IN2012DN00453A - - Google Patents

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Publication number
IN2012DN00453A
IN2012DN00453A IN453DEN2012A IN2012DN00453A IN 2012DN00453 A IN2012DN00453 A IN 2012DN00453A IN 453DEN2012 A IN453DEN2012 A IN 453DEN2012A IN 2012DN00453 A IN2012DN00453 A IN 2012DN00453A
Authority
IN
India
Prior art keywords
octahydro
indole
preparation
acid hydrochloride
hydrochloride
Prior art date
Application number
Inventor
R Chemburkar Sanjay
E Reddy Rajarathnam
M Reamer Douglas
T Pavlina John
S Ulrey Stephen
J Kotecki Brian
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of IN2012DN00453A publication Critical patent/IN2012DN00453A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for the preparation of (2S, 3aR, 7aS)-octahydro-1H-indole-20carboxylic acid hydrochloride.
IN453DEN2012 2009-07-16 2010-07-16 IN2012DN00453A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22603009P 2009-07-16 2009-07-16
PCT/US2010/042219 WO2011009021A1 (en) 2009-07-16 2010-07-16 Processes for the synthesis of (2s, 3ar, 7as)-octahydro-1h-indole carboxylic acid as an intermediate for trandolapril

Publications (1)

Publication Number Publication Date
IN2012DN00453A true IN2012DN00453A (en) 2015-05-15

Family

ID=42585097

Family Applications (1)

Application Number Title Priority Date Filing Date
IN453DEN2012 IN2012DN00453A (en) 2009-07-16 2010-07-16

Country Status (10)

Country Link
US (1) US8288565B2 (en)
EP (1) EP2454235A1 (en)
JP (1) JP2012533563A (en)
CN (1) CN102498098A (en)
AU (1) AU2010273259B2 (en)
CA (1) CA2768239A1 (en)
CO (1) CO6491043A2 (en)
IN (1) IN2012DN00453A (en)
RU (1) RU2012103753A (en)
WO (1) WO2011009021A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111620788B (en) * 2020-04-20 2022-09-30 广东莱佛士制药技术有限公司 Method for preparing (2S,3S) -3-amino-bicyclo [2.2.2] octane-2-formic ether

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US487932A (en) 1892-12-13 George b
US4350704A (en) 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
US4490386A (en) 1982-09-23 1984-12-25 Warner-Lambert Company Phosphate salts of 1-[2-[(1-alkoxycarbonyl-3-aralkyl)-amino]-1-oxoalkyl]octahydro-1H-indole-2-carboxylic acids, preparation of, and medical compositions thereof
US4556655A (en) 1984-09-24 1985-12-03 Schering Corporation Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activity
FR2605630B1 (en) 1986-10-22 1989-06-30 Roussel Uclaf PROCESS FOR THE PREPARATION OF OCTAHYDROINDOLE DERIVATIVES AND PREPARATION INTERMEDIATES
DE19900205A1 (en) 1999-01-07 2000-07-13 Basf Ag Process for the preparation of (2S, 4R, 9S) -octahydro-1H-indole-2-carboxylic acid and intermediates therefor
WO2004065368A1 (en) 2003-01-21 2004-08-05 Ohara Chemical Industries, Ltd. Process for producing intermediate for trandolapril
PT1354874E (en) * 2003-04-15 2005-03-31 Servier Lab NEW SYNTHESIS PROCESS OF (2S, 3S, 7S) -PERHYDROINDOLE-2-CARBOXYLIC ACID AND ITS ESTERS AND APPLY THE SYNTHESIS OF THE PERINDOPRIL PROCESS
SI21507A (en) 2003-05-16 2004-12-31 LEK farmacevtska dru�ba d.d. Procedure of preparation of compounds with ace inhibition effect
WO2005054194A1 (en) * 2003-11-25 2005-06-16 Texcontor Etablissement A method for the preparation of (2s, 3ar, 7as)-octahydro-1h-indole-2-carboxylic acid as key intermediate in the preparation of trandolapril by reacting a cyclohexyl aziridine with a dialkyl malonate
WO2005051909A1 (en) 2003-11-28 2005-06-09 Azad Pharmaceuticals Ingredients Ag Method for producing {n-[1-(s)-carbalkoxy-3-phenylpropyl]-s-alanyl-2s, 3ar, 7as-octahydroindol-2-carboxylic acid} compounds
WO2006014916A2 (en) 2004-07-26 2006-02-09 Dr. Reddy's Laboratories Ltd. Preparation of trandolapril
AU2005327440A1 (en) 2005-02-14 2006-08-17 Lupin Limited Improved process for preparation of highly pure trandolapril
EP1724260B1 (en) 2005-05-06 2008-02-20 Sochinaz SA Process for the synthesis of (2S, 3aR, 7aS)octahydroindole-2-carboxylic acid and its conversion to trandolapril
US7973173B2 (en) 2005-07-05 2011-07-05 Cipla Limited Process for the synthesis of an ACE inhibitor
WO2009015166A1 (en) 2007-07-24 2009-01-29 Bristol-Myers Squibb Company Piperidine derivatives as modulators of chemokine receptor activity
CN101423490B (en) * 2008-06-16 2012-07-18 重庆南松医药科技股份有限公司 Synthetic method of trandolapril key intermediate (2S,3aR,7as)-octahydro-1H-indole-2-carboxylic acid

Also Published As

Publication number Publication date
US20110065930A1 (en) 2011-03-17
JP2012533563A (en) 2012-12-27
US8288565B2 (en) 2012-10-16
WO2011009021A1 (en) 2011-01-20
RU2012103753A (en) 2013-08-27
CA2768239A1 (en) 2011-01-20
AU2010273259A1 (en) 2012-02-09
CO6491043A2 (en) 2012-07-31
CN102498098A (en) 2012-06-13
AU2010273259B2 (en) 2013-03-07
EP2454235A1 (en) 2012-05-23

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