) |
| IN (1) | IN2012DN00453A (enExample) |
| RU (1) | RU2012103753A (enExample) |
| WO (1) | WO2011009021A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111620788B (zh) * | 2020-04-20 | 2022-09-30 | 广东莱佛士制药技术有限公司 | 一种制备(2s,3s)-3-氨基-二环[2.2.2]辛烷-2-甲酸酯的方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US487932A (en) | 1892-12-13 | George b | ||
| US4350704A (en) | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
| GR78413B (enExample) * | 1981-12-29 | 1984-09-27 | Hoechst Ag | |
| US4490386A (en) | 1982-09-23 | 1984-12-25 | Warner-Lambert Company | Phosphate salts of 1-[2-[(1-alkoxycarbonyl-3-aralkyl)-amino]-1-oxoalkyl]octahydro-1H-indole-2-carboxylic acids, preparation of, and medical compositions thereof |
| US4556655A (en) | 1984-09-24 | 1985-12-03 | Schering Corporation | Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activity |
| FR2605630B1 (fr) | 1986-10-22 | 1989-06-30 | Roussel Uclaf | Procede de preparation de derives de l'octahydroindole et intermediaires de preparation |
| DE19900205A1 (de) | 1999-01-07 | 2000-07-13 | Basf Ag | Verfahren zur Herstellung von (2S,4R,9S)-Octahydro-1H-indol-2-carbonsäure und Zwischenprodukte dafür |
| JPWO2004065368A1 (ja) | 2003-01-21 | 2006-05-18 | 大原薬品工業株式会社 | トランドラプリル合成中間体の製造方法 |
| DK1354874T3 (da) * | 2003-04-15 | 2005-03-14 | Servier Lab | Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og estere heraf og anvendelse heraf ved syntese af perindopril |
| SI21507A (sl) | 2003-05-16 | 2004-12-31 | LEK farmacevtska dru�ba d.d. | Postopek za pripravo spojin z ace inhibitornim delovanjem |
| US20070225505A1 (en) * | 2003-11-25 | 2007-09-27 | Pau Cid | Method for the Preparation of (2S, 3AR, 7AS)-Octahydro-III-Indole-2-Carboxylic Acid as Key Intermediate in the Preparation of Trandolapril by Reacting a Cyclohexyl Aziridine with a Dialkyl Malonate |
| WO2005051909A1 (de) | 2003-11-28 | 2005-06-09 | Azad Pharmaceuticals Ingredients Ag | Verfahren zur herstellung von {n-[1-(s)-carbalkoxy-3-phenylpropyl]-s-alanyl-2s, 3ar, 7as-octahydroindol-2-carbonsäure}verbindungen |
| WO2006014916A2 (en) | 2004-07-26 | 2006-02-09 | Dr. Reddy's Laboratories Ltd. | Preparation of trandolapril |
| US20080171885A1 (en) | 2005-02-14 | 2008-07-17 | Lupin Limited | Process for Preparation of Highly Pure Trandolapril |
| DE602005004897D1 (de) | 2005-05-06 | 2008-04-03 | Sochinaz Sa | Verfahren zur Herstellung von i(2S, 3aR, 7aS)-octahydroindole-2-Carbonsäure und Umwandlung zum Trandolapril |
| WO2007003947A2 (en) | 2005-07-05 | 2007-01-11 | Cipla Limited | Process for the synthesis of the ace inhibitor trandolapril |
| CN101808990B (zh) | 2007-07-24 | 2012-09-05 | 百时美施贵宝公司 | 作为趋化因子受体活性调节剂的哌啶衍生物 |
| CN101423490B (zh) * | 2008-06-16 | 2012-07-18 | 重庆南松医药科技股份有限公司 | 群多普利关键中间体（2S,3aR,7as）-八氢－1H－吲哚－2－羧酸的合成方法 |
-
2010
- 2010-07-16 IN IN453DEN2012 patent/IN2012DN00453A/en unknown
- 2010-07-16 CN CN2010800413803A patent/CN102498098A/zh active Pending
- 2010-07-16 CA CA2768239A patent/CA2768239A1/en not_active Abandoned
- 2010-07-16 RU RU2012103753/04A patent/RU2012103753A/ru not_active Application Discontinuation
- 2010-07-16 WO PCT/US2010/042219 patent/WO2011009021A1/en not_active Ceased
- 2010-07-16 US US12/837,686 patent/US8288565B2/en not_active Expired - Fee Related
- 2010-07-16 AU AU2010273259A patent/AU2010273259B2/en not_active Ceased
- 2010-07-16 JP JP2012520807A patent/JP2012533563A/ja active Pending
- 2010-07-16 EP EP10737165A patent/EP2454235A1/en not_active Withdrawn
-
2012
- 2012-01-16 CO CO12005568A patent/CO6491043A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP2454235A1 (en) | 2012-05-23 |
| CO6491043A2 (es) | 2012-07-31 |
| RU2012103753A (ru) | 2013-08-27 |
| WO2011009021A1 (en) | 2011-01-20 |
| US20110065930A1 (en) | 2011-03-17 |
| US8288565B2 (en) | 2012-10-16 |
| AU2010273259B2 (en) | 2013-03-07 |
| JP2012533563A (ja) | 2012-12-27 |
| CA2768239A1 (en) | 2011-01-20 |
| AU2010273259A1 (en) | 2012-02-09 |
| CN102498098A (zh) | 2012-06-13 |
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